Related ArticlesA phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers. Invest New Drugs. 2018 10;36(5):886-894 Authors: Roohullah A, Cooper A, Lomax AJ, Aung J, Barge A, Chow L, McHale M, Desai J, Whittle JR, Tran B, de Souza P, Horvath LG Abstract Background The MET tyrosine kinase and its ligand, hepatocyte growth factor (HGF) also known...
Sat Aug 31, 2019 13:56
Related Articles"Perceptions, expectations and satisfaction levels of occupational therapy students prior to and after practice placement and comparison of practice placement models". BMC Med Educ. 2019 Aug 29;19(1):324 Authors: Golos A, Tekuzener E Abstract BACKGROUND: Practice placements in occupational therapy are fundamental components in developing a student's professional identity. Various models of placements are available to expose and expand...
Fri Aug 30, 2019 15:40
Related ArticlesEducational efficacy of high-fidelity simulation in neonatal resuscitation training: a systematic review and meta-analysis. BMC Med Educ. 2019 Aug 29;19(1):323 Authors: Huang J, Tang Y, Tang J, Shi J, Wang H, Xiong T, Xia B, Zhang L, Qu Y, Mu D Abstract BACKGROUND: The training of neonatal resuscitation is an important part in the clinical teaching of neonatology. This study aimed to identify the educational efficacy of high-fidelity...
Fri Aug 30, 2019 15:40
Related ArticlesFostering cultural responsiveness in physiotherapy: curricula survey of Australian and Aotearoa New Zealand physiotherapy programs. BMC Med Educ. 2019 Aug 30;19(1):326 Authors: Te M, Blackstock F, Chipchase L Abstract BACKGROUND: Developing cultural responsiveness among physiotherapists is considered essential to promote quality and equity in healthcare provision for our culturally diverse populations. The aim of this study was to evaluate...
Sun Sep 01, 2019 13:22
Related ArticlesTraining to reduce LGBTQ-related bias among medical, nursing, and dental students and providers: a systematic review. BMC Med Educ. 2019 Aug 30;19(1):325 Authors: Morris M, Cooper RL, Ramesh A, Tabatabai M, Arcury TA, Shinn M, Im W, Juarez P, Matthews-Juarez P Abstract BACKGROUND: Lesbian, gay, bisexual, transgender and questioning (LGBTQ) individuals experience higher rates of health disparities. These disparities may be driven, in part,...
Sun Sep 01, 2019 13:22
Related ArticlesIntralesional triamcinolone acetonide therapy for inflammatory oral ulcers. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Aug 13;: Authors: Fantozzi PJ, Treister N, Shekar R, Woo SB, Villa A Abstract OBJECTIVES: The aim of this study was to report on the clinical indications and treatment outcomes of intralesional steroid therapy (IST) for oral ulcerative conditions in an oral medicine practice. STUDY DESIGN: This was a retrospective...
Sat Aug 31, 2019 13:14
Related ArticlesComputed tomography-based differential diagnosis of fungus balls in the maxillary sinus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Aug 13;: Authors: Lee DH, Yoon TM, Lee JK, Lim SC Abstract OBJECTIVE: We investigated the computed tomography (CT) features of the maxillary sinus fungus ball and compared them with those of other maxillary sinus diseases. STUDY DESIGN: The CT findings of 98 fungus ball lesions in 96 patients,...
Sun Sep 01, 2019 13:22
Related ArticlesValproate in Pregnancy: Recent Research and Regulatory Responses. J Clin Psychiatry. 2018 May/Jun;79(3): Authors: Andrade C Abstract Valproate and formulations thereof are approved for the management of seizure disorders, bipolar disorder, and migraine. Valproate is also used for many off-label indications. Unfortunately, data from observational studies indicate that valproate is perhaps the most teratogenic drug in the neuropsychiatric...
