IJMS, Vol. 20, Pages 4286: Functional Characterization of Resistance to Powdery Mildew of VvTIFY9 from Vitis vinifera International Journal of Molecular Sciences doi: 10.3390/ijms20174286 Authors: Yihe Yu Yutong Wan Zeling Jiao Lu Bian Keke Yu Guohai Zhang Dalong Guo Powdery mildew is a disease caused by fungal pathogens that harms grape leaves and fruits. The TIFY gene family is a plant-specific super-family involved in the process of plants’ development...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4287: MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function International Journal of Molecular Sciences doi: 10.3390/ijms20174287 Authors: Hyun Kyung Ahn Sehui Kim Dohee Kwon Jaemoon Koh Young A. Kim Kwangsoo Kim Doo Hyun Chung Yoon Kyung Jeon The MET tyrosine receptor kinase is essential for embryonic development...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4285: Confined Dynamics of Water in Transmembrane Pore of TRPV1 Ion Channel International Journal of Molecular Sciences doi: 10.3390/ijms20174285 Authors: Yury A. Trofimov Nikolay A. Krylov Roman G. Efremov Solvation effects play a key role in chemical and biological processes. The microscopic properties of water near molecular surfaces are radically different from those in the bulk. Furthermore, the behavior of water in confined volumes of a nanometer scale,...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4284: Dynamic mRNA Expression Analysis of the Secondary Palatal Morphogenesis in Miniature Pigs International Journal of Molecular Sciences doi: 10.3390/ijms20174284 Authors: Jia Liu Jing Chen Dong Yuan Lindong Sun Zhipeng Fan Songlin Wang Juan Du Normal mammalian palatogenesis is a complex process that requires the occurrence of a tightly regulated series of specific and sequentially regulated cellular events. Cleft lip/palate (CLP), the most frequent...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4282: Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Rats and the Modulatory Effect of Fluoxetine International Journal of Molecular Sciences doi: 10.3390/ijms20174282 Authors: Yunfeng Zhou Xue Tao Zhi Wang Li Feng Lisha Wang Xinmin Liu Ruile Pan Yonghong Liao Qi Chang An olfactory bulbectomy (OBX) rodent is a widely-used model for depression (especially for agitated depression). The present study aims...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4278: Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies International Journal of Molecular Sciences doi: 10.3390/ijms20174278 Authors: Salvador Harguindey Julian Polo Orozco Khalid O. Alfarouk Jesús Devesa The treatment of cancer has been slowly but steadily progressing during the last fifty years. Some tumors with a high mortality in the past are curable nowadays....
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4281: Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice International Journal of Molecular Sciences doi: 10.3390/ijms20174281 Authors: Kazunari Nohara Travis Nemkov Angelo D’Alessandro Seung-Hee Yoo Zheng Chen Cholesterol and bile acid (BA) homeostasis plays a central role in systemic metabolism. Accumulating evidence suggests a key regulatory function of the circadian clock,...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4280: Gold Nanoparticle Enhanced Proton Therapy: Monte Carlo Modeling of Reactive Species’ Distributions Around a Gold Nanoparticle and the Effects of Nanoparticle Proximity and Clustering International Journal of Molecular Sciences doi: 10.3390/ijms20174280 Authors: Peukert Kempson Douglass Bezak Gold nanoparticles (GNPs) are promising radiosensitizers with the potential to enhance radiotherapy. Experiments have shown GNP enhancement of proton therapy...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4279: Ginsenoside Compound K Induces Ros-Mediated Apoptosis and Autophagic Inhibition in Human Neuroblastoma Cells In Vitro and In Vivo International Journal of Molecular Sciences doi: 10.3390/ijms20174279 Authors: Jung-Mi Oh Eunhee Kim Sungkun Chun Autophagy can result in cellular adaptation, as well as cell survival or cell death. Modulation of autophagy is increasingly regarded as a promising cancer therapeutic approach. Ginsenoside compound K (CK), an active...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4283: Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau International Journal of Molecular Sciences doi: 10.3390/ijms20174283 Authors: Hyeanjeong Jeong Seulgi Shin Jun-Seok Lee Soo Hyun Lee Ja-Hyun Baik Sungsu Lim Yun Kyung Kim Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4277: Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair
IJMS, Vol. 20, Pages 4277: Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair International Journal of Molecular Sciences doi: 10.3390/ijms20174277 Authors: Katharina Krüger Sebastian Schmid Friedrich Paulsen Anita Ignatius Patricia Klinger Thilo Hotfiel Bernd Swoboda Kolja Gelse The aim of the study was to explore the possible role of Trefoil Factor Family peptide 3 (TFF3) for skeletal repair. The expression of TFF3 was analyzed in human joint...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4276: Mapping the Interactions of HBV cccDNA with Host Factors International Journal of Molecular Sciences doi: 10.3390/ijms20174276 Authors: Mohd-Ismail Lim Gunaratne Tan Hepatitis B virus (HBV) infection is a major health problem affecting about 300 million people globally. Although successful administration of a prophylactic vaccine has reduced new infections, a cure for chronic hepatitis B (CHB) is still unavailable. Current anti-HBV therapies slow...
