Related ArticlesAlyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization. Biomol Ther (Seoul). 2019 Aug 13;: Authors: Pocasap P, Weerapreeyakul N, Thumanu K Abstract To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane...
Related ArticlesPancratistatin Inhibits the Growth of Colorectal Cancer Cells by Inducing Apoptosis, Autophagy, and G2/M Cell Cycle Arrest. Med Sci Monit. 2019 Aug 12;25:6015-6022 Authors: Xiong Y, Xiong YJ, Liu DY, Shen RR Abstract BACKGROUND Worldwide, colorectal cancer is ranked as the third most prevalent cancer. The natural compound, pancratistatin, extracted from the spider lily, has previously been shown to target apoptosis in cancer cells lines....
Related ArticlesmiR-214-5p inhibits human prostate cancer proliferation and migration through regulating CRMP5. Cancer Biomark. 2019 Jul 30;: Authors: Zheng C, Guo K, Chen B, Wen Y, Xu Y Abstract OBJECTIVES: In men, human prostate cancer (PCa) has become the second most common cancer. miRNAs are short non-coding RNAs that can inhibit target gene mRNAs. Studies have showed that the alternation of miRNAs expression in cancer is relevant to pathogenesis...
Related ArticlesPurification, crystallization and anti-cancer activity evaluation of the compound Alternariol Methyl Ether (AME) from endophytic fungi Alternaria alternata. J Appl Microbiol. 2019 Aug 12;: Authors: Prabha P, Kannan S, Murugan D, Alagusundaram P, Marudhamuthu M Abstract AIMS: Medicinal plants associated endophytic fungi are important sources of precious bioactive compounds, contributing more than 80% of the natural drugs for various ailments....
Related ArticlesBRD4 inhibitor and histone deacetylase inhibitor synergistically inhibit the proliferation of gallbladder cancer in vitro and in vivo. Cancer Sci. 2019 Aug;110(8):2493-2506 Authors: Liu S, Li F, Pan L, Yang Z, Shu Y, Lv W, Dong P, Gong W Abstract Gallbladder cancer (GBC) is the most common malignancy of the bile duct and has a high mortality rate. Here, we demonstrated that BRD4 inhibitor JQ1 and histone deacetylase inhibitor suberoylanilide...
Related ArticlesQuiescence Entry, Maintenance, and Exit in Adult Stem Cells. Int J Mol Sci. 2019 May 01;20(9): Authors: Mohammad K, Dakik P, Medkour Y, Mitrofanova D, Titorenko VI Abstract Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do not divide, but can re-enter the cell cycle and resume proliferation if exposed...
Related ArticlesROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer. ACS Appl Mater Interfaces. 2019 Apr 24;11(16):14647-14659 Authors: Xin X, Lin F, Wang Q, Yin L, Mahato RI Abstract Ineffective drug delivery and poor prognosis are two major challenges in the treatment of pancreatic ductal adenocarcinoma (PDAC). While there is significant downregulation...
Related ArticlesCurcumin exerts cytotoxicity dependent on reactive oxygen species accumulation in non-small-cell lung cancer cells. Future Oncol. 2019 Apr;15(11):1243-1253 Authors: Wang C, Song X, Shang M, Zou W, Zhang M, Wei H, Shao H Abstract AIM: Curcumin induces cytotoxic cell death in several human cancer cells. Here, we have investigated the effects of curcumin on non-small-cell lung cancer (NSCLC) with an aim to identify underlying mechanisms...
Related ArticlesTIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress. EMBO Rep. 2019 01;20(1): Authors: Lafarga V, Sung HM, Haneke K, Roessig L, Pauleau AL, Bruer M, Rodriguez-Acebes S, Lopez-Contreras AJ, Gruss OJ, Erhardt S, Mendez J, Fernandez-Capetillo O, Stoecklin G Abstract The G2/M checkpoint coordinates DNA replication with mitosis and thereby prevents chromosome segregation in the presence of unreplicated...
Related ArticlesFoxO1 enhances differentiation and apoptosis in human primary keratinocytes. Exp Dermatol. 2018 11;27(11):1254-1260 Authors: Shi G, Liao PY, Cai XL, Pi XX, Zhang MF, Li SJ, Quan JH, Fan YM Abstract Forkhead box-O1 (FoxO1) is a key nutrient- and growth factor-dependent regulator of metabolism, but its functional role in human primary keratinocytes (HPKs) is less known. To investigate the role of FoxO1 in HPKs and effect of insulin-like...
Related ArticlesSilencing of Long Noncoding RNA SOX21-AS1 Relieves Neuronal Oxidative Stress Injury in Mice with Alzheimer's Disease by Upregulating FZD3/5 via the Wnt Signaling Pathway. Mol Neurobiol. 2019 May;56(5):3522-3537 Authors: Zhang L, Fang Y, Cheng X, Lian YJ, Xu HL Abstract Alzheimer's disease (AD) represents a progressive neurodegenerative disorder characterized by distinctive neuropathological changes. Recently, long noncoding RNAs (lncRNAs)...
Related ArticlesDeletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells. Cancer Biol Ther. 2018 08 03;19(8):676-686 Authors: Cheng L, Tang Y, Chen X, Zhao L, Liu S, Ma Y, Wang N, Zhou K, Zhou J, Zhou M Abstract Aberrant methylation of tumour suppressor genes is associated with the progression to a blast crisis in chronic myeloid leukaemia (CML). Methyl-CpG-binding domain protein 2 (MBD2) has been studied as a "reader"...
