Hippocampal sharp-wave ripples (SWRs) constitute one of the most synchronized activation events in the brain and play a critical role in offline memory consolidation. Yet their cognitive content and function during awake, conscious behavior remains unclear. We directly examined this question using intracranial recordings in human patients engaged in episodic free recall of previously viewed photographs. Our results reveal a content-selective increase in hippocampal ripple rate emerging 1 to 2 seconds...
Here we report a solution-processing strategy to stabilize the perovskite-based heterostructure. Strong Pb–Cl and Pb–O bonds formed between a [CH(NH2)2]x[CH3NH3]1–xPb1+yI3 film with a Pb-rich surface and a chlorinated graphene oxide layer. The constructed heterostructure can selectively extract photogenerated charge carriers and impede the loss of decomposed components from soft perovskites, thereby reducing damage to the organic charge-transporting semiconductors. Perovskite solar cells with an...
Colloidal semiconductor quantum dots (QDs) are attractive materials for realizing highly flexible, solution-processable optical gain media, but they are difficult to use in lasing because of complications associated with extremely short optical-gain lifetimes limited by nonradiative Auger recombination. By combining compositional grading of the QD’s interior for hindering Auger decay with postsynthetic charging for suppressing parasitic ground-state absorption, we can reduce the lasing threshold...
Steady-state turnover is a hallmark of epithelial tissues throughout adult life. Intestinal epithelial turnover is marked by continuous cell migration, which is assumed to be driven by mitotic pressure from the crypts. However, the balance of forces in renewal remains ill-defined. Combining biophysical modeling and quantitative three-dimensional tissue imaging with genetic and physical manipulations, we revealed the existence of an actin-related protein 2/3 complex–dependent active migratory force,...
The general theory of relativity predicts that a star passing close to a supermassive black hole should exhibit a relativistic redshift. In this study, we used observations of the Galactic Center star S0-2 to test this prediction. We combined existing spectroscopic and astrometric measurements from 1995–2017, which cover S0-2’s 16-year orbit, with measurements from March to September 2018, which cover three events during S0-2’s closest approach to the black hole. We detected a combination of special...
The high-temperature, all-inorganic CsPbI3 perovskite black phase is metastable relative to its yellow, nonperovskite phase at room temperature. Because only the black phase is optically active, this represents an impediment for the use of CsPbI3 in optoelectronic devices. We report the use of substrate clamping and biaxial strain to render black-phase CsPbI3 thin films stable at room temperature. We used synchrotron-based, grazing incidence, wide-angle x-ray scattering to track the introduction...
An essential prerequisite for the survival of an organism is the ability to detect and respond to aversive stimuli. Current belief is that noxious stimuli directly activate nociceptive sensory nerve endings in the skin. We discovered a specialized cutaneous glial cell type with extensive processes forming a mesh-like network in the subepidermal border of the skin that conveys noxious thermal and mechanical sensitivity. We demonstrate a direct excitatory functional connection to sensory neurons and...
Szuwalski argues that varying age structure can affect surplus production and that recruitment is a better metric of productivity. We explain how our null model controlled for age structure and other processes as explanations for the temperature-production relationship. Surplus production includes growth, recruitment, and other processes and provides a more complete description of food production impacts than does recruitment alone.
Increased planting densities have boosted maize yields. Upright plant architecture facilitates dense planting. Here, we cloned UPA1 (Upright Plant Architecture1) and UPA2, two quantitative trait loci conferring upright plant architecture. UPA2 is controlled by a two-base sequence polymorphism regulating the expression of a B3-domain transcription factor (ZmRAVL1) located 9.5 kilobases downstream. UPA2 exhibits differential binding by DRL1 (DROOPING LEAF1), and DRL1 physically interacts with LG1 (LIGULELESS1)...
Walking and running have fundamentally different biomechanics, which makes developing devices that assist both gaits challenging. We show that a portable exosuit that assists hip extension can reduce the metabolic rate of treadmill walking at 1.5 meters per second by 9.3% and that of running at 2.5 meters per second by 4.0% compared with locomotion without the exosuit. These reduction magnitudes are comparable to the effects of taking off 7.4 and 5.7 kilograms during walking and running, respectively,...
Quantum-state-selective electron recombination studies suggest enhanced abundance of primordial HeH+
The epoch of first star formation in the early Universe was dominated by simple atomic and molecular species consisting mainly of two elements: hydrogen and helium. Gaining insight into this constitutive era requires a thorough understanding of molecular reactivity under primordial conditions. We used a cryogenic ion storage ring combined with a merged electron beam to measure state-specific rate coefficients of dissociative recombination, a process by which electrons destroy molecular ions. We found...
