What can we do to help young cancer survivors minimize financial hardship in the United States? Expert Rev Anticancer Ther. 2019 Aug 13;: Authors: Zheng Z, Han X, Zhao J, Yabroff KR PMID: 31408395 [PubMed - as supplied by publisher]
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Related ArticlesBig Data in sleep apnoea: Opportunities and challenges. Respirology. 2019 Aug 14;: Authors: Pépin JL, Bailly S, Tamisier R Abstract Sleep apnoea is now regarded as a highly prevalent systemic, multimorbid, chronic disease requiring a combination of long-term home-based treatments. Optimization of personalized treatment strategies requires accurate patient phenotyping. Data to describe the broad variety of phenotypes can come from electronic...
Related ArticlesObstructive sleep apnoea and susceptibility to cardiovascular disease: A blessing or curse of old age? Respirology. 2019 Aug 14;: Authors: Jun JC, Polotsky VY PMID: 31411783 [PubMed - as supplied by publisher]
Related ArticlesIs there a relationship between hematological parameters and duration of respiratory events in severe OSA. Aging Male. 2019 Aug 14;:1-7 Authors: Durmaz DY, Güneş A Abstract Aim: The aim of this study was to compare hematological parameters with the mean obstructive apnea duration (MOAD), mean mixed apnea duration (MMAD), mean central apnea duration (MCAD), mean total apnea duration (MTAD) and mean hypopnea duration (MHD), and blood oxygenation,...
Related ArticlesAfrican ethnicity is associated with a higher prevalence of diabetes in obstructive sleep apnea patients: results of a retrospective analysis. Sleep Breath. 2019 Aug 14;: Authors: Andreozzi F, Van Overstraeten C, Ben Youssef S, Bold I, Carlier S, Gruwez A, André S, Bruyneel AV, Bruyneel M Abstract PURPOSE: Obstructive sleep apnea (OSA) syndrome is a well-recognized independent risk factor for cardiovascular disease and its prevalence...
Related ArticlesValidation of a portable monitoring device for the diagnosis of obstructive sleep apnea: electrocardiogram-based cardiopulmonary coupling. Sleep Breath. 2019 Aug 13;: Authors: Lu M, Fang F, Sanderson JE, Ma C, Wang Q, Zhan X, Xie F, Xiao L, Liu H, Liu H, Wei Y Abstract PURPOSE: We aimed to evaluate the validity of the cardiopulmonary coupling (CPC) device, a limited-channel portable monitoring device for obstructive sleep apnea (OSA)...
Development of positional obstructive sleep apnea (POSA) after upper airway surgery in OSA patients.
Related ArticlesDevelopment of positional obstructive sleep apnea (POSA) after upper airway surgery in OSA patients. Sleep Breath. 2019 Aug 13;: Authors: Martínez Ruiz de Apodaca P, Carrasco Llatas M, Matarredona Quiles S, Dalmau Galofre J Abstract PURPOSE: Positional therapy (PT) has become more reliable for obstructive sleep apnea (OSA) patients with the use of new devices. The objectives of this study were to determine the preoperative prevalence...
Related ArticlesThe Association of Obstructive Sleep Apnea and Hypertension. Cureus. 2019 Jun 07;11(6):e4858 Authors: Patel AR, Patel AR, Singh S, Singh S, Khawaja I Abstract Obstructive sleep apnea (OSA) is a condition characterized by recurrent episodes of partial or complete upper airway obstruction during sleep. Hypertension (HTN) is defined by the presence of a chronic elevation of systemic arterial pressure above a certain threshold value (≥140...
Related ArticlesAugmented O-GlcNAcylation attenuates intermittent hypoxia-induced cardiac remodeling through the suppression of NFAT and NF-κB activities in mice. Hypertens Res. 2019 Aug 13;: Authors: Nakagawa T, Furukawa Y, Hayashi T, Nomura A, Yokoe S, Moriwaki K, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M Abstract Type 2 diabetes mellitus (T2DM) has been reported to be associated with cardiac remodeling. Although O-GlcNAcylation is...
Related ArticlesChronic insomnia remitting after maxillomandibular advancement for mild obstructive sleep apnea: a case series. J Med Case Rep. 2019 Aug 14;13(1):252 Authors: Proothi M, Grazina VJR, Gold AR Abstract BACKGROUND: Chronic insomnia and obstructive sleep apnea are both common sleep disorders. Chronic insomnia is thought to result from stress-related physiologic hyperarousal (somatic arousal) that makes it difficult for an individual to fall...
Related ArticlesCausative Factors for Complications in Transpalatal Advancement. Ann Otol Rhinol Laryngol. 2019 Aug 13;:3489419867969 Authors: Chan L, Kitpornchai L, Mackay S Abstract INTRODUCTION: Transpalatal advancement (TPA) is a procedure that is used when modern variants of uvulopharyn-gopalatoplasty are unable to provide enough anterior traction. Although successful in reduction of obstructive sleep apnea (OSA) parameters, it also comes with procedure-specific...