Sun Sep 01, 2019 03:00
IJMS, Vol. 20, Pages 4275: Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine Model International Journal of Molecular Sciences doi: 10.3390/ijms20174275 Authors: Valadez-Bustos Escamilla-Silva García-Vázquez Gallegos-Corona Amaya-Llano Ramos-Gómez The Insulin-like growth factor-I/Insulin-like growth factor-I receptor (IGF-1/IGF-1R) system is a major determinant in colorectal...
Sat Aug 31, 2019 03:00
IJMS, Vol. 20, Pages 4273: Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study International Journal of Molecular Sciences doi: 10.3390/ijms20174273 Authors: Chengchen Li Zeyuan Wang Theresa Hardy Yunfeng Huang Qin Hui Cindy A. Crusto Michelle L. Wright Jacquelyn Y. Taylor Yan V. Sun African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally,...
Sat Aug 31, 2019 03:00
IJMS, Vol. 20, Pages 4274: Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications International Journal of Molecular Sciences doi: 10.3390/ijms20174274 Authors: Yazun Bashir Jarrar Su-Jun Lee Enzymes in the cytochrome P450 4 (CYP4) family are involved in the metabolism of fatty acids, xenobiotics, therapeutic drugs, and signaling molecules, including eicosanoids, leukotrienes, and prostanoids. As CYP4 enzymes play a role in the maintenance...
Sat Aug 31, 2019 03:00
IJMS, Vol. 20, Pages 4271: Mismatch Recognition by Saccharomyces cerevisiae Msh2-Msh6: Role of Structure and Dynamics International Journal of Molecular Sciences doi: 10.3390/ijms20174271 Authors: Yan Li Zane Lombardo Meera Joshi Manju M. Hingorani Ishita Mukerji The mismatch repair (MMR) pathway maintains genome integrity by correcting errors such as mismatched base pairs formed during DNA replication. In MMR, Msh2–Msh6, a heterodimeric protein, targets single...
Sat Aug 31, 2019 03:00
IJMS, Vol. 20, Pages 4272: Neurodegeneration and Neuro-Regeneration—Alzheimer’s Disease and Stem Cell Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20174272 Authors: Verica Vasic Kathrin Barth Mirko H.H. Schmidt Aging causes many changes in the human body, and is a high risk for various diseases. Dementia, a common age-related disease, is a clinical disorder triggered by neurodegeneration. Brain damage caused by neuronal death leads to cognitive decline,...
Sat Aug 31, 2019 03:00
IJMS, Vol. 20, Pages 4270: Bone Diseases in Patients with Chronic Liver Disease International Journal of Molecular Sciences doi: 10.3390/ijms20174270 Authors: Hae Min Jeong Dong Joon Kim Osteoporosis is a frequently observed complication in patients with chronic liver disease, particularly liver cirrhosis and cholestatic liver diseases. In addition, osteoporosis is critical in patients receiving a liver transplant. Nevertheless, few studies have evaluated bone diseases in patients...
Sat Aug 31, 2019 03:00
IJMS, Vol. 20, Pages 4269: Identifying Methylation Pattern and Genes Associated with Breast Cancer Subtypes International Journal of Molecular Sciences doi: 10.3390/ijms20174269 Authors: Lei Chen Tao Zeng Xiaoyong Pan Yu-Hang Zhang Tao Huang Yu-Dong Cai Breast cancer is regarded worldwide as a severe human disease. Various genetic variations, including hereditary and somatic mutations, contribute to the initiation and progression of this disease. The diagnostic parameters...