Spin-triplet superconductors potentially host topological excitations that are of interest for quantum information processing. We report the discovery of spin-triplet superconductivity in UTe2, featuring a transition temperature of 1.6 kelvin and a very large and anisotropic upper critical field exceeding 40 teslas. This superconducting phase stability suggests that UTe2 is related to ferromagnetic superconductors such as UGe2, URhGe, and UCoGe. However, the lack of magnetic order and the observation...
Isotope compositions of basalts provide information about the chemical reservoirs in Earth’s interior and play a critical role in defining models of Earth’s structure. However, the helium isotope signature of the mantle below depths of a few hundred kilometers has been difficult to measure directly. This information is a vital baseline for understanding helium isotopes in erupted basalts. We measured He-Sr-Pb isotope ratios in superdeep diamond fluid inclusions from the transition zone (depth of...
Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at high spatial and temporal resolution. However, the utility of existing GEVIs has been limited by the brightness and photostability of fluorescent proteins and rhodopsins. We engineered a GEVI, called Voltron, that uses bright and photostable synthetic dyes instead of protein-based fluorophores, thereby extending the number of neurons imaged simultaneously in vivo by a factor of 10 and enabling imaging for significantly...
DNA viruses typically eject genomic DNA into the nuclei of host cells after entry. It is unclear, however, how nuclear pathogen–derived DNA triggers innate immune responses. We report that heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) recognizes pathogenic DNA and amplifies interferon-α/β (IFN-α/β) production. Upon DNA virus infection, nuclear-localized hnRNPA2B1 senses viral DNA, homodimerizes, and is then demethylated at arginine-226 by the arginine demethylase JMJD6. This results in...
Free et al. (Reports, 1 March 2019, p. 979) linked sea surface temperature (SST) to surplus production and estimated a 4% decline in maximum sustainable yield (MSY) since 1930. Changes in MSY are expected when fitting production models to age-structured data, so attributing observed changes to SST is problematic. Analyses of recruitment (a metric of productivity in the same database) showed increases in global productivity.
Mitochondria are organelles with their own genome that arose from α-proteobacteria living within single-celled Archaea more than a billion years ago. This step of endosymbiosis offered tremendous opportunities for energy production and metabolism and allowed the evolution of fungi, plants, and animals. However, less appreciated are the downsides of this endosymbiosis. Coordinating gene expression between the mitochondrial genomes and the nuclear genome is imprecise and can lead to proteotoxic stress....
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This Surgical Pearl describes the use of frontal sinus transillumination during cranioplasty surgery for facial feminization.
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Ekso Bionics, the California company that makes some of the most advanced exoskeletons out there, is releasing its latest neurorehabilitation suit, the EksoNR. Designed primarily to help people recovering from a stroke, the device recreates the natural movement of the legs and helps patients re-learn how to walk, sit, and do all the things they used to do. The EksoNR is based on the EksoGT device, the most popular rehab robotic exoskeleton on the market. The new model features...
Researchers at Ecole Polytechnique Fédérale de Lausanne in Switzerland have developed a flexible and stretchable pump for soft robotics. The existence of the device, described in the latest journal Nature, means that soft robots may no longer need to be tethered to rigid and bulky pumps, allowing for greater versatility in soft medical devices, such as artificial muscles and assistive wearables. Soft robots offer significant advantages in medical devices, as they can more safely interact...
Dignitana, a company out of Lund, Sweden, won FDA clearance and is now distributing its DigniCap Delta scalp cooling system in the U.S. The University of California, San Francisco (UCSF) will be the first recipient in America of the fourth generation system that’s designed to prevent hair loss in patients undergoing chemotherapy to fight solid tumors. The system pumps a cool liquid, carefully controlled thanks to a number of sensors, through a cap worn by patients undergoing chemo....
Mixonix, a Farmingdale, New York company that focuses on ultrasonic devices for surgical applications, including osteotomies and debridements, landed European CE Mark approval for its Nexus surgical platform. The system was FDA cleared earlier this year. The Nexus combines the capabilities of Mixonix’s three existing products, namely BoneScalpel, SonicOne and Sonastar, into a single system that can be used to perform tumor resections, bone corrections, and a variety of other procedures....
TARA Biosystems, a firm based in New York City, and GlaxoSmithKline have managed to grow adult cardiac tissue inside the Biowire II platform developed by TARA, and have used this live tissue as a test bed for cardiac drug research. Previously, growing cardiac tissue from human induced pluripotent stem cells that can be used in laboratory experiments has resulted in fetal-like cell phenotypes. Heart diseases, though, typically affect adult patients and the drugs that treat them will have different...