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Related ArticlesMolecular portraits and trastuzumab responsiveness of estrogen receptor-positive, progesterone receptor-positive, and HER2-positive breast cancer. Theranostics. 2019;9(17):4935-4945 Authors: Zhao S, Liu XY, Jin X, Ma D, Xiao Y, Shao ZM, Jiang YZ Abstract Background: Estrogen receptor-positive, progesterone receptor-positive, and HER2-positive breast cancers (triple-positive breast cancers, TPBCs) account for 5% to 10% of all breast cancers....
Related ArticlesNeoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis. Breast Cancer Res. 2019 Aug 13;21(1):94 Authors: Nagpal A, Redvers RP, Ling X, Ayton S, Fuentes M, Tavancheh E, Diala I, Lalani A, Loi S, David S, Anderson RL, Smith Y, Merino D, Denoyer D, Pouliot N Abstract BACKGROUND: Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong...
Related ArticlesDynamic Contrast-enhanced Breast MRI for Evaluating Residual Tumor Size after Neoadjuvant Chemotherapy. Radiology. 2018 11;289(2):327-334 Authors: Kim SY, Cho N, Park IA, Kwon BR, Shin SU, Kim SY, Lee SH, Chang JM, Moon WK Abstract Purpose To investigate the accuracy of dynamic contrast material-enhanced (DCE) breast MRI for determining residual tumor size after neoadjuvant chemotherapy (NAC). Materials and Methods For this retrospective...
Tumor infiltrating B-cells signal functional humoral immune responses in breast cancer. JCI Insight. 2019 Aug 13;5: Authors: Garaud S, Buisseret L, Solinas C, Gu-Trantien C, de Wind A, Van den Eynden G, Naveaux C, Lodewyckx JN, Boisson A, Duvillier H, Craciun L, Ameye L, Veys I, Paesmans M, Larsimont D, Piccart-Gebhart M, Willard-Gallo K Abstract Tumor-infiltrating B-cells (TIL-B) in breast cancer (BC) have previously been associated with improved clinical...
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Related ArticlesPhase III study of tri-modality combination therapy with induction docetaxel plus cisplatin and 5-fluorouracil versus definitive chemoradiotherapy for locally advanced unresectable squamous-cell carcinoma of the thoracic esophagus (JCOG1510: TRIANgLE). Jpn J Clin Oncol. 2019 Aug 14;: Authors: Terada M, Hara H, Daiko H, Mizusawa J, Kadota T, Hori K, Ogawa H, Ogata T, Sakanaka K, Sakamoto T, Kato K, Kitagawa Y Abstract A randomized phase...
Related ArticlesRisk factors for acute exacerbation of idiopathic interstitial pneumonia in patients undergoing lung cancer treatment. Jpn J Clin Oncol. 2019 Aug 14;: Authors: Taya T, Chiba H, Yamada G, Takahashi M, Ikeda K, Mori Y, Otsuka M, Takahashi H Abstract OBJECTIVE: Identifying risk factors for cancer treatment-related acute exacerbations (AEs) of idiopathic interstitial pneumonia (IIP) in patients with lung cancer. METHODS: We retrospectively...
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Related ArticlesComparison Between the Protector™ Laryngeal Mask Airway and the Endotracheal Tube for Minimally Invasive Thyroid and Parathyroid Surgery. World J Surg. 2019 Aug 13;: Authors: Kotsovolis G, Pliakos I, Panidis S, Gkinas D, Papavramidis T Abstract BACKGROUND: Pharyngolaryngeal symptoms are a main concern after neck surgery. The Protector™ LMA is a new supraglottic airway device. The main purpose of this study was to evaluate whether application...
Related ArticlesRecurrence Patterns After Resection of Colorectal Liver Metastasis are Modified by Perioperative Systemic Chemotherapy. World J Surg. 2019 Aug 13;: Authors: Buisman FE, Galjart B, van der Stok EP, Balachandran VP, Boerner T, Drebin JA, Grünhagen DJ, Jarnagin WR, Kingham TP, Verhoef C, D'Angelica MI, Groot Koerkamp B Abstract BACKGROUND: This study investigated the impact of perioperative systemic chemotherapy on the recurrence rate and...
Related ArticlesOncologic Risk of Rectal Preservation Against Medical Advice After Chemoradiotherapy for Rectal Cancer: A Multicenter Comparative Cross-Sectional Study with Rectal Preservation as Supported by Surgeon. World J Surg. 2019 Aug 13;: Authors: Song KS, Park SC, Sohn DK, Oh JH, Kim MJ, Park JW, Ryoo SB, Jeong SY, Park KJ, Oh HK, Kim DW, Kang SB, Seoul Colorectal Research Group (SECOG) Abstract BACKGROUND: Rectal preservation against medical...
Preoperative Clinical Factors Associated with Short-Stay Laparoscopic Appendectomy. World J Surg. 2019 Aug 12;: Authors: Vuagniaux A, Gié O, Butti F, Marques-Vidal PM, Demartines N, Mantziari S Abstract BACKGROUND: Outpatient appendectomy for acute appendicitis is a feasible, yet not widely performed procedure, as there are no universally accepted criteria for patient selection. The aim of this study was to assess preoperative clinical factors associated...
Postoperative Pancreatic Fistula in Surgery for Perihilar Cholangiocarcinoma. World J Surg. 2019 Aug 12;: Authors: Watanabe N, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Nagino M Abstract BACKGROUND: There are numerous studies on postoperative pancreatic fistula (POPF) in pancreatic surgery but few studies on POPF in extrahepatic bile duct resection with or without hepatectomy for perihilar cholangiocarcinoma (PHCC). The aim of this...
