Summary Purpose BAL101553, the prodrug of the microtubule-destabilizer BAL27862, previously showed signs of antitumor activity when administered as a 2-h infusion, but its use was limited by vascular toxicity. We investigated an alternative dosing strategy aimed at improving the safety profile of BAL101553. Methods This multicenter, open-label, Phase 1 dose-escalation study used a 3 + 3 design to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), pharmacokinetics,...
Fri Aug 30, 2019 03:00
The Journal of Antibiotics, Published online: 30 August 2019; doi:10.1038/s41429-019-0225-5Synthesis and biological activity of analogs of CPZEN-45, a novel antituberculosis drug
Fri Aug 30, 2019 03:00
The Journal of Antibiotics, Published online: 30 August 2019; doi:10.1038/s41429-019-0227-3Mechanism of action of nucleoside antibacterial natural product antibiotics
Fri Aug 30, 2019 03:00
A 9-year-old girl with a single dysplastic kidney and chronic kidney disease presented to the hospital to undergo transplantation of a kidney from a deceased donor. During preparation of the kidney for transplantation, the donor kidney was found to have five renal arteries. During fetal…
Thu Aug 29, 2019 03:00
A previously healthy, fully immunized 48-year-old man presented to an urgent care clinic with a 3-day history of odynophagia, fever with temperatures of up to 40°C, and progressive shortness of breath. A lateral radiograph of the neck showed the "thumb sign" (Panel A, arrow), which was suggestive…
Thu Aug 29, 2019 03:00
Related ArticlesPrevalence of Impulsive-Compulsive Symptoms in Elderly Parkinson's Disease Patients: A Case-Control Study. J Clin Psychiatry. 2018 May/Jun;79(3): Authors: Lo Monaco MR, Petracca M, Weintraub D, Fusco D, Liperoti R, Zuccalà G, La Carpia D, Vetrano DL, Genovese D, Pisciotta MS, Brandi V, Padua L, Imbimbo I, Ricciardi D, Bernabei R, Silveri MC, Laudisio A, Bentivoglio AR Abstract BACKGROUND: Impulse-control disorders (ICDs) are frequently...
Fri Aug 30, 2019 13:05
Related ArticlesAn Analysis of Aesthetic Refinements in 120 Secondary Cleft Rhinoplasties. Ann Plast Surg. 2019 Aug 28;: Authors: Kehrer A, Nijhuis THJ, Lonic D, Heidekrueger PI, Kehrer M, Taeger CD, Willemsen S, Prantl L, van der Meulen JJJNM Abstract BACKGROUND: Secondary cleft nose rhinoplasty remains a challenging procedure. Cartilage memory and scar contraction are problematic factors. The need for more detailed procedures for secondary reconstruction...
Fri Aug 30, 2019 15:15
Related ArticlesTriangular Fossa Graft for Philtral Reconstruction After Facial Burns: A 34-Year Experience. Ann Plast Surg. 2019 Aug 28;: Authors: Roh DS, Bojovic B, Woolard AC, Donelan MB Abstract BACKGROUND: Upper lip burns and skin grafts used for the resulting deformities all contract, leading to distortion of regional tissues and producing a flattened upper lip devoid of normal anatomic landmarks. Absence of the philtral contour draws attention...
Fri Aug 30, 2019 15:15
Related ArticlesAnterior Neck Resurfacing Using a Single Free Flap: Comparison of Flap Descent in Patients With Burn Sequelae of the Neck/Chest and Patients With Burn Sequelae of Only the Neck. Ann Plast Surg. 2019 Aug 28;: Authors: Angrigiani C, Neligan P, Thrikutam N Abstract BACKGROUND: Burn sequelae involving the anterior neck and thorax produce a difficult challenge for reconstruction because contracture of anterior thoracic burns in addition to...
Fri Aug 30, 2019 15:15
Related ArticlesLeft Ventricular Hypertrophy Assessed by Using Cardiac MRI as a Risk Predictor for Cardiovascular Events. Radiology. 2019 Aug 27;:191578 Authors: Hanneman K PMID: 31464578 [PubMed - as supplied by publisher]
Fri Aug 30, 2019 15:24
Related ArticlesCorrection. Mol Biol Cell. 2019 Sep 01;30(19):2535 Authors: PMID: 31465253 [PubMed - in process]
Fri Aug 30, 2019 15:23
Related ArticlesOptimizing your undergraduate teaching as you would an experiment: developing the next generation of cell biologists. Mol Biol Cell. 2019 Sep 01;30(19):2439-2440 Authors: Segarra VA, Styers ML, Dolan EL Abstract The American Society for Cell Biology (ASCB) is a community dedicated to helping prepare the next generation of scientists to advance our understanding of the cell to an unprecedented level of sophistication and detail. Its Education...
