Growth arrest‐specific transcript 5 (GAS5) regulates the proliferation, cell cycle, and apoptosis of myocardial infarction (MI) through regulation of microRNA (miR)‐525‐5p/calmodulin 2 (CALM2) axis. This is the first study to uncover the expression and biological role of GAS5 in MI and supply the basis for the clinical investigation of GAS5 as biomarker for diagnosis of MI Abstract Long noncoding RNAs (lncRNAs) play critical roles in the pathogenesis of cardiovascular diseases, especially in...
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IJERPH, Vol. 16, Pages 2988: Factors and Contingencies for the “It Pays to Be Green Hypothesis”. The European Union’s Emissions Trading System (EU ETS) and Financial Crisis as Contexts International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162988 Authors: Joaquín Cañón-de-Francia Concepión Garcés-Ayerbe This study provides empirical evidence related to the “it pays to be green” hypothesis. Based on information from panel data approximately...
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Necrotizing enterocolitis (NEC) is a serious disease that affects premature neonates, causing high mortality. In the search for new options of treatment it was investigated whether fecal microbiota transplantation (FMT) decreased the inflammatory response during NEC development in experimental model.
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Omphaloceles can be some of the more challenging cases managed by pediatric surgeons. Single center studies have not been meaningful in delineating outcomes due to the length of time required to accumulate a large enough series with historical changes in management negating the results. The purpose of this study was to evaluate factors impacting the morbidity and mortality of neonates with omphaloceles.
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The authors regret
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Many people feel anxiety when they go to the dentist. For a child with autism, the sensory elements of the dentist might overwhelm them and make them resist visits. However, through home practice, familiarization appointments, and support, most children with autism or other communication disorders can overcome their anxieties about dental care and enjoy positive appointments for years to come. I’ve been practicing family dentistry for 17 years. I always try to make patients as comfortable as possible...
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Abstract This quasi-experimental pilot study describes preliminary impacts of the “Home Visitation Enhancing Linkages Project (HELP),” a pragmatic screen-and-refer approach for promoting identification of and linkage to treatment for maternal depression (MD), substance use (SU), and intimate partner violence (IPV) within early childhood home visiting. HELP includes screening for MD, SU, and IPV followed by a menu of motivational interviewing and case management interventions aimed...
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Abstract The PAX Good Behavior Game (PAX GBG) is a behavior management strategy that has demonstrated positive effects on children’s behavior and well-being in trials conducted mainly in the USA. This study assessed the impact of the PAX GBG on students’ mental health and behavior 7 and 19 months post-baseline in Estonia. This matched-pair, cluster-randomized, waitlist-controlled, open-label trial included 42 Estonian elementary schools with 708 first-grade...
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Abstract Severe combined immune deficiency (SCID) is caused by an array of genetic disorders resulting in a diminished adaptive immune system due to impaired T lymphocytes. In these patients, active infection at the time of hematopoietic transplantation has been shown to increase morbidity and mortality. To prevent transmission of infections in SCID patients, standardized infection control precautions should be implemented. An online survey regarding SCID-specific protocols was...
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Abstract Unmanned aerial vehicles (UAVs) are increasingly used for many scientific applications, including archaeological surveys. We test the suitability and practicability of UAV surveying in the tropical lowlands of Brazil and techniques for visualizing the resulting digital elevation models, specifically the Red Relief Image Map (RRIM). We present the results of UAV surveys conducted at four diverse archaeological earthwork sites situated in interfluvial southwestern Amazonia, in the state of...
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An interview with Dr. Joanne S. Tornow, Assistant Director for the National Science Foundation's (NSF) Directorate for Biological Sciences (BIO), has been published in the August 2019 issue of BioScience. James M. Verdier, Senior Editor for BioScience, interviewed Dr. Tornow about BIO's current operations and future plans. The article entitled, "Joanne S. Tornow: Advancing Opportunities for Convergence," is available at https://doi.org/10.1093/biosci/biz068. An audio version of this conversation...