Letter to the Editor: Perioperative Mortality Rates as a Health Metric for Acute Abdominal Surgery in Low- and Middle-Income Countries: A Systematic Review and Future Recommendations. World J Surg. 2019 Aug 12;: Authors: Usubillaga Villa A, García-Perdomo HA PMID: 31407094 [PubMed - as supplied by publisher]
Trends in Demographics and Surgical Treatment of Weapon-Related Limb Injuries Over Two Decades in a Resource-Scarce Setting. World J Surg. 2019 Aug 12;: Authors: Muhrbeck M, Holmgren K, Osman Z, von Schreeb J, Wladis A, Andersson P Abstract BACKGROUND: In the past decades, surgical management of limb injuries in high-resource settings has improved. The possibility of limb salvage has increased. It is not known whether similar changes have transpired...
Hypercoagulability After Resection of Thoracic Malignancy: A Prospective Evaluation. World J Surg. 2019 Aug 12;: Authors: Mulder MB, Proctor KG, Valle EJ, Livingstone AS, Nguyen DM, Van Haren RM Abstract BACKGROUND: Rates of venous thromboembolism are increased in thoracic malignancy; however, coagulation patterns are not established. We hypothesize that patients with esophageal and lung malignancy have similar hypercoagulable pre- and postoperative...
An Exploratory Analysis of Fecal Immunochemical Test Performance for Colorectal Cancer Screening in Nigeria. World J Surg. 2019 Aug 12;: Authors: Knapp GC, Sharma A, Olopade B, Alatise OI, Olasehinde O, Arije OO, Castle PE, Kingham TP Abstract INTRODUCTION: The fecal immunochemical test (FIT) for hemoglobin is recommended for colorectal cancer (CRC) screening in resource-limited environments. However, there are several unique variables that may alter...
Outcomes After Urgent Thyroidectomy Following Rapid Control of Thyrotoxicosis in Graves' Disease are Similar to Those After Elective Surgery in Well-Controlled Disease. World J Surg. 2019 Aug 12;: Authors: Ali A, Debono M, Balasubramanian SP Abstract BACKGROUND: Surgery for Graves' disease (GD) is usually performed after adequate control with medical treatment. Occasionally, rapid pre-operative optimization is required. The primary objective was to compare...
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Related ArticlesTrends in Incidence and Treatment of Herniated Lumbar Disc in Republic of Korea : A Nationwide Database Study. J Korean Neurosurg Soc. 2019 Aug 14;: Authors: Jung JM, Lee SU, Hyun SJ, Kim KJ, Jahng TA, Oh CW, Kim HJ Abstract Objective: This study aimed to determine the incidence and analyze trends of the herniated lumbar disc (HLD) based on a national database in the Republic of Korea (ROK) from January 2008 to December 2016. ...
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Related ArticlesMelatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro. Front Neurosci. 2019;13:760 Authors: Chen X, Xi Z, Liang H, Sun Y, Zhong Z, Wang B, Bian L, Sun Q Abstract Secondary injuries mediated by oxidative stress lead to deterioration of neurological functions after intracerebral hemorrhage (ICH). Cortical astrocytes are among the most important cells in the central nervous...
Related ArticlesEEG Correlates of Self-Managed Neurofeedback Treatment of Central Neuropathic Pain in Chronic Spinal Cord Injury. Front Neurosci. 2019;13:762 Authors: Vučković A, Altaleb MKH, Fraser M, McGeady C, Purcell M Abstract Background: Neurofeedback (NFB) is a neuromodulatory technique that enables voluntary modulation of brain activity in order to treat neurological condition, such as central neuropathic pain (CNP). A distinctive feature of...
Related ArticlesEditorial: Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection. Front Neurosci. 2019;13:770 Authors: Nalivaeva NN, Rybnikova EA PMID: 31404249 [PubMed]
Related ArticlesUric Acid Has Different Effects on Spontaneous Brain Activities of Males and Females: A Cross-Sectional Resting-State Functional MR Imaging Study. Front Neurosci. 2019;13:763 Authors: Lin L, Zheng LJ, Joseph Schoepf U, Varga-Szemes A, Savage RH, Wang YF, Zhang H, Zhang XY, Lu GM, Zhang LJ Abstract Objective: To explore the relationship among serum uric acid (SUA) levels in different states of disease, human cognition, and spontaneous...
Related ArticlesEvaluation of Functional Connectivity in the Brain Using Positron Emission Tomography: A Mini-Review. Front Neurosci. 2019;13:775 Authors: Watabe T, Hatazawa J Abstract Resting-state networks (RSNs) exhibit spontaneous functional connectivity in the resting state. Previous studies have evaluated RSNs mainly based on spontaneous fluctuations in blood oxygenation level-dependent (BOLD) signals during functional magnetic resonance imaging...
Related ArticlesIntermittent Theta Burst Stimulation of the Prefrontal Cortex in Cocaine Use Disorder: A Pilot Study. Front Neurosci. 2019;13:765 Authors: Sanna A, Fattore L, Badas P, Corona G, Cocco V, Diana M Abstract Transcranial Magnetic Stimulation (TMS) is earning a role in the therapeutic arsenal of cocaine use disorder (CUD). A widespread and still growing number of studies have reported beneficial use of repeated TMS (rTMS) in reduction of craving,...
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Related ArticlesIntravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies. Am J Case Rep. 2019 Aug 14;20:1199-1204 Authors: Tokushima M, Katsuki NE, Tago M, Yamashita SI Abstract BACKGROUND Intravascular large B-cell lymphoma (IVLBCL) is characteristically diagnosed by histological examination of biopsies of bone marrow or randomly harvested skin specimens in the absence of any diagnostic abnormalities...
