Cancers, Vol. 11, Pages 1324: Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients Cancers doi: 10.3390/cancers11091324 Authors: Balázs Kis Badie Bogdándi Candéias Garcia Dominczyk Frey Gaipl Jurányi Kocsis Rutten Sáfrány Widlak Lumniczky Though radiotherapy is a local therapy, it has systemic effects mainly influencing immune and inflammation processes. This has important...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1319: Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma Cancers doi: 10.3390/cancers11091319 Authors: Hendriksma Ruler Verbist Jong Langeveld Benthem Sjögren Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1318: PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition Cancers doi: 10.3390/cancers11091318 Authors: Cretella Digiacomo Giovannetti Cavazzoni The recent approval of immune checkpoint inhibitors drastically changed the standard treatments in many advanced cancer patients, but molecular changes within the tumor can prevent the activity of immunotherapy drugs. Thus, the introduction of the inhibitors of the immune...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1321: Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research Cancers doi: 10.3390/cancers11091321 Authors: Inoue Deem Kopetz Heffernan Draetta Carugo Our poor understanding of the intricate biology of cancer and the limited availability of preclinical models that faithfully recapitulate the complexity of tumors are primary contributors to the high failure rate of novel therapeutics in oncology...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1317: Real-World Outcomes and Prognostic Factors in Patients Receiving Nivolumab Therapy for Recurrent or Metastatic Head and Neck Carcinoma Cancers doi: 10.3390/cancers11091317 Authors: Ryusuke Hori Shogo Shinohara Tsuyoshi Kojima Hiroki Kagoshima Morimasa Kitamura Ichiro Tateya Hisanobu Tamaki Yohei Kumabe Ryo Asato Hiroyuki Harada Yoshiharu Kitani Takashi Tsujimura Keigo Honda Kazuyuki Ichimaru Koichi Omori Recently,...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1316: Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors
Cancers, Vol. 11, Pages 1316: Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors Cancers doi: 10.3390/cancers11091316 Authors: Violeta Bakardjieva-Mihaylova Karolina Skvarova Kramarzova Martina Slamova Michael Svaton Katerina Rejlova Marketa Zaliova Alena Dobiasova Karel Fiser Jan Stuchly Marek Grega Blanka Rosova Roman Zachoval Petr Klezl Vaclav Eis Eva Kindlova Tomas Buchler Jan Trka Ludmila Boublikova The emergence...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1315: TREM2 Acts as a Tumor Suppressor in Colorectal Carcinoma through Wnt1/β-catenin and Erk Signaling Cancers doi: 10.3390/cancers11091315 Authors: Su-Man Kim Eun-Mi Kim Kon-Young Ji Hwa-Youn Lee Su-Min Yee Su-Min Woo Ja-Woon Yi Chul-Ho Yun Harim Choi Hyung-Sik Kang TREM2 (triggering receptor expressed on myeloid cells) is involved in the development of malignancies. However, the function of TREM2 in colorectal cancer has not been...
Fri Sep 06, 2019 03:00
Cancers, Vol. 11, Pages 1314: Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy Cancers doi: 10.3390/cancers11091314 Authors: Yingxuan Zhang Zheyan Fang Ruizhen Li Xiaotian Huang Qiong Liu Cancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and Talimogene...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1055: The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer Cells doi: 10.3390/cells8091055 Authors: Yang Wu Yen Liu Hwang Stern Chiu The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells...
Sun Sep 08, 2019 03:00
Cells, Vol. 8, Pages 1054: Identification of Transcriptional Markers and microRNA–mRNA Regulatory Networks in Colon Cancer by Integrative Analysis of mRNA and microRNA Expression Profiles in Colon Tumor Stroma Cells doi: 10.3390/cells8091054 Authors: Md. Nazim Uddin Mengyuan Li Xiaosheng Wang The aberrant expression of microRNAs (miRNAs) and genes in tumor microenvironment (TME) has been associated with the pathogenesis of colon cancer. An integrative exploration of transcriptional...
Sun Sep 08, 2019 03:00
Cells, Vol. 8, Pages 1053: Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy Cells doi: 10.3390/cells8091053 Authors: Alessandra Stacchiotti Ilaria Grossi Raquel García-Gómez Gaurangkumar Arvindbhai Patel Alessandro Salvi Antonio Lavazza Giuseppina De Petro Maria Monsalve Rita Rezzani Melatonin, an indole produced by pineal and extrapineal tissues, but also taken with a vegetarian diet, has strong anti-oxidant,...
