JCM, Vol. 8, Pages 1472: Strategies in Developing Immunotherapy for Pancreatic Cancer: Recognizing and Correcting Multiple Immune “Defects” in the Tumor Microenvironment Journal of Clinical Medicine doi: 10.3390/jcm8091472 Authors: Sireesha Upadhrasta Lei Zheng With the advent of cancer immunotherapies, significant advances have been made in the treatment of many tumor types including melanoma, lung cancer, squamous cell carcinoma of the head and neck, renal cell carcinoma, bladder...
Mon Sep 16, 2019 03:00
JFB, Vol. 10, Pages 42: Effect of Process Parameters on the Initial Burst Release of Protein-Loaded Alginate Nanospheres Journal of Functional Biomaterials doi: 10.3390/jfb10030042 Authors: Farhana Yasmin Xiongbiao Chen Brian Eames The controlled release or delivery of proteins encapsulated in micro/nanospheres is an emerging strategy in regenerative medicine. For this, micro/nanospheres made from alginate have drawn considerable attention for the use as a protein delivery device...
Mon Sep 16, 2019 03:00
Life, Vol. 9, Pages 76: The Naked Mole-Rat: An Unusual Organism with an Unexpected Latent Potential for Increased Intelligence? Life doi: 10.3390/life9030076 Authors: Dirk Schulze-Makuch Naked mole-rats are eusocial, hairless mammals that are uniquely adapted to their harsh, low-oxygen subsurface habitat. Although their encephalization quotient, a controversial marker of intelligence, is low, they exhibit many features considered tell-tale signs of highly intelligent species on our planet...
Mon Sep 16, 2019 03:00
Life, Vol. 9, Pages 75: Prebiotic Peptide Bond Formation Through Amino Acid Phosphorylation. Insights from Quantum Chemical Simulations Life doi: 10.3390/life9030075 Authors: Berta Martínez-Bachs Albert Rimola Condensation reactions between biomolecular building blocks are the main synthetic channels to build biopolymers. However, under highly diluted prebiotic conditions, condensations are thermodynamically hampered since they release water. Moreover, these reactions are also kinetically...
Mon Sep 16, 2019 03:00
Medicina, Vol. 55, Pages 597: Psychosocial Interventions for Patients with Severe COPD—An Up-to-Date Literature Review Medicina doi: 10.3390/medicina55090597 Authors: Rzadkiewicz Nasiłowski Background and Objectives: Chronic obstructive pulmonary disease (COPD) is a life limiting condition with a long list of serious psychosocial consequences, aggravating with illness progression. In advanced stages, chronic respiratory failure often develops, which might undermine mental health...
Mon Sep 16, 2019 03:00
Medicina, Vol. 55, Pages 596: Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus Medicina doi: 10.3390/medicina55090596 Authors: Malgorzata Dec-Gilowska Marcin Trojnar Boguslaw Makaruk Marcin Czop Sylwia Przybylska-Kuc Barbara Mosiewicz-Madejska Grzegorz Dzida Jerzy Mosiewicz Diabetes mellitus represents a metabolic disorder the incidence of which has been on the increase in recent years. The well-known long-term...
Mon Sep 16, 2019 03:00
Medicina, Vol. 55, Pages 595: Comparison of Two Different Approaches to Treat a Hallux Valgus Deformity: Intramedullary Self-Locked Plates and Herbert Screws Medicina doi: 10.3390/medicina55090595 Authors: Zekeriya Okan Karaduman Ozan Turhal Yalçın Turhan Mehmet Arıcan Cemal Güler Sengul Cangur Background and objectives: Hallux valgus is a complex deformity of the first metatarsophalangeal joint characterized by varus deformity of the first metatarsal bone, valgus deformity...
Mon Sep 16, 2019 03:00
Metabolites, Vol. 9, Pages 186: Untargeted Metabolomics Toward Systematic Characterization of Antioxidant Compounds in Betulaceae Family Plant Extracts Metabolites doi: 10.3390/metabo9090186 Authors: Sunmin Lee Dong-Gu Oh Digar Singh Hye Jin Lee Ga Ryun Kim Sarah Lee Jong Seok Lee Choong Hwan Lee Plant species have traditionally been revered for their unparalleled pharmacognostic applications. We outline a non-iterative multi-parallel metabolomic-cum-bioassay-guided...
Mon Sep 16, 2019 03:00
Microorganisms, Vol. 7, Pages 359: MicroRNAs in Ocular Infection Microorganisms doi: 10.3390/microorganisms7090359 Authors: Shunbin Xu Linda D. Hazlett MicroRNAs (miRNAs) are small, non-coding, regulatory RNA molecules and constitute a newly recognized, important layer of gene-expression regulation at post-transcriptional levels. miRNAs quantitatively fine tune the expression of their downstream genes in a cell type- and developmental stage-specific fashion. miRNAs have been proven...
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Microorganisms, Vol. 7, Pages 358: A Discovery of Relevant Hepatoprotective Effects and Underlying Mechanisms of Dietary Clostridium butyricum Against Corticosterone-Induced Liver Injury in Pekin Ducks Microorganisms doi: 10.3390/microorganisms7090358 Authors: Yanhan Liu Cun Liu Liqing Huang Zhaofei Xia Clostridium butyricum (C. butyricum) can attenuate oxidative stress, inflammation, and hepatic fatty deposition in poultry, however, the underlying mechanisms for this in Pekin...
Mon Sep 16, 2019 03:00
Microorganisms, Vol. 7, Pages 357: Identification of Microbial Profiles in Heavy-Metal-Contaminated Soil from Full-Length 16S rRNA Reads Sequenced by a PacBio System Microorganisms doi: 10.3390/microorganisms7090357 Authors: Moonsuk Hur Soo-Je Park Heavy metal pollution is a serious environmental problem as it adversely affects crop production and human activity. In addition, the microbial community structure and composition are altered in heavy-metal-contaminated soils. In this study,...
Mon Sep 16, 2019 03:00
Microorganisms, Vol. 7, Pages 356: Nanomaterials as Delivery Vehicles and Components of New Strategies to Combat Bacterial Infections: Advantages and Limitations Microorganisms doi: 10.3390/microorganisms7090356 Authors: Atanu Naskar Kwang-sun Kim Life-threatening bacterial infections have been well-controlled by antibiotic therapies and this approach has greatly improved the health and lifespan of human beings. However, the rapid and worldwide emergence of multidrug resistant (MDR)...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3371: Bifunctional Bioactive Polymer Surfaces with Micrometer and Submicrometer-sized Structure: The Effects of Structure Spacing and Elastic Modulus on Bioactivity Molecules doi: 10.3390/molecules24183371 Authors: Elsayed 2, Widyaya Shafi Eickenscheidt Lienkamp This study presents a comparison of two types of bifunctional structured surface that were made from the same polymer –– an antimicrobial polycation (a synthetic...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3373: Purification, Characterization, and Application for Preparation of Antioxidant Peptides of Extracellular Protease from Pseudoalteromonas sp. H2 Molecules doi: 10.3390/molecules24183373 Authors: Dan Liu Jiafeng Huang Cuiling Wu Congling Liu Ran Huang Weng Wang Tingting Yin Xiaotao Yan Hailun He Leilei Chen The study reported on the isolation of a metalloprotease named EH2 from Pseudoalteromonas sp. H2. EH2 maintained more than...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3372: Autophagy Modulation as a Treatment of Amyloid Diseases Molecules doi: 10.3390/molecules24183372 Authors: Zoe Mputhia Eugene Hone Timir Tripathi Tim Sargeant Ralph Martins Prashant Bharadwaj Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders. More than 30 diseases show deposition of fibrous amyloid proteins associated with cell loss and degeneration in the affected tissues. Evidence...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3370: Intermolecular Non-Covalent Carbon-Bonding Interactions with Methyl Groups: A CSD, PDB and DFT Study Molecules doi: 10.3390/molecules24183370 Authors: Tiddo J. Mooibroek A systematic evaluation of the CSD and the PDB in conjunction with DFT calculations reveal that non-covalent Carbon-bonding interactions with X–CH3 can be weakly directional in the solid state (P ≤ 1.5) when X = N or O. This is comparable to very weak CH hydrogen bonding...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3368: Identification of Resveratrol as Bioactive Compound of Propolis from Western Romania and Characterization of Phenolic Profile and Antioxidant Activity of Ethanolic Extracts Molecules doi: 10.3390/molecules24183368 Authors: Alexandra Duca Adrian Sturza Elena-Alina Moacă Monica Negrea Virgil-Dacian Lalescu Diana Lungeanu Cristina-Adriana Dehelean Danina-Mirela Muntean Ersilia Alexa The present study aimed to assess the phenolic content...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3369: Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier Molecules doi: 10.3390/molecules24183369 Authors: Gongsen Chen Juyuan Luo Mengru Cai Liuying Qin Yibo Wang Lili Gao Pingqing Huang Yingchao Yu Yangming Ding Xiaoxv Dong Xingbin Yin Jian Ni Oridonin (ORI) is a natural active ingredient with strong anticancer activity. But its clinical use is restricted due to its poor...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3366: Effect of Nanocrystallization of Anthocyanins Extracted from Two Types of Red-Fleshed Apple Varieties on Its Stability and Antioxidant Activity Molecules doi: 10.3390/molecules24183366 Authors: Jihua Xu Xinxin Li Shifeng Liu Peilei Zhao Heqiang Huo Yugang Zhang Red-fleshed apple (Malus sieversii f. neidzwetzkyana (Dieck) Langenf) has attracted more and more attention due to its enriched anthocyanins and high antioxidant activity. In this...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3367: Improving Interlaminar Fracture Toughness and Impact Performance of Carbon Fiber/Epoxy Laminated Composite by Using Thermoplastic Fibers Molecules doi: 10.3390/molecules24183367 Authors: Ling Chen Li-Wei Wu Qian Jiang Da Tian Zhili Zhong Yan Wang Hong-Jun Fu The effects of thermoplastic polyimide (PI) and polypropylene (PP) fibers and areal density of toughened layer on interlaminar fracture toughness and impact performance of carbon...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3364: Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway Molecules doi: 10.3390/molecules24183364 Authors: Liang Jing Jing-Ru Jiang Dong-Mei Liu Ji-Wen Sheng Wei-Fen Zhang Zhi-Jian Li Liu-Ya Wei The purpose of this study was to characterize the polysaccharides from Athyrium multidentatum (Doll.) Ching (AMC) rhizome and explore...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3365: Development and Validation of a Virtual Gelatin Model Using Molecular Modeling Computational Tools Molecules doi: 10.3390/molecules24183365 Authors: Lukasz Radosinski Karolina Labus Piotr Zemojtel Jakub W. Wojciechowski To successfully design and optimize the application of hydrogel matrices one has to effectively combine computational design tools with experimental methods. In this context, one of the most promising techniques is molecular modeling,...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3363: Neutral Lipid Content in Lipid Droplets: Potential Biomarker of Cordycepin Accumulation in Cordycepin-Producing Fungi Molecules doi: 10.3390/molecules24183363 Authors: Peng Qin ZhiYe Wang DengXue Lu HongMei Kang Guang Li Rui Guo YuHui Zhao RongBing Han Bing Ji Yang Zeng To clarify the relationship between neutral lipid content and cordycepin accumulation in Cordyceps militaris, mutants were generated from mixed spores of two...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3362: A High Throughput Apoptosis Assay using 3D Cultured Cells Molecules doi: 10.3390/molecules24183362 Authors: Sang-Yun Lee Il Doh Dong Woo Lee A high throughput apoptosis assay using 3D cultured cells was developed with a micropillar/microwell chip platform. Live cell apoptosis assays based on fluorescence detection have been useful in high content screening. To check the autofluorescence of drugs, controls (no caspase-3/7 reagent in the assay) for...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3359: Improved Antioxidant, Anti-inflammatory, and Anti-adipogenic Properties of Hydroponic Ginseng Fermented by Leuconostoc mesenteroides KCCM 12010P Molecules doi: 10.3390/molecules24183359 Authors: Ji Eun Hwang Kee-Tae Kim Hyun-Dong Paik Hydroponic ginseng (HPG) has been known to have various bio-functionalities, including an antioxidant effect. Recently, fermentation by lactic acid bacteria has been studied to enhance bio-functional activities in plants...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3360: Comparison of the Interactions of Different Growth Factors and Glycosaminoglycans Molecules doi: 10.3390/molecules24183360 Authors: Fuming Zhang Langhong Zheng Shuihong Cheng Yanfei Peng Li Fu Xing Zhang Robert J. Linhardt Most growth factors are naturally occurring proteins, which are signaling molecules implicated in cellular multiple functions such as proliferation, migration and differentiation under patho/physiological conditions...
Mon Sep 16, 2019 03:00
Molecules, Vol. 24, Pages 3361: A Novel One-Dimensional Porphyrin-Based Covalent Organic Framework Molecules doi: 10.3390/molecules24183361 Authors: Miao Zhang Ruijin Zheng Ying Ma Ruiping Chen Xun Sun Xuan Sun A novel one-dimensional covalent organic framework (COF-K) was firstly designed and synthesized through a Schiff-based reaction from a porphyrin building block and a nonlinear right-angle building block. The COF-K exhibited high BET surface area and narrow pore...
Mon Sep 16, 2019 03:00
Nanomaterials, Vol. 9, Pages 1330: Carbon-Based Nanomaterials in Sensors for Food Safety Nanomaterials doi: 10.3390/nano9091330 Authors: Mingfei Pan Zongjia Yin Kaixin Liu Xiaoling Du Huilin Liu Shuo Wang Food safety is one of the most important and widespread research topics worldwide. The development of relevant analytical methods or devices for detection of unsafe factors in foods is necessary to ensure food safety and an important aspect of the studies of food safety....
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Nanomaterials, Vol. 9, Pages 1329: Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging Nanomaterials doi: 10.3390/nano9091329 Authors: Febrina Sandra Nisar Ul Khaliq Anwar Sunna Andrew Care In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio–nano”...
Mon Sep 16, 2019 03:00
Nanomaterials, Vol. 9, Pages 1327: Strain-Mediated Bending of InP Nanowires through the Growth of an Asymmetric InAs Shell Nanomaterials doi: 10.3390/nano9091327 Authors: Ya’akov Greenberg Alexander Kelrich Shimon Cohen Sohini Kar-Narayan Dan Ritter Yonatan Calahorra Controlling nanomaterial shape beyond its basic dimensionality is a concurrent challenge tackled by several growth and processing avenues. One of these is strain engineering of nanowires, implemented through...
Mon Sep 16, 2019 03:00
Nanomaterials, Vol. 9, Pages 1328: Solution-Processed PEDOT:PSS/MoS2 Nanocomposites as Efficient Hole-Transporting Layers for Organic Solar Cells Nanomaterials doi: 10.3390/nano9091328 Authors: Madeshwaran Sekkarapatti Ramasamy Ka Yeon Ryu Ju Won Lim Asia Bibi Hannah Kwon Ji-Eun Lee Dong Ha Kim Kyungkon Kim An efficient hole-transporting layer (HTL) based on functionalized two-dimensional (2D) MoS2-poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)...