Rare Huge Tubular Papillary Adenoma on the Buttock Demonstrated by Magnetic Resonance Imaging (MRI).
Rare Huge Tubular Papillary Adenoma on the Buttock Demonstrated by Magnetic Resonance Imaging (MRI). Am J Case Rep. 2019 Aug 13;20:1195-1198 Authors: Jhuang YH, Hsiao CW Abstract BACKGROUND Tubular papillary adenoma is a rare eccrine-derivate dermal adnexal tumor, located in the scalp mostly. Earlier, the sebaceous cyst size was larger than 5 cm in diameter and may be confused with subcutaneous tumor. Cases of the tumor on the buttock with rapid growth...
Related ArticlesGrill Brush Bristle Case Series: Three Unique Presentations of Ingested Foreign Bodies. Am J Case Rep. 2019 Aug 12;20:1189-1194 Authors: Appelbaum R, Nowakowski T, Zhang A, Cesanek PB, Beman S, Harrison TD Abstract BACKGROUND Much of the medical literature regarding injury from the ingestion of wire bristles from grill brushes has been published only in the last decade. Grill brushes are often used to clean grills, and small wire bristles...
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Timing and Outcomes of Tracheostomy in Patients with Hemorrhagic Stroke. World Neurosurg. 2019 Aug 10;: Authors: Chen W, Liu F, Chen J, Ma L, Li G, You C Abstract OBJECTIVES: In the present study, we sought to evaluate the timing and outcomes in patients with hemorrhagic stroke who received tracheostomy. METHODS: A retrospective database search was undertaken to identify patients with hemorrhagic stroke between January 2010 and December 2018....
Duplicated vagus nerve in adolescence: A case report and review of the literature. World Neurosurg. 2019 Aug 10;: Authors: Labuschagne JJ, Hammer N PMID: 31408750 [PubMed - as supplied by publisher]
Revascularization of the Remaining Branch of the Aorta in Advanced Takayasu Arteritis Protects Against a Wide Range of Perfusion: A case report. World Neurosurg. 2019 Aug 10;: Authors: Haji K, Ishihara H, Oka F, Nishimoto T, Morikage N, Kubo M, Suzuki M Abstract BACKGROUND: Stroke is a major factor of morbidity in the patients with Takayasu arteritis (TA). Restenosis is more common with endovascular intervention than after bypass surgery, but vascular...
A multidisciplinary team approach to brain and spine stereotactic radiosurgery conferences: A unique, institutional model. World Neurosurg. 2019 Aug 10;: Authors: Chidambaram S, Winston GM, Knisely JPS, Ramakrishna R, Juthani R, Salah K, McKenna JT, Jozsef G, Cardona D, Pannullo SC Abstract OBJECTIVE: The use of multidisciplinary teams (MDTs) comprised of all members of the patient care team is becoming increasingly popular in the field of oncology....
Related ArticlesChanges of the Expression and Activity of Phosphodiesterase Ⅴ in the Basilar Artery Before and After Cerebral Vasospasm in a Rabbit Model. World Neurosurg. 2019 Aug 09;: Authors: Huang D, Ju J, Jiang B, Wang Y, He W, Yin X, Guo W, Wang Z Abstract OBJECTIVE: To examine changes of expression and activity of phosphodiesterase Ⅴ (PDEⅤ) in the basilar artery following cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) in a rabbit...
Related ArticlesDoes nimodipine interruption due to high catecholamine doses lead to a higher incidence of delayed cerebral ischemia in the setting of aneurysmal subarachnoid hemorrhage? World Neurosurg. 2019 Aug 09;: Authors: Hernández-Durán S, Mielke D, Rohde V, Malinova V Abstract BACKGROUND: Current guidelines recommend the administration of nimodipine for the prevention of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage...
Related ArticlesLaminectomy versus Corpectomy for Spinal Metastatic Disease-Complications, Costs, and Quality Outcomes. World Neurosurg. 2019 Aug 09;: Authors: Azad TD, Varshneya K, Ho AL, Veeravagu A, Sciubba DM, Ratliff JK PMID: 31404695 [PubMed - as supplied by publisher]
Related ArticlesConfirming diagnosis and effective treatment for rare epithelioid glioblastoma variant: an integrated survival analysis of the literature. World Neurosurg. 2019 Aug 09;: Authors: Lu VM, George ND, Brown DA, Akinduro OO, Raghunathan A, Jentoft M, Quinones-Hinojosa A, Chaichana KL Abstract BACKGROUND: Epithelioid glioblastoma (eGBM) is a very rare histologic variant of glioblastoma which has not been studied in isolation, and therefore...
Related ArticlesSurgical outcome of endoscopic endonasal surgery of large and giant pituitary adenomas: An institutional experience from the Middle East. World Neurosurg. 2019 Aug 09;: Authors: Fallah N, Taghvaei M, Sadaghiani S, Sadrhosseini SM, Esfahanian F, Zeinalizadeh M Abstract OBJECTIVE: Surgical treatment of large and giant pituitary adenomas is challenging and associated with higher risk of complications and lower rate of gross total resection....
Related ArticlesInfluence of preoperative magnetic resonance imaging on the surgical decision-making for patients with acute traumatic cervical spinal cord injury: a survey among experienced spine surgeons. World Neurosurg. 2019 Aug 09;: Authors: Grassner L, Wutte C, Zimmermann G, Grillhösl A, Schmid K, Weiß T, Maier W, Hauck S, Hollerith T, Vogel M, Bierschneider M, Vastmans J, Thomé C, Gonschorek O, Strowitzki M Abstract BACKGROUND: Early decompression...
