IJERPH, Vol. 17, Pages 2911: Perceptions on Connecting Respite Care Volunteers and Caregivers International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082911 Authors: Solange Campos-Romero Valeria Herskovic Carolina Fuentes Esmeralda Abarca The most common requirement for informal caregivers is to experience a respite or temporary break from their caregiving routine. Some initiatives have been undertaken to provide respite care through volunteer...
Thu Apr 23, 2020 03:00
IJERPH, Vol. 17, Pages 2913: Continuity of Care Is Associated with Medical Costs and Inpatient Days in Children with Cerebral Palsy International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082913 Authors: Kuang-Tsu Yang Chun-Hao Yin Yao-Min Hung Shih-Ju Huang Ching-Chih Lee Tsu-Jen Kuo Background: Children with cerebral palsy (CP) place a considerable burden on medical costs and add to an increased number of inpatient days in Taiwan. Continuity...
Thu Apr 23, 2020 03:00
IJERPH, Vol. 17, Pages 2912: Impact of an Individualized Cognitive Training Intervention in Preschoolers from Poor Homes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082912 Authors: Federico Giovannetti Marcos Luis Pietto María Soledad Segretín Sebastián Javier Lipina Over the last few decades, different interventions were shown to be effective in changing cognitive performance in preschoolers from poor homes undertaking tasks with executive...
Thu Apr 23, 2020 03:00
IJERPH, Vol. 17, Pages 2910: Influence of Puerperal Health Literacy on Tobacco Use during Pregnancy among Spanish Women: A Transversal Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082910 Authors: Rafael Vila-Candel Esther Navarro-Illana Desirée Mena-Tudela Pilar Pérez-Ros Enrique Castro-Sánchez Francisco Javier Soriano-Vidal Jose Antonio Quesada Background: Despite the fact that tobacco use during pregnancy produces adverse...
Thu Apr 23, 2020 03:00
IJERPH, Vol. 17, Pages 2907: Role of Gambling in Payback Failure in Consumer Credit—Data from a Large Body of Material Regarding Consumer Loan Recipients in Sweden International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082907 Authors: A. Håkansson Indebtedness is associated with poor health outcomes, and problem gambling may contribute to indebtedness through consumer credits related to gambling expenses. The assessment of consumers’ applications...
Thu Apr 23, 2020 03:00
IJERPH, Vol. 17, Pages 2908: Obstetricians’ and Gynecologists’ Communication Practices around Smoking Cessation in Pregnancy, Secondhand Smoke and Sudden Infant Death Syndrome (SIDS): A Survey International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082908 Authors: Jennah M. Sontag Binu Singh Barbara M. Ostfeld Thomas Hegyi Michael B. Steinberg Cristine D. Delnevo Secondhand smoke (SHS) is a potential direct cause of Sudden Infant Death Syndrome...
Thu Apr 23, 2020 03:00
IJERPH, Vol. 17, Pages 2906: The Use of Digital Health in the Detection and Management of COVID-19 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082906 Authors: Meshari F. Alwashmi Digital health is uniquely positioned to enhance the way we detect and manage infectious diseases. This commentary explores the potential of implementing digital technologies that can be used at different stages of the COVID-19 outbreak, including data-driven disease...
Thu Apr 23, 2020 03:00
IJERPH, Vol. 17, Pages 2909: Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17082909 Authors: Hsin-Liang Liu Hung-Yi Chuang Chien-Ning Hsu Su-Shin Lee Chen-Cheng Yang Kuan-Ting Liu Chronic exposure to lead is neurotoxic to the human peripheral sensory system. Variant vitamin D...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 3000: HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6 International Journal of Molecular Sciences doi: 10.3390/ijms21083000 Authors: Laura D’Ignazio Dilem Shakir Michael Batie H. Arno Muller Sonia Rocha NF-κB signalling is crucial for cellular responses to inflammation but is also associated with the hypoxia response. NF-κB and hypoxia inducible factor (HIF) transcription factors possess an intense molecular...
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IJMS, Vol. 21, Pages 3001: Epidemiological and Genomic Characterization of Campylobacter jejuni Isolates from a Foodborne Outbreak at Hangzhou, China International Journal of Molecular Sciences doi: 10.3390/ijms21083001 Authors: Hua Yu Mohammed Elbediwi Xiaohong Zhou Huiqun Shuai Xiuqin Lou Haoqiu Wang Yan Li Min Yue Background: Foodborne outbreaks caused by Campylobacter jejuni have become a significant public health problem worldwide. Applying genomic sequencing...