After a cancer is discovered in a patient, the biggest fear is that it will metastasize to other parts of the body. Currently, there’s really nothing that doctors can do to alter a cancer’s ability to shed tumor cells that can easily travel far away from their birth site. Now, researchers at Ohio State University have discovered that low intensity electromagnetic fields can be used to halt the ability of cancer cells to spread around the body. What’s particularly remarkable, and will hopefully...
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Abstract Introduction Menopause can lead to osteoporosis, which is characterized by destruction of bone microstructure, poor mechanical properties, and prone to fracture. LIPUS can effectively promote bone formation and fracture healing. MSTN is a transforming growth factor-β family member that acts as a negative regulator of skeletal muscle growth. A MSTN deficiency also has a positive effect on bone formation. However, whether LIPUS...
Abstract The RDT population, initially at 215 patients, exceeded 300,000 in 2011, with a total of 329,609 patients at the end of December 2016. In our Institute, the number of patients with destructive spondylosis is increasing with the increase in the number of dialysis patients in Japan. We had 14 Cases in the 1990s, and then 82 cases in the 2000s and have already had 131 cases in the 2010s. The purpose of this study was to investigate the incidence of dialysis-related amyloidosis...
Abstract High-resolution melting (HRM) analysis has been shown to be a time-saving method for the screening of genetic variants. To increase the precision of the diagnosis of osteogenesis imperfecta (OI), we used HRM to explore COL1A1/COL1A2 mutations in 87 Chinese OI patients and to perform population-based studies of the relationships between their genotypes and phenotypes. Peripheral blood samples were collected from the 87 non-consanguineous probands. The coding regions and...
Abstract Treatment strategies of medication-related osteonecrosis of the jaw (MRONJ) are controversial. Recently, surgical treatment has been reported as superior to nonsurgical treatment, but the contribution discontinued antiresorptive agent use during MRONJ treatment remains unclear. This study aimed to evaluate the efficacy of drug holidays and treatment strategies in MRONJ cases. Four-hundred and twenty-seven patients with MRONJ treated at nine hospitals from 2009 to 2017...
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Authors: Sónia Rocha, Carlos Azevedo, Ângela Alves, Carlos Antunes and Graça Casal.Parasite Vol. 26 , page 48 Keywords: Myxosporea ; Myxobolidae ; Cypriniformes ; phylogeny ; SSU rDNA gene.
Authors: Sónia Rocha, Carlos Azevedo, Ângela Alves, Carlos Antunes and Graça Casal.<br />Parasite Vol. 26 , page 48<br /> Keywords: Myxosporea ; Myxobolidae ; Cypriniformes ; phylogeny ; SSU rDNA gene.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/MqQCNVAgQTQ" height="1" width="1" alt=""/>
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Publication date: Available online 15 August 2019Source: Sleep MedicineAuthor(s): Caroline Kroll, Melody Cristina Mansoni Carraro Trombelli, Lidiane Ferreira Schultz, Renatha El Rafihi-Ferreira, Marco F. MastroeniAbstractObjectivesTo evaluate the association of leptin rs7799039 and adiponectin rs2241766 gene polymorphisms on daily sleep duration in 4-5-year-old children.MethodsData were obtained from the Predictors of Maternal and Infant Excess Body Weight - PREDI Study, a cohort study conducted...
Publication date: Available online 14 August 2019Source: Sleep MedicineAuthor(s): Priscila Farias Tempaku, Marcos Leite SANTORO, Lia Bittencourt, Vania D’Almeida, Sintia Iole Belangero, Sergio TufikAbstractObjective/background: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that has a complex phenotype. Currently, few genes have been linked with OSA. Thus, the aim of this study was to conduct a genome-wide association study (GWAS) of the apnea-hypopnea index (AHI) variation along...
Publication date: Available online 14 August 2019Source: Sleep MedicineAuthor(s): Kun-Tai Kang, Shuenn-Nan Chiu, Che-Yi Lin, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung HsuObjectiveLimited information is currently available on 24-h ambulatory blood pressure (ABP) changes after adenotonsillectomy (T&A) in children with obstructive sleep apnea (OSA). In this study, the trajectory of 24-h ABP changes after surgery in children with OSA was examined at 3-month and 6-month follow-up.MethodsChildren aged...
Publication date: Available online 14 August 2019Source: Sleep MedicineAuthor(s): Claudio Liguori, Evi Holzknecht, Fabio Placidi, Francesca Izzi, Nicola Biagio Mercuri, Birgit Högl, Ambra StefaniAbstractIntroductionRestless legs syndrome (RLS) is a common sensorimotor neurological disorder, with symptoms that might cause sleep fragmentation leading to excessive daytime sleepiness. A seasonality of RLS symptoms has been suggested; however, to date, no study focused on this aspect. In order to detect...