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Study Shows Low Incidence of Early Toxicity Using Stereotactic Body Radiation Therapy (SBRT) While Eliminating Potential Complications and Costs Associated with Implanted Markers CLEVELAND, Aug. 19, 2019 -- (Healthcare Sales & Marketing Network) -- Vie... Devices, Oncology ViewRay, Stereotactic, MR-guided, radiotherapy, prostate cancer (Source: HSMN NewsFeed)
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In this study, Warmack produced crystals, both the normal and kinked types, in 15 of beta amyloid ’s amino acids. She used a modified type of cryo-electron microscopy to analyze the crystals. Cryo-electron microscopy, whose development won its creators the 2017 Nobel Prize in chemistry, enables scientists to see large biomolecules in extraordinary detail. Professor Tamir Gonen pioneered the mo dified microscopy, called microcrystal electron diffraction, which enables scientists to study biomolecules...
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(CNN) — Water fluoridation has been hailed by the US Centers for Disease Control and Prevention as one of the top great public health achievements of the 20th century, but a new study raises questions about its role as a potential neurotoxin in utero. The study, published in the journal JAMA Pediatrics on Monday, found that increased levels of fluoride exposure during pregnancy were associated with declines in IQ in children. Previous research has made similar findings, but this is the first such...
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More than 248 hospital sites (pictured, Great Ormond Street in London) - 17 per cent of all those in the UK - have unsafe levels of toxic particles in the air. (Source: the Mail online | Health)
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(Natural News) The excessive blooming of blue-green algae might be responsible for the recent spate of deaths among dolphins. A pathological study found toxic compounds in the harmful algae that might cause a neurodegenerative problem similar to Alzheimer’s disease. Researchers from the University of Miami autopsied the brains and bodies of 14 dead dolphins. For... (Source: NaturalNews.com)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for...
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According to a new study, the buildup of toxic tau protein in key areas of the brain leads to major brain cell loss and daytime sleepiness in Alzheimer's. (Source: Health News from Medical News Today)
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Abstract Zooplankton biomass and water environment factors in Xiaoxingkai Lake were investigated, and the correlation between biomass and water environment factors was performed using the Pearson correlation analysis and redundancy analysis (RDA). The results showed that the highest zooplankton biomass was recorded in summer and the lowest in spring. Water depth, transparency (SD), electric conductivity, and total nitrogen were the highest in spring, while temperature and total...
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Abstract In this study, a pot experiment was piloted in a greenhouse to evaluate the potential of Celosia argentea var. cristata L. for tolerating/accumulating heavy metals in synthetic wastewater in the presence of Pseudomonas japonica and organic amendment, i.e., moss and compost. Two-week-old seedlings were transferred to pots, and after 4 weeks, the bacterial strain was inoculated, then watered with synthetic wastewater for 5 weeks and harvested after 9 weeks. After harvesting,...
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Abstract Fluoroquinolones (FQs) occur broadly in natural media due to its extensive use, and it has systematic effects on our ecosystem and human immunity. In this study, long-root Eichhornia crassipes was reclaimed as a multi-functional activated carbon (MFAC) to remove fluoroquinolones (FQs) from contaminated water. To get insight into the adsorption mechanism, multiple measurements, including FTIR and XPS analyses, were employed to investigate the adsorption processes of ciprofloxacin...
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Abstract The excellent hierarchical porous carbon was fabricated from corn straw–derived hydrochar by chemical activation using potassium oxalate (K2C2O4). SEM, BET, XPS, XRD, and Raman analysis were carried out for the characterization of the as-obtained samples. The morphology of the as-obtained porous carbon with hierarchical porous structures is made up of a large number of nano-particle aggregates and some nanosheet-like structures, possessing a super-large specific surface...
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Estrogen receptor 1 (ESR1) mutations have been identified in hormone therapy–resistant breast cancer and primary endometrial cancer. Analyses in breast cancer suggest that mutant ESR1 exhibits estrogen-independent activity. In endometrial cancer, ESR1 mutations are associated with worse outcomes and less obesity, however, experimental investigation of these mutations has not been performed. Using a unique CRISPR/Cas9 strategy, we introduced the D538G mutation, a common endometrial cancer mutation...
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Sialyl Lewis A (sLeA, also known as CA19-9), a tetrasaccharide selectively and highly expressed on advanced adenocarcinomas including colon, stomach, and pancreatic cancers, has long been considered as an attractive target for active and passive vaccination. While progress in antibodies targeting tumor-associated protein antigens resulted in an impressive array of therapeutics for cancer treatment, similar progress in exploiting tumor-associated carbohydrate antigens, such as sLeA, has been hampered...
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Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration-resistant prostate cancers become androgen receptor (AR) signaling independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity. These NEPC tumors, associated with aggressive disease and poor prognosis, are driven, in part, by aberrant expression of N-Myc, through mechanisms that remain unclear. Integrative analysis of the N-Myc transcriptome,...