Related ArticlesCorrelation between laminar wall shear stress and growth of unruptured cerebral aneurysms: an in vivo assessment. World Neurosurg. 2019 Aug 09;: Authors: Brunozzi D, Theiss P, Andrews A, Amin-Hanjani S, Charbel FT, Alaraj A Abstract BACKGROUND: Cerebral aneurysm growth is significantly associated with aneurysm rupture, but risk factors for aneurysm growth are not well-characterized. It is believed that altered intracranial hemodynamics...
Related ArticlesA Descriptive Analysis of Spinal Cord Arteriovenous Malformations: Clinical Features, Outcomes, and Trends in Management. World Neurosurg. 2019 Aug 09;: Authors: Varshneya K, Pendharkar AV, Azad TD, Ratliff JK, Veeravagu A Abstract BACKGROUND: Spinal arteriovenous malformations (AVM) are an abnormal interconnection of vasculature in the spine than can lead to significant neurological deficit if left untreated. OBJECTIVE: The...
Related ArticlesTreatment outcomes of burr hole surgery for chronic subdural hematoma in the elderly living beyond life expectancy: a study comparing cure, recurrence and complications in patients age 80 years or older versus 79 years of age or under. World Neurosurg. 2019 Aug 09;: Authors: Watanabe S, Kato N, Sato M, Aiyama H, Fujiwara Y, Goto M, Yamazaki T, Yasuda S, Ishikawa E, Matsumura A Abstract BACKGROUND: Few reports have focused on CSDH in the...
Related ArticlesEffect of direct neurological evaluation on outcomes during treatment of unruptured intracranial aneurysms under local anesthesia. World Neurosurg. 2019 Aug 09;: Authors: Kawabata S, Imamura H, Tani S, Adachi H, Tokunaga S, Funatsu T, Suzuki K, Adachi H, Sasaki N, Matsui Y, Akiyama R, Horiuchi K, Sakai C, Sakai N PMID: 31404688 [PubMed - as supplied by publisher]
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Case report: Laparoscopic totally extraperitoneal repair of an obturator hernia with self-gripping mesh under spinal anaesthesia. Int J Surg Case Rep. 2019 Jul 22;62:14-16 Authors: Petrushnko W, Isaacs A, Hackland T, Ghusn M Abstract INTRODUCTION: Obturator hernias account for less than 0.073% of all hernias and less than 1.6% of all cases of mechanical bowel obstructions. PRESENTATION OF CASE: We present a case of a 79 year-old elderly female...
Related ArticlesIntra-articular osteoid osteoma of tempromandibular joint: A case report. Int J Surg Case Rep. 2019 Aug 01;62:9-13 Authors: Issa SA, Abdulnabi HA, Alshewered ASH Abstract INTRODUCTION: An osteoid osteoma is a benign bone neoplasm with limited growth potential, characterized by significant nocturnal pain that usually responds to non-steroidal anti-inflammatory drugs (NSAIDs). The tumor may occur in any part of the skeleton, most commonly...
Related ArticlesDuodenectomy with jejunal advancement and reimplantation of the ampulla of Vater for recurrent right colon cancer: A case report. Int J Surg Case Rep. 2019 Jul 19;62:1-4 Authors: Sugarbaker PH Abstract BACKGROUND: Local or regional recurrence of colon or rectal cancer frequently occurs if there is a positive margin of resection or spillage of cancer cells during the operation. METHODS: The clinical course of a patient with right...
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Related ArticlesAssociation of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo. JAMA Neurol. 2019 Aug 12;: Authors: Absinta M, Sati P, Masuzzo F, Nair G, Sethi V, Kolb H, Ohayon J, Wu T, Cortese ICM, Reich DS Abstract Importance: In multiple sclerosis (MS), chronic active lesions, which previously could only be detected at autopsy, can now be identified on susceptibility-based magnetic resonance imaging (MRI) in vivo as non-gadolinium-enhancing...
Related ArticlesClinical outcome prediction after thrombectomy of proximal middle cerebral artery occlusions by the appearance of lenticulostriate arteries on magnetic resonance angiography: A retrospective analysis. J Cereb Blood Flow Metab. 2018 11;38(11):1911-1923 Authors: Kaesmacher J, Kreiser K, Manning NW, Gersing AS, Wunderlich S, Zimmer C, Kleine JF, Wiestler B, Boeckh-Behrens T Abstract Post-ischemic vasodynamic changes in infarcted brain parenchyma...
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Related ArticlesAn overview of late-stage functionalization in today's drug discovery. Expert Opin Drug Discov. 2019 Aug 14;:1-13 Authors: Moir M, Danon JJ, Reekie TA, Kassiou M Abstract Introduction: Late-stage functionalization (LSF) can introduce important chemical groups in the very last steps of the synthesis. LSF has the potential to speed up the preparation of novel chemical entities and diverse chemical libraries and have a major impact on drug...
Related ArticlesAdvances in preclinical approaches to Chagas disease drug discovery. Expert Opin Drug Discov. 2019 Aug 14;:1-14 Authors: Villalta F, Rachakonda G Abstract Introduction: Chagas disease affects 8-10 million people worldwide, mainly in Latin America. The current therapy for Chagas disease is limited to nifurtimox and benznidazole, which are effective in treating only the acute phase of the disease but with severe side effects. Therefore,...
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Related ArticlesComprehensive Genomic Profiling of Adult Renal Sarcomas Provides Insight into Disease Biology and Opportunities for Targeted Therapies. Eur Urol Oncol. 2019 Apr 22;: Authors: Yakirevich E, Madison R, Fridman E, Mangray S, Carneiro BA, Lu S, Cooke M, Bratslavsky G, Webster J, Ross JS, Ali SM Abstract BACKGROUND: Primary adult renal sarcomas (RSs) are rare aggressive neoplasms. Clinical outcomes are extremely poor, and optimal treatment...
