Abstract Purpose The purpose of the study was to analyze the total prevalence, morphologic, and morphometric characteristics of the pterygospinous (PS) bar and its gender and ethnic differences among populations. PS bar is an ossified anatomic structure stretching between the posterior margin of the lateral pterygoid lamina to the angular spine of the undersurface of the sphenoid, with potential clinical implications. There is no consensus...
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Abstract Purpose To evaluate the reliability of cone beam computed tomography (CBCT) imagining in the assessment of the frequency, location, and morphological characteristics of accessory maxillary ostia (AMOs), and to analyze a potential association with sinus and dentoalveolar pathologies. Methods CBCT scans with bilateral maxillary sinuses that were acquired...
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Zusammenfassung Verletzungen der unteren Extremität bei multimorbiden und geriatrischen Patienten stellen eine zunehmende Herausforderung dar, wobei ein interdisziplinäres Setting für den Erfolg der Therapie erforderlich ist. Ziel der interdisziplinären Therapie ist die funktionelle Extremitätenrekonstruktion durch knöcherne Rekonstruktion, Revaskularisation und Defektdeckung mit Erhalt der Mobilität sowie der möglichst schnellen Rückkehr ins gewohnte Umfeld und Vermeidung morbiditäts-...
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Zusammenfassung Untersuchungen zeigen, dass die Anzahl der Verletzungen der Halswirbelsäule (HWS) im Alter zunimmt. Eine zeitnahe klinische Untersuchung und adäquate Diagnostik sind notwendig, um eine regelrechte Therapie einzuleiten. Daher wird eine Computertomographie empfohlen, um Verletzungen der HWS auszuschließen. Bei Fragen zur Stabilität kann eine dynamische Durchleuchtung respektive Magnetresonanztomographie (MRT) zusätzlich notwendig werden. Die Therapie der Verletzung...
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A relatively low-cost blood test was able to detect concussions in patients...Read more on AuntMinnie.comRelated Reading: MEG might be new way to evaluate concussions Could a blood test rule out most CT for brain injury? FDA clears blood test to assist concussion evaluation Transcranial Doppler headset tests athletes for concussion Kids with concussion usually normal on CT, MRIComments: 8/27/2019 5:14:26 AMGerald Partan Great. What will be the consequence in patients with elevated GFAP?...
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Researchers from Australia plan to explore media coverage of the benefits and...Read more on AuntMinnie.comRelated Reading: AI may help reduce overdiagnosis of breast cancer Lung cancer overdiagnosis varies widely on CT screening Annals: Overdiagnosis must be better defined How serious is the risk of breast cancer overdiagnosis? ACR disputes NEJM paper on overdiagnosis (Source: AuntMinnie.com Headlines)
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Researchers have developed a new model to predict the individualized risk of sudden cardiac death (SCD) in children with hypertrophic cardiomyopathy.Reuters Health Information (Source: Medscape Radiology Headlines)
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A 60-lb. loggerhead sea turtle named Seaweed underwent an MRI exam at Sentara...Read more on AuntMinnie.comRelated Reading: Pediatric patients go to the dogs for MRI anxiety relief Giant python receives CT scan RSNA to show x-ray 'nature scenes' by Dutch medical physicist See Spot think: fMRI shows how dogs respond to rewards Troubled Texas sea turtles aided by CT (Source: AuntMinnie.com Headlines)
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The U.S. Food and Drug Administration (FDA) on August 26 released a draft guidance...Read more on AuntMinnie.comRelated Reading: Men need breast cancer screening too SBI: Don't overlook men when it comes to breast cancer FDG-PET/CT helps stage men with breast cancer, too Male breast masses require careful investigation Mammography, US help diagnose male breast cancer (Source: AuntMinnie.com Headlines)
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Introduction: Metastatic melanoma is a devastating disease with high morbidity and mortality. Melanoma is able to spread through both lymphatic and hematogenous routes, which can lead to widespread metastases. Metastatic melanoma to the skin and subcutaneous tissue commonly presents as bluish-black papules and nodules that grow rapidly in size. Ulceration and bleeding of these metastases are common. Amelanontic cutaneous metastases are much less common and more difficult to diagnose, usually presenting...
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Although the majority of patients with psoriasis are diagnosed clinically, skin biopsy is often required in atypical cases or early in the disease process. Even then, histopathological changes may be unequivocal in the primary stages. Development of highly sensitive and specific biomarkers can substantially aid dermatologists in diagnosis and subsequent monitoring of disease progression. Additionally, some markers could serve as therapeutic targets for the development of new medications. We utilized...