Related ArticlesRisk Assessment for Self Reported Obstructive Sleep Apnea and Excessive Daytime Sleepiness in a Greek Nursing Staff Population. Medicina (Kaunas). 2019 Aug 12;55(8): Authors: Alexandropoulou A, Vavougios GD, Hatzoglou C, Gourgoulianis KI, Zarogiannis SG Abstract Background and objectives: The risk assessment of Obstructive Sleep Apnea (OSA) and Excessive Daytime Sleepiness (EDS) in specific occupational populations is important due to...
Pilot study of the potential of 3D ultrasound to measure tonsillar volume and hypertrophy. Int J Pediatr Otorhinolaryngol. 2019 Jul 31;126:109612 Authors: Chung D, Bandarkar A, Rana MS, Tabrizi PR, Preciado D, Jago J, Linguraru MG, Reilly BK Abstract OBJECTIVE: Obstructive sleep apnea (OSA), results in approximately 4-5 million outpatient visits per year in the United States. In pediatric patients, OSA is primarily caused by adenotonsillar hypertrophy,...
BPAP is an effective second-line therapy for obese patients with OSA failing regular CPAP: A prospective observational cohort study. Respirology. 2019 Aug 12;: Authors: Ishak A, Ramsay M, Hart N, Steier J Abstract BACKGROUND AND OBJECTIVE: Continuous positive airway pressure (CPAP) is the most common treatment for obstructive sleep apnoea (OSA), but many patients fail long-term therapy. Bilevel positive airway pressure (BPAP) is a potential alternative....
Interventional techniques to increase implantation success of transvenous phrenic nerve stimulation for central sleep apnea treatment. Sleep Breath. 2019 Aug 12;: Authors: Gutleben KJ, Fox H, Sommer P, Rudolph V, Nölker G Abstract PURPOSE: Central sleep apnea (CSA) is a highly common comorbidity in heart failure (HF) patients and is known to deteriorate quality of life and prognosis. Effective treatment options are scarce. Transvenous phrenic nerve stimulation...
Conversion of Laparoscopic Roux en Y Gastric Bypass (RYGB) to Single Anastomosis Duodenal Switch (SADS). Obes Surg. 2019 Aug 12;: Authors: Casajoana A, Borden B, Zarabi S, Roslin M Abstract BACKGROUND: The surgical management of weight regain following RYGB remains controversial. Simpler modifications such as endoscopic suturing and banding the bypass have had variable efficacy. Distalization of the bypass has resulted in a high risk of malabsorption-related...
Prevalence of obstructive sleep apnea in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2463-2468 Authors: Fallahi A, Jamil DI, Karimi EB, Baghi V, Gheshlagh RG Abstract Obstructive sleep apnea (OSA) is highly prevalent among patients with diabetes, intensifying the complications of the disease. Various studies in Iran have reported different prevalence rates. This systematic review and...
CBCT analysis of pharyngeal airway volume and comparison of airway volume among patients with skeletal Class I, Class II, and Class III malocclusion: A retrospective study. Cranio. 2019 Aug 12;:1-12 Authors: Nath M, Ahmed J, Ongole R, Denny C, Shenoy N Abstract Objective: To study the influence of skeletal malocclusion on the oropharyngeal airway volume and the difference in the airway volume among gender and the different types of skeletal malocclusion....
Related ArticlesEffects of Continuous Positive Airway Pressure on Body Composition in Individuals with Obstructive Sleep Apnea: A Non-Randomized, Matched Before-After Study. J Clin Med. 2019 Aug 10;8(8): Authors: Shechter A, Airo M, Valentin J, Dugas NC, Abdalla M, St-Onge MP, Louh IK Abstract A reciprocal relationship between obesity and obstructive sleep apnea (OSA) likely exists, wherein obesity contributes to OSA, and OSA-related sleep disturbances...
Related ArticlesA Pilot Study About the Dysfunction of Adipose Tissue in Male, Sleep Apneic Patients in Relation to Psychological Symptoms. Front Psychiatry. 2019;10:527 Authors: Trakada G, Nikolaidis PT, Economou NT, Sakkas D, Giagkou G, Sakellariou S, Kyriakopoulou K, Patsouris E, Ferini-Strambi L, Velentza L, Kallianos A, Rosemann T, Knechtle B, Mitrakou A Abstract Introduction: Obstructive sleep apnea (OSA) and its cardiometabolic alterations are...
Related ArticlesRisk factors of sleep-disordered breathing in haemodialysis patients. PLoS One. 2019;14(8):e0220932 Authors: Chu G, Suthers B, Moore L, Paech GM, Hensley MJ, McDonald VM, Choi P Abstract BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with kidney disease; but often underdiagnosed as it is infrequently assessed in clinical practice. The objective of this study was to assess the risk factors of SDB in haemodialysis patients,...