Sat Aug 31, 2019 03:00
IJMS, Vol. 20, Pages 4268: Accelerated Molecular Dynamics Applied to the Peptaibol Folding Problem International Journal of Molecular Sciences doi: 10.3390/ijms20174268 Authors: Chetna Tyagi Tamás Marik Csaba Vágvölgyi László Kredics Ferenc Ötvös The use of enhanced sampling molecular dynamics simulations to facilitate the folding of proteins is a relatively new approach which has quickly gained momentum in recent years. Accelerated molecular dynamics (aMD) can elucidate...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4266: Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats International Journal of Molecular Sciences doi: 10.3390/ijms20174266 Authors: Eva Nora Bukosza Tamás Kaucsár Mária Godó Enikő Lajtár Pál Tod Gábor Koncsos Zoltán V. Varga Tamás Baranyai Nguyen Minh Tu Helga Schachner Csaba Sőti Péter Ferdinandy Zoltán Giricz Gábor Szénási Péter Hamar Feeding rats with...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4267: Ceritinib-Induced Regression of an Insulin-Like Growth Factor-Driven Neuroepithelial Brain Tumor International Journal of Molecular Sciences doi: 10.3390/ijms20174267 Authors: Alexandra Russo Claudia Paret Francesca Alt Jürgen Burhenne Margaux Fresnais Wolfgang Wagner Martin Glaser Hannah Bender Sabrina Huprich Patrick N. Harter Katharina Filipski Nadine Lehmann Nora Backes Lea Roth Larissa Seidmann Clemens Sommer Marc...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4264: Membrane Lipid Remodeling in Response to Salinity International Journal of Molecular Sciences doi: 10.3390/ijms20174264 Authors: Qi Guo Lei Liu Bronwyn J. Barkla Salinity is one of the most decisive environmental factors threatening the productivity of crop plants. Understanding the mechanisms of plant salt tolerance is critical to be able to maintain or improve crop yield under these adverse environmental conditions. Plant membranes act as biological...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4265: THP-1 Cells and Pro-inflammatory Cytokine Production: An in Vitro Tool for Functional Characterization of NOD1/NOD2 Antagonists International Journal of Molecular Sciences doi: 10.3390/ijms20174265 Authors: Jakopin Corsini THP-1 cells express high levels of native functional nucleotide-binding oligomerization domain 1 (NOD1), NOD2, and Toll-like receptor 4 (TLR4) receptors, and have often been used for investigating the immunomodulatory effects of small...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4263: The Evaluation of Response to Immunotherapy in Metastatic Renal Cell Carcinoma: Open Challenges in the Clinical Practice International Journal of Molecular Sciences doi: 10.3390/ijms20174263 Authors: Alessandra Raimondi Giovanni Randon Pierangela Sepe Melanie Claps Elena Verzoni Filippo de Braud Giuseppe Procopio Immunotherapy has changed the therapeutic scenario of metastatic renal cell carcinoma (mRCC), however the evaluation of disease...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4261: Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms20174261 Authors: Johannes Wild Rebecca Schüler Tanja Knopp Michael Molitor Sabine Kossmann Thomas Münzel Andreas Daiber Ari Waisman Philip Wenzel Susanne Helena Karbach Background: Psoriasis is hallmarked by vascular dysfunction, arterial hypertension,...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4262: Cyclo-Oxygenase (COX) Inhibitors and Cardiovascular Risk: Are Non-Steroidal Anti-Inflammatory Drugs Really Anti-Inflammatory? International Journal of Molecular Sciences doi: 10.3390/ijms20174262 Authors: Shanzana Khan Karen L. Andrews Jaye P. F. Chin-Dusting Cyclo-oxygenase (COX) inhibitors are among the most commonly used drugs in the western world for their anti-inflammatory and analgesic effects. However, they are also well-known to increase the risk...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4257: Highly Efficient and Heritable Targeted Mutagenesis in Wheat via the Agrobacterium tumefaciens-Mediated CRISPR/Cas9 System International Journal of Molecular Sciences doi: 10.3390/ijms20174257 Authors: Shujuan Zhang Rongzhi Zhang Jie Gao Tiantian Gu Guoqi Song Wei Li Dandan Li Yulian Li Genying Li The CRISPR/Cas9 system has been successfully used in hexaploid wheat. Although it has been reported that the induced mutations can be passed...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4255: HSP-Target of Therapeutic Agents in Sepsis Treatment International Journal of Molecular Sciences doi: 10.3390/ijms20174255 Authors: Anderson Vulczak Carlos Henrique Rocha Catalão Luiz Alexandre Pedro de Freitas Maria José Alves Rocha Sepsis is a syndrome characterized by a dysregulated inflammatory response, cellular stress, and organ injury. Sepsis is the main cause of death in intensive care units worldwide, creating need for research and new therapeutic...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4259: Water-Soluble Fullerenol C60(OH)36 toward Effective Anti-Air Pollution Induced by Urban Particulate Matter in HaCaT Cell International Journal of Molecular Sciences doi: 10.3390/ijms20174259 Authors: Chiang-Wen Lee Miao-Ching Chi Kuo-Ti Peng Yao-Chang Chiang Lee-Fen Hsu Yi-Ling Yan Hsing-Yen Li Ming-Chun Chen I-Ta Lee Chian-Hui Lai Particulate matter (PM), a widespread air pollutant, consists of a complex mixture of solid and liquid...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4258: Oxidative Stress: Role and Response of Short Guanine Tracts at Genomic Locations International Journal of Molecular Sciences doi: 10.3390/ijms20174258 Authors: Anju Singh Ritushree Kukreti Luciano Saso Shrikant Kukreti Over the decades, oxidative stress has emerged as a major concern to biological researchers. It is involved in the pathogenesis of various lifestyle-related diseases such as hypertension, diabetes, atherosclerosis, and neurodegenerative...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4260: CNNDLP: A Method Based on Convolutional Autoencoder and Convolutional Neural Network with Adjacent Edge Attention for Predicting lncRNA–Disease Associations International Journal of Molecular Sciences doi: 10.3390/ijms20174260 Authors: Ping Xuan Nan Sheng Tiangang Zhang Yong Liu Yahong Guo It is well known that the unusual expression of long non-coding RNAs (lncRNAs) is closely related to the physiological and pathological processes of diseases....