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IJMS, Vol. 21, Pages 2998: From Snapshots to Flipbook—Resolving the Dynamics of Ribosome Biogenesis with Chemical Probes International Journal of Molecular Sciences doi: 10.3390/ijms21082998 Authors: Kofler Prattes Bergler The synthesis of ribosomes is one of the central and most resource demanding processes in each living cell. As ribosome biogenesis is tightly linked with the regulation of the cell cycle, perturbation of ribosome formation can trigger severe diseases, including...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2997: Arctigenin Enhances the Cytotoxic Effect of Doxorubicin in MDA-MB-231 Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21082997 Authors: Lee Lee Kwon Nam Several reports have described the anti-cancer activity of arctigenin, a lignan extracted from Arctium lappa L. Here, we investigated the effect of arctigenin (ATG) on doxorubicin (DOX)-induced cell death using MDA-MB-231 human breast cancer cells. The results showed...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2996: RNA-Targeted Therapies and High-Throughput Screening Methods International Journal of Molecular Sciences doi: 10.3390/ijms21082996 Authors: Zhu Rooney Michlewski RNA-binding proteins (RBPs) are involved in regulating all aspects of RNA metabolism, including processing, transport, translation, and degradation. Dysregulation of RNA metabolism is linked to a plethora of diseases, such as cancer, neurodegenerative diseases, and neuromuscular disorders....
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2999: An Affibody Molecule Is Actively Transported into the Cerebrospinal Fluid via Binding to the Transferrin Receptor International Journal of Molecular Sciences doi: 10.3390/ijms21082999 Authors: Meister Hjelm Dannemeyer Tegel Lindberg Ståhl Löfblom The use of biotherapeutics for the treatment of diseases of the central nervous system (CNS) is typically impeded by insufficient transport across the blood–brain barrier. Here, we...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2994: Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21082994 Authors: Gao Kong Huang Xie Lung squamous cell carcinoma (LUSC) is often diagnosed at the advanced stage with poor prognosis. The mechanisms of its pathogenesis and prognosis require urgent elucidation. This study was performed to screen potential biomarkers related to the occurrence,...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2995: Extracellular Matrix Derived from High Metastatic Human Breast Cancer Triggers Epithelial-Mesenchymal Transition in Epithelial Breast Cancer Cells through αvβ3 Integrin International Journal of Molecular Sciences doi: 10.3390/ijms21082995 Authors: M. Brandão-Costa Helal-Neto M. Vieira Barcellos-de-Souza Morgado-Diaz Barja-Fidalgo Alterations in the composition and architecture of the extracellular matrix (ECM) can influence cancer growth...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2990: A Novel CD147 Inhibitor, SP-8356, Attenuates Pathological Fibrosis in Alkali-Burned Rat Cornea International Journal of Molecular Sciences doi: 10.3390/ijms21082990 Authors: Chanmin Joung Hyojin Noh Jeein Jung Hwa Young Song Hwanse Bae Kisoo Pahk Won-Ki Kim The corneal fibrotic responses to corneal damage often lead to severe corneal opacification thereby resulting in severe visual impairment or even blindness. The persistence of corneal opacity...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2993: 3D Bioprinted Vascularized Tumour for Drug Testing International Journal of Molecular Sciences doi: 10.3390/ijms21082993 Authors: Han Kim Chen Shin Lee Moon Paek Park An in vitro screening system for anti-cancer drugs cannot exactly reflect the efficacy of drugs in vivo, without mimicking the tumour microenvironment (TME), which comprises cancer cells interacting with blood vessels and fibroblasts. Additionally, the tumour size...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2986: Nutrition and Genetics in NAFLD: The Perfect Binomium International Journal of Molecular Sciences doi: 10.3390/ijms21082986 Authors: Marica Meroni Miriam Longo Alice Rustichelli Paola Dongiovanni Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis,...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2991: Growth Modulatory Role of Zinc in Prostate Cancer and Application to Cancer Therapeutics International Journal of Molecular Sciences doi: 10.3390/ijms21082991 Authors: Phuong Kim To Manh Hung Do Jin-Hyoung Cho Chaeyong Jung Zinc is a group IIB heavy metal. It is an important regulator of major cell signaling pathways in most mammalian cells, functions as an antioxidant and plays a role in maintaining genomic stability. Zinc deficiency leads to severe...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2982: Use of 3D Human Liver Organoids to Predict Drug-Induced Phospholipidosis International Journal of Molecular Sciences doi: 10.3390/ijms21082982 Authors: Ji-Young Lee Hyo-Jeong Han Sang-Joon Lee Eun-Ho Cho Han-Byul Lee Ju-Hyung Seok Hee Seon Lim Woo-Chan Son Drug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because of the diversity of PL between species, human cell-based...