Fri Aug 30, 2019 13:51
Related ArticlesChronotherapeutic implications of cyclic seizure patterns. Nat Rev Neurol. 2018 Dec;14(12):696-697 Authors: Sánchez Fernández I, Loddenkemper T AbstractPMID: 30349013 [PubMed - indexed for MEDLINE]
Fri Aug 30, 2019 13:51
Related ArticlesThe paroxysmal depolarization shift in epilepsy research. Int J Biochem Cell Biol. 2019 02;107:77-81 Authors: Hotka M, Kubista H Abstract Several shortcomings with currently available pharmacotherapy of epilepsy necessitate the search for new drug targets. Paroxysmal depolarization shifts (PDS) represent the cellular correlates of electrographic (e.g. interictal) spikes. While the ionic basis of PDS is understood in great detail, controversy...
Fri Aug 30, 2019 13:51
Related ArticlesT-type calcium channels: From molecule to therapeutic opportunities. Int J Biochem Cell Biol. 2019 03;108:34-39 Authors: Weiss N, Zamponi GW Abstract T-type calcium channels serve an essential role in the functioning of the nervous system. They exhibit unique properties among voltage-gated calcium channels, and mediate specific roles in brain function. Over the recent years, it has come to light that a number of chronic neurological...
Fri Aug 30, 2019 13:51
Related ArticlesAwake craniotomies for epileptic gliomas: intraoperative and postoperative seizure control and prognostic factors. J Neurooncol. 2019 May;142(3):577-586 Authors: Wang YC, Lee CC, Takami H, Shen S, Chen KT, Wei KC, Wu MH, Worrell G, Chen PY Abstract PURPOSE: Awake craniotomy is well-established for tumors resected in eloquent brain areas. Whether awake craniotomy provides improved seizure control in patients with epileptic gliomas has...
Fri Aug 30, 2019 13:51
Related ArticlesEpilepsy Therapy Goes Viral. Epilepsy Curr. 2019 Aug 28;:1535759719870506 Authors: Lim BC, Hunt RF Abstract Epilepsy Gene Therapy Using an Engineered Potassium Channel Snowball A, Chabrol E, Wykes RC, Shekh-Ahmad T, Cornford JH, Lieb A, Hughes MP, Massaro G, Rahim AA, Hashemi KS, Kullmann DM, Walker MC, Schorge S. J Neurosci. 2019;39(16):3159-3169. Refractory focal epilepsy is a devastating disease for which there is frequently no effective...
Fri Aug 30, 2019 13:51
Related ArticlesFactors affecting adherence to antiepileptic medications among Sudanese individuals with epilepsy: A cross-sectional survey. J Family Med Prim Care. 2019 Jul;8(7):2312-2317 Authors: Elsayed MA, El-Sayed NM, Badi S, Ahmed MH Abstract Background: Nonadherence to medication is widespread in epilepsy and other chronic diseases. Studies reporting adherence to antiepileptic medications are very limited in African countries. Adherence reports...
Fri Aug 30, 2019 13:51
Limited evidence of physical therapy on balance after stroke: A systematic review and meta-analysis.
Related ArticlesLimited evidence of physical therapy on balance after stroke: A systematic review and meta-analysis. PLoS One. 2019;14(8):e0221700 Authors: Hugues A, Di Marco J, Ribault S, Ardaillon H, Janiaud P, Xue Y, Zhu J, Pires J, Khademi H, Rubio L, Hernandez Bernal P, Bahar Y, Charvat H, Szulc P, Ciumas C, Won H, Cucherat M, Bonan I, Gueyffier F, Rode G Abstract BACKGROUND: Stroke results in balance disorders and these directly affect autonomy...
Fri Aug 30, 2019 15:29
Related ArticlesHealth literacy and quality of life in patients with treatment-resistant epilepsy. Epilepsy Behav. 2019 Aug 26;99:106480 Authors: Scrivner B, Szaflarski M, Baker EH, Szaflarski JP Abstract This exploratory study examined the impact of health literacy on quality of life (QoL) in patients with treatment-resistant epilepsy (TRE). Health literacy is a discrete form of literacy in which an individual can readily interpret prose and apply that...