Related ArticlesDigging through a genomic goldmine: Defining the optimum upper urinary tract surveillance strategy for Lynch Syndrome. BJU Int. 2019 Aug 13;: Authors: Khan-Ruf S, Thurairajah R, Khan MS, Bultitude M, Thomas K, Nair R Abstract Clinical practice is witnessing a genomics revolution through the introduction of innovative molecular technologies and the continuing identification of novel disease-related genes. This rapidly developing field...
Related ArticlesPrimary Angiosarcoma of the Kidney: Case Report and Comprehensive Literature Review. Open Med (Wars). 2019;14:443-455 Authors: Boni A, Cochetti G, Sidoni A, Bellezza G, Lepri E, Giglio A, Turco M, Vermandois JAR, Zingaro MD, Cirocchi R, Mearini E Abstract Purpose: Angiosarcoma (AS) is an aggressive malignant tumour of endothelial origin, most frequently compelling the skin. The kidney is a rare site of primary occurrence of AS with a...
Related ArticlesA Rare Case of Syndrome of Inappropriate Anti-diuretic Hormone in Non-small Cell Lung Cancer Presenting as Superior Vena Cava Syndrome. Cureus. 2019 Jun 07;11(6):e4861 Authors: Ishihara R, Stoos C, Jagadesh S, Nguyen C Abstract Syndrome of inappropriate anti-diuretic hormone (SIADH) secretion is uncommon in small cell lung cancer (SCLC), but even more rare in cases of non-small cell lung cancer (NSCLC). We report a case of a 59-year-old...
Related ArticlesIntegrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma. Theranostics. 2019;9(17):4946-4958 Authors: Calsina B, Castro-Vega LJ, Torres-Pérez R, Inglada-Pérez L, Currás-Freixes M, Roldán-Romero JM, Mancikova V, Letón R, Remacha L, Santos M, Burnichon N, Lussey-Lepoutre C, Rapizzi E, Graña O, Álvarez-Escolá C, de Cubas AA, Lanillos J, Cordero-Barreal A,...
Related ArticlesTumor-to-tumor metastasis from appendiceal adenocarcinoma to an ovarian mature teratoma, mimicking malignant transformation of a teratoma: a case report. Diagn Pathol. 2019 Aug 14;14(1):88 Authors: Yano M, Katoh T, Hamaguchi T, Kozawa E, Hamada M, Nagata K, Yasuda M Abstract BACKGROUND: Tumor-to-tumor metastasis (TTM) is a rare but well-documented phenomenon that is defined as metastasis in a histologically distinct tumor. Ovarian mature...
Related ArticlesBAP1 Syndrome - Predisposition to Malignant Mesothelioma, Skin and Uveal Melanoma, Renal and Other Cancers. Klin Onkol. 2019;32(Supplementum2):118-122 Authors: Foretová L, Navrátilová M, Svoboda M, Házová J, Vašíčková P, Sťahlová EH, Fabian P, Schneiderová M, Macháčková E Abstract BACKGROUND: BAP1 syndrome is an autosomal dominant hereditary cancer syndrome associated with increased risk of malignant mesothelioma; uveal and cutaneous...
Related ArticlesGenetic Causes of Rare Pediatric Ovarian Tumors. Klin Onkol. 2019;32(Supplementum2):79-91 Authors: Plevová P, Geržová H Abstract BACKGROUND: Ovarian tumors in childhood and adolescence are distinguished from those that arise in adulthood by their histological subtype. These tumors may arise as the first manifestation of a cancer predisposition syndrome. Correct diagnosis of the syndrome may offer the possibility of surveillance for other...
Related ArticlesIsolated Primary MDR Tuberculosis of a Lumbar Spinous Process, in an Immunocompetent Patient, Mimicking a Spinal Tumour. J Assoc Physicians India. 2018 Jun;66(6):109-110 Authors: Dadlani R, Dadlani R, Manam G Abstract Spinal tuberculosis (STB) accounts for a large proportion of extra-pulmonary tuberculosis. STB usually begins in the peri-discal region of the vertebral bodies and isolated involvement of the posterior elements of the spine...
Related ArticlesAn Unusual Case of Chronic Hepatitis E in Haematological Malignancy. J Assoc Physicians India. 2018 Jun;66(6):97-98 Authors: Chandak S, Mandot A, Rathi S Abstract Hepatitis E is an enterically transmitted and typically self-limited infection, that is caused by the hepatitis E virus. Hepatitis E viral infection has traditionally been considered an acute. Chronic hepatitis E is rare and occurs mainly in immunosuppressed individuals such...
Related ArticlesA unique case of aggressive uterine cancer in a 45-year-old man with persistent Müllerian duct syndrome. Arch Esp Urol. 2019 05;72(4):435-438 Authors: Dimasis N, Koukourikis P, Klampatsas A, Xirou P, Sountoulides P Abstract OBJECTIVE: Persistent Müllerian Duct Syndrome (PMDS), one of the causes of male pseudohermaphroditism, is a rare syndrome characterized by the presence of internal female genitalia (uterus, fallopian, tubes, cervix...
Related Articles[Laparoscopic renal cyst excision: Large simple renal cyst treatment with renal cell carcinoma cells in its wall. Histogenetic considerations and bibliographic review.] Arch Esp Urol. 2019 May;72(4):422-428 Authors: Serrano Á, Sánchez M, Ciappara M, López E, Laso S, Jerez T, Barrera J, Cortés JA, González-Peramato P, Blazquez J, Moreno J Abstract OBJECTIVE: The incidence of simple renal cysts is very high, especially in elderly people....