Related ArticlesReliability of lateral cephalometric radiographs in the assessment of the upper airway in children: A retrospective study. Angle Orthod. 2019 Aug 12;: Authors: Savoldi F, Xinyue G, McGrath CP, Yang Y, Chow SC, Tsoi JKH, Gu M Abstract OBJECTIVES: To test the reliability of Lateral cephalometric radiographs (LCRs) for use in the assessment of the upper airway, hyoid bone, soft palate, and tongue. MATERIALS AND METHODS: The records...
Related ArticlesAssociation Between Adherence to CPAP Treatment and Cost Among Medicare Enrollees. Sleep. 2019 Aug 12;: Authors: Chhatre S, Chang YHA, Gooneratne NS, Kuna S, Strollo P, Jayadevappa R Abstract OBJECTIVE: To analyze the cost associated with sleep apnea, and effects of CPAP treatment on costs among fee-for-service Medicare beneficiaries. METHODS: Retrospective cohort design using 5% Medicare claims between 2006 and 2010. Medicare...
Related ArticlesMinimally Invasive Hysterectomy and Bariatric Surgery to Improve Endometrial Cancer Survivorship. Obstet Gynecol. 2019 Aug 07;: Authors: Shafa A, Kumar A, Torres D, McKenzie TJ Abstract BACKGROUND: Surgery is curative for the majority of early-stage endometrial cancers. Postoperatively, patients are actually at much higher risk of mortality from obesity-related comorbidities unless they have sustained weight loss. CASE: A 54-year-old...
Related ArticlesOpioid-induced Ventilatory Depression in Sleep Apnea: Reply. Anesthesiology. 2019 Aug 06;: Authors: Doufas AG, Shafer SL, Henthorn TK PMID: 31403499 [PubMed - as supplied by publisher]
Related ArticlesOpioid-induced Ventilatory Depression in Sleep Apnea: Comment. Anesthesiology. 2019 Aug 06;: Authors: Overdyk FJ, Dahan A, Chung F, Warner MA PMID: 31403497 [PubMed - as supplied by publisher]
Related ArticlesCognitive and behavioral therapy for insomnia increases the use of continuous positive airway pressure therapy in obstructive sleep apnea participants with co-morbid insomnia: A randomized clinical trial. Sleep. 2019 Aug 12;: Authors: Sweetman A, Lack L, Catcheside PG, Antic NA, Smith S, Chai-Coetzer CL, Douglas J, O'Grady A, Dunn N, Robinson J, Paul D, Williamson P, McEvoy RD Abstract STUDY OBJECTIVES: Insomnia and obstructive sleep...
Related ArticlesCost-effectiveness of continuous positive airway pressure therapy for obstructive sleep apnea: health care system and societal perspectives. Sleep. 2019 Aug 12;: Authors: Streatfeild J, Hillman D, Adams R, Mitchell S, Pezzullo L Abstract STUDY OBJECTIVES: To determine cost effectiveness of continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea (OSA) in Australia for 2017-18 to facilitate public health decision-making....
Related ArticlesSleep and hypertension. Sleep Breath. 2019 Aug 12;: Authors: Han B, Chen WZ, Li YC, Chen J, Zeng ZQ Abstract PURPOSE: Hypertension is a global public issue, and sleep status was regarded as its risk factor; however, the results were inconsistent. This study aims to deeply investigate the correlation between sleep status and hypertension. METHODS: The electronic databases Cochrane Library, Pubmed, and Embase updated to May 31,...
Related ArticlesDetecting central sleep apnea in adult patients using WatchPAT-a multicenter validation study. Sleep Breath. 2019 Aug 11;: Authors: Pillar G, Berall M, Berry R, Etzioni T, Shrater N, Hwang D, Ibrahim M, Litman E, Manthena P, Koren-Morag N, Rama A, Schnall RP, Sheffy K, Spiegel R, Tauman R, Penzel T Abstract STUDY OBJECTIVES: To assess the accuracy of WatchPAT (WP-Itamar-Medical, Caesarea, Israel) enhanced with a novel systolic upstroke...
Related ArticlesUse of noninvasive positive pressure ventilation in patients with severe obesity undergoing esophagogastroduodenoscopy: a randomized controlled trial. Surg Obes Relat Dis. 2019 Jun 29;: Authors: Gedeon M, Gomes S, Roy K, Duclos-Miller P, Rose JS Abstract BACKGROUND: Patients with severe obesity being considered for bariatric surgery often undergo preoperative esophagogastroduodenoscopy (EGD). Severe obesity is a risk factor for oxygen...
Related ArticlesPredictability of pharyngeal airway space dimension changes after orthognathic surgery in class II patients: A mathematical approach. J Craniomaxillofac Surg. 2019 Jul 25;: Authors: Wiedemeyer V, Berger M, Martini M, Kramer FJ, Heim N Abstract INTRODUCTION: Angle Class II malocclusion due to mandibular retrognathia is a common dentofacial deformity. It is well known that mandibular advancement increases pharyngeal airway dimensions. The...
