Mucosal Immunology, Published online: 09 September 2019; doi:10.1038/s41385-019-0201-1Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis
Mon Sep 09, 2019 03:00
Mucosal Immunology, Published online: 09 September 2019; doi:10.1038/s41385-019-0202-0Class-switch recombination to IgA in the Peyer’s patches requires natural thymus-derived Tregs and appears to be antigen independent
Mon Sep 09, 2019 03:00
Mucosal Immunology, Published online: 09 September 2019; doi:10.1038/s41385-019-0199-4Norovirus encounters in the gut: multifaceted interactions and disease outcomes
Mon Sep 09, 2019 03:00
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Laryngo-Rhino-Otol 2019; 98: 636-637DOI: 10.1055/a-0954-7260© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 602-603DOI: 10.1055/a-0857-3923Gunes A et al. Effects of treatment on anxiety levels among patients with benign paroxysmal positional vertigo. Eur Arch Otorhinolaryngol 2019; doi: 10.1007/s00405–019–05297–9 Der Zusammenhang von Schwindel und Angststörungen ist bekannt. Türkische HNO-Ärzte untersuchten bei Patienten mit benigner paroxysmaler positionaler Vertigo...
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 608-611DOI: 10.1055/a-0960-6274Das Prinzip der einfachen Transpositionslappenplastik (TLP) (Synonym: Schwenklappenplastik) besteht darin, dass in der unmittelbaren Umgebung eines Hautdefektes ein gestielter Lappen mit axialer oder randomisierter Gefäßversorgung generiert und durch eine geringfügige Drehbewegung an seiner Basis über eine dazwischenliegende Zone von normaler Haut in...
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 603-604DOI: 10.1055/a-0898-7732Sirin S et al. Psychosocial effects of otoplasty in adult patients: a prospective cohort study. Eur Arch Otorhinolaryngol 2019: 276: 1533–1539 Die operative Korrektur abstehender Ohren ist der häufigste ästhetische Eingriff im Alter unter 18 Jahren. Der psychosoziale Nutzen: Weniger Ängste, ein höheres Selbstwertgefühl und eine bessere Körperbildwahrnehmung....
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 651-652DOI: 10.1055/a-0954-7271© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 604-605DOI: 10.1055/a-0898-8845Naunheim MR and Woo P. Topical Anesthetic Techniques in Office-Based Laryngeal Surgery: A Comparison of Patient Preferences. Laryngoscope, 00:1–5, 2019; doi: 10.1002/lary.27894 Bei ambulanten Kehlkopfoperationen gibt es verschiedene Techniken für die Lokalanästhesie. Bisher besteht jedoch keine Einigkeit über die optimale Applikationsform...
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 612-616DOI: 10.1055/a-0960-6451Wenn die ärztliche Tätigkeit und alle sonstigen Eigenschaften der eigenen Behandlungseinrichtung öffentlich im Internet bewertet werden, empfinden viele Ärzte dies als unbequem, ehrenrührig oder sehen gar ein Risiko für den wirtschaftlichen Erfolg. Die Rechtsprechung in Deutschland ist eindeutig: Es gibt keine Vermeidungsstrategie. Dieser Beitrag führt einige...
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 606-607DOI: 10.1055/a-0954-7238© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 638-650DOI: 10.1055/a-0901-9863Entsprechend der ICSD-3 wird eine obstruktive Schlafapnoe (OSA) dann diagnostiziert, wenn die Atmungsstörung durch keine andere Schlafstörung oder medizinische Erkrankung oder durch Medikamente oder andere Substanzen erklärbar ist und entweder ein AHI (Apnoe-Hypopnoe-Index-Anzahl der Apnoen und Hypopnoen pro Stunde Schlaf) > 15/h (Ereignis ≥ 10 s)...
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 653-657DOI: 10.1055/a-0954-7315© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 09, 2019 02:00
Laryngo-Rhino-Otol 2019; 98: 599-599DOI: 10.1055/a-0954-7205© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Mon Sep 09, 2019 02:00
Abstract Purpose Our aim was to test whether the newly modified rhizotomy protocol which could be effectively used to guide single-level approach selective dorsal rhizotomy (SL-SDR) to treat spastic hemiplegic cases by mainly releasing those spastic muscles (target muscles) marked pre-operatively in their lower limbs was still applicable in spastic quadriplegic or diplegic cerebral palsy (CP) cases in pediatric population. ...