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Background: Dermoid cysts arise from skin trapped within embryonic fusion plane. Precise diagnosis of dermoid cyst is important, because dermoid cyst occasionally recurred as a result of incomplete excision. To date, there are few studies about clinical and ultrasonographic findings of dermoid cyst.
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Introduction: Previous research has demonstrated that topical application of growth factors can elicit new collagen formation and epidermal thickening. Few studies have examined the effect of multiple growth factors topically. The purpose of this study was to evaluate the efficacy of a proprietary blend of 8 synthetic human growth factors (PolyGF-8) topically in decreasing the signs of skin aging.
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Background: Smoking is a common lifestyle trait that negatively affects postsurgical wound-healing. Previous smaller studies have shown that smoking may increase the rate of flap necrosis and surgical-site complications. Smoking can also down-regulate TGF-β signalling and lead to poor collagen synthesis. Therefore, smoking may also affect postsurgical scarring. Our study investigates if smoking is a risk factor for acute postsurgical complications and poor long-term cosmesis after Mohs reconstructions...
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Background: Due the recurrent nature of Hidradenitis Suppurativa, patients spend a lot of time and money on treatments. HS patients have lower socioeconomic status compared with patients with other dermatological conditions. The purpose is to assess the level of resource utilization in HS patients.
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Background: Glomus tumors are benign perivascular neoplasms originating from the neuromyoarterial plexus: modified smooth muscle cells of the glomus body. Diagnosis of glomus tumors is difficult as patients often seek medical attention when the mass is oftentimes too small to detect upon physical examination. Magnetic resonance imaging is the most sensitive diagnostic tool, and considered the imaging modality of choice for glomus tumors. Optical coherence tomography (OCT) is a noninvasive, real-time...
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Kwashiorkor is a type of protein energy malnutrition most commonly seen in children in impoverished nations. However, it is important to keep in mind that these cases may present in adults and in developed nations such as the United States. We present a case of kwashiorkor seen in a 60-year-old male in Detroit, Michigan. Our patient had a history of seizures, heart failure, and alcohol dependence and presented to the hospital with a rash on the arms, legs, groin, and buttocks. The rash began about...
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We present the case of a 56-year-old female with past medical history significant for melanoma on her right sole (unknown Breslow thickness) in 2013 that was excised. In 2016, she presented to our clinic with seronegative dermatomyositis and PET-CT Scan showed hypermetabolic lymph nodes. Subsequent inguinal lymph node biopsies showed melanoma metastasis and was diagnosed with stage 4 melanoma (TxN3bM1a). Ipilimumab and nivolumab combined therapy was started. Approximately ten days after starting...
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Background: Outside the well-established role of the Sonic hedgehog (Shh) pathway in basal cell carcinoma(BCC) carcinogenesis, the transcriptional landscape of BCC remains incompletely understood. In particular, the contribution of ectopically expressed genes such as cancer testis(CT), embryonic stem cell(ESC) and meiomitosis genes is unknown. Using bioinformatics analyses on previously published BCC RNA-Sequencing(RNA-Seq) data, and experimental validation on our BCC samples, we searched for novel...
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We present a patient with scabies who had fail treatment with permethrin 5% and deteriorated to a widespread infection – crusted (Norwegian) scabies, due to continuous locus of scabies under and within the patient’s fingernails. In this paper we will elaborate on the disease and the following complication which is uncommon since a similar case was only published more than 30 years ago. Since scabies diagnosis is becoming more relevant with the increasing use of immunosuppressive medications and the...