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Induction of memory CD8+ T cells is important for controlling infections such as malaria and HIV/AIDS and for cancer immunotherapy. Accurate assessment of antigen-specific (Ag-specific) CD8+ T cells is critical for vaccine optimization and for defining correlates of protection. However, conditions for determining Ag-specific CD8+ T cell responses ex vivo using intracellular cytokine staining (ICS) may be variable, especially in humans with complex antigens. Here, we used an attenuated whole parasite...
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New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ03653A, PaperHuiping Wang, Libang He, Peng Zhang, Jie Zhang, Zhenhua Chen, Xiuli Ren, Xifan Mei Targeted delivery of therapeutic drug into cancer cells is a facile method to improve the therapeutic efficacy. Focused on this point, the doxorubicin (DOX) -loaded hydroxyapatite (HAP) nanorods consisting of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
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Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC03379C, CommunicationAnnemiek Uvyn, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, Bruno De Geest Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
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Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC05826E, CommunicationJia Li, Le Li Zeng, Kai Xiong, Thomas Wheildon Rees, Chengzhi Jin, Weijun Wu, Yu Chen, Liangnian Ji, Hui Chao Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(II) complex as photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem....
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ConclusionsImmunosuppressed patients have poor tolerance of chemotherapy and response to chemoradiation, and an increased rate of recurrence. This finding is possibly due to the relationship between immunosuppression and hypoalbuminemia, which was associated with worse overall and progression-free survival. (Source: The American Journal of Surgery)
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ConclusionsAbdominal wall defects from resection of cancerous masses of the abdominal wall can be closed with a contralateral rectus abdominis muscle transplant in the absence of mesh. (Source: International Journal of Surgery Case Reports)
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This Teachable Moment describes challenges faced by clinicians in getting patients to engage in colorectal cancer screening and strategies that clinicians can use to maximize patient adherence to colorectal cancer screening. (Source: JAMA Internal Medicine)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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The list of unmet clinical needs in prostate cancer is long. Although the problems of overdiagnosis and overtreatment of prostate cancer are increasingly acknowledged by the medical community, the fact remains that this disease is still the second most common cause of cancer-related deaths in men. Nevertheless, significant progress has been made toward characterizing the complex biology of this disease, and advances in imaging techniques that improve the detection of clinically significant cancers...
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ConclusionsOur results are consonant with current clinical guidelines and other evidence reviews. For both HBeAg-positive and HBeAg-negative populations, TDF and TAF are the most effective agents for virologic suppression, and TAF is effective across all outcomes. (Source: Systematic Reviews)
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ConclusionWhile signet cells are a negative prognostic feature, they should not be a contraindication to CRS-HIPEC in patients with well-moderately differentiated tumors with negative lymph nodes, where complete cytoreduction can be achieved. (Source: Journal of Gastrointestinal Surgery)
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ConclusionOur study is the largest population-based analysis of patients with T1N0M0 malignant colon polyps. Overall survival was higher in patients who underwent surgery compared with polypectomy. This remained consistent even after adjusting for multiple patient and tumor factors between the two groups. (Source: Journal of Gastrointestinal Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the...
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An altered immune microenvironment may contribute to papillary thyroid cancer development, as immune infiltrates are identified postoperatively in many papillary thyroid cancer cases with or without diagnosed thyroiditis. Oxygen radicals, endogenous or inflammation-induced, can generate DNA damage, which causes mutations when repaired incorrectly. We hypothesized that infiltrating immune cells might promote aberrant DNA repair, predisposing thyrocytes to papillary thyroid cancer. (Source: Surgery)
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Dr Scott Wilhelm (Cleveland, OH): Since you are thinking translationally about this, one of the problems we all see is the Hashimoto's patient with a nodule. The patient gets a biopsy. It comes back Bethesda III with atypia, and now we're trying to decide cancer or no cancer. Maybe we do molecular testing in those patients next. Will you be able to potentially do sequencing from FNA samples to get information about POLQ? (Source: Surgery)
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AbstractLeft ventricular papillary muscles are small myocardial structures that play an important role in the functioning of mitral valve and left ventricle. Typically, there are two groups of papillary muscles, namely the anterolateral and the posteromedial groups. Cardiovascular magnetic resonance (CMR) is a valuable imaging modality in the evaluation of papillary muscles, providing both morphological and functional information. There is a remarkably wide variation in the morphology of papillary...