Mon Sep 09, 2019 03:00
Abstract Purpose Lumbosacral lipoma (LSL) is a severe occult spinal dysraphism, frequently associated with neurological, urological and orthopaedic complications. Whole spine imaging is typically performed to identify concomitant, but spatially separate, congenital anomalies. Our hypothesis: the incidence of additional, clinically significant abnormalities of the neuraxis is low; thus, imaging should be optimised at the lumbosacral region....
Mon Sep 09, 2019 03:00
Abstract Objective The aim of this study was to identify specific ictal hand postures (HP) as localizing signs of the epileptogenic zone (EZ) in patients with frontal or temporal lobe epilepsy. Methods In this study we retrospectively analyzed ictal semiology of 489 temporal lobe or frontal lobe seizures recorded over a 6‐year period at the Seizure Disorder Center of UCLA ‐ USA (45 patients) or at the “C. Munari” Epilepsy Surgery Centre of the Niguarda Hospital in Milan ‐ Italy (34 patients)....
Mon Sep 09, 2019 19:17
Objectives The purpose of this study was to investigate the influence of laryngeal afferent inputs on brainstem circuits that mediate and transmit swallowing activity to the orofacial musculature. Methods Experiments were performed on 19 arterially perfused juvenile rats. The activities of swallowing interneurons in relation to their respective motor outputs in the hypoglossal and vagus nerves were assessed during fictive swallowing with or without concurrent laryngeal sensory stimulation...
Mon Sep 09, 2019 22:00
Objectives/Hypothesis Voice rest is often prescribed following phonosurgery by most surgeons despite limited empiric evidence to support its practice. This study assessed the effect of postphonosurgery voice rest on vocal outcomes. Study Design Prospective, randomized controlled trial. Methods Patients with unilateral vocal fold lesions undergoing CO2 laser excision were recruited in a prospective manner and randomized into one of two groups: 1) an experimental arm consisting of 7 days...
Mon Sep 09, 2019 18:14
Objectives/Hypothesis Identify predictors of decannulation failure after cricotracheal resection (CTR) and thyrotracheal anastomosis (TTA) in patients with subglottic stenosis (SGS). Study Design Retrospective cohort study. Methods Charts of patients undergoing CTR and TTA for SGS at the University Health Network, Toronto, Ontario, Canada between 1988 and 2017 were reviewed. Patient, pathology, treatment, and outcome data were collected. The end points for statistical analysis were development...
Mon Sep 09, 2019 18:04
Objectives/Hypothesis Combine techniques commonly employed in the clinical workup of patients with isolated globus sensation to identify the most common pharyngoesophageal abnormality. The primary aim was to retrospectively review high‐resolution manometry, pH probe testing, contrast videofluoroscopy, and endoscopy studies in patients with a primary complaint of globus sensation. The specific hypothesis was esophageal high‐resolution manometry identifies the most significant proportion of abnormalities...
Mon Sep 09, 2019 18:04
Objective To investigate the association between rheumatoid arthritis (RA) and deep neck infection (DNI). Study Design Retrospective cohort study. Methods Patients newly diagnosed with RA between 2000 and 2011 were identified from the National Health Insurance Research Database in Taiwan. Moreover, patients without RA were randomly selected and matched at a 1:4 ratio by age, sex, urbanization level, income, and diabetes mellitus. The patients were followed up until death or the end of...
Mon Sep 09, 2019 17:54
Objectives/Hypothesis To compare the identification of safety‐relevant environmental sounds between experienced cochlear implant (CI) users and CI candidates. Study Design Cross‐sectional. Methods A sample of 19 adult, postlingually deaf CI candidates (CI‐Cs), 47 experienced CI users (CI‐Es), and a control group of 37 age‐matched normal‐hearing adults were assessed using the Familiar Environmental Sounds Test–Identification (FEST‐I). A subset of 11 sounds relevant for safety were selected...
Mon Sep 09, 2019 17:46
Objectives Tracheoplasty or tracheal resection and are essential components of the care of patients with severe tracheal stenosis. We aimed to study the perioperative outcomes of patients after tracheoplasty or resection using a national surgical registry. Methods We analyzed the 2014 to 2016 American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) participant use file for patients who underwent tracheal resection or tracheoplasty (CPT codes 31750, 31760, 31780,...
Mon Sep 09, 2019 17:41
Objective Spontaneous vocal recovery from idiopathic vocal fold paralysis (VFP) appears to differ in time course from recovery in iatrogenic VFP. This study aimed to determine if this difference could be explained by differing mechanisms causing recurrent laryngeal nerve (RLN) dysfunction, specifically whether idiopathic VFP is consistent with a focal RLN axonal lesion. Study Design Case series with mathematical modeling. Methods A review of 1267 cases of unilateral VFP over a 10‐year...
Mon Sep 09, 2019 17:40
Objectives Non‐selective laryngeal reinnervation (NSLR) using the ansa cervicalis to the recurrent laryngeal nerve (RLN) is a promising treatment option for pediatric unilateral neuronal vocal fold movement impairment (VFMI). The aim is to describe our clinical outcomes with this technique and to identify preoperative characteristics that may predict postoperative voice outcomes. Methods This is a cohort study of pediatric patients with unilateral neuronal VFMI, who underwent NSLR from March...
Mon Sep 09, 2019 17:38
Objective To identify different presentations, referral patterns, comorbidities, and laryngoscopy findings in children and young adults with exercise‐induced laryngeal obstruction (EILO). Methods We performed a retrospective chart review of 112 patients, age <26 years, with EILO between 2013 and 2016. Results Of the 112 patients who met criteria, 91 were female and 21 were male. Patients were most frequently referred by pulmonologists (60.7%). The majority of patients (93%) participated...
Mon Sep 09, 2019 17:25
Objective Patients with laryngeal pathology are often treated with CO2 laser surgery, usually in the operating room under general anesthesia. Although office‐based laser surgery using several other laser types has been investigated, prospective studies on office‐based CO2 laser surgery are scarce. Our goal was to investigate the feasibility of office‐based CO2 laser surgery for benign and premalignant laryngeal pathology by analyzing completion rate, safety, effect on voice quality, and success...
Mon Sep 09, 2019 17:21
In their article, Iorio and colleagues make the case that measurement of the global burden of hemophilia is an important step in developing strategies to address global gaps in access to care for this potentially devastating condition. The editorialist discusses the findings.
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Background:Recent studies have reported that low-income adults living in more affluent areas of the United States have longer life expectancies. Less is known about the relationship between the affluence of a geographic area and morbidity of the low-income population.Objective:To evaluate the association between the prevalence of chronic conditions among low-income, older adults and the economic affluence of a local area.Design:Cross-sectional association study.Setting:Medicare in 2015.Participants:6 363 097...
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Background:The large observed variability in hemophilia prevalence prevents robust estimation of burden of disease.Objective:To estimate the prevalence and prevalence at birth of hemophilia and the associated life expectancy disadvantage.Design:Random-effects meta-analysis of registry data.Setting:Australia, Canada, France, Italy, New Zealand, and the United Kingdom.Participants:Male patients with hemophilia A or B.Measurements:Prevalence of hemophilia as a proportion of cases to the male population,...
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Clinical research in the United States is under siege. A sharp decline in clinical trials has occurred, whether measured as number of trials performed, number of participants enrolled, or number of investigators. This commentary discusses factors contributing to an environment that does not promote clinical trial research and offers suggestions for actions that academic health centers can take to counter these pressures.
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Background:Whether health outcomes of menopausal estrogen therapy differ between women with and without bilateral salpingo-oophorectomy (BSO) is unknown.Objective:To examine estrogen therapy outcomes by BSO status, with additional stratification by 10-year age groups.Design:Subgroup analyses of the randomized Women's Health Initiative Estrogen-Alone Trial. (ClinicalTrials.gov: NCT00000611)Setting:40 U.S. clinical centers.Participants:9939 women aged 50 to 79 years with prior hysterectomy and known...
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