Fri Aug 30, 2019 15:23
Related ArticlesSpatial and temporal tools for building a human cell atlas. Mol Biol Cell. 2019 Sep 01;30(19):2435-2438 Authors: Cool J, Conroy RS, Hanlon SE, Hughes SK, Roy AL Abstract Improvements in the sensitivity, content, and throughput of microscopy, in the depth and throughput of single-cell sequencing approaches, and in computational and modeling tools for data integration have created a portfolio of methods for building spatiotemporal cell...
Fri Aug 30, 2019 15:23
Related ArticlesCase report of hepatic pseudocyst: A rare manifestation of liver metastasis from an anal squamous cell carcinoma. Int J Surg Case Rep. 2019 Aug 17;62:77-84 Authors: Bekki T, Takakura Y, Kochi M, Kushitani K, Mori K, Arihiro K, Teraoka Y, Egi H, Ohdan H Abstract INTRODUCTION: Liver metastasis of an anal squamous cell carcinoma (SCC) with a pseudocyst is uncommon. There are many diseases which form hepatic cystic lesions and sometimes it...
Fri Aug 30, 2019 15:31
Related ArticlesThe PI3K-Akt-HIF-1α Pathway Reducing Nasal Airway Inflammation and Remodeling in Nasal Polyposis. Ear Nose Throat J. 2019 Aug 28;:145561319857697 Authors: He F, Liu H, Luo W Abstract OBJECTIVE: Previous studies suggested that hypoxia-inducible factor-1α (HIF-1α) plays an important role in the progression of inflammation and remodeling of chronic rhinosinusitis with nasal polyposis. However, the molecule mechanisms of HIF-1α activation...
Fri Aug 30, 2019 13:29
Related ArticlesThe future of otology. J Laryngol Otol. 2019 Aug 29;:1-12 Authors: Jackler RK, Jan TA Abstract BACKGROUND: The field of otology is increasingly at the forefront of innovation in science and medicine. The inner ear, one of the most challenging systems to study, has been rendered much more open to inquiry by recent developments in research methodology. Promising advances of potential clinical impact have occurred in recent years in biological...
Fri Aug 30, 2019 13:38
Related ArticlesDoes surgical treatment of nasal airway obstruction improve sexual functions? J Laryngol Otol. 2019 Aug 29;:1-5 Authors: Cayir S, Hizli O, Gul M Abstract OBJECTIVE: To investigate the effects of surgical treatment for nasal obstruction on sexual functions, regardless of the condition causing the nasal obstruction. METHODS: Of 238 patients identified with nasal obstruction, 57 complained of erectile dysfunction and were included...
Fri Aug 30, 2019 13:38
Related ArticlesMeasuring rank robustness in scored protein interaction networks. BMC Bioinformatics. 2019 Aug 28;20(1):446 Authors: Bozhilova LV, Whitmore AV, Wray J, Reinert G, Deane CM Abstract BACKGROUND: Protein interaction databases often provide confidence scores for each recorded interaction based on the available experimental evidence. Protein interaction networks (PINs) are then built by thresholding on these scores, so that only interactions...
Fri Aug 30, 2019 13:39
Related ArticlesDetermination of growth-coupling strategies and their underlying principles. BMC Bioinformatics. 2019 Aug 28;20(1):447 Authors: Alter TB, Ebert BE Abstract BACKGROUND: Metabolic coupling of product synthesis and microbial growth is a prominent approach for maximizing production performance. Growth-coupling (GC) also helps stabilizing target production and allows the selection of superior production strains by adaptive laboratory evolution....
Fri Aug 30, 2019 13:39
Background: There has been increasing interest in transnasal pulmonary aerosol administration, but the dose-response relationship has not been reported. Objectives: To determine the accumulative bronchodilator dose at which patients with stable mild-to-moderate asthma and chronic obstructive pulmonary disease (COPD) achieve similar spirometry responses before and after bronchodilator tests using albuterol via a metered dose inhaler with a valved holding chamber (MDI + VHC). Method: Adult patients...
Fri Aug 30, 2019 12:52
Related ArticlesMitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore. Cell Physiol Biochem. 2019;53(3):465-479 Authors: Castillo EC, Morales JA, Chapoy-Villanueva H, Silva-Platas C, Treviño-Saldaña N, Guerrero-Beltrán CE, Bernal-Ramírez J, Torres-Quintanilla A, García N, Youker K, Torre-Amione G, García-Rivas G Abstract BACKGROUND/AIMS:...
Fri Aug 30, 2019 15:50
Related ArticlesInhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Oncogene. 2019 Aug 28;: Authors: Sun B, Mason S, Wilson RC, Hazard SE, Wang Y, Fang R, Wang Q, Yeh ES, Yang M, Roberts TM, Zhao JJ, Wang Q Abstract Resistance of breast cancer to human epidermal growth factor receptor 2 (HER2) inhibitors involves reprogramming of the kinome through HER2/HER3 signaling via the activation of multiple...
Fri Aug 30, 2019 14:13
Related ArticlesContrast-Enhanced Mammography and Radiomics Analysis for Noninvasive Breast Cancer Characterization: Initial Results. Mol Imaging Biol. 2019 Aug 28;: Authors: Marino MA, Pinker K, Leithner D, Sung J, Avendano D, Morris EA, Jochelson M Abstract PURPOSE: To investigate the potential of contrast-enhanced mammography (CEM) and radiomics analysis for the noninvasive differentiation of breast cancer invasiveness, hormone receptor status, and...
Fri Aug 30, 2019 16:10
Related ArticlesPoorly Differentiated Neuroendocrine Carcinoma of the Head and Neck: HPV Tumor Status / p16 Status and Impact on Overall Survival. Histopathology. 2019 Aug 29;: Authors: Benzerdjeb N, Traverse-Glehen A, Philouze P, Bishop J, Devouassoux-Shisheboran M Abstract AIMS: Poorly differentiated neuroendocrine carcinoma (PDNEC) in the head and neck is a rare high-grade neuroendocrine neoplasms. Human papillomavirus (HPV) status and p16 status...
Fri Aug 30, 2019 14:27
Related ArticlesImproved glucose homeostasis in male obese Zucker rats coincides with enhanced baroreflexes and activation of the nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol. 2018 12 01;315(6):R1195-R1209 Authors: Chaudhary P, Schreihofer AM Abstract Young adult male obese Zucker rats (OZR) develop insulin resistance and hypertension with impaired baroreflex-mediated bradycardia and activation of nucleus tractus solitarius (NTS)....
Fri Aug 30, 2019 14:34
Related ArticlesAnemia and Low Albumin Levels Are Associated with Severe Community-Acquired Pneumonia in Pregnancy: A Case-Control Study. Tohoku J Exp Med. 2019;248(4):297-305 Authors: He Y, Li M, Mai C, Chen L, Zhang X, Zhou J, Yang Z, Ni J, Chen Y, Cai M, Qi Q, Yang Z Abstract Community-acquired pneumonia (CAP) is the most common form of pneumonia in pregnancy and may lead to severe adverse maternal and fetal outcomes. Severe CAP (SCAP) is defined...
Fri Aug 30, 2019 14:44
Related ArticlesFetal Sinus Bradycardia Is Associated with Congenital Hypothyroidism: An Infant with Ectopic Thyroid Tissue. Tohoku J Exp Med. 2019;248(4):307-311 Authors: Nakanomori A, Nagano N, Seimiya A, Okahashi A, Morioka I Abstract Hypothyroidism is rarely included in the differential diagnosis for fetal sinus bradycardia. We report an infant with congenital hypothyroidism caused by ectopic thyroid tissue, who showed antenatal bradycardia. The...
Fri Aug 30, 2019 14:44
Abstract Background Radioiodine (RI) treatments can destroy the cellular components of salivary glands (SG) and disrupt their function. This study investigated whether fucoidan could attenuate radioiodine-induced SG dysfunction in a mouse model. Methods Female C57BL/6 mice (n = 36) were classified into three groups; i) a normal (control) group,...
Fri Aug 30, 2019 03:00
Fri Aug 30, 2019 03:00
Abstract Background Antibiotic prophylaxis before invasive treatments, including dental extractions, is still recommended for patients at high risk of infective endocarditis. However, the risk from self-extraction of teeth in daily life of patients with intellectual disabilities is uncertain. Case presentation A 6-year-old patient with Ebstein’s...
Fri Aug 30, 2019 03:00
Abstract Background Periodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox regulation. The hypothesis of this study was that a host’s redox regulation, as modified by genetic polymorphisms, may affect periodontal disease activities (including the plaque index (PlI), bleeding on probing (BOP), and pocket depth (PD)) during periodontal therapy. ...
Fri Aug 30, 2019 03:00
Related ArticlesElectric acoustic stimulation (EAS) with the Naída CI Q90 sound processor in experienced cochlear implant users. Cochlear Implants Int. 2019 Aug 29;:1-10 Authors: Battmer RD, Scholz S, Geissler G, Ernst A Abstract Objectives: The benefit of using the electroacoustic functionality was tested compared to electric stimulation alone. Two different cut-off frequencies between acoustic and electric stimulation were tried. Methods: Performance...
Fri Aug 30, 2019 16:31
Related ArticlesAccuracy of intraoperative electrophysiological testing in confirming correct cochlear implant electrode positions. Cochlear Implants Int. 2019 Aug 29;:1-7 Authors: Al Omari A, Nuseir A, Ata MB, Khasawneh L, Alhowary AA, Alzoubi F Abstract Objective: To investigate the accuracy of intraoperative electrophysiological studies in detecting incorrectly positioned electrodes in cochlear implant surgery. Study design: A retrospective chart...
Fri Aug 30, 2019 16:31
Publication date: Available online 29 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Pamela A. Kisala, David S. Tulsky, Aaron J. Boulton, Allen Heinemann, David Victorson, Mark Sherer, Angelle M. Sander, Nancy Chiaravalloti, Noelle E. Carlozzi, Robin HanksAbstractObjectiveTo develop an item response-theory (IRT)-calibrated, patient-reported outcome measure of subjective independence for individuals with traumatic brain injury (TBI).DesignLarge-scale item calibration...
Fri Aug 30, 2019 16:41
Publication date: Available online 29 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Javier Martinez-Calderon, Mar Flores-Cortés, Jose Miguel Morales-Asencio, Alejandro Luque-SuarezAbstractObjectiveTo systematically review and critically appraise the effectiveness of conservative and surgical interventions to reduce fear in studies of people with chronic low back pain, based on the analysis of randomized controlled trials for which fear was a primary or secondary outcome.Data...
Fri Aug 30, 2019 16:41
Publication date: Available online 29 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Allen W. Heinemann, Pamela A. Kisala, Aaron J. Boulton, Mark Sherer, Angelle M. Sander, Nancy Chiaravalloti, Tamara Bushnik, Robin Hanks, Elliot Roth, David S. TulskyAbstractObjectiveTo develop traumatic brain injury (TBI)-optimized versions of the Neuro-QoL Ability to Participate in Social Roles and Activities (SRA) and Satisfaction with Participation in SRA item banks; evaluate the...
Fri Aug 30, 2019 16:41
Publication date: Available online 30 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Jessica Burggraaff, Jonas Dorn, Marcus D`Souza, Cecily Morrison, Christian P. Kamm, Peter Kontschieder, Prejaas Tewarie, Saskia Steinheimer, Abigail Sellen, Frank Dahlke, Ludwig Kappos, Bernard UitdehaagAbstractObjectivesTo examine the feasibility, reliability, granularity, and convergent validity of a video-based pairwise comparison technique that uses algorithmic support to enable...
Fri Aug 30, 2019 16:41
New Findings The effects of acute mental stress on the mechanisms regulating cerebral blood flow remain unclear. The major novel findings of this study were that: 1) high mental stress and hypercapnia had an interactive effect on mean middle cerebral artery blood velocity; 2) high mental stress altered the regulation of cerebral blood flow; 3) the increased cerebrovascular hypercapnic reactivity was not driven by changes in mean arterial pressure alone; and 4) this increased perfusion with mental...
Thu Aug 29, 2019 11:52
New Findings What is the central question of this study? Does immunosuppression restore the baroreflex control of renal sympathetic nerve activity (RSNA) in an animal model of kidney injury? What is the main finding and its importance? Tacrolimus, a calcineurin inhibitor, restored the high and low‐pressure baroreflex control of RSNA following cisplatin induced renal injury. Abstract Cisplatin administration causes depression of renal haemodynamic and excretory function and is associated...
Thu Aug 29, 2019 15:33
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