Related ArticlesSubspecialization … and Clinical Guidelines. Anesth Analg. 2018 10;127(4):815-816 Authors: Hillman DR PMID: 30216284 [PubMed - indexed for MEDLINE]
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Related ArticlesFocus on sleep-disordered breathing and central nervous hypersomnolence. J Sleep Res. 2018 08;27(4):e12740 Authors: Riemann D PMID: 29998538 [PubMed - indexed for MEDLINE]
Related ArticlesUnderstanding Brain Functions in Children with Sleep-disordered Breathing. Am J Respir Crit Care Med. 2018 06 01;197(11):1380-1381 Authors: Amin R PMID: 29444411 [PubMed - indexed for MEDLINE]
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Related ArticlesChronic insomnia remitting after maxillomandibular advancement for mild obstructive sleep apnea: a case series. J Med Case Rep. 2019 Aug 14;13(1):252 Authors: Proothi M, Grazina VJR, Gold AR Abstract BACKGROUND: Chronic insomnia and obstructive sleep apnea are both common sleep disorders. Chronic insomnia is thought to result from stress-related physiologic hyperarousal (somatic arousal) that makes it difficult for an individual to fall...
Related ArticlesCausative Factors for Complications in Transpalatal Advancement. Ann Otol Rhinol Laryngol. 2019 Aug 13;:3489419867969 Authors: Chan L, Kitpornchai L, Mackay S Abstract INTRODUCTION: Transpalatal advancement (TPA) is a procedure that is used when modern variants of uvulopharyn-gopalatoplasty are unable to provide enough anterior traction. Although successful in reduction of obstructive sleep apnea (OSA) parameters, it also comes with procedure-specific...
Related ArticlesSleep and hypertension. Sleep Breath. 2019 Aug 12;: Authors: Han B, Chen WZ, Li YC, Chen J, Zeng ZQ Abstract PURPOSE: Hypertension is a global public issue, and sleep status was regarded as its risk factor; however, the results were inconsistent. This study aims to deeply investigate the correlation between sleep status and hypertension. METHODS: The electronic databases Cochrane Library, Pubmed, and Embase updated to May 31,...
Related ArticlesDetecting central sleep apnea in adult patients using WatchPAT-a multicenter validation study. Sleep Breath. 2019 Aug 11;: Authors: Pillar G, Berall M, Berry R, Etzioni T, Shrater N, Hwang D, Ibrahim M, Litman E, Manthena P, Koren-Morag N, Rama A, Schnall RP, Sheffy K, Spiegel R, Tauman R, Penzel T Abstract STUDY OBJECTIVES: To assess the accuracy of WatchPAT (WP-Itamar-Medical, Caesarea, Israel) enhanced with a novel systolic upstroke...
Related ArticlesPerformance of the STOP-Bang in the Detection of OSA, a Brazilian study. Rev Assoc Med Bras (1992). 2019 Aug 05;65(7):995-1000 Authors: Rodrigues Filho JC, Neves DD, Araujo-Melo MH Abstract OBJECTIVES: Assess the performance of the Stop-Bang questionnaire in Brazilian patients for the screening of OSA. METHODS: A cross-sectional study with historical and consecutive analysis of all patients who underwent polysomnography tests...
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Assessments of Otolaryngology Resident Operative Experiences Using Mobile Technology: A Pilot Study.
Assessments of Otolaryngology Resident Operative Experiences Using Mobile Technology: A Pilot Study. Otolaryngol Head Neck Surg. 2019 Aug 13;:194599819868165 Authors: Chen JX, Kozin E, Bohnen J, George B, Deschler DG, Emerick K, Gray ST Abstract OBJECTIVES: Surgical education has shifted from the Halstedian model of "see one, do one, teach one" to a competency-based model of training. Otolaryngology residency programs can benefit from a fast and simple...
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Related ArticlesCrosstalk Between Long Non-coding RNAs, Micro-RNAs and mRNAs: Deciphering Molecular Mechanisms of Master Regulators in Cancer. Front Oncol. 2019;9:669 Authors: López-Urrutia E, Bustamante Montes LP, Ladrón de Guevara Cervantes D, Pérez-Plasencia C, Campos-Parra AD Abstract Cancer is a complex disease, and its study requires deep understanding of several biological processes and their regulation. It is an accepted fact that non-coding...
Related ArticlesComparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer. Front Oncol. 2019;9:667 Authors: Kwon MJ, Lee JE, Jeong J, Woo SU, Han J, Kang BI, Kim JE, Moon Y, Lee SB, Lee S, Choi YL, Kwon Y, Song K, Gong G, Shin YK Abstract Introduction: The GenesWell Breast Cancer Test (BCT) is a recently developed multigene assay that predicts...
Related ArticlesDosimetric and Radiobiological Comparison of External Beam Radiotherapy Using Simultaneous Integrated Boost Technique for Esophageal Cancer in Different Location. Front Oncol. 2019;9:674 Authors: Wang L, Li C, Meng X, Li C, Sun X, Shang D, Pang L, Li Y, Lu J, Yu J Abstract Objectives: To compare treatment plans of intensity modulated radiotherapy (IMRT), volumetric modulated arc radiotherapy (VMAT), and helical tomotherapy (HT) with simultaneous...
