Related ArticlesPhenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes. Proc Natl Acad Sci U S A. 2019 Sep 04;: Authors: Lok LSC, Dennison TW, Mahbubani KM, Saeb-Parsy K, Chilvers ER, Clatworthy MR Abstract Neutrophils play a key role in innate immunity. As the dominant circulating phagocyte, they are rapidly recruited from the bloodstream to sites of infection or injury to internalize and destroy microbes. More recently, neutrophils...
Fri Sep 06, 2019 17:13
Related ArticlesTopographic modeling of early human osteoarthritis in sheep. Sci Transl Med. 2019 Sep 04;11(508): Authors: Oláh T, Reinhard J, Gao L, Haberkamp S, Goebel LKH, Cucchiarini M, Madry H Abstract Articular cartilage damage occurring during early osteoarthritis (OA) is a key event marking the development of the disease. Here, we modeled early human OA by gathering detailed spatiotemporal data from surgically induced knee OA development in sheep....
Fri Sep 06, 2019 17:13
Related ArticlesHigh-fat diet-induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel. JCI Insight. 2019 Sep 05;4(17): Authors: Grabauskas G, Wu X, Zhou S, Li J, Gao J, Owyang C Abstract Research shows that rats and humans on a high-fat diet (HFD) are less sensitive to satiety signals known to act via vagal afferent pathways. We hypothesize that HFD causes an upregulation of 2-pore domain potassium channels, resulting...
Fri Sep 06, 2019 17:13
Related ArticlesThe histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Nature. 2019 Sep 04;: Authors: Weinberg DN, Papillon-Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan KN, Horth C, McGuire JT, Xu X, Nikbakht H, Lemiesz AE, Marchione DM, Marunde MR, Meiners MJ, Cheek MA, Keogh MC, Bareke E, Djedid A, Harutyunyan AS, Jabado N, Garcia BA, Li H, Allis CD, Majewski J, Lu C Abstract Enzymes that catalyse CpG methylation...
Fri Sep 06, 2019 17:13
Related ArticlesProoxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells. Oxid Med Cell Longev. 2019;2019:6793957 Authors: Moreira H, Szyjka A, Paliszkiewicz K, Barg E Abstract Cancer resistance to chemotherapy is closely related to tumor heterogeneity, i.e., the existence of distinct subpopulations of cancer cells in a tumor mass. An important role is assigned to cancer stem cells...
Fri Sep 06, 2019 17:13
Related ArticlesMitochondrial biology in airway pathogenesis and the role of NRF2. Arch Pharm Res. 2019 Sep 04;: Authors: Cho HY, Kleeberger SR Abstract A constant improvement in understanding of mitochondrial biology has provided new insights into mitochondrial dysfunction in human disease pathogenesis. Impaired mitochondrial dynamics caused by various stressors are characterized by structural abnormalities and leakage, compromised turnover, and reactive...
Fri Sep 06, 2019 17:13
Related ArticlesReview: Other Helicobacter species. Helicobacter. 2019 Sep;24 Suppl 1:e12645 Authors: Ménard A, Smet A Abstract This article is a review of the most important, accessible, and relevant literature published between April 2018 and April 2019 in the field of Helicobacter species other than Helicobacter pylori. The initial part of the review covers new insights regarding the presence of gastric and enterohepatic non-H. pylori Helicobacter...
Fri Sep 06, 2019 17:13
Related ArticlesReview: Pathogenesis of Helicobacter pylori infection. Helicobacter. 2019 Sep;24 Suppl 1:e12638 Authors: Chmiela M, Kupcinskas J Abstract In this review, we shall focus on the last year progression understanding the pathogenesis of Helicobacter pylori infection in the light of recent data related to adaptation of H pylori to the harsh acidic environment in the stomach, colonization of gastric mucosa via interaction with mucin 5 (MUC5AC)...
Fri Sep 06, 2019 17:13
Related ArticlesAssociation Between aquaporin-1 and Endurance Performance: A Systematic Review. Sports Med Open. 2019 Sep 05;5(1):40 Authors: Rivera MA, Fahey TD Abstract BACKGROUND: There is abundant and mounting information related to the molecular and biological structure and function of the Aquaporin-1 (AQP1) gene and the AQP1-Aquaporin channel. Regulation of water flow across cell membranes is essential for supporting inter- and intracellular fluid...
Fri Sep 06, 2019 17:13
Related ArticlesRegulation of the amount of ceramide-1-phosphate synthesized in differentiated human podocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep 02;:158517 Authors: Mallela SK, Mitrofanova A, Merscher S, Fornoni A Abstract Sphingolipids have important functions as structural components of cells but they also function as signaling molecules regulating different cellular processes such as apoptosis, cell proliferation, cell migration,...