Fri Aug 30, 2019 15:29
Related ArticlesMotivational Interviewing Techniques to Improve Psychotherapy Adherence and Outcomes for Patients With Psychogenic Nonepileptic Seizures. J Neuropsychiatry Clin Neurosci. 2019 Aug 30;:appineuropsych19020045 Authors: Tolchin B, Baslet G, Martino S, Suzuki J, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA Abstract Psychogenic nonepileptic seizures (PNES) are a highly disabling disorder frequently encountered by neurologists, psychiatrists,...
Sat Aug 31, 2019 14:24
Related ArticlesPOSITION STATEMENT ON THE USE OF MEDICAL CANNABIS FOR THE TREATMENT OF EPILEPSY IN CANADA. Can J Neurol Sci. 2019 Aug 30;:1-39 Authors: Appendino JP, Boelman C, Brna PM, Burneo JG, Claassen CS, Connolly MB, De Guzman M, Federico P, Floyd D, Huntsman R, Javidan M, Jetté N, Jurasek LL, Keezer M, Lau JC, McCoy B, McLachlan R, Ng MC, Nguyen D, Reid A, Rho JM, Snead C, Téllez-Zenteno JF, Wang L, Zak M PMID: 31466531 [PubMed - as supplied by publisher]
Sat Aug 31, 2019 14:24
Related ArticlesEffect of Ambroxol chaperone therapy on Glucosylsphingosine (Lyso-Gb1) levels in two Canadian patients with type 3 Gaucher disease. Mol Genet Metab Rep. 2019 Sep;20:100476 Authors: Charkhand B, Scantlebury MH, Narita A, Zimran A, Al-Hertani W Abstract Type 3 Gaucher disease (GD3) is characterized by progressive neurological features in addition to the typical systemic manifestations. Enzyme replacement therapy (ERT), the main stay treatment...
Sat Aug 31, 2019 14:24
Related ArticlesHSV-1 encephalitis relapse after epilepsy surgery: a case report and review of the literature. J Neurovirol. 2019 Aug 29;: Authors: Mantero V, Cossu M, Rigamonti A, Fiumani A, Basilico P, Tassi L, Salmaggi A Abstract Herpes simplex encephalitis relapses have been rarely reported, with only few cases occurring after neurosurgical interventions. A young man presented a late herpes simplex encephalitis relapse after left antero-mesial temporal...
Sat Aug 31, 2019 14:24
Related ArticlesOperative posterior disconnection in epilepsy surgery: Experience with 29 patients. Epilepsia. 2019 Aug 29;: Authors: Kalbhenn T, Cloppenborg T, Wörmann FG, Blümcke I, Coras R, May TW, Polster T, Simon M, Bien CG Abstract OBJECTIVE: It has been suggested that multilobar epilepsies caused by lesions restricted to the posterior cerebral quadrant (ie, the parietal, temporal, and occipital lobes) can be treated successfully by a procedure...
Sat Aug 31, 2019 14:24
Related ArticlesValidated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening. Neuropharmacology. 2019 Aug 27;:107750 Authors: Barker-Haliski M, Steve White H Abstract Since 1993, over 20 new anti-seizure drugs (ASDs) have been identified in well-established animal seizure and epilepsy models and subsequently demonstrated to be clinically effective in double-blinded, placebo-controlled clinical trials...
Sat Aug 31, 2019 14:24
Related ArticlesDifferential expression of miR-34a, 451, 1260, 1275 and 1298 in the neocortex of patients with mesial temporal lobe epilepsy. Epilepsy Res. 2019 Aug 12;157:106188 Authors: Organista-Juárez D, Jiménez A, Rocha L, Alonso-Vanegas M, Guevara-Guzmán R Abstract Mesial temporal lobe epilepsy (mTLE) is the most common epilepsy syndrome which will eventually become pharmacologically intractable partial-onset seizures. Regulation of gene expression...