Related ArticlesCOMplot, A Graphical Presentation of Complication Profiles and Adverse Effects for the Curative Treatment of Gastric Cancer: A Systematic Review and Meta-Analysis. Front Oncol. 2019;9:684 Authors: van den Ende T, Abe Nijenhuis FA, van den Boorn HG, Ter Veer E, Hulshof MCCM, Gisbertz SS, van Oijen MGH, van Laarhoven HWM Abstract Background: For the curative treatment of gastric cancer, several neoadjuvant, and adjuvant treatment-regimens...
Related ArticlesComprehensive Genomic Profiling of EBV-Positive Diffuse Large B-cell Lymphoma and the Expression and Clinicopathological Correlations of Some Related Genes. Front Oncol. 2019;9:683 Authors: Zhou Y, Xu Z, Lin W, Duan Y, Lu C, Liu W, Su W, Yan Y, Liu H, Liu L, Zhong M, Zhou J, Zhu H Abstract Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (EBV+ DLBCL) is a rare type of lymphoma with a high incidence in elderly patients,...
Related ArticlesSecond-Line Systemic Treatment for Metastatic Urothelial Carcinoma: A Network Meta-Analysis of Randomized Phase III Clinical Trials. Front Oncol. 2019;9:679 Authors: Yoon HS, Kwak C, Kim HH, Kim HS, Ku JH Abstract Purpose: We aimed to evaluate and compare relative impacts of various second-line treatments on overall survival (OS) in metastatic urothelial carcinoma (mUC). Method: A literature search was conducted in PubMed, Embase, and...
Related ArticlesA Full-Image Deep Segmenter for CT Images in Breast Cancer Radiotherapy Treatment. Front Oncol. 2019;9:677 Authors: Schreier J, Attanasi F, Laaksonen H Abstract Radiation therapy is one of the key cancer treatment options. To avoid adverse effects in the healthy tissue, the treatment plan needs to be based on accurate anatomical models of the patient. In this work, an automatic segmentation solution for both female breasts and the heart...
Related ArticlesAssociation Between Simian Virus 40 and Human Tumors. Front Oncol. 2019;9:670 Authors: Rotondo JC, Mazzoni E, Bononi I, Tognon M, Martini F Abstract Simian virus 40 (SV40) is a small DNA tumor virus of monkey origin. This polyomavirus was administered to human populations mainly through contaminated polio vaccines, which were produced in naturally infected SV40 monkey cells. Previous molecular biology and recent immunological assays have...
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Related ArticlesCRISPR technology to combat plant RNA viruses: A theoretical model for Potato virus Y (PVY) resistance. Microb Pathog. 2019 Aug;133:103551 Authors: Hameed A, Shan-E-Ali Zaidi S, Sattar MN, Iqbal Z, Tahir MN Abstract RNA viruses are the most diverse phytopathogens which cause severe epidemics in important agricultural crops and threaten the global food security. Being obligatory intracellular pathogens, these viruses have developed fine-tuned...
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Risk Factors for Problem Drinking among Evacuees in Fukushima following the Great East Japan Earthquake: The Fukushima Health Management Survey. Tohoku J Exp Med. 2019;248(4):239-252 Authors: Ueda Y, Murakami M, Maeda M, Yabe H, Suzuki Y, Orui M, Yasumura S, Ohira T, Fukushima Health Management Survey Group Abstract Many studies have consistently reported the bidirectional relationship between problem drinking and psychological distress following a disaster,...
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Related ArticlesA case of near-sudden unexpected death in epilepsy due to ventricular fibrillation. Open Access Emerg Med. 2019;11:161-166 Authors: Seo MH, Sung WY Abstract Sudden unexpected death in epilepsy (SUDEP) refers to the sudden and unexpected death of an epileptic patient with no other health issues, during normal activity, and for whom no other particular cause of death can be found. The exact cause of SUDEP has not been established yet; however,...
Related ArticlesEncapsulated Neuroprotection to the Rescue-or How to Safely Protect a Brain From Seizing. Epilepsy Curr. 2019 Aug 13;:1535759719868464 Authors: Gross C Abstract Long-Term, Targeted Delivery of GDNF From Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy Paolone G, Falcicchia C, Lovisari F, et al. J Neurosci. 2019;39(11):2144-2156. doi:10.1523/JNEUROSCI.0435-18.2018. Epub 2019 Jan 21. Neurotrophic...
Related ArticlesPredicting Response to Treatment of Epileptic Seizures: How Much Time and How Many AEDs Do We Need to Try? Epilepsy Curr. 2019 Aug 13;:1535759719868466 Authors: Hogan RE Abstract Identification of Patients Who Will Not Achieve Seizure Remission Within 5 Years on AEDs Hughes DM, Bonnett LJ, Czanner G, Komárek A, Marson AG, García Fiñana M. Neurology. 2018;91(22):e2035-e2044. doi: 10.1212/WNL.0000000000006564. Epub 2018 Nov 2. PMID: 30389894...