Sun Sep 08, 2019 03:00
Cells, Vol. 8, Pages 1052: Cyclosporin A Increases Mitochondrial Buffering of Calcium: An Additional Mechanism in Delaying Mitochondrial Permeability Transition Pore Opening Cells doi: 10.3390/cells8091052 Authors: Jyotsna Mishra Ariea J. Davani Gayathri K. Natarajan Wai-Meng Kwok David F. Stowe Amadou K.S. Camara Regulation of mitochondrial free Ca2+ is critically important for cellular homeostasis. An increase in mitochondrial matrix free Ca2+ concentration ([Ca2+]m)...
Sat Sep 07, 2019 03:00
Cells, Vol. 8, Pages 1051: How to Avoid a No-Deal ER Exit Cells doi: 10.3390/cells8091051 Authors: Tiziana Anelli Paola Panina-Bordignon Efficiency and fidelity of protein secretion are achieved thanks to the presence of different steps, located sequentially in time and space along the secretory compartment, controlling protein folding and maturation. After entering into the endoplasmic reticulum (ER), secretory proteins attain their native structure thanks to specific chaperones...
Sat Sep 07, 2019 03:00
Cells, Vol. 8, Pages 1050: Assessing the Epigenetic Status of Human Telomeres Cells doi: 10.3390/cells8091050 Authors: María I. Vaquero-Sedas Miguel A. Vega-Palas The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest. These epigenetic modifications are usually analyzed by microscopy or by chromatin immunoprecipitation (ChIP). However, these analyses could be challenged...
Sat Sep 07, 2019 03:00
Cells, Vol. 8, Pages 1049: How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice Cells doi: 10.3390/cells8091049 Authors: Ruth Thompson Rachel Gatenby Samuel Sidi Mitosis is controlled by a complex series of signaling pathways but mitotic control following DNA damage remains poorly understood. Effective DNA damage sensing and repair is integral to survival but is largely thought to occur primarily in interphase and be repressed during mitosis...
Sat Sep 07, 2019 03:00
Cells, Vol. 8, Pages 1048: Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism Cells doi: 10.3390/cells8091048 Authors: Marrocco Altieri Rubini Paglia Chichiarelli Giamogante Macone Perugia Magliocca Gurtner Maras Ragno Patsilinakos Manganaro Eufemi Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1046: Viscosity of Plasma as a Key Factor in Assessment of Extracellular Vesicles by Light Scattering Cells doi: 10.3390/cells8091046 Authors: Božič Sitar Junkar Štukelj Pajnič Žagar Kralj-Iglič Kogej Extracellular vesicles (EVs) isolated from biological samples are a promising material for use in medicine and technology. However, the assessment methods that would yield repeatable concentrations, sizes and compositions of the harvested...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1047: The Role of PARPs in Inflammation—and Metabolic—Related Diseases: Molecular Mechanisms and Beyond Cells doi: 10.3390/cells8091047 Authors: Ke Wang Zhang Zhong Wang Zeng Ba Poly(ADP-ribosyl)ation (PARylation) is an essential post-translational modification catalyzed by poly(ADP-ribose) polymerase (PARP) enzymes. Poly(ADP-ribose) polymerase 1 (PARP1) is a well-characterized member of the PARP family. PARP1 plays a crucial role in multiple...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1044: The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus Cells doi: 10.3390/cells8091044 Authors: Anselm Mak Herbert Schwarz Costimulatory molecules facilitate cross-talks among leukocytes via mutual stimulatory and inhibitory signalling, contributing to diverse immunological outcomes in normal physiological responses and pathological conditions. Systemic lupus erythematosus (SLE) is a complex multi-systemic...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1045: Systematic Assessment of Blood-Borne MicroRNAs Highlights Molecular Profiles of Endurance Sport and Carbohydrate Uptake Cells doi: 10.3390/cells8091045 Authors: Fabian Kern Nicole Ludwig Christina Backes Esther Maldener Tobias Fehlmann Artur Suleymanov Eckart Meese Anne Hecksteden Andreas Keller Tim Meyer Multiple studies endorsed the positive effect of regular exercise on mental and physical health. However, the molecular mechanisms...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1042: Plasma Fibrinogen-Like 1 as a Potential Biomarker for Radiation-Induced Liver Injury Cells doi: 10.3390/cells8091042 Authors: Na-Kyung Han Myung Gu Jung Ye Ji Jeong Yeonghoon Son Su Chul Han Seungwoo Park Young-Bin Lim Yoon-Jin Lee Sung-Ho Kim Su Cheol Park Hae-June Lee Liver damage upon exposure to ionizing radiation, whether accidental or because of therapy can contribute to liver dysfunction. Currently, radiation therapy is...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1043: mRNA-Driven Generation of Transgene-Free Neural Stem Cells from Human Urine-Derived Cells Cells doi: 10.3390/cells8091043 Authors: Phil Jun Kang Daryeon Son Tae Hee Ko Wonjun Hong Wonjin Yun Jihoon Jang Jong-Il Choi Gwonhwa Song Jangbo Lee In Yong Kim Seungkwon You Human neural stem cells (NSCs) hold enormous promise for neurological disorders, typically requiring their expandable and differentiable properties for regeneration...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1040: Prediction of Potential miRNA–Disease Associations Through a Novel Unsupervised Deep Learning Framework with Variational Autoencoder Cells doi: 10.3390/cells8091040 Authors: Li Zhang Xing Chen Jun Yin The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder...
