Tumour‐cell‐derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma

P. Riihilä, K. Viiklepp, L. Nissinen, M. Farshchian, M. Kallajoki, A. Kivisaari, S. Meri, J. Peltonen, S. Peltonen, V.‐M. Kähäri

Version of Record online: 28 July 2019

What's already known about this topic?

• The incidences of actinic keratosis, cutaneous squamous cell carcinoma (cSCC) in situ and invasive cSCC are increasing globally.
• Few specific biomarkers for progression of cSCC have been identified, and no biological markers are in clinical use to predict the aggressiveness of actinic keratosis, cSCC in situ and invasive cSCC.

What does this study add?

• Our results provide novel evidence for the role of complement classical pathway components C1r and C1s in the progression of cSCC.

What is the translational message?

• Our results identify complement classical pathway components C1r and C1s as biomarkers and putative therapeutic targets in cSCC.