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The French Ministry of Health has officially recognized the country's professional...Read more on AuntMinnieEurope.comRelated Reading: French radiology responds strongly to 'disdainful' criticism French group links up with ACR on AI JFR 2018: French radiology backs new nonprofit AI plan Chang: Why I admire French approach to AI French unveil new initiative in artificial intelligence
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A Scandinavian-led research group has developed a virtual 3D modeling technique...Read more on AuntMinnieEurope.comRelated Reading: Neurosurgery gets boost from 3D-printed head model 3D-printed guides optimize pelvic tumor surgery Milan group uses AR, 3D printing to assist in heart surgery 3D MRI captures changes to fetal head during birth
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Researchers from Australia plan to explore media coverage of the benefits and...Read more on AuntMinnieEurope.comRelated Reading: Support grows for mpMRI before prostate biopsy BMJ: Mammography skeptics attack AgeX trial design Opinion: Stop misleading women on breast screening Would risk-based breast screening be more cost-effective? Breast cancer overdiagnosis varies based on study design
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Israeli 3D printing company Haifa 3D is providing patient-specific 3D-printed...Read more on AuntMinnieEurope.comRelated Reading: 3D-printed bionic prosthesis restores arm movement French team uses 3D printing for kidney cancer surgery Spanish apply 3D printing to pediatric tumor surgery 3D printing guides kidney transplant for 2-year-old boy 3D printing assists spinal surgery of French 6-year-old
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Medical applications appear to dominate the 3D printing industry in Europe,...Read more on AuntMinnieEurope.comRelated Reading: Kumovis launches 3D printer for medical devices 3D-printed bionic prosthesis restores arm movement Axial3D raises 2.7M euros to expand 3D printing services to U.S. WASP offers free software for 3D printing medical devices Hungary invests nearly 1M euros in medical 3D printing
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Introduction: Psoriatic arthritis (PsA) is characterized by peripheral synovitis, enthesitis, dactylitis and spondylitis, and IL-23 is involved in the pathogenesis of these conditions either directly or indirectly. Risankizumab (RZB), a potent humanized IgG1 monoclonal antibody and selective IL23p19 inhibitor, exhibited superior efficacy vs placebo via ACR responses and PASI scores in patients (pts) with active PsA over 24 weeks (wks). Here, the objective is to report the safety and efficacy of RZB...
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Objective: To compare the racial and ethnic distribution of pediatric oncology patients seen by outpatient dermatology and examine differences in referral patterns, reasons for outpatient visit, dermatologic diagnoses and the proportion of outpatient visits for skin cancer surveillance.
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In the United States, acne treatment adherence ranges from 35 to 44 percent, depending on the specific treatment regimen. Efforts must be directed to improve treatment adherence, and technology is a notable avenue to accomplish this goal. With advancements in mobile technology, the development of phone applications to monitor skin health has accelerated. In 2017, a total of 526 dermatology mobile apps were available on Apple, Android and Windows platforms, representing an 80.8% boom in dermatology...
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Background: Mycoplasma pneumoniae, known to be a common cause of pneumonia, has been recognized to cause extrapulmonary manifestations such as mucositis and was previously described as an atypical Stevens–Johnson syndrome (SJS) without skin lesions. However, now the condition is being acknowledged as a separate entity termed Mycoplasma pneumoniae–induced rash and mucositis (MIRM) and is characterized by a prominent mucositis with or without skin lesions (sine rash).
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Background: Real-world long-term safety of adalimumab (ADA) and ustekinumab (UST) for moderate-to-severe chronic plaque psoriasis has been reported independently in two registries: ESPRIT (NCT00799877) and PSOLAR (NCT00508547). However, different methodologies were utilized to report safety data from the respective registries. We compared long-term safety outcomes (all-cause mortality [ACM], serious infections [SI], and malignancy) in psoriasis patients who were treated with ADA or UST in ESPRIT...
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Skin-perfecting formulas are often not suitable for dry skin. A lightweight, noncomedogenic, universal tinted moisturizer that contains amino acid technology and antioxidation/antipollution activity was developed to provide multiple benefits. Two open-label, split-face and forearm, two-center studies were conducted on healthy female subjects ages 25-55, Fitzpatrick I-VI, with self-perceived normal-to-dry skin and mild-to-moderate uneven skin tone who frequently use foundation. Skin attributes were...
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Background: Pediatric psoriasis is a common and disfiguring cutaneous disease that has significant consequences on patient quality of life. The current biologic regimens for moderate to severe pediatric psoriasis vulgaris include ustekinumab, which inhibits IL-12 and IL-23, and etanercept or adalimumab, which inhibit TNF-alpha. The evidence for use of other biologic agents for moderate to severe pediatric psoriasis has been limited. Objective: To provide evidence of the efficacy of ixekizumab, an...
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A 98-year-old woman with longstanding cardiovascular disease and noninsulin-dependent diabetes mellitus was admitted to the hospital for evaluation of a chronic, nonhealing, postauricular ulceration. History revealed an episode of right-sided unilateral tinnitus approximately two years prior prompting otolaryngology evaluation and external auditory canal debridement. Within weeks of the procedure, a small, pruritic, hypoalgesic ulcer developed over the right posterolateral scalp which rapidly expanded...