Fri Sep 06, 2019 03:00
Cells, Vol. 8, Pages 1041: Melatonin Supplementation Attenuates the Pro-Inflammatory Adipokines Expression in Visceral Fat from Obese Mice Induced by A High-Fat Diet Cells doi: 10.3390/cells8091041 Authors: Talita da Silva Mendes de Farias Regislane Ino da Paixao Maysa Mariana Cruz Roberta Dourado Cavalcante da Cunha de Sa Jussara de Jesus Simão Vitor Jaco Antraco Maria Isabel Cardoso Alonso-Vale Obesity is defined as a condition of abnormal or excessive fat accumulation...
Fri Sep 06, 2019 03:00
Children, Vol. 6, Pages 101: Adolescent and Parent Experiences of Acceptance and Commitment Therapy for Pediatric Chronic Pain: An Interpretative Phenomenological Analysis Children doi: 10.3390/children6090101 Authors: Marie Kanstrup Abbie Jordan Mike K. Kemani Pediatric chronic pain is common and can be related to reduced functioning in many domains for the young person and their parents. Existing psychological treatments such as Acceptance and Commitment Therapy (ACT) have shown...
Sat Sep 07, 2019 03:00
Children, Vol. 6, Pages 100: The Arc of Migration and the Impact on Children’s Health and Well-Being Forward to the Special Issue-Children on the Move Children doi: 10.3390/children6090100 Authors: Oberg Since the start of this millennium the diaspora of families with children has continued unabated. UNICEF estimates that nearly 31 million children have been forcibly displaced from their homes by the end of 2017. This includes 13 million child refugees, an estimated 17 million children...
Fri Sep 06, 2019 03:00
Children, Vol. 6, Pages 99: Go Girls!—Dance-Based Fitness to Increase Enjoyment of Exercise in Girls at Risk for PCOS Children doi: 10.3390/children6090099 Authors: King McGill-Meeks Beller Burt Solorzano Weight loss can reduce the hyperandrogenemia associated with polycystic ovary syndrome (PCOS) in peripubertal girls. Yet, adolescent girls have the lowest rates of physical activity and enjoyment of exercise. We created a dance-based support group (Go Girls!) to entice...
Fri Sep 06, 2019 03:00
Diagnostics, Vol. 9, Pages 116: Test Your Memory (TYM) and Test Your Memory for Mild Cognitive Impairment (TYM-MCI): A Review and Update Including Results of Using the TYM Test in a General Neurology Clinic and Using a Telephone Version of the TYM Test Diagnostics doi: 10.3390/diagnostics9030116 Authors: Brown Wiggins Dawson Rittman Rowe This paper summarises the current status of two novel short cognitive tests (SCT), known as Test Your Memory (TYM) and Test Your Memory...
Sun Sep 08, 2019 03:00
Diagnostics, Vol. 9, Pages 114: Thirty-Five Years of Computerized Cognitive Assessment of Aging—Where Are We Now? Diagnostics doi: 10.3390/diagnostics9030114 Authors: Avital Sternin Alistair Burns Adrian M. Owen Over the past 35 years, the proliferation of technology and the advent of the internet have resulted in many reliable and easy to administer batteries for assessing cognitive function. These approaches have great potential for affecting how the health care system monitors...
Fri Sep 06, 2019 03:00
Diagnostics, Vol. 9, Pages 115: The Seven Deadly Sins of Measuring Brain Structural Connectivity Using Diffusion MRI Streamlines Fibre-Tracking Diagnostics doi: 10.3390/diagnostics9030115 Authors: Fernando Calamante There is great interest in the study of brain structural connectivity, as white matter abnormalities have been implicated in many disease states. Diffusion magnetic resonance imaging (MRI) provides a powerful means to characterise structural connectivity non-invasively, by...
Fri Sep 06, 2019 03:00
Diversity, Vol. 11, Pages 160: Influence of Forest Structure and Composition on Summer Habitat Use of Wildlife in an Upland Hardwood Forest Diversity doi: 10.3390/d11090160 Authors: Brent S. Pease Eric J. Holzmueller Clayton K. Nielsen Oak-hickory (Quercus-Carya spp.) forest types are widespread across the midwestern United States, but changes in forest disturbance regimes are resulting in little to no oak recruitment and a compositional shift to shade-tolerant, mesophytic species,...