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Conclusion: The addition of DWI apparently improves the diagnostic accuracy of MRI in the preoperative assessment of the depth of myometrial invasion in endometrial cancer, which may be particularly helpful in patients for whom contrast agents are contraindicated.Resumo Objetivo: Determinar o valor adicional da difus ão (DWI) em ressonância magnética (RM) na avaliação pré-operatória da invasão miometrial do câncer do endométrio, em comparação com sequências T2 e com o estudo dinâmico após contraste...
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(Source: Radiologia Brasileira)
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Abstract The elastic properties of tissue have always been of interest in clinical practice. In the past, the identification of structures that were stiffer on physical palpation would raise the suspicion that “ there was something wrong ” . With the development and advancement of medicine, there proved to be a true correlation in the prediction of malignancy of a lesion: malignant disease tends to stiffen the affected tissue, either by increased cell proliferation or fibrosis. Palpation is the oldest...
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Abstract More than half of patients over 50 years of age have had at least one focal renal lesion detected as an incidental finding during an ultrasound, computed tomography, or magnetic resonance imaging examination. Although the majority of such lesions can be easily detected and correctly characterized, misdiagnoses may occur and are often related to methodological limitations, inappropriate imaging protocols, or misinterpretation. This pictorial essay provides recommendations on how to recognize...
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Conclusion: Breast MRI is an useful tool for the locoregional staging of breast cancer, because it provides useful information that can have a positive impact on patient treatment.Resumo Objetivo: Avaliar o impacto do uso da resson ância magnética (RM) no estadiamento pré-operatório do câncer de mama. Materiais e Métodos: Foram avaliadas 61 pacientes com carcinoma mamário submetidas a RM das mamas, no período de agosto de 2015 a abril de 2016. Um mastologista foi questionado sobre a conduta terapêutica...
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ConclusionsOur data suggested that miR-1307 may be involved in the resistance of ovarian cancer to chemotherapy drugs via regulation of CIC, and should be further explored as a potential therapeutic target. (Source: Pathology Research and Practice)
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We report an unusual case of a leiomyosarcoma arising six months post myomectomy in a 16-year old female.Graphical abstractRadiographic images (A) starting with the CT of mass on day 0 followed by the CT abdomen/pelvis of second pelvic mass leiomyosarcoma on day 185, the MRI prior to staging surgery on day 317, and finishing up with the MRI of the recurrence of malignancy. Timeline of patient events (B). Our patient initially underwent a diagnostic laparoscopy with pelvic mass biopsies showing leiomyoma...
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Publication date: October 2019Source: Journal of Functional Foods, Volume 61Author(s): Francesco Di Meo, Riccardo Aversano, Gianfranco Diretto, Olivia Costantina Demurtas, Clizia Villano, Salvatore Cozzolino, Stefania Filosa, Domenico Carputo, Stefania CrispiAbstractMalignant mesothelioma is a tumor that affects pleural surface and has very poor prognosis. The standard therapeutic modalities for this cancer have yielded unsatisfactory outcomes, therefore the development of alternative and effective...
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Contributors : Xin-Yu Shi ; Kan Zhai ; Huan-Zhong ShiSeries Type : Expression profiling by arrayOrganism : Mus musculus ; synthetic constructThe interactions between tumor cells and the host vasculature and immune cells results in increased net fluid production via enhanced plasma extravasation into the pleural space.Understanding the regulatory mechanism of IL-10 in MPE formation is essential both for deciphering how IL-10 acts in regulating tumor immunity and for discovering key molecular targets...
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Contributors : Todd W Miller ; Sarah R HosfordSeries Type : SNP genotyping by SNP array ; Genome variation profiling by SNP arrayOrganism : Homo sapiensEstrogens have been shown to elicit anti-cancer effects against estrogen receptor alpha (ER)-positive breast cancer. We sought to determine the underlying mechanism of therapeutic response. Response to 17b-estradiol was assessed in ER+ breast cancer models with resistance to estrogen deprivation: WHIM16 patient-derived xenografts, C7-2-HI and C4-HI...
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Contributors : Ryan C Gimple ; Leo J Kim ; Briana C Prager ; Stephen C Mack ; Qi Xie ; Jeremy N RichSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma ranks among the most aggressive and lethal of all human cancers. Functionally defined glioma stem cells (GSCs) contribute to this poor prognosis by driving therapeutic resistance and maintenance of cellular heterogeneity. To understand the molecular processes essential for GSC maintenance and tumorigenicity,...