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Cutaneous T-cell lymphoma (CTCL) is associated with a propensity for developing subsequent, distinct malignancies—a phenomenon likely related both to treatment side effects and decreased numbers of functional T-cells in the setting of a dominant clonal population. Patients are at highest risk for developing a second hematologic malignancy. We describe three patients, each with a histologically distinct subtype of CTCL, who were subsequently found to have new-onset lymphadenopathy during routine follow-up.
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Sweet’s syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition, initially described in 1964. Sweet’s syndrome may present in several clinical and histopathologic variants. It is categorized into several diagnostic classes based on underlying etiology, including classic Sweet’s syndrome, malignancy associated, and drug induced Sweet’s syndrome. All diagnostic categories include common factors including the acute onset of pyrexia, dermal neutrophlic lesions,...
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A 23-year-old male presented to clinic with a 3-month history of an isolated, asymptomatic, enlarging growth on his right medial ankle. He did not recall any preceding trauma to the area. On physical exam he was noted to have a large, soft, 0.5-cm red to violaceous papule with overlying collarette of scale. Dermoscopy showed a uniform erythematous papule without prominent vasculature with thin collarette of scale and peripheral hyperpigmentation. A shave biopsy was performed and showed a well-delineated...
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Introduction: Vitamin C deficiency, or scurvy, was a historical cause of morbidity in sailors who lacked dietary sources of the vitamin such as fresh fruit. Cutaneous findings include follicular hyperkeratosis, perifollicular hemorrhage, and corkscrew hairs. Systemic findings include gingival bleeding, poor wound healing, and spontaneous hemorrhage. These findings are due to the role of vitamin C in collagen synthesis. Prevalence of deficiency in the United States is estimated to be 7.1%. Known risk...
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Background: Narrowband ultraviolet B (NB-UVB) phototherapy is a widely used treatment for various dermatoses. The risk of skin cancer following long-term NB-UVB phototherapy has rarely been explored in skin phototypes III-V.
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Background: Psoriatic disease is often linked to a psychological burden, which is especially high in cases of face/scalp and palmoplantar involvement. The negative effect of a moderate-to-severe psoriatic manifestation in these hard-to-treat special locations prompts the physician to initiate a systemic treatment even in cases of low Psoriasis Area and Severity Index (PASI) and body surface area (BSA) score. Interleukin-17 inhibitor secukinumab is indicated for the treatment of moderate-to-severe...
9h
Progressive symmetric erythrokeratoderma; A case to support the categorization of erythrokeratoderma
Introduction: Progressive symmetric erythrokeratoderma (PSEK) is an extremely rare genodermatosis characterized by symmetrically distributed erythematous scaly plaques that slowly progress in size. Disease onset begins in early childhood, and the plaques most commonly involve the extremities and palmoplantar surfaces with sparing of the trunk and abdomen.
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Fingolimod is an oral treatment for relapsing multiple sclerosis. Several adverse effects have been described, namely lymphopenia, elevation of liver enzymes, cardiovascular effects and infections. We report a rare case of peripheral vasculopathy associated with fingolimod. A 40-year-old Caucasian female, with medical history of multiple sclerosis, presented with erythemato-violaceous nonpruritic, painless macules, located in the extremities of her fingers, for the last year. The patient related...
9h
Sweet syndrome, or acute febrile neutrophilic dermatosis, is an uncommon skin disorder characterized by erythematous, painful papules or plaques. Sweet syndrome lesions typically occur on the head, neck and upper extremities. A limited number of cases with plaques occurring on the palms have been described. A 73-year-old female patient presented to the University of Texas Dermatology Clinic with painful fixed annular macules on her palms that had been present for five days. The patient was afebrile,...
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Hawaii will ban the sale and distribution of any sunscreens containing oxybenzone (benzophenone-3) or octinoxate (octyl methoxycinnamate) beginning January 1, 2021. The legislature introduced this act because of concerns that these ingredients can have a harmful impact on Hawaii’s marine environment and residing ecosystems, including coral reefs. We performed a literature review on the risks and benefits of sunscreen use to human health but also reviewed the data on the impact of sunscreens on the...
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Introduction: Plasminogen deficiency is a rare genetic disorder that can lead to multiple mucocutaneous manifestations that can simulate other genodermatoses. This disease is caused by mutations in the plasminogen gene, located on chromosome 6, and it presents with hypoplasminogenemia and several clinical features, predominantly in the eyes (typically as ligneous conjunctivitis) and other mucous membranes, such as the respiratory tract, the middle ear and the genital tract. We present a case of plasminogen...