Related ArticlesAdult Neurogenesis in the Development of Epilepsy. Epilepsy Curr. 2019 Aug 13;:1535759719868186 Authors: Danzer SC Abstract Compelling evidence indicates that hippocampal dentate granule cells are generated throughout human life and into old age. While animal studies demonstrate that these new neurons are important for memory function, animal research also implicates these cells in the pathogenesis of temporal lobe epilepsy. Several recent...
Related ArticlesWhat Is the Best Target for Ablation of Mesial Temporal Lobe Epilepsy? Epilepsy Curr. 2019 Aug 13;:1535759719868460 Authors: King-Stephens D Abstract Effects of Surgical Targeting in Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy: A Multicenter Study of 234 Patients Wu C, Jermakowicz WJ, Chakravorti S, Cajigas I, Sharan AD, Jagid JR, Matias CM, Sperling MR, Buckley R, Ko A, Ojemann JG, Miller JW, Youngerman B, Sheth...
Related ArticlesGeometric morphometrics reveal altered corpus callosum shape in pyridoxine-dependent epilepsy. Neurology. 2018 07 03;91(1):e78-e86 Authors: Oesch G, Maga AM, Friedman SD, Poliachik SL, Budech CB, Wright JN, Bok LA, Gospe SM Abstract OBJECTIVE: To evaluate the features and maturational changes in overall callosal shape in patients with pyridoxine-dependent epilepsy (PDE). METHODS: Measurements were conducted through landmark-based...
Related ArticlesHigh plasma levels of ghrelin and des-acyl ghrelin in responders to antiepileptic drugs. Neurology. 2018 07 03;91(1):e62-e66 Authors: Marchiò M, Roli L, Giordano C, Caramaschi E, Guerra A, Trenti T, Biagini G Abstract OBJECTIVE: To reconsider ghrelin and des-acyl ghrelin plasma levels in children with epilepsy in order to establish a possible relation with response to antiepileptic drugs (AEDs). METHODS: We designed an observational...
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
59 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
59 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related ArticlesThe senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. Aging (Albany NY). 2019 Aug 14;: Authors: Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone MA, Peluso G, Galderisi U Abstract Senescent cells secrete inflammatory cytokines, proteases, and other factors, which are indicated as senescence-associated...
Related ArticlesRedox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death. Redox Biol. 2019 Aug 02;26:101290 Authors: El Banna N, Hatem E, Heneman-Masurel A, Léger T, Baïlle D, Vernis L, Garcia C, Martineau S, Dupuy C, Vagner S, Camadro JM, Huang ME Abstract Vitamin C (VitC) possesses pro-oxidant properties at high pharmacologic concentrations which favor...
Related ArticlesYiqi Chutan Tang Reduces Gefitinib-Induced Drug Resistance in Non-Small-Cell Lung Cancer by Targeting Apoptosis and Autophagy. Cytometry A. 2019 Aug 14;: Authors: Zhang J, Sun L, Cui J, Wang J, Liu X, Aung TN, Qu Z, Chen Z, Adelson DL, Lin L Abstract High incidence and mortality rates for non-small-cell lung cancer (NSCLC) lead to low survival rates. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) are commonly first...
Related ArticlesModerate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;: Authors: You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD, Pabelick CM, Prakash YS Abstract Hyperoxia exposure in premature infants increases the risk of subsequent lung diseases such as asthma and bronchopulmonary dysplasia. Fibroblasts help maintain bronchial...
Related ArticlesMIM1 induces COLO829 melanoma cells death trough mitochondrial membrane breakdown, GSH depletion and DNA damage. Fundam Clin Pharmacol. 2019 Aug 14;: Authors: Respondek M, Beberok A, Rzepka Z, Rok J, Wrześniok D Abstract Malignant melanoma is a high aggressive malignancy in humans and causes 60-80% of deaths from skin cancer. Defect in an intrinsic pathway of apoptosis via overexpression of Mcl-1 is responsible for malignant melanoma...
Related ArticlesExploration of quinolone and quinoline derivatives as potential anticancer agents. Daru. 2019 Aug 13;: Authors: Iqbal J, Ejaz SA, Khan I, Ausekle E, Miliutina M, Langer P Abstract BACKGROUND: Among the different types of cancers, breast cancer, bone cancer and cervical cancer are the most common gender specific cancer types that are affecting the women worldwide. Currently, many enzymatic and cellular pathways are known as drug targets...
Related ArticlesIdentification of crucial genes based on expression profiles of hepatocellular carcinomas by bioinformatics analysis. PeerJ. 2019;7:e7436 Authors: Liu ZK, Zhang RY, Yong YL, Zhang ZY, Li C, Chen ZN, Bian H Abstract Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant cancers with no effective targets and treatments. However, the molecular pathogenesis of HCC remains largely uncertain. The aims of our study were to...