Sun Sep 08, 2019 03:00
Diversity, Vol. 11, Pages 159: Activity Patterns of Cave-Dwelling Bat Species During Pre-Hibernation Swarming and Post-Hibernation Emergence in the Central Appalachians Diversity doi: 10.3390/d11090159 Authors: Muthersbaugh Ford Silvis Powers In North America, bat research efforts largely have focused on summer maternity colonies and winter hibernacula, leaving the immediate pre- and post-hibernation ecology for many species unstudied. Understanding these patterns and processes...
Fri Sep 06, 2019 03:00
Diversity, Vol. 11, Pages 158: Inventory and Historical Changes in the Marine Flora of Tomioka Peninsula (Amakusa Island), Japan Diversity doi: 10.3390/d11090158 Authors: Eduard A. Titlyanov Tamara V. Titlyanova Mutsunori Tokeshi Xiubao Li Intensive algal sampling was conducted from 2012 to 2017 in the Tomioka Peninsula, Amakusa-Shimoshima Island (the East China Sea, Japan), yielding a total of 293 benthic macroalgal taxa, of which 63% were red algae, 16% were brown algae, and...
Fri Sep 06, 2019 03:00
Diversity, Vol. 11, Pages 157: Are Wildland Fires Increasing Large Patches of Complex Early Seral Forest Habitat? Diversity doi: 10.3390/d11090157 Authors: Dominick A. DellaSala Chad T. Hanson High-severity fire creates patches of complex early seral forest (CESF) in mixed-severity fire complexes of the western USA. Some managers and researchers have expressed concerns that large high-severity patches are increasing and could adversely impact old forest extent or lead to type conversions....
Fri Sep 06, 2019 03:00
Environments, Vol. 6, Pages 104: Nature Conservation and Nature-Based Tourism: A Paradox? Environments doi: 10.3390/environments6090104 Authors: Isabelle D. Wolf David B. Croft Ronda J. Green Throughout the world, areas have been reserved for their exceptional environmental values, such as high biodiversity. Financial, political and community support for these protected areas is often dependent on visitation by nature-based tourists. This visitation inevitably creates environmental...
Fri Sep 06, 2019 03:00
Epigenomes, Vol. 3, Pages 19: Targeting HDAC Complexes in Asthma and COPD Epigenomes doi: 10.3390/epigenomes3030019 Authors: Martijn R. H. Zwinderman Sander de Weerd Frank J. Dekker Around three million patients die due to airway inflammatory diseases each year. The most notable of these diseases are asthma and chronic obstructive pulmonary disease (COPD). Therefore, new therapies are urgently needed. Promising targets are histone deacetylases (HDACs), since they regulate posttranslational...
Sat Sep 07, 2019 03:00
Foods, Vol. 8, Pages 399: Effect of Moist Cooking Blanching on Colour, Phenolic Metabolites and Glucosinolate Content in Chinese Cabbage (Brassica rapa L. subsp. chinensis) Foods doi: 10.3390/foods8090399 Authors: Millicent G. Managa Fabienne Remize Cyrielle Garcia Dharini Sivakumar Non-heading Chinese cabbage (Brassica rapa L. subsp. chinensis) is a widely consumed leafy vegetable by the rural people in South Africa. Traditional blanching methods (5%, 10% or 20% lemon juice...
Sun Sep 08, 2019 03:00
Foods, Vol. 8, Pages 398: Lime (Citrus aurantifolia (Christm.) Swingle) Essential Oils: Volatile Compounds, Antioxidant Capacity, and Hypolipidemic Effect Foods doi: 10.3390/foods8090398 Authors: Li-Yun Lin Cheng-Hung Chuang Hsin-Chun Chen Kai-Min Yang Lime peels are mainly obtained from the byproducts of the juice manufacturing industry, which we obtained and used to extract essential oil (2.3%) in order to examine the antioxidant and hypolipidaemic effects. We identified 60...
Sat Sep 07, 2019 03:00
Foods, Vol. 8, Pages 397: Nutrient Properties and Nuclear Magnetic Resonance-Based Metabonomic Analysis of Macrofungi Foods doi: 10.3390/foods8090397 Authors: Dan Liu Yu-Qing Chen Xiao-Wei Xiao Ru-Ting Zhong Cheng-Feng Yang Bin Liu Chao Zhao Many delicious and nutritional macrofungi are widely distributed and used in East Asian regions, considered as edible and medicinal foods. In this study, 11 species of dried and fresh, edible and medicinal macrofungi, Ganoderma...
Sat Sep 07, 2019 03:00
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