Related Articles[Cysts in the lung : A practical guide to differential diagnosis]. Radiologe. 2019 May;59(5):473-486 Authors: van Dijk R, Schaefer-Prokop C Abstract Solitary or multiple pulmonary cysts are a relatively rare finding and should always prompt the search for an underlying cause. High-resolution computed tomography (HRCT) plays a crucial role in the differential diagnosis with morphological findings, such as cyst shape and size, wall consistency,...
Two Rare Cases of Therapy-Related Acute Lymphoblastic Leukemia in Patients With Plasma Cell Myeloma.
Related ArticlesTwo Rare Cases of Therapy-Related Acute Lymphoblastic Leukemia in Patients With Plasma Cell Myeloma. Ann Lab Med. 2019 Sep;39(5):496-498 Authors: Lee HY, Park CJ, Ahn A, Lee MY, Cho YU, Jang S, Seo EJ, Lee KH, Lee JH PMID: 31037870 [PubMed - indexed for MEDLINE]
Related Articles[Quantitative proteomics of inhibitory mechanism of Dendrobium denneanum ether extract on lung cancer cells]. Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(4):765-773 Authors: Zhang XQ, Li Y, Liu J, Zhao TM, Zhao RX, Zheng SG, Chun Z, Hu YD Abstract Dendrobium denneanum have been used for a long time as rare medicinal herbs in traditional Chinese medicine. Our previous works found that ether extract of D. denneanum had higher anticancer activities...
Related Articles[Iodinated contrast medium in patients with thyroid disorders]. Radiologe. 2019 May;59(5):413-424 Authors: Leidig-Bruckner G Abstract BACKGROUND: Adequate intake of iodine is essential for normal thyroid function. However, sudden exposure to high amounts of iodine may cause thyroid dysfunction. AIM: The aims of this paper are to summarize the literature on the effects of iodinated contrast medium (CM) on thyroid function, the...
Related Articles[A Case of Laparoscopic Abdominoperineal Resection of Anorectal Malignant Melanoma]. Gan To Kagaku Ryoho. 2019 Mar;46(3):573-575 Authors: Okuda H, Nakahara M, Yano T, Bekki T, Hirohata R, Hakoda K, Hirata F, Abe T, Fujikuni N, Sasada T, Yamaki M, Amano H, Noriyuki T Abstract A 56-year-old woman with complaints of anal bleeding and pain visited our hospital, and an elastic soft mass was detected in the anal canal on digital examination.Colonoscopy...
Related Articles[Metachronous Gastric Intramural Metastasis following Esophageal Cancer ESD-A Case Study]. Gan To Kagaku Ryoho. 2019 Mar;46(3):570-572 Authors: Ogasawara H, Oishi S, Hasebe T, Nara M, Nozaki T, Yoshihara S Abstract We report a case of metachronous gastric intramural metastasis following esophageal cancer endoscopic submucosal dissection( ESD). The patient was an 80s man who was referred to the department of gastroenterology of our hospital...
Related Articles[Two Cases of Pancreatectomy for Pancreatic Metastasis from Renal Cell Carcinoma]. Gan To Kagaku Ryoho. 2019 Mar;46(3):561-563 Authors: Teranishi R, Hatanaka N, Hara S, Takayama K, Shimura Y, Ohashi T, Osawa H, Sakai K, Yasumasa K, Noro H, Hirao T, Iwasaki T, Yamasaki Y, Fujimoto N Abstract Metastasis of renal cell carcinoma to the pancreas is a relatively rare condition. We encountered 2 such cases. The first case was a 72-year-old...
Related Articles[A Resected Case of Reactive Lymphoid Hyperplasia of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma]. Gan To Kagaku Ryoho. 2019 Mar;46(3):540-542 Authors: Yoshioka R, Tomimaru Y, Noguchi K, Nagase H, Ogino T, Hirota M, Oshima K, Tanida T, Noura S, Imamura H, Iwazawa T, Akagi K, Tamura H, Adachi S, Dono K Abstract A60s woman was followed-up regularly for primary biliary cholangitis and a solitary enlarging hepatic mass...
Related Articles[The Strategy for the Treatment of Perforated Gastric Cancer]. Gan To Kagaku Ryoho. 2019 Mar;46(3):508-510 Authors: Tsuchida K, Saeki H, Matsumoto A, Kamioka Y, Watanabe H, Kato A, Numata K, Harada H, Matsukawa H, Rino Y, Masuda M Abstract Perforated gastric cancer reported to be relatively rare and to have a poor prognosis. This study examined 9 patients with perforated gastric cancer. Two-thirds of the patients were male and the median...
[Ⅰ.New TNM Classification of Bone and Soft Tissue Sarcoma-Changes between the 7th and 8th Editions].
Related Articles[Ⅰ.New TNM Classification of Bone and Soft Tissue Sarcoma-Changes between the 7th and 8th Editions]. Gan To Kagaku Ryoho. 2019 Mar;46(3):433-436 Authors: Mori T, Kobayashi E, Kawai A PMID: 30914579 [PubMed - indexed for MEDLINE]
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Related Articles[Outcomes of primary central nervous system lymphoma patients treated with high-dose methotrexate and rituximab]. Rinsho Ketsueki. 2019;60(2):87-92 Authors: Shiota Y, Dobashi N, Ito Y, Hosoba R, Yamauchi H, Ishii H, Nakano A, Fukushima R, Ohba R, Yahagi Y, Usui N, Yano S Abstract Primary central nervous system lymphoma (PCNSL) is a rare, aggressive type of non-Hodgkin lymphoma with a poor prognosis and no defined optimal therapeutic...