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Introduction: Hailey-Hailey disease (HHD) or familial benign chronic pemphigus is rare genodermatosis that manifests as chronic and recurrent red plaques involving intertriginous sites. Affected areas develop painful vesicles, erosions, fissures, and maceration predisposing to superinfection. HHD patients are often significantly impaired by their disease and unable to find adequate treatment with minimal side effects. We report success in treatment of this challenging disease with an old remedy.
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Spiradenomas commonly present as solitary tender nodules. There are less than 50 cases reported of linear spiradenomas. We present a case of a 20-year-old female who presented to the dermatology clinic with several tender papules on her right medial leg. These papules had been present since age 12 with a slow increase in number. She had not developed any new lesions over the past year. On examination of the right leg, there were approximately twenty discrete blue, rubbery papules in a linear distribution...
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Background: The management of keratoacanthoma varies among physicians. While some clinicians observe these lesions and believe they regress spontaneously, others regard keratoacanthoma as a variant of squamous cell carcinoma and prefer to treat them.
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Background: Hyperhidrosis (Hh) is characterized by extreme sweating beyond what is necessary/expected for thermoregulation or as a stress reaction. There are ∼15.3 million individuals with Hh in the US (prevalence 4.8%). Related discomfort, occupational hindrances, and psychosocial impacts are noted in the literature. Treatment options exist, but patient satisfaction can be low and access challenging. To add to the understanding of what would constitute patient-centric approaches, the International...
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Introduction: Talimogene laherparepvec (T-Vec) is an FDA approved injectable live herpes virus type 1 for the treatment of advanced melanoma that selectively infects tumor cells, resulting in local and distant antitumor immunity. Quantitative multiplex immunofluorescence (qmIF) is a novel pathology technique that allows several biomarkers to be precisely visualized and quantified within a tissue section. Using qmIF, we previously showed that whereas melanoma stained nuclear SOX10, melanophages in...
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Introduction: Secukinumab (SEC), a fully human monoclonal antibody that selectively neutralizes IL-17A, has shown long-lasting efficacy and safety in the complete spectrum of psoriasis (PsO) manifestations, including nails, scalp, palms and soles, and psoriatic arthritis. PURE is an international registry of adult patients (pts) from Canada and Latin America with moderate to severe PsO treated with SEC vs other approved therapies. This abstract describes the clinical outcomes over 24 months of treatment...
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Introduction: Leprosy is a chronic granulomatous infection with Mycobacterium leprae. Persistent granulomas on posttreatment histopathologic examinations have been in question on whether it indicates ongoing infection or merely reflects a delay in histopathologic change. This research aimed to determine the association between persistent granulomas and treatment outcomes (lepra reactions, neuropathy, and treatment extension) of leprosy patients seen at a tertiary hospital in the Philippines.
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Langerhans cell histiocytosis (LCH) is more often observed in the pediatric than in the adult population. Adult-onset LCH is exceedingly rare, with an estimated prevalence of 1-2 cases per million. We report 2 cases of adult LCH- both highlighting the challenges involved with this condition, including variable clinical presentations and disease recurrence. Case A: The patient is a 32-year-old male who was admitted with progressive shortness of breath and productive cough. Dermatology was consulted...
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Background: Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disorder associated with increased PDE4 activity. Of the four known PDE4 subtypes, the B isoform has been identified in animal models as a key regulatory and therapeutic target to reduce inflammation. Thus, PDE4B-selective inhibitors may provide additional clinical effect in the treatment of AD compared with nonspecific PDE4 inhibitors.
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Background: Psoriasis is a chronic inflammatory skin disorder that often begins in childhood. We evaluated the safety and efficacy of apremilast (APR) in pediatric pts.
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Background: Chronic hand eczema (CHE) is an inflammatory skin disease with multifactorial etiology (eg, irritant or allergic contact dermatitis or atopic hand dermatitis). Although the molecular mechanisms underlying CHE are not fully understood, cytokines and the JAK-STAT signalling pathway have been implicated in the pathophysiology. Topical delgocitinib is a novel, pan-JAK inhibitor that blocks several cytokine-mediated signalling cascades, thereby inhibiting inflammation. Delgocitinib might therefore...
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Advances in technology continue to revolutionize the study and practice of medicine. While some residencies are technology-dependent in nature, others may be slower or more-hesitant to incorporate innovative technologies into their teaching paradigms. While new technologies in dermatology are skyrocketing, the extent to which these tools are currently integrated into dermatology resident education is unknown. Here we survey dermatology residents about the access and use of mobile devices and newer...