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4251: Molecular Subtyping and Prognostic Assessment Based on Tumor Mutation Burden in Patients with Lung Adenocarcinomas International Journal of Molecular Sciences doi: 10.3390/ijms20174251 Authors: Changzheng Wang Han Liang Cong Lin Fuqiang Li Guoyun Xie Sitan Qiao Xulian Shi Jianlian Deng Xin Zhao Kui Wu Xiuqing Zhang The distinct molecular subtypes of lung cancer are defined by monogenic biomarkers, such as EGFR, KRAS, and ALK rearrangement....
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4254: Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174254 Authors: Lien Van Hoecke Laurens Raes Stephan Stremersch Toon Brans Juan C. Fraire Ria Roelandt Wim Declercq Peter Vandenabeele Koen Raemdonck Kevin Braeckmans Xavier Saelens Modern molecular medicine demands techniques to...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4253: Supplementation with 45S5 Bioactive Glass Reduces In Vivo Resorption of the β-Tricalcium-Phosphate-Based Bone Substitute Material Vitoss International Journal of Molecular Sciences doi: 10.3390/ijms20174253 Authors: Fabian Westhauser Christopher Essers Maria Karadjian Bruno Reible Gerhard Schmidmaier Sébastien Hagmann Arash Moghaddam Compared to other materials such as 45S5 bioactive glass (BG), β-tricalcium phosphate (β-TCP)-based...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4252: The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees International Journal of Molecular Sciences doi: 10.3390/ijms20174252 Authors: Solomon Zewdu Altaye Lifeng Meng Yao Lu Jianke Li Advances in instrumentation and computational analysis in proteomics have opened new doors for honeybee biological research at the molecular and biochemical levels. Proteomics has greatly expanded the understanding of honeybee biology...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4256: Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials International Journal of Molecular Sciences doi: 10.3390/ijms20174256 Authors: Rossella Avallone Giovanni Vitale Marco Bertolotti A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, since there is no effective therapy for these diseases so...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4249: Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis International Journal of Molecular Sciences doi: 10.3390/ijms20174249 Authors: Piotr Wójcik Michał Biernacki Adam Wroński Wojciech Łuczaj Georg Waeg Neven Žarković Elżbieta Skrzydlewska The aim of this study was to investigate possible stress-associated disturbances in lipid metabolism in mononuclear...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4250: mRNA and miRNA Expression Analysis Reveal the Regulation for Flower Spot Patterning in Phalaenopsis ‘Panda’ International Journal of Molecular Sciences doi: 10.3390/ijms20174250 Authors: Anjin Zhao Zheng Cui Tingge Li Huiqin Pei Yuhui Sheng Xueqing Li Ying Zhao Yang Zhou Wenjun Huang Xiqiang Song Ting Peng Jian Wang Phalaenopsis cultivar ‘Panda’ is a beautiful and valuable ornamental for its big flower and...
Fri Aug 30, 2019 03:00
IJMS, Vol. 20, Pages 4243: Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury International Journal of Molecular Sciences doi: 10.3390/ijms20174243 Authors: Nina Rühl Elena Lopez-Rodriguez Karolin Albert Bradford J Smith Timothy E Weaver Matthias Ochs Lars Knudsen High surface tension at the alveolar air-liquid interface is a typical feature of acute...
Fri Aug 30, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου