Abstract Purpose of Review This review presents an overview of the diagnostic approach to esophageal dysphagia and summarizes recent epidemiological trends and technical advancements. Recent Findings The evaluation of dysphagia begins with a detailed history followed by endoscopy to evaluate for any structural abnormalities including malignancy....
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People genetically predisposed to sleep problems have greater risk of heart failure and stroke, say researchersPeople who struggle with sleep might be at greater risk of developing cardiovascular problems, research suggests.Scientists have found that people who are genetically predisposed to insomnia have a greater risk of heart failure, stroke and coronary artery disease.Continue reading... (Source: Guardian Unlimited Science)
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MONDAY, Aug. 19, 2019 -- Symptomatic gastroesophageal reflux disease (GERD) is associated with chronic temporomandibular disorder (TMD), and the correlation is partially mediated by somatization, anxiety, and undermined sleep, according to a study... (Source: Drugs.com - Pharma News)
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Babies in the neonatal ICU who are exposed to their mothers'voice during sleep are less likely to awaken after loud bursts of ambient noise, especially if they were born at or after 35 weeks'gestation, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Reuters Health) - Soldiers who experience sleep problems during basic combat training may be more likely to struggle with psychological distress, attention difficulties, and anger issues during their entry into the military, a recent study suggests. (Source: Reuters: Health)
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America is going gray. According to U.S. Census data, in 2030 even the youngest Baby Boomers will have reached 65, and older Americans will make up 21 percent of the population. Thatâs up from 15 percent today. By 2060, nearly a quarter of Americans will be at least 65 and a half million will reach age 100. These changing demographics give urgency to the concept of âaging in place.â Nobody wants to lose their independence, but thatâs the reality for many who are forced from their homes by cardiovascular...
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Later school start times found high schoolers and middle-schoolers less sleepy and generally more engaged in academics. (Source: Washington Post: To Your Health)
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MONDAY, Aug. 19, 2019 -- If you spend a lot of nights watching the clock instead of sleeping, new research suggests you may need to be as concerned about your heart health as you are about lost shut-eye. People with genetic variants linked to... (Source: Drugs.com - Daily MedNews)
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People genetically predisposed to sleep problems have greater risk of stroke and coronary artery diseasePeople who struggle with sleep might be at greater risk of developing cardiovascular problems, research suggests.Scientists have found that people who are genetically predisposed to insomnia have a greater risk of heart failure, stroke and coronary artery disease.Continue reading... (Source: Guardian Unlimited Science)
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OBJECTIVES: Sleep complaints, such as insomnia and sleep disturbances caused by posttraumatic stress disorder (PTSD), are more common among women veterans than nonveteran women. Alcohol use among some women may be partially motivated by the desire to impro... (Source: SafetyLit)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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IJMS, Vol. 20, Pages 4055: Glucose Restriction Plus Refeeding in Vitro Induce Changes of the Human Adipocyte Secretome with an Impact on Complement Factors and Cathepsins International Journal of Molecular Sciences doi: 10.3390/ijms20164055 Authors: Qi Qiao Freek G. Bouwman Marleen A. van Baak Johan Renes Edwin C.M. Mariman Adipose tissue is a major endocrine organ capable of secreting adipokines with a role in whole-body metabolism. Changes in the secretome profile during...
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IJMS, Vol. 20, Pages 4053: IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis International Journal of Molecular Sciences doi: 10.3390/ijms20164053 Authors: Sho Miake Gaku Tsuji Masaki Takemura Akiko Hashimoto-Hachiya Yen Hai Vu Masutaka Furue Takeshi Nakahara Severe pruritus is a characteristic feature of atopic dermatitis (AD) and is closely related to its activity....
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IJMS, Vol. 20, Pages 4052: Neuroprotective Properties of Linagliptin: Focus on Biochemical Mechanisms in Cerebral Ischemia, Vascular Dysfunction and Certain Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20164052 Authors: Michał Wiciński Karol Górski Maciej Walczak Eryk Wódkiewicz Maciej Słupski Katarzyna Pawlak-Osińska Bartosz Malinowski Linagliptin is a representative of dipeptidyl peptidase 4 (DPP-4) inhibitors which are registered...
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IJMS, Vol. 20, Pages 4051: Perinatal Micro-Bleeds and Neuroinflammation in E19 Rat Fetuses Exposed to Utero-Placental Ischemia International Journal of Molecular Sciences doi: 10.3390/ijms20164051 Authors: Ashtin B. Giambrone Omar C. Logue Qingmei Shao Gene L. Bidwell Junie P. Warrington Offspring of preeclampsia patients have an increased risk of developing neurological deficits and cognitive impairment. While low placental perfusion, common in preeclampsia and growth restriction,...
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IJMS, Vol. 20, Pages 4049: Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders International Journal of Molecular Sciences doi: 10.3390/ijms20164049 Authors: Meneses Silvestre Sousa-Lima Macedo Metabolic disorders are characterized by an overall state of inflammation and oxidative stress, which highlight the importance of a functional antioxidant system and normal activity of some endogenous enzymes, namely...
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IJMS, Vol. 20, Pages 4050: Stereoselective Synthesis and Investigation of Isopulegol-Based Chiral Ligands International Journal of Molecular Sciences doi: 10.3390/ijms20164050 Authors: Le Szilasi Volford Szekeres Fülöp Szakonyi A library of isopulegol-based bi-, tri- and tetrafunctional chiral ligands has been developed from commercially available (−)-isopulegol and applied as chiral catalysts in the addition of diethylzinc to benzaldehyde. Michael addition...
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IJMS, Vol. 20, Pages 4048: Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1 International Journal of Molecular Sciences doi: 10.3390/ijms20164048 Authors: Antje Garten Theresa Grohmann Katarina Kluckova Gareth G. Lavery Wieland Kiess Melanie Penke Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to sorafenib develops frequently and could...
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IJMS, Vol. 20, Pages 4047: A Novel Method for Controlled Gene Expression via Combined Bleomycin and Plasmid DNA Electrotransfer International Journal of Molecular Sciences doi: 10.3390/ijms20164047 Authors: Sonam Chopra Paulius Ruzgys Milda Jakutaviciute Aiste Rimgailaite Diana Navickaitė Saulius Satkauskas Electrochemotherapy is an efficient method for the local treatment of cutaneous and subcutaneous metastases, but its efficacy as a systemic treatment remains low. The...
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IJMS, Vol. 20, Pages 4045: Modern Trends in Plant Genome Editing: An Inclusive Review of the CRISPR/Cas9 Toolbox International Journal of Molecular Sciences doi: 10.3390/ijms20164045 Authors: Ali Razzaq Fozia Saleem Mehak Kanwal Ghulam Mustafa Sumaira Yousaf Hafiz Muhammad Imran Arshad Muhammad Khalid Hameed Muhammad Sarwar Khan Faiz Ahmad Joyia Increasing agricultural productivity via modern breeding strategies is of prime interest to attain global food security....
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IJMS, Vol. 20, Pages 4046: Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes International Journal of Molecular Sciences doi: 10.3390/ijms20164046 Authors: Valerie R. Wiersma Alex Clarke Simon D. Pouwels Elizabeth Perry Trefa M. Abdullah Clive Kelly Anthony De Soyza David Hutchinson Paul Eggleton Edwin Bremer The aetiology of rheumatoid arthritis (RA) is unknown,...
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IJERPH, Vol. 16, Pages 2987: My Mind is Working Overtime—Towards an Integrative Perspective of Psychological Detachment, Work-Related Rumination, and Work Reflection International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162987 Authors: Oliver Weigelt Petra Gierer Christine J. Syrek In the literature on occupational stress and recovery from work, several facets of thinking about work during off-job time have been conceptualized. However, research...
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IJERPH, Vol. 16, Pages 2986: Field Study on the Microclimate of Public Spaces in Traditional Residential Areas in a Severe Cold Region of China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162986 Authors: Yujie Lin Yumeng Jin Hong Jin As residential environment science advances, the environmental quality of outdoor microclimates has aroused increasing attention of scholars majoring in urban climate and built environments. Taking the microclimate...
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IJERPH, Vol. 16, Pages 2985: Impact of Safety Warning on Domperidone Prescribing for Geriatric Patients in South Korea: Analysis of National Insurance Claim Data International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162985 Authors: Kiyon Rhew Nayoung Han Jung Mi Oh Domperidone is a dopamine antagonist used for the symptomatic management of nausea and vomiting. Many countries banned or add a black box warning due to an increased risk of serious adverse...
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IJERPH, Vol. 16, Pages 2984: Prediction and Analysis of Electrical Accidents and Risk Due to Climate Change International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162984 Authors: Min-Chang Jeong Jaehyuck Kim The industrial development and the increase in the use of fossil fuels have been accelerating global warming and climate change, thereby causing more frequent and intense natural disasters than ever before. Since electrical facilities are generally...
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IJERPH, Vol. 16, Pages 2983: The Impact of Particulate Matter on Outdoor Activity and Mental Health: A Matching Approach International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162983 Authors: Miyeon Jung Daegon Cho Kwangsoo Shin Exposure to air pollution affects human activity and health. Particularly, in Asian countries, the influence of particulate matter on humans has received wide attention. However, there is still a lack of research about the...
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IJERPH, Vol. 16, Pages 2982: Optimization of Location-Routing Problem in Emergency Logistics Considering Carbon Emissions International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162982 Authors: Shen Tao Shi Qin In order to solve the optimization problem of emergency logistics system, this paper provides an environmental protection point of view and combines with the overall optimization idea of emergency logistics system, where a fuzzy low-carbon...
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IJERPH, Vol. 16, Pages 2981: Colonization of Dental Unit Waterlines by Helicobacter pylori: Risk of Exposure in Dental Practices International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162981 Authors: Monica Giacomuzzi Carla M. Zotti Savina Ditommaso Dental unit waterlines (DUWLs) can be considered one of the possible routes of H. pylori transmission, although its presence in DUWLs has not yet been investigated thoroughly. The present study aimed...
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IJERPH, Vol. 16, Pages 2979: Understanding the Barriers and Pathways to Male Help-Seeking and Help-Offering: A Mixed Methods Study of the Impact of the Mates in Construction Program International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162979 Authors: Victoria Ross Neil Caton Jorgen Gullestrup Kairi Kõlves The Mates in Construction (MATES) program was developed to address the issue of high suicide rates among males in the Australian construction...
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IJERPH, Vol. 16, Pages 2978: Association Between Carotid Artery Intima-Media Thickness and Combinations of Mild Cognitive Impairment and Pre-Frailty in Older Adults International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162978 Authors: Jinkee Park Jong-Hwan Park Hyuntae Park Carotid intima-media thickness (CIMT) has been proposed as a surrogate marker of cardiovascular disease. Mild cognitive impairment (MCI) and pre-frailty are reportedly associated...
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IJERPH, Vol. 16, Pages 2980: Evolution of the Physical and Social Spaces of ‘Village Resettlement Communities’ from the Production of Space Perspective: A Case Study of Qunyi Community in Kunshan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162980 Authors: Lei Zhou Liyang Xiong Village resettlement communities (VRCs) are a special type of urban community that the government has promoted considerably during China’s rapid urbanization....
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IJERPH, Vol. 16, Pages 2975: Combining Resource, Structure and Institutional Environment: A Configurational Approach to the Mode Selection of the Integrated Healthcare in County International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162975 Authors: Li Zhu Zixuan Peng Lihang Liu Shuang Ling Integrated healthcare has received considerable attention and has developed into the highly important health policy known as Integrated Healthcare in County...
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IJERPH, Vol. 16, Pages 2977: College Students’ Experience of a Food Safety Class and Their Responses to the MSG Issue International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162977 Authors: Hyun Joung Jin Dae Hee Han This study examines whether students’ experience in a food safety class affected their responses to the monosodium glutamate (MSG) issue and to message framing. We differentiated students into two groups depending on their involvement...
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IJERPH, Vol. 16, Pages 2976: Air Pollution Exposure and Cognitive Function in Taiwanese Older Adults: A Repeated Measurement Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162976 Authors: Yuan-Ting C. Lo Ya-Chi Lu Yu-Hung Chang Senyeong Kao Han-Bin Huang Studies related to air pollution exposure and neurocognitive disorders, specifically cognitive impairment, among older adults are limited. We investigated the association between...
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IJMS, Vol. 20, Pages 4043: Control of Translation at the Initiation Phase During Glucose Starvation in Yeast International Journal of Molecular Sciences doi: 10.3390/ijms20164043 Authors: Yoshika Janapala Thomas Preiss Nikolay E. Shirokikh Glucose is one of the most important sources of carbon across all life. Glucose starvation is a key stress relevant to all eukaryotic cells. Glucose starvation responses have important implications in diseases, such as diabetes and cancer. In...
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IJMS, Vol. 20, Pages 4044: Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo International Journal of Molecular Sciences doi: 10.3390/ijms20164044 Authors: Istvan Kovanecz Robert Gelfand Guiting Lin Sheila Sharifzad Alec Ohanian Randy Ricks Tom Lue Nestor F. Gonzalez-Cadavid Female stress urinary incontinence (FSUI)...
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IJMS, Vol. 20, Pages 4042: Role of Autophagy in Zinc Oxide Nanoparticles-Induced Apoptosis of Mouse LEYDIG Cells International Journal of Molecular Sciences doi: 10.3390/ijms20164042 Authors: Jingcao Shen Dan Yang Xingfan Zhou Yuqian Wang Shichuan Tang Hong Yin Jinglei Wang Rui Chen Jiaxiang Chen Zinc oxide nanoparticles (ZnO NPs) have shown adverse health impact on the human male reproductive system, with evidence of inducing apoptosis. However, whether or not...
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Astrocytic G protein‐coupled receptor 30 (GPR30) was involved in the neuroprotection. Autophagic deficiency of astrocytes induced by glutamate‐promoted inflammatory cytokine release. GPR30 activation restored autophagy balance in astrocytes by regulating the p38 mitogen‐activated protein kinase pathway. Abstract Ischemic stroke leads to neuronal damage induced by excitotoxicity, inflammation, and oxidative stress. Astrocytes play diverse roles in stroke and ischemia‐induced inflammation,...
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Abstract Objective The aim of this study was to compare the diagnostic accuracy of nuclear imaging modalities in the detection of aseptic loosening of total knee arthroplasty (TKA). Materials and methods MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched from database inception to December 2018 in accordance with...
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Abstract There is a large variety of conditions that can result in ‘bone marrow edema’ or ‘bone marrow lesions’ (BML) in the wrist on magnetic resonance imaging (MRI). The combination of clinical history and the distribution of the BML can serve as a valuable clue to a specific diagnosis. This article illustrates the different patterns of BML in the wrist to serve as a useful guide when reviewing wrist MRI studies. Imaging artefacts will also be briefly covered.
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Thyroid, Ahead of Print.
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Opening GCSE and A-level results can mean tears or elation for students – but also for their teachers Continue reading...
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Compulsory Christian worship is divisive and excludes many children. Why not teach them all to think about religions and philosophies instead?Back in the early 1990s, a lone Pakistani boy appeared in my otherwise entirely white primary school class. If that wasn’t isolating enough for him, each week, as we went into the assembly hall for hymn practice, he would be quietly ushered away. An hour later, we were reunited – the rest of us with heightened voices, him with a box of freshly sharpened pencils,...
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Bindmans law firm are investigating the lawfulness of St Christopher’s school closureParents shocked by the sudden closure of a residential unit at a special needs school in Bristol, which resulted in children with severe and complex learning difficulties having to move out, have won legal aid funding to investigate a possible legal challenge to the lawfulness of the decision.Parents were called at work and summoned to pick up their children from St Christopher’s – an independent special school and...
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Thousands sign petition to reverse decision that will result in many getting lower grades Students could lose out on college places next month after the UK’s largest exam board unexpectedly raised the grade boundaries for a new BTec qualification, which will result in many getting lower grades than anticipated.Teachers have expressed outrage and thousands have signed a petition calling on Pearson, which owns the Edexcel exam board, to reverse its decision to raise the boundaries just days before...
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Pupils and parents use the search engine’s ratings to complain about teachers, food and fellow students – and sometimes apparently to make digs at rival schoolsIt all started because Willow was going back to school. The 17-year-old American was complaining about the new school year, when a friend struck upon an idea. Why not check Google for reviews of their schools? “Go here if you want depression!” read the first one-star review they stumbled upon.Willow immediately tweeted her findings, encouraging...
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The prevalence of osteopenia and osteoporosis in patients with inflammatory bowel disease (IBD) is estimated between 17% and 41%, partly due to repeat courses of glucocorticoids which enhance the risk for bone disease. Multiple gastroenterological and endocrine societies have established guidelines for bone mineral density (BMD) screening in patients with IBD, with estimates suggesting providers vary in their adherence. We aimed to improve the rate of BMD screening in patients with IBD in a large...
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Recovery of upper limb function after stroke is currently sub-optimal, despite good quality evidence showing that interventions enabling repetitive practice of task-specific activity are effective in improving function. Therapists need to access and engage with such evidence to optimise outcomes with people with stroke, but this is challenging in fast-paced stroke rehabilitation services. This quality improvement project aimed to investigate acceptability and service impact of a new, international...
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BackgroundThe provision of patient-centred discharge instructions is a pivotal goal for improving quality of care for patients with heart failure (HF) during care transitions. We tested the feasibility and performance of a novel discharge instruction tool co-designed with patients and adapted for HF; the patient-oriented discharge summary (PODS-HF) with the aim of improving communication, comprehension and adherence to discharge instructions. MethodsAn iterative process was used to adapt and implement...
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BackgroundCritical incident reporting systems (CIRS) can be an important tool for the identification of organisational safety needs and thus to improve patient safety. In German primary care, CIRS use is obligatory but remains rare. Studies on CIRS implementation in primary care are lacking, but those from secondary care recommend involving management personnel. ObjectiveThis project aimed to increase CIRS use in 69 practices belonging to a local practice network. MethodsThe intervention consisted...
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ObjectivePaediatric resuscitation is highly stressful, technically challenging and infrequently performed by paramedics. Length-based equipment selection, weight-based medication dosing and less familiar paediatric clinical scenarios create high cognitive load. Our project aimed to decrease cognitive load and increase paramedic comfort by providing standardised paediatric resuscitation cards across an entire Emergency Medical Services (EMS) system. MethodsAfter 2 years of collaboration between EMS...
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Interactive patient portals are a valuable tool for engaging patients in their healthcare, with various functionalities including viewing laboratory results, refilling prescriptions and communicating directly with nurses, physicians and other healthcare providers via electronic messaging. The utility of patient portals is limited primarily from lack of patient uptake and enrolment due to a variety of factors including lack of awareness, low health literacy, poor technology mastery, lack of availability...
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Cancelled operations represent a significant burden on the National Health Service in terms of theatre efficiency, financial implications and lost training opportunities. Moreover, they carry considerable physical and psychological effects to patients and their relatives. Evidence has shown that up to 93% of cancelled operations are due to patient-related factors. An analysis at our District General Hospital revealed that approximately 18 operations are cancelled on the day of surgery each month....
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Infection is the most frequent indication for non-scheduled admission to paediatric hospitals, leading to high levels of empiric antibiotic prescribing. Antibiotic prescribing in line with local guidelines, improves patient outcomes, reduces adverse drug events and helps to reduce the emergence of antimicrobial resistance. We undertook an improvement project at Temple Street Children’s University Hospital targeting documentation of indication and compliance with empiric antibiotic prescribing guidelines...
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Abstract Cationic polyethyleneimine (PEI)-conjugated gold nanoparticles (AuNPs) that are chemically and physically stable under physiological conditions are an ideal candidate for certain bio-medical applications, in particular DNA transfection. However, the issue remains in reproducibly generating uniform stable species, which can cause the inadequate characterization of the resulting product under relevant conditions and timepoints. The principal objective of the present study...
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Abstract A facile method was developed to prepare mesoporous graphic C3N4 (MGCN)/TiO2 composites by synthesizing MGCN through a chemical template method and combining it with TiO2 by a solvothermal route. The as-prepared nanocomposites were respectively characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and diffuse reflectance UV-vis spectroscopy (DR-UV-Vis). The specific surface areas and pore sizes...
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