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Introduction: There has been a significant increase in dermatologic adverse events with the extended use of targeted therapies. Their appropriate recognition and management can save lives and have prognostic implications.
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Introduction: Kaposi’s sarcoma (KS) is an angioproliferative malignancy, thought to be dependent on viral replication, immune modulation, and inflammatory cytokines. It is commonly subclassified as classic, African (endemic), AIDS-associated, and iatrogenic (eg, KS in organ transplant recipients). Human herpesvirus-8 (HHV-8) is thought to cause KS and is documented in more than 95% of patients. We present three unusual cases of healthy HIV-negative men who have sex with men (MSM) who developed asymptomatic...
10h
Background: Apremilast (APR), an oral phosphodiesterase 4 inhibitor, has demonstrated efficacy and a favorable safety/tolerability profile in the ESTEEM phase 3 trials in patients (pts) with moderate to severe psoriasis and in UNVEIL, a phase 4 trial in pts with moderate plaque psoriasis. Less is known about the real-world efficacy of APR in pts in the US. To further understand the clinical profile of APR in moderate psoriasis pts, efficacy outcomes were described among pts with moderate plaque psoriasis...
10h
Introduction: Crisaborole ointment is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD). The effect of coapplication of other topical therapies with crisaborole on skin permeation and penetration is difficult to predict. The objective of this study was to compare delivery of crisaborole through human skin when coapplied with other topical formulations.
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Background: 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) deactivates cortisol to cortisone. It is up-regulated in nonmelanoma skin cancer (NMSC) cells. We found that glycyrrhetinic acid (GA)-mediated inhibition of 11βHSD2 protein caused a significant reduction in tumor number, weight, incidence, and significant delay in tumor onset. In addition to the use of specific inhibitors such as GA to sustain the bioavailability of glucocorticoids (GC), modifying the structure of GC molecule to prevent...
10h
Knowledge regarding continuous monitoring of wounds during the healing process may provide insights regarding when and how to intervene. Recently, wearable sensors have gained attention due to their ability for real-time health and environmental monitoring. Measurements of pH, oxygen, moisture, bacterial metabolites, temperature, and endogenous biomarkers have been studied. Uric acid (UA) is a biomarker associated with oxidative stress and bacterial infection within the wound. Interestingly, nonhealing...
10h
Spiradenocarcinomas (SpAdcs) or malignant eccrine spiradenomas are potentially aggressive skin adnexal tumors. They often present as solitary nodules and are classified as low-grade (LG) or high grade (HG) tumors. We review the clinical and histological features of a LG SpAdc in a 57-year-old male and review treatment options for this tumor. Our patient first noticed a small, subcutaneous nodule two years prior to presentation. Over the course of a year, the nodule doubled in size and became darker...
10h
Background and Objective: Using health insurance claims to indirectly study medical conditions is becoming more common. To our knowledge the epidemiology of vitiligo has not been previously validated using health insurance claims data. Therefore, our purpose is to develop a method for vitiligo ascertainment using health administrative data.
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Introduction: Patients experience perioperative anxiety in Mohs micrographic surgery (MMS) related to cancer diagnosis, fear of intraoperative pain, or surgical complications. Perioperative patient anxiety in MMS is associated with increased postoperative pain and decreased satisfaction. Recently, it was suggested that optimized education may reduce anxiety in MMS. Three-dimensional printed (3DP) models have demonstrated effectiveness in medical education. We aimed to determine if a 3DP MMS model...
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Background: Injection-site reactions (ISRs) are commonly reported with biologic therapies. The objective of this posthoc analysis was to evaluate spontaneous reporting of ISRs; specifically, the type and severity of ISRs over time and discontinuation due to ISRs among patients (pts) receiving the anti-interleukin-17A monoclonal antibody ixekizumab (IXE) vs. etanercept (ETN) or placebo (PBO).
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Autosensitization dermatitis, or Id reaction, is a cutaneous phenomenon in which an acute secondary dermatitis develops at a location distant from a primary inflammatory focus due to excess circulation of cytokines. Autosensitization frequently results from cases of infection, and multiple infectious organisms including bacteria, viruses, parasites, and fungi have been shown to cause reactions at sites distant to the infection. Many cutaneous morphologies have been reported in Id reactions. There...
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Introduction: Several studies have shown an association between psoriasis and hepatitis C virus infection. To assess this relationship, we have evaluated the frequency of psoriasis among a population of patients receiving treatment for hepatitis C infection.
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