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Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrotic lung disease with an unknown aetiology. Persistent myofibroblast differentiation is a prominent feature of IPF. Cigarette smoking is a risk factor for IPF and an indicator of poor prognosis. Cigarette smoking induces endoplasmic reticulum (ER) stress, and it has been shown that ER stress promotes fibroblast-to-myofibroblast differentiation in lung fibrosis. In this study, we investigated whether cigarette smoke extract...
Background: Chronic hypersensitivity pneumonitis (CHP) is characterized by lymphocytic inflammation and progressive fibrosis of the lung caused by a variety of inhaled antigens. Due to the difficulty of accurately diagnosing CHP, and the poor prognosis associated with the condition, a novel clinical biomarker is urgently needed. Objective: To investigate the usefulness of C-C motif chemokine ligand 15 (CCL15), which had been demonstrated to highly express in the lungs of CHP patients, as a clinical...
Introduction: In adults, linear endobronchial ultrasound (EBUS) is the preferred modality to sample intrathoracic adenopathy and radial EBUS is a useful tool to biopsy peripheral pulmonary nodules. Utility in children is less well known. Objectives: The objective of this study was to review the EBUS experience of two specialist centres to better define the current role of EBUS in paediatric practice. Methods: A retrospective record review of EBUS procedures undertaken in patients aged 0–17 years...
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94 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
94 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
236 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
97 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Mucosal Immunology, Published online: 15 August 2019; doi:10.1038/s41385-019-0194-9IL-10 signaling in dendritic cells controls IL-1β-mediated IFNγ secretion by human CD4+ T cells: relevance to inflammatory bowel disease
Mucosal Immunology, Published online: 14 August 2019; doi:10.1038/s41385-019-0192-yThe antibody/microbiota interface in health and disease
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Publication date: Available online 14 August 2019Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): A. Picard, F. Zazurca, G. Franchi, N. Kadlub, E. Galliani, C. Neiva-Vaz, V. Soupre, M. Mitrofanoff, R.H. Khonsari, P.A. Diner, M.P. VazquezRésuméLa déformation nasale résiduelle chez les patients porteurs de fente labiopalatine reste la demande principale de ces derniers. La réalisation d’une chirurgie primaire nasale a considérablement amélioré les résultats. Cependant, il est encore souvent...
Publication date: Available online 14 August 2019Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): U. Lancien, N. Brault, N. Ouar, M. Atlan, Q. Qassemyar
Publication date: Available online 14 August 2019Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): S. de MortilletRésuméLes complications de l’augmentation mammaire par implants sont rares au regard du bénéfice morphologique et psychologique induit par cette intervention. Les principales complications sont ; l’hématome, l’infection, le sérome avec la nécessité absolue de rechercher un lymphome anaplasique à grandes cellules associé aux implants mammaires et la contraction de la capsule...
Publication date: Available online 14 August 2019Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): P. Ridel, M. Lemesle, N. Vabres, U. Lancien, P. PerrotRésuméObjectifDix pour cent des brûlures de l’enfant seraient dû à des abus. En rapportant une série de 6 cas graves de brûlures infligées chez l’enfant par immersion, nous exposons notre démarche diagnostique systématique de maltraitance et confirmons le caractère particulièrement grave des brûlures lorsqu’elles sont infligées.Patients...
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Publication date: Available online 14 August 2019Source: Allergology InternationalAuthor(s): Minoru Gotoh, Kimihiro Okubo, Atsushi Yuta, Yukiko Ogawa, Hitoshi Nagakura, Shigehiro Ueyama, Tomoyo Ueyama, Kayoko Kawashima, Masashi Yamamoto, Shigeharu Fujieda, Masafumi Sakashita, Hirokazu Sakamoto, Naruhito Iwasaki, Eri Mori, Tomonori Endo, Nobuo Ohta, Hiroshi Kitazawa, Mitsuhiro Okano, Mikiya Asako, Masami TakadaAbstractBackgroundThere have been no studies of dual administration of sublingual immunotherapy...
Publication date: Available online 13 August 2019Source: Allergology InternationalAuthor(s): Toshihiro Osada, Akira Yamada, Eiji Sasaki, Teruhiro Utsugi
Publication date: Available online 13 August 2019Source: Allergology InternationalAuthor(s): Yuka Kimura, Toshiyuki Koya, Takashi Hasegawa, Hiroshi Ueno, Kazutaka Yoshizawa, Yosuke Kimura, Masachika Hayashi, Satoshi Watanabe, Toshiaki Kikuchi, the Niigata Asthma Treatment Study GroupAbstractBackgroundAdherence Starts with Knowledge-12 (ASK-12) is a useful indicator of drug adherence. In this study, we analyzed patient background including social and psychological factors in a low-adherence group...
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20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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2159 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
2159 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
6895 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
6895 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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96 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
96 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
389 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
389 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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