Mon Sep 16, 2019 03:00
Nanomaterials, Vol. 9, Pages 1326: Buckling Behavior of Nanobeams Placed in Electromagnetic Field Using Shifted Chebyshev Polynomials-Based Rayleigh-Ritz Method Nanomaterials doi: 10.3390/nano9091326 Authors: Subrat Kumar Jena Snehashish Chakraverty Francesco Tornabene In the present investigation, the buckling behavior of Euler–Bernoulli nanobeam, which is placed in an electro-magnetic field, is investigated in the framework of Eringen’s nonlocal theory. Critical...
Mon Sep 16, 2019 03:00
Nutrients, Vol. 11, Pages 2234: A Web-Based 24-H Dietary Recall Could Be a Valid Tool for the Indicative Assessment of Dietary Intake in Older Adults Living in Slovenia Nutrients doi: 10.3390/nu11092234 Authors: Matej Gregorič Katja Zdešar Kotnik Igor Pigac Mojca Gabrijelčič Blenkuš The methodology used in dietary surveys could, to a large extent, follow the instructions of the European Food Safety Authority (EFSA), where 24-h dietary recall (24HDR) is recommended for (sub)...
Mon Sep 16, 2019 03:00
Nutrients, Vol. 11, Pages 2235: Potential Oral Health Care Agent from Coffee Against Virulence Factor of Periodontitis Nutrients doi: 10.3390/nu11092235 Authors: Tsou Hu Yang Yan Lin Background: Coffee is a major dietary source of polyphenols. Previous research found that coffee had a protective effect on periodontal disease. In this study, we aimed to investigate whether coffee extract and its primary phenolic acid, chlorogenic acid, affect the growth and protease activity...
Mon Sep 16, 2019 03:00
Nutrients, Vol. 11, Pages 2233: Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention. Nutrients doi: 10.3390/nu11092233 Authors: Salameh Morel Zeilani Déchelotte Marion-Letellier : Undernutrition is a major public health problem leading to 1 in 5 of all deaths in children under 5 years. Undernutrition leads to growth stunting and/or wasting and is often associated with environmental enteric dysfunction (EED). EED mechanisms...
Mon Sep 16, 2019 03:00
Nutrients, Vol. 11, Pages 2232: A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals Nutrients doi: 10.3390/nu11092232 Authors: Lauren M Young Andrew Pipingas David J White Sarah Gauci Andrew Scholey A systematic review and meta-analysis was undertaken to examine and quantify the effects of B vitamin supplementation on mood in both healthy and ‘at-risk’...
Mon Sep 16, 2019 03:00
Nutrients, Vol. 11, Pages 2231: Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects Nutrients doi: 10.3390/nu11092231 Authors: Baltasar Mayo Lucía Vázquez Ana Belén Flórez Epidemiological data suggest that regular intake of isoflavones from soy reduces the incidence of estrogen-dependent and aging-associated disorders, such as menopause symptoms in women, osteoporosis, cardiovascular diseases and cancer. Equol, produced from daidzein,...
Mon Sep 16, 2019 03:00
Nutrients, Vol. 11, Pages 2230: Accounting for the Nutritional Context to Correctly Interpret Results from Studies of Exercise and Sedentary Behavior Nutrients doi: 10.3390/nu11092230 Authors: Barry Braun Alissa Newman There is a wealth of research lauding the benefits of exercise to oppose cardiometabolic disease such as diabetes, CVD and hypertension. However, in the great majority of these studies, the nutritional context (energy balance, deficit, or surplus) has been ignored,...
Mon Sep 16, 2019 03:00
Nutrients, Vol. 11, Pages 2229: Sustainable Food Systems and the Mediterranean Diet Nutrients doi: 10.3390/nu11092229 Authors: Elliot M Berry During the past decade, the concept of sustainability has been added to the factors involved in food security. This has led to a more comprehensive and holistic approach to sustainable food systems which considers drivers—environment, geopolitics, demographics, policy regulations, socio-cultural-economic factors, science and technology...
Mon Sep 16, 2019 03:00
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