Related Articles[Cytomegalovirus meningoencephalitis in a diffuse large B-cell lymphoma patient undergoing salvage chemotherapy]. Rinsho Ketsueki. 2019;60(2):124-129 Authors: Yoshida K, Kosako H, Yamashita Y, Kobata H, Oiwa T, Hosoi H, Murata S, Mushino T, Nishikawa A, Araoka H, Sonoki T, Tamura S Abstract A 63-year-old woman was admitted to our hospital to receive a fourth course of modified rituximab-ESHAP chemotherapy for relapsed primary breast...
Related ArticlesClinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study. Eur J Med Res. 2019 Feb 28;24(1):16 Authors: Wu X, Li B, Zheng C, Hong T, He X Abstract BACKGROUND: Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular neoplasm with increasing incidence. However, its clinical characteristics remain unclear due to its low incidence. This study aimed to investigate the features of EHE. ...
Related ArticlesRetroperitoneal fibrosis after chemo-radiotherapy for cervical cancer: A case report. J Obstet Gynaecol Res. 2019 Apr;45(4):938-941 Authors: Takahashi Y, Matsushima H, Mori T, Kokabu T, Ito F, Kitawaki J Abstract Retroperitoneal fibrosis (RPF) is a rare disease characterized by proliferation of fibro-inflammatory tissue in the retroperitoneum. Multiple studies have reported on the idiopathic cases of the disease, but reports of RPF secondary...
Related ArticlesHematological Malignancies in Adults With a Family Predisposition. Dtsch Arztebl Int. 2018 12 14;115(50):848-854 Authors: Bochtler T, Haag GM, Schott S, Kloor M, Krämer A, Müller-Tidow C Abstract BACKGROUND: Some hematological malignancies arise in persons with a hereditary predisposition. The hereditary nature of these diseases often goes unrecognized, particularly when symptoms begin in adulthood. METHODS: This review is...
Related ArticlesPure large cell neuroendocrine carcinoma of ovary: A rare clinical entity. J Exp Ther Oncol. 2019 Jan;13(1):55-58 Authors: Doğanay M, Cengaver N, Kızılkanat KT, Öz M, Akbay S, Kokanali MK Abstract Objective: Large cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare tumour. Its pure form without any associated surface epithelial stromal or germ cell component is more rarely seen. Its prognosis is generally very poor even when...
Related ArticlesManagement options for a patient with squamous cell carcinoma arising in a mature cystic teratoma of the ovary. J Exp Ther Oncol. 2019 Jan;13(1):45-48 Authors: Baum S, DiGregorio K, Alhassan R, Jormark S, Villella J Abstract Objective: Mature cystic teratomas, also referred to as dermoid cysts, are one of the commonly occurring ovarian germ cell tumors. Malignant transformation of a germ cell tumor occurs approximately 1-2% of the time....
Related ArticlesMultiple Cardiac Papillary Fibroelastomas - Are They Really Rare or Underdiagnosed? Heart Lung Circ. 2019 Apr;28(4):e83-e85 Authors: Nowacka A, Rancati V, Roumy A, Monney P, Marcucci CE, Kirsch M PMID: 30415831 [PubMed - indexed for MEDLINE]
Related Articles[Neuroendocrine Neoplasia within the German NET Registry]. Z Gastroenterol. 2018 Oct;56(10):1237-1246 Authors: Im Namen aller Teilnehmer/innen am Deutschen NET-Registers, Authors, Kollaboratoren: Abstract Neuroendocrine neoplasias (NEN) comprise a rare tumor entity with heterogeneous biology, prognosis and therapeutic options. Together with the recent publication of the first German guidelines on diagnostics and therapy of NEN, an analysis...
Related ArticlesColorectal MALT lymphoma: a rare clinical entity. Z Gastroenterol. 2018 08;56(8):905-911 Authors: Fischbach W Abstract BACKGROUND: Data on colorectal lymphoma in general and on MALT (mucosa-associated-lymphoid tissue) lymphoma, in particular are, very rare. There are no existing recommendations from current guidelines for how to manage these patients. We here report our experience from a clinical series. AIM: The aim of this...
Related Articles[Imaging findings of intramammary malignant lymphoproliferative disease]. Radiologe. 2018 Oct;58(10):929-934 Authors: Wienbeck S, Meyer HJ, Surov A Abstract Intramammary manifestation of lymphoproliferative disease is rare. The radiological evaluation follows in most cases the clinical suspicion and therefore the radiologist takes an important place in diagnostics. The aim of this work is to demonstrate typical radiological patterns...
Related ArticlesRecurrent diffuse gastric bleeding as a leading symptom of gastrointestinal AL amyloidosis. Z Gastroenterol. 2017 Dec;55(12):1318-1322 Authors: Franck C, Venerito M, Weigt J, Roessner A, Malfertheiner P Abstract Amyloidosis is a rare disease (incidence about 0.8/100 000) characterized by extracellular tissue deposition of fibrils composed of low molecular weight subunits of a variety of serum proteins. Clinical manifestations are largely...
Related ArticlesGastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) - a rare recently described gastric polyposis syndrome - report of a case. Z Gastroenterol. 2017 Nov;55(11):1131-1134 Authors: Beer A, Streubel B, Asari R, Dejaco C, Oberhuber G Abstract In rare cases with multiple gastric polyps in the corpus and fundus, a recently described gastric polyposis syndrome called gastric adenocarcinoma and proximal polyposis of the stomach...
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