Fri Sep 06, 2019 17:13
48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/09/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 07, 2019 14:01
48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/09/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 07, 2019 16:05
Related ArticlesPhenotypical and Functional Polymorphism of Liver Resident Macrophages. Cells. 2019 Sep 05;8(9): Authors: Elchaninov AV, Fatkhudinov TK, Vishnyakova PA, Lokhonina AV, Sukhikh GT Abstract Liver diseases are one of the main causes of mortality. In this regard, the development of new ways of reparative processes stimulation is relevant. Macrophages play a leading role in the regulation of liver homeostasis in physiological conditions and...
Sun Sep 08, 2019 14:54
Related ArticlesCrosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper. Nutrients. 2019 Sep 05;11(9): Authors: Schwarz M, Lossow K, Kopp JF, Schwerdtle T, Kipp AP Abstract Trace elements, like Cu, Zn, Fe, or Se, are important for the proper functioning of antioxidant enzymes. However, in excessive amounts, they can also act as pro-oxidants. Accordingly, trace elements influence redox-modulated signaling pathways, such as the Nrf2...
Sun Sep 08, 2019 14:54
Related ArticlesImmune Regulation of Metabolic Homeostasis by Helminths and Their Molecules. Trends Parasitol. 2019 Sep 03;: Authors: van der Zande HJP, Zawistowska-Deniziak A, Guigas B Abstract Since time immemorial, humans have coevolved with a wide variety of parasitic helminths that have contributed to shape their immune system. The recent eradication of helminth infections in modern societies has coincided with a spectacular rise in inflammatory...
Sun Sep 08, 2019 14:54
Related ArticlesA small bioactive glycoside inhibits epsilon toxin and protects host cell death. Dis Model Mech. 2019 Sep 06;: Authors: Shivappagowdar A, Pati S, Narayana C, Ayana R, Kaushik H, Sah R, Garg S, Khanna A, Kumari J, Garg L, Sagar R, Singh S Abstract Clostridium perfringens Epsilon toxin is categorized as third most lethal bioterrorism agent by CDC, with no therapeutic counter measures available for humans. Here we have developed a high affinity...
Sun Sep 08, 2019 14:54
Related ArticlesALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis. Nat Commun. 2019 Sep 06;10(1):4068 Authors: Yang JS, Hsu JW, Park SY, Lee SY, Li J, Bai M, Alves C, Tseng W, Michelet X, Ho IC, Hsu VW Abstract The aldehyde dehydrogenase (ALDH) family of metabolic enzymes converts aldehydes to carboxylates. Here, we find that the reductive consequence of ALDH7A1 activity, which...
Sun Sep 08, 2019 14:54
Related ArticlesNew Effect in Physiology of Human Nervous Muscle System. Bull Exp Biol Med. 2019 Sep 06;: Authors: Zilov VG, Khadartsev AA, Eskov VM, Ilyashenko LK Abstract A new phenomenon (or paradox) consisting in higher statistical stability of samples, for example, tremorograms, in a group of different subjects than in the same subject in unchanged homeostasis. At the same time, it turns out that 15 different subjects are more similar (statistically)...
Sun Sep 08, 2019 14:54
27 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2019/09/06PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Sep 06, 2019 17:43
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2019/09/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 07, 2019 13:20
21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2019/09/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 07, 2019 15:16
Related ArticlesSubcortical connectivity correlates selectively with attention's effects on spatial choice bias. Proc Natl Acad Sci U S A. 2019 Sep 06;: Authors: Sreenivasan V, Sridharan D Abstract Neural mechanisms of attention are extensively studied in the neocortex; comparatively little is known about how subcortical regions contribute to attention. The superior colliculus (SC) is an evolutionarily conserved, subcortical (midbrain) structure that...
Sun Sep 08, 2019 14:57
Related ArticlesRNA editing alterations define manifestation of prion diseases. Proc Natl Acad Sci U S A. 2019 Sep 06;: Authors: Kanata E, Llorens F, Dafou D, Dimitriadis A, Thüne K, Xanthopoulos K, Bekas N, Espinosa JC, Schmitz M, Marín-Moreno A, Capece V, Shormoni O, Andréoletti O, Bonn S, Torres JM, Ferrer I, Zerr I, Sklaviadis T Abstract Prion diseases are fatal neurodegenerative disorders caused by misfolding of the normal prion protein into an...
Sun Sep 08, 2019 14:57
Related ArticlesRegulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin. Proc Natl Acad Sci U S A. 2019 Sep 06;: Authors: He L, Fei DL, Nagiec MJ, Mutvei AP, Lamprakis A, Kim BY, Blenis J Abstract The mTORC1 pathway regulates cell growth and proliferation by properly coupling critical processes such as gene expression, protein translation, and metabolism to the availability of growth factors and...
Sun Sep 08, 2019 14:57
Related ArticlesPreserved capacity for learning statistical regularities and directing selective attention after hippocampal lesions. Proc Natl Acad Sci U S A. 2019 Sep 06;: Authors: Rungratsameetaweemana N, Squire LR, Serences JT Abstract Prior knowledge about the probabilistic structure of visual environments is necessary to resolve ambiguous information about objects in the world. Expectations based on stimulus regularities exert a powerful influence...
Sun Sep 08, 2019 14:57
Related ArticlesFluid pumping and active flexoelectricity can promote lumen nucleation in cell assemblies. Proc Natl Acad Sci U S A. 2019 Sep 06;: Authors: Duclut C, Sarkar N, Prost J, Jülicher F Abstract We discuss the physical mechanisms that promote or suppress the nucleation of a fluid-filled lumen inside a cell assembly or a tissue. We discuss lumen formation in a continuum theory of tissue material properties in which the tissue is described as...
Sun Sep 08, 2019 14:57
Related ArticlesAn ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc Natl Acad Sci U S A. 2019 Sep 06;: Authors: Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y Abstract TRiC/CCT assists the folding of ∼10% of cytosolic proteins through an ATP-driven conformational cycle and is essential in maintaining protein homeostasis. Here, we determined an ensemble of cryo-electron microscopy (cryo-EM)...
Sun Sep 08, 2019 14:57
Related ArticlesRevealing the metabolic capacity of Streblomastix strix and its bacterial symbionts using single-cell metagenomics. Proc Natl Acad Sci U S A. 2019 Sep 06;: Authors: Treitli SC, Kolisko M, Husník F, Keeling PJ, Hampl V Abstract Lower termites harbor in their hindgut complex microbial communities that are involved in the digestion of cellulose. Among these are protists, which are usually associated with specific bacterial symbionts found...
Sun Sep 08, 2019 14:57
1253 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/09/06PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Sep 06, 2019 17:29
3671 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/09/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 07, 2019 13:22
3671 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/09/07PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 07, 2019 15:22
734 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/09/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Sep 08, 2019 13:14
734 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/09/08PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sun Sep 08, 2019 15:14
Related ArticlesThe ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications. Int J Mol Sci. 2019 Sep 03;20(17): Authors: Nesterenko Y, Hill CJ, Fleming JR, Murray P, Mayans O Abstract The development of cell culture systems for the naturalistic propagation, self-renewal and differentiation of cells ex vivo is a high goal of molecular engineering. Despite significant success in recent years, the high cost of up-scaling cultures, the...
Fri Sep 06, 2019 18:05
Related ArticlesA Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients. 2019 Sep 03;11(9): Authors: Minich DM, Brown BI Abstract Glutathione is a tripeptide that plays a pivotal role in critical physiological processes resulting in effects relevant to diverse disease pathophysiology such as maintenance of redox balance, reduction of oxidative stress, enhancement of metabolic detoxification, and regulation of immune system function. The...
Fri Sep 06, 2019 18:05
Related ArticlesThe Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia. Int J Mol Sci. 2019 Sep 03;20(17): Authors: Vitale JA, Bonato M, La Torre A, Banfi G Abstract The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression...
Fri Sep 06, 2019 18:05
Related ArticlesAdipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice. Biol Sex Differ. 2019 Sep 04;10(1):45 Authors: Shoemaker R, Tannock LR, Su W, Gong M, Gurley SB, Thatcher SE, Yiannikouris F, Ensor CM, Cassis LA Abstract BACKGROUND: Obesity increases the risk for hypertension in both sexes, but the prevalence of hypertension is lower in females than in males until menopause, despite a higher prevalence of obesity...
Fri Sep 06, 2019 18:05
Related ArticlesComprehensive analysis of lncRNA-chromatin interactions reveals lncRNA functions dependent on binding diverse regulatory elements. J Biol Chem. 2019 Sep 04;: Authors: Zhang G, Lan Y, Xie A, Shi J, Zhao H, Xu L, Zhu S, Luo T, Zhao T, Xiao Y, Li X Abstract Over the past decade, thousands of long non-coding RNAs (lncRNAs) have been identified, many of which play crucial roles in normal physiology and human disease. LncRNAs can interact with...
Fri Sep 06, 2019 18:05
Related ArticlesThe transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition. Nat Commun. 2019 Sep 04;10(1):3979 Authors: Oliveira-Mateos C, Sánchez-Castillo A, Soler M, Obiols-Guardia A, Piñeyro D, Boque-Sastre R, Calleja-Cervantes ME, Castro de Moura M, Martínez-Cardús A, Rubio T, Pelletier J, Martínez-Iniesta M, Herrero-Martín D, Tirado OM, Gentilella A, Villanueva A, Esteller M, Farré L,...
Fri Sep 06, 2019 18:05
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