Sat Aug 31, 2019 14:24
Related ArticlesEvaluation of the effects of liraglutide on the development of epilepsy and behavioural alterations in two animal models of epileptogenesis. Brain Res Bull. 2019 Aug 27;153:133-142 Authors: Citraro R, Iannone M, Leo A, De Caro C, Nesci V, Tallarico M, Abdalla K, Palma E, Arturi F, De Sarro G, Constanti A, Russo E Abstract Liraglutide (LIR) is a novel long-lasting glucagon-like peptide-1 (GLP-1) analogue that facilitates insulin signalling...
Sat Aug 31, 2019 14:24
Related ArticlesWhen can we trust responders? Serious concerns when using 50% response rate to assess clinical trials. Epilepsia. 2019 Aug 31;: Authors: Karoly PJ, Romero J, Cook MJ, Freestone DR, Goldenholz DM Abstract Individual seizure rates are highly volatile, with large fluctuations from month-to-month. Nevertheless, changes in individual mean seizure rates are used to measure whether or not trial participants successfully respond to treatment....
Sun Sep 01, 2019 13:24
Related ArticlesDehydroepiandrosterone alleviates oxidative stress and apoptosis in iron-induced epilepsy via activation of Nrf2/ARE signal pathway. Brain Res Bull. 2019 Aug 28;: Authors: Prakash C, Mishra M, Kumar P, Kumar V, Sharma D Abstract Epilepsy is a neurological disorder characterized by the prevalence of spontaneous and recurrent seizures. Oxidative stress has been recognized as an intrinsic mechanism for the initiation and progression of epilepsy....
Sun Sep 01, 2019 15:02
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Zhiru Hu, Ting Yang, Jilin Liu, Zhiquan Zhang, Guodong FengAbstractAt first, a conjugated polymer (poly(2,5-bis(4-(bis(pyridin-2-ylmethyl)amino) butoxyl)-1,4-Phenylethynylene-1,4-poly(phenylene ethynylene), PPE-DPA) was synthesized based on our earlier report. In this work, a highly selective and sensitive composite fluorescent sensor (PPE-DPA-Cu2+), which was PPE-DPA complexed with copper ions, has been developed and used to...
Fri Aug 30, 2019 18:03
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Abbas Salman, Helen Carney, Simon Bateson, Zulfiqur AliAbstractPolymerase chain reaction (PCR) is commonly used for the analysis of nucleic acids in a variety of applications including clinical. There is, however, a need for a low cost portable PCR device that allows rapid identification of pathogenic bacteria. We report a shunting PCR microfluidic device comprising: polycarbonate microfluidic PCR chip; shunting thermal cycler...
Sun Sep 01, 2019 13:27
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Lipei Luo, Liangliang Wang, Lupeng Zeng, Yuru Wang, Yunping Weng, Yijuan Liao, Tingting Chen, Yaokun Xia, Jing Zhang, Jinghua ChenAbstractThe detection of exosomal microRNAs (miRNAs) derived from cancer cells with sensitive and selective methods has stimulated increasing interest due to its potential utility in the application of tumor diagnosis. Here, we developed a ratiometric electrochemical DNA biosensor based on a locked...
Sun Sep 01, 2019 13:27
Publication date: 15 January 2020Source: Talanta, Volume 207Author(s): Long Yu, Hongxia Chen, Ji Yue, Xinfeng Chen, Mingtai Sun, Jing Hou, Khalid A. Alamry, Hadi M. Marwani, Xiangke Wang, Suhua WangAbstractMetal-organic framework is an extended coordination compound with repeating coordination entities and voids, which shows potential applications in gas storage, separation, catalysis, and etc. This work reports the synthesis of a new functional metal-organic framework of pyromellitic acid and europium,...
Sun Sep 01, 2019 13:27
Related ArticlesIntra- and subretinal neovascularization following radiation therapy: Contribution of OCT-angiography. J Fr Ophtalmol. 2018 Dec;41(10):e481-e483 Authors: Mathis T, Levron A, Pommier P, Denis P, Thariat J, Kodjikian L PMID: 30446345 [PubMed - indexed for MEDLINE]
Fri Aug 30, 2019 14:44
Related ArticlesTrans-eyebrow supraorbital keyhole approach to tuberculum sellae meningiomas: a series of 30 cases with long-term visual outcomes and recurrence rates. J Neurooncol. 2019 May;142(3):545-555 Authors: Cai M, Hou B, Luo L, Zhang B, Guo Y Abstract BACKGROUND: Approach selection paradigm for tuberculum sellae meningiomas (TSMs) is still a point of discussion. The trans-eyebrow supraorbital keyhole approach (TSKA) is a minimally invasive transcranial...