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Contributors : Eva-Laure Matera ; Julien Fouret ; Estelle Baulu ; Emeline Perrial ; Zineb Bousfiha ; Lars P Jordheim ; Chettab Abdelkamel ; Joel Lachuer ; Charles dumontetSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBCR pathway inhibitors idelalisib and ibrutinib are the first small molecule targeted agents for B-cell malignancies. In spite of encouraging response rates in various forms of B cell diseases, patients will eventually develop relapse due to the...
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Contributors : Todd W Miller ; Sarah R HosfordSeries Type : Expression profiling by arrayOrganism : Homo sapiensEstrogens have been shown to elicit anti-cancer effects against estrogen receptor alpha (ER)-positive breast cancer. We sought to determine the underlying mechanism of therapeutic response. Response to 17b-estradiol was assessed in ER+ breast cancer models with resistance to estrogen deprivation: WHIM16 patient-derived xenografts, C7-2-HI and C4-HI murine mammary adenocarcinomas, and long-term...
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This study aimed to assess the knowledge, attitude and practice of cervical cancer screening and associated factors among female students of Wollega University, western Ethiopia in 2017. (Source: BMC Research Notes)
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Cervical cancer is among the leading cancer related causes of morbidity and mortality of women in the world. Ethiopia is among the highest risk countries with age adjusted incidence of cervical cancer 35.9 per... (Source: BMC Research Notes)
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We evaluated survival of patients with pulmonary recurrence-based oligometastatic non-small cell lung cancer (NSCLC) whose lesions were all treated with stereotactic ablative radiotherapy (SABR) and the prognostic value of peripheral immune cells. (Source: International Journal of Radiation Oncology * Biology * Physics)
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Semin intervent Radiol 2019; 36: 279-284 DOI: 10.1055/s-0039-1694066 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Full text (Source: Seminars in Interventional Radiology)
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This article is an up-to-date review of the management of chest tumors with embolization and its variants. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Interventional Radiology)
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. (Source: Pediatric Hematology and Oncology)
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. (Source: Pediatric Hematology and Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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. (Source: Pediatric Hematology and Oncology)
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. (Source: Pediatric Hematology and Oncology)
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. (Source: Pediatric Hematology and Oncology)
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Semin intervent Radiol 2019; 36: 255-263 DOI: 10.1055/s-0039-1693121Image-guided percutaneous needle biopsies (PNBs) are one of the most common procedures performed in radiology departments today. Rapid developments in precision medicine, which identifies molecular and genomic biomarkers in cancers, have ushered a new paradigm of oncologic workup and treatment. PNB has conventionally been used to establish a benign or malignant nature of a lesion during initial diagnosis or in suspected metastatic...
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This article presents an approach to assess extraspinal metastases, reviews available interventional techniques in use today, and offers example cases as an introductory primer to the thought process used for selecting the appropriate interventional treatment. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Interventional Radiology)MedWorm Message: Have you tried our new medical...
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Semin intervent Radiol 2019; 36: 203-212 DOI: 10.1055/s-0039-1693118Interventional radiologists have multiple points of involvement in the treatment and management of patients with pancreatic adenocarcinoma. There is increasing interest in cytoreductive treatment of the primary tumor as well as metastatic disease via arterial and ablative techniques. The focus of this article is on the current evidence for pancreatic irreversible electroporation. For patients undergoing curative surgery or terminal...
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This article discusses the epidemiology of renal cell cancers; discusses the current management guidelines from multiple specialty societies; discusses some of the surgical and interventional techniques used in the treatment of such lesions; and provides a review of the literature regarding treatments of early-stage renal cell cancers. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars...
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Semin intervent Radiol 2019; 36: 183-193 DOI: 10.1055/s-0039-1694714With the increased incidence of stage T1a renal cell carcinoma (RCC) has come the recognition that these lesions tend to be low grade and slow growing, with low probability of metastasis not necessarily requiring surgery. As alternatives to surgery, both active surveillance and ablation have been advocated for the management of selected patients with stage T1a renal cancers due to slow rate of tumor growth and low metastatic potential...