Related ArticlesEpigenetic modification in the expression of p73 p73 - epigenetic target for anticancer therapy. Oncol Rev. 2019 Jul 22;13(2):421 Authors: Naseer F, Saleem M Abstract A p73 is a new member of p53 family of transcription factor, having two types. First is TAp73, transcriptionally active and expressed via upstream promoter as a tumor suppressor and vital apoptotic inductor, it also has a key role in cell cycle arrest/differentiation and...
Related ArticlesGefitinib suppresses cervical cancer progression by inhibiting cell cycle progression and epithelial-mesenchymal transition. Exp Ther Med. 2019 Sep;18(3):1823-1830 Authors: Zheng J, Yu J, Yang M, Tang L Abstract Cervical cancer (CC) is the second most common malignant cancer among women. Gefitinib was one of the first-generation epidermal growth factor receptor-tyrosine kinase inhibitors in clinical trials. However, the underlying mechanism...
Related ArticlesTargeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release. Int J Nanomedicine. 2019;14:5503-5526 Authors: Shahein SA, Aboul-Enein AM, Higazy IM, Abou-Elella F, Lojkowski W, Ahmed ER, Mousa SA, AbouAitah K Abstract Background and purpose: Glioma is one of the most aggressive primary brain tumors and is incurable. Surgical resection, radiation,...
Related ArticlesIdentification of AUNIP as a candidate diagnostic and prognostic biomarker for oral squamous cell carcinoma. EBioMedicine. 2019 Aug 10;: Authors: Yang Z, Liang X, Fu Y, Liu Y, Zheng L, Liu F, Li T, Yin X, Qiao X, Xu X Abstract BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors worldwide. Patients with poorly differentiated OSCC often exhibit a poor prognosis. AUNIP (Aurora Kinase A and Ninein Interacting...
Related ArticlesThe Novel Nature Microtubule Inhibitor Ivalin Induces G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells In Vitro. Medicina (Kaunas). 2019 Aug 12;55(8): Authors: Liu F, Lin S, Zhang C, Ma J, Han Z, Jia F, Xie W, Li X Abstract Background and Objectives: Microtubules are an attractive target for cancer chemotherapy. Previously, we reported that Ivalin exhibited excellent anti-migration and anti-invasion activities...
Related ArticlesCheckpoints and beyond - Immunotherapy in colorectal cancer. Semin Cancer Biol. 2019 04;55:78-89 Authors: Gutting T, Burgermeister E, Härtel N, Ebert MP Abstract Immunotherapy is the latest revolution in cancer therapy. It continues to show impressive results in malignancies like melanoma and others. At least so far, effects are modest in colorectal cancer (CRC) and only a subset of patients benefits from already approved checkpoint...
A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae. Chin Med. 2019;14:27 Authors: Luo Y, Feng Y, Song L, He GQ, Li S, Bai SS, Huang YJ, Li SY, Almutairi MM, Shi HL, Wang Q, Hong M Abstract Background: Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular carcinoma...
Related ArticlesSLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8): Authors: Gomes S, Bosco B, Loureiro JB, Ramos H, Raimundo L, Soares J, Nazareth N, Barcherini V, Domingues L, Oliveira C, Bisio A, Piazza S, Bauer MR, Brás JP, Almeida MI, Gomes C, Reis F, Fersht AR, Inga A, Santos MMM, Saraiva L Abstract Half of human cancers harbor TP53 mutations...
Related ArticlesLentivirus-mediated RNA interference targeting EBNA1 gene inhibits the growth of GT-38 cells in vitro and in vivo. Oncol Lett. 2019 Sep;18(3):2286-2291 Authors: Wang J, Liang C, Meng F, Xu X, Wu Y, Lu L Abstract Epstein-Barr virus nuclear antigen 1 (EBNA1) is associated with the pathogenesis of Epstein-Barr virus-associated gastric carcinoma (EBVaGC). However, the function of EBNA1 in the growth of EBVaGC cells remains unclear. In the...
Related ArticlesFormononetin: A Review of Its Anticancer Potentials and Mechanisms. Front Pharmacol. 2019;10:820 Authors: Tay KC, Tan LT, Chan CK, Hong SL, Chan KG, Yap WH, Pusparajah P, Lee LH, Goh BH Abstract Cancer, a complex yet common disease, is caused by uncontrolled cell division and abnormal cell growth due to a variety of gene mutations. Seeking effective treatments for cancer is a major research focus, as the incidence of cancer is on the...
Related ArticlesEffects of astragalus injection on different stages of early hepatocarcinogenesis in a two-stage hepatocarcinogenesis model using rats. J Toxicol Pathol. 2019 Jul;32(3):155-164 Authors: Tang Q, Zhang M, Hong Z, Chen Y, Wang P, Wang J, Wang Z, Fang R, Jin M Abstract To clarify the suppressive effects of astragalus injection (AI) on different stages of early hepatocarcinogenesis induced by weak promotion, SD rats initiated with a single...
Enhancing the cytotoxic efficacy of combined effect of doxorubicin and Cyclosporin encapsulated photoluminescent graphene dotted mesoporous nanoparticles against lung cancer cell-specific drug targeting for the nursing care of cancer patients. J Photochem Photobiol B. 2019 Jul 24;198:111578 Authors: Chen F, Zhang H, Jiang L, Wei W, Liu C, Cang S Abstract In recent years, biological nanomedicine-based biomaterials have an extreme attention for biomedical...
Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents. Eur J Med Chem. 2019 Jul 31;181:111570 Authors: Cury NM, Capitão RM, Almeida RDCB, Artico LL, Corrêa JR, Simão Dos Santos EF, Yunes JA, Correia CRD Abstract Despite the success achieved in the treatment of acute lymphoblastic leukemia (ALL), the search for new drugs featuring selectivity against leukemia cells and effectiveness to prevent relapsed ALL...
Arnicolide D exerts anti-melanoma effects and inhibits the NF-κB pathway. Phytomedicine. 2019 Aug 02;64:153065 Authors: Zhu P, Zheng Z, Fu X, Li J, Yin C, Chou J, Wang Y, Liu Y, Chen Y, Bai J, Wu J, Chen S, Yu ZL Abstract BACKGROUND: Melanoma is a lethal cancer. NF-κB has been validated as a molecular target for melanoma treatment. Current therapies for melanoma have limitations. Novel targeted therapeutics are needed. Arnicolide D (Ar-D), a sesquiterpene...
APLNR is involved in ATRA-induced growth inhibition of nasopharyngeal carcinoma and may suppress EMT through PI3K-Akt-mTOR signaling. FASEB J. 2019 Aug 13;:fj201802416RR Authors: Liu Y, Liu Q, Chen S, Liu Y, Huang Y, Chen P, Li X, Gao G, Xu K, Fan S, Zeng Z, Xiong W, Tan M, Li G, Zhang W Abstract The apelin receptor (APLNR) is a GPCR involved in many pathophysiological processes; however, the correlation between APLNR expression and nasopharyngeal carcinoma...
Induction of ROS and DNA damage-dependent senescence by icaritin contributes to its antitumor activity in hepatocellular carcinoma cells. Pharm Biol. 2019 Dec;57(1):424-431 Authors: Wang S, Wang Q, Wang H, Qin C, Cui X, Li L, Liu Y, Chang H Abstract Context: Icaritin (ICT), a prenylflavonoid derivative extracted from the Epimedium (Berberidaceae) genus, has been identified to exhibit antitumor effect in hepatocellular carcinoma (HCC) cells by inducing...
Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma. Oncogene. 2019 Aug 12;: Authors: Nakagawa M, Nakatani F, Matsunaga H, Seki T, Endo M, Ogawara Y, Machida Y, Katsumoto T, Yamagata K, Hattori A, Fujita S, Aikawa Y, Ishikawa T, Soga T, Kawai A, Chuman H, Yokoyama N, Fukushima S, Yahiro K, Kimura A, Shimada E, Hirose T, Fujiwara T, Setsu N, Matsumoto Y, Iwamoto Y, Nakashima Y, Kitabayashi...
Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe. Sci Rep. 2019 Aug 12;9(1):11635 Authors: Ishii S, Matsuura A, Itakura E Abstract Lysosomes are largely responsible for significant degradation of intracellular and extracellular proteins via the secretory pathway, autophagy, and endocytosis. Therefore, dysregulation of lysosomal homeostasis influences diverse cellular functions. However, a straightforward...
Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells. Sci Rep. 2019 Aug 12;9(1):11628 Authors: Chang YT, Teng YN, Lin KI, Wang CCN, Morris-Natschke SL, Lee KH, Hung CC Abstract Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant...
Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway. Med Sci Monit. 2019 Aug 13;25:6023-6033 Authors: Chen Y, Zhu W Abstract BACKGROUND The PCK1 gene encodes phosphoenolpyruvate carboxykinase (PEPCK), which has been shown have a role in metabolic events in hepatocellular carcinoma (HCC). This study aimed to investigate the role of the SHH gene...
Deletion of INMAP postpones mitotic exit and induces apoptosis by disabling the formation of mitotic spindle. Biochem Biophys Res Commun. 2019 Aug 09;: Authors: Wang Y, Gu Q, Yan K, Zhu Y, Tan T, Zheng Y, Wang X, Zou T, Liang Q Abstract INMAP was first identified as a spindle protein that plays important roles in cell-cycle progression, and previous studies have revealed that its abnormal expression leads to mitotic disorder and the growth inhibition...
Related ArticlesAlyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization. Biomol Ther (Seoul). 2019 Aug 13;: Authors: Pocasap P, Weerapreeyakul N, Thumanu K Abstract To determine the chemopreventive potential of alyssin and iberin, the in vitro anticancer activities and molecular targets of isothiocyanates (ITCs) were measured and compared to sulforaphane...
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