Fri Aug 30, 2019 14:44
Related ArticlesStenotrophomonas skull base osteomyelitis presenting as necrotizing otitis externa: Unmasking by CT and MRI-case report and review. Radiol Case Rep. 2019 Oct;14(10):1241-1245 Authors: Ahmed M, Syed R, More YI, Basha SI Abstract Necrotizing or malignant otitis externa in patients presenting with mild clinical findings can pose as a tip of the iceberg; computed tomography (CT) and/or magnetic resonance imaging (MRI) unveils the clinical-imaging...
Fri Aug 30, 2019 14:44
Related ArticlesUnusual skull base metastasis from neuroendocrine tumor: a case report. J Med Case Rep. 2019 Aug 30;13(1):273 Authors: Lim KHJ, Valle JW, Lamarca A Abstract BACKGROUND: With increasing treatment options available, neuroendocrine tumor has become a chronic disease and may present later on with atypical manifestation of disease spread once resistant to treatment. CASE PRESENTATION: A 74-year-old white British woman undergoing treatment...
Sat Aug 31, 2019 14:20
Related ArticlesManagement and clinical outcome of concomitant pulmonary embolism and paradoxical saddle aortic arch embolism. BMJ Case Rep. 2019 Aug 28;12(8): Authors: Mancuso E, Winterbottom AP, Boyle JR, Hildebrand DR Abstract A 65-year-old man presented in a peri-arrest situation after collapse, he was found hypoxic with ischaemic arms. CT imaging showed massive bilateral pulmonary embolisms (PEs) and an aortic arch embolus extending from brachiocephalic...
Sat Aug 31, 2019 14:20
Related ArticlesExosomal hsa-miR-21-5p derived from growth hormone-secreting pituitary adenoma promotes abnormal bone formation in acromegaly. Transl Res. 2019 Aug 10;: Authors: Xiong Y, Tang Y, Fan F, Zeng Y, Li C, Zhou G, Hu Z, Zhang L, Liu Z Abstract Growth hormone-secreting pituitary adenoma (GHPA), a benign endocrine tumor located in the base of the skull, results in acromegaly. In addition to the mass effect of the tumor itself in the sellar region,...
Sat Aug 31, 2019 14:20
Related ArticlesPediatric nonoperative skull fractures: delayed complications and factors associated with clinic and imaging utilization. J Neurosurg Pediatr. 2019 Aug 30;:1-9 Authors: Northam W, Chandran A, Quinsey C, Abumoussa A, Flores A, Elton S Abstract OBJECTIVE: Skull fractures represent a common source of morbidity in the pediatric trauma population. This study characterizes the type of follow-up that these patients receive and discusses predictive...
Sat Aug 31, 2019 14:20
Related ArticlesResponse to: Comments on "Nasolacrimal Duct Management During Endoscopic Sinus and Skull Base Surgery". Ann Otol Rhinol Laryngol. 2019 Aug 30;:3489419873000 Authors: Lieberman SM, Rotsides JM, Franco A, Casiano RR PMID: 31470736 [PubMed - as supplied by publisher]
Sun Sep 01, 2019 13:46
Related ArticlesManagement of Giant Pituitary Adenomas: Role and Outcome of the Endoscopic Endonasal Surgical Approach. Neurosurg Clin N Am. 2019 Oct;30(4):433-444 Authors: Marigil Sanchez M, Karekezi C, Almeida JP, Kalyvas A, Castro V, Velasquez C, Gentili F Abstract Giant adenomas represent a significant surgical challenge. Although traditionally several transcranial and transsphenoidal microscopic approaches have had a central role in their management,...
Sun Sep 01, 2019 13:46
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