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CONCLUSION: Elderly patients with complicated colorectal cancer undergoing emergency surgery have high morbidity and mortality rates. Advanced age is significantly associated with worse outcomes. (Source: Clinics)
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The purpose of the present study was to examine maternal pain management in children with cancer and the associated factors. (Source: Journal of Pediatric Nursing)
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(Source: Annals of Hematology)
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ConclusionAblative therapies display promising potential as treatment modalities for iCCA. However, further research is necessary to validate these findings. (Source: Journal of Clinical and Experimental Hepatology)
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We read with interest the article by Kuellmer et al1 evaluating endoscopic full-thickness resection (EFTR) for early colorectal cancer. The authors found that EFTR for early colorectal cancer was feasible and safe. Because their findings are important to current practice, several questions deserve attention. (Source: Gastrointestinal Endoscopy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Gastric cancer remains one of the most common causes of cancer deaths worldwide. The best current option for reducing gastric cancer deaths is Helicobacter pylori eradication combined with risk assessment and surveillance programs for those deemed to be at high risk for gastric cancer so as to identify lesions at a stage amenable to curative therapy. In this issue, Nam et al1 report a retrospective study of Helicobacter pylori eradication on gastric cancer incidence among 10,328 Korean adults undergoing...
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Gastric cancer remains one of the most common cancers worldwide and is the third leading cause of cancer-related mortality, trailing only lung and colon cancer.1 Given its historically low survival rates, early detection and resection is the most effective strategy to improve prognosis. Endoscopic submucosal dissection (ESD), a technique developed in Japan, enables en bloc resection of early gastric cancer (EGC) and can be curative for selected lesions, depending on the histologic features, size,...
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We have read with great interest the study by Januszewicz et al1 describing the concept of endoscopist biopsy rate (EBR) as a potential quality indicator for routine diagnostic outpatient EGD. The authors found a significant variability in EBR among 26 endoscopists and an association between higher EBR, a higher detection of gastric precancerous conditions, and a lower risk of missed gastric cancers.1 (Source: Gastrointestinal Endoscopy)
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We read with great interest the comment by Dr Li and colleagues1 referring to our study on endoscopic full-thickness resection (EFTR) for early colorectal cancer.2 We would like to thank the editors for the opportunity to reply. (Source: Gastrointestinal Endoscopy)
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The zymogen form of circulating Factor VII activating protease (FSAP) is activated by histones that are released as a consequence of tissue damage or excessive inflammation. This is likely to have consequences in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer. To investigate the existence, as well as the concentration, of active FSAP (FSAPa) in complex biological systems an active site probe is needed. We used Hybrid Combinatorial Substrate Library...
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Cancer patients are prone to higher risk of venous thromboembolism (VTE) compared to the general population. However, the estimated incidence of cancer-associated VTE varied among the studies. The primary objective of this study was to determine the national annual incidence and examine the trend of cancer-associated VTE in the US over the years from 2005 to 2014. (Source: Thrombosis Research)
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Blood Cancer Journal, Published online: 19 August 2019; doi:10.1038/s41408-019-0230-8Molecular characteristics of diffuse large B-cell lymphoma in the Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin lymphomas (PETAL) trial: correlation with interim PET and outcome (Source: Blood Cancer Journal)
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ConclusionsRLN LND can be safely performed in ESCC patients who had undergone nCRT, ultimately resulting in an improved local control, and should be practiced as part of the surgical routine. (Source: Esophagus)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Bipaddle Pectoralis Major Myocutaneous Flap for Single Stage Reconstruction of Oromandibular Defects
In this study, we have presented our experience with the use of bipaddle pectoralis major myocutaneous (PMMC) flap as a single stage reconstruction option for defects of the oral cavity. After undergoing resection of oral cancer, 12 patients with full thickness defects of the oral cavity were reconstructed using bipaddle/bilobed/double-island/folded PMMC flap in a single stage procedure. The results of PMMC flaps were studied. All the patients had through and through defects of oral cavity, which...
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ConclusionAge and gender are risk factors for doxorubicin-induced serious HG-ADRs; males and older patients are more likely to suffer a serious outcome following such a reaction. (Source: Diabetes Therapy)
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Conclusions Rikkunshito could mitigate CIA and ameliorate plasma AG levels during the delayed phase of CDDP-based chemotherapy in lung cancer patients. Clinical trial registration numbers:UMIN000010748. (Source: Investigational New Drugs)
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Publication date: Available online 19 August 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Chong Li, Jiancheng Wang, Yiguang Wang, Huile Gao, Gang Wei, Yongzhuo Huang, Haijun Yu, Yong Gan, Yongjun Wang, Lin Mei, Huabing Chen, Haiyan Hu, Zhiping Zhang, Yiguang JinAbstractDrug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to...
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ConclusionsHospitals vary more in late survival than early mortality after glioblastoma surgery. Widely varying biopsy percentages indicate treatment variation. Patient-related factors have a stronger association with overall survival than hospital-related factors. (Source: Journal of Neuro-Oncology)
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ConclusionsSCO are uncommon sellar lesions with a propensity for progression or recurrence. Based on the clinically aggressive course of these tumors, adjuvant SRS after STR or at the time of tumor recurrence should be considered. Further case accumulation and follow-up is required to better understand the long-term treatment outcomes after single-fraction SRS for these rare tumors. (Source: Journal of Neuro-Oncology)MedWorm Message: If you are looking to buy something in the January Sales please...
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ConclusionSalvage re-RT provides good local control and encouraging survival outcomes with acceptable toxicity in selected patients with recurrent/progressive MB. (Source: Journal of Neuro-Oncology)
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ConclusionsBevacizumab may arrest both tumor progression and hearing loss in select NF2 patients presenting with VS lesions. However, a considerable proportion of patients are anticipated to experience serious adverse events; correspondingly, judicious use of bevacizumab for symptomatic management of VS in NF2 is recommended. (Source: Journal of Neuro-Oncology)
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Issues with data analysis have recently been highlighted by a reader of our article. These have been addressed with changes to Tables 2&4, as shown below, and Online Resources 5-7. T2 and peritumoral signal are no longer prognostic factors on simple pooled (Online Resource 5) and IPD (Table 4) analyses respectively. In Table 5, the number of patients which informed the outcomes symptom development and intervention were 575 and 947 respectively; 69 developed symptoms (pooled proportion %8.4 [95%...
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ConclusionsOur results suggest a role of decreased MPC1 copy number segments in reducing overall survival in glioblastoma. MPC1 deletion is associated with poor response to TMZ chemotherapy in GBM. (Source: Journal of Neuro-Oncology)
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ConclusionsFatigue is a major problem for patients with BM. Different patterns over time were observed for the various aspects of fatigue in patients with BM. Information on the various aspects of fatigue is important because fatigue may negatively affect patients' functional independence, health-related quality of life, and adherence to therapy. (Source: Journal of Neuro-Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media...
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The Editor-in-Chief has retracted this article [1]. An investigation by Kurume University has not been able to establish what the appropriate authorship should be because one of the authors, Yoshihiro Sato, is now deceased. As the appropriate authorship cannot be determined the Editor-in-Chief no longer has confidence in this article. Kurume University has also stated that it has not been possible to verify the data presented as none of the research material is available for investigation. We have...
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ConclusionTogether these results emphasize an anti-tumorigenic role with a potential therapeutic value for PRL in HER-2 and luminal B breast cancer subtypes targeting the cancer stem-like cells. (Source: Stem Cell Research)
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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Mohammad Ansari, Ashkan Bigham, Hossein Abbastabar AhangarAbstractSpinel ferrite-based nanoparticles are being widely applied in bone tissue regeneration because of their outstanding properties such as their capability to be applied in hyperthermia-based bone cancer therapy. In the present study, Cu0.3Zn0.2Mg0.5Fe2O4 nanoparticles are synthesized through thermal-treatment method followed by calcination...
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Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Buddolla Anantha Lakshmi, Sanghyo KimAbstractNanostructured metal-organic frameworks (N-MOFs) are crystalline coordination nanopolymers in which metals are conjugated with organic and inorganic linker molecules. At present, N-MOFs have attracted significant interest owing to their intrinsically high porosity and ultrahigh surface areas, which allow them to be loaded with a broad array of materials, including...
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Oncogene, Published online: 19 August 2019; doi:10.1038/s41388-019-0960-xInduction of NKG2D ligand expression on tumor cells by CD8+ T-cell engagement-mediated activation of nuclear factor-kappa B and p300/CBP-associated factor (Source: Oncogene)
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Oncogene, Published online: 19 August 2019; doi:10.1038/s41388-019-0952-xAn miR-340-5p-macrophage feedback loop modulates the progression and tumor microenvironment of glioblastoma multiforme (Source: Oncogene)
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