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2983: Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness International Journal of Molecular Sciences doi: 10.3390/ijms21082983 Authors: Valerio Ciccone Arianna Filippelli Andrea Angeli Claudiu T. Supuran Lucia Morbidelli Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO2. An acidification of tumor microenvironment contributes...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2981: Regulation of Translation in the Protozoan Parasite Leishmania International Journal of Molecular Sciences doi: 10.3390/ijms21082981 Authors: Zemfira N. Karamysheva Sneider Alexander Gutierrez Guarnizo Andrey L. Karamyshev Leishmaniasis represents a serious health problem worldwide and drug resistance is a growing concern. Leishmania parasites use unusual mechanisms to control their gene expression. In contrast to many other species, they do not have...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2979: LINC00312/YBX1 Axis Regulates Myofibroblast Activities in Oral Submucous Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21082979 Authors: Chuan-Hang Yu Chih-Yuan Fang Cheng-Chia Yu Pei-Ling Hsieh Yi-Wen Liao Lo-Lin Tsai Pei-Ming Chu Oral submucous fibrosis (OSF) has been recognized as a precancerous disorder in the oral cavity. Great effort has been made to inhibit the malignant progression of OSF over the past decades,...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2985: ABC Efflux Transporters and the Circuitry of miRNAs: Kinetics of Expression in Cancer Drug Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21082985 Authors: Bruno C. Gomes Mónica Honrado Ana Armada Miguel Viveiros José Rueff António S. Rodrigues Cancer drug resistance (CDR) is a major problem in therapeutic failure. Over 90% of patients with metastatic cancer present CDR. Several mechanisms underlie CDR, including the...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2989: Fluorinated Molecules and Nanotechnology: Future ‘Avengers’ against the Alzheimer’s Disease? International Journal of Molecular Sciences doi: 10.3390/ijms21082989 Authors: Dabur Loureiro Pereira Alzheimer’s disease (AD) is a serious health concern, affecting millions of people globally, which leads to cognitive impairment, dementia, and inevitable death. There is still no medically accepted treatment for AD. Developing therapeutic treatments...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2984: Genome-Wide Identification of M35 Family Metalloproteases in Rhizoctonia cerealis and Functional Analysis of RcMEP2 as a Virulence Factor during the Fungal Infection to Wheat International Journal of Molecular Sciences doi: 10.3390/ijms21082984 Authors: Lijun Pan Shengxian Wen Jinfeng Yu Lin Lu Xiuliang Zhu Zengyan Zhang Rhizoctonia cerealis is the causal pathogen of the devastating disease, sharp eyespot, of the important crop wheat (Triticum...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2992: Current Advances in the Diagnostic Imaging of Atherosclerosis: Insights into the Pathophysiology of Vulnerable Plaque International Journal of Molecular Sciences doi: 10.3390/ijms21082992 Authors: Nataliya V. Mushenkova Volha I. Summerhill Dongwei Zhang Elena B. Romanenko Andrey V. Grechko Alexander N. Orekhov Atherosclerosis is a lipoprotein-driven inflammatory disorder leading to a plaque formation at specific sites of the arterial tree. After...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2987: SGLT2 Inhibitor Empagliflozin and DPP4 Inhibitor Linagliptin Reactivate Glomerular Autophagy in db/db Mice, a Model of Type 2 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms21082987 Authors: Korbut Taskaeva Bgatova Muraleva Orlov Dashkin Khotskina Zavyalov Konenkov Klein Klimontov Recent data have indicated the emerging role of glomerular autophagy in diabetic kidney disease. We aimed to assess...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2980: Non-Apoptotic Cell Death Signaling Pathways in Melanoma International Journal of Molecular Sciences doi: 10.3390/ijms21082980 Authors: Mariusz L. Hartman Resisting cell death is a hallmark of cancer. Disturbances in the execution of cell death programs promote carcinogenesis and survival of cancer cells under unfavorable conditions, including exposition to anti-cancer therapies. Specific modalities of regulated cell death (RCD) have been classified based on...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2988: Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project International Journal of Molecular Sciences doi: 10.3390/ijms21082988 Authors: Karine Audouze Denis Sarigiannis Paloma Alonso-Magdalena Celine Brochot Maribel Casas Martine Vrijheid Patrick J. Babin Spyros Karakitsios Xavier Coumoul Robert Barouki Exposure to chemical substances that...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2977: Update on the Neurobiology of Vascular Cognitive Impairment: From Lab to Clinic International Journal of Molecular Sciences doi: 10.3390/ijms21082977 Authors: Luisa Vinciguerra Giuseppe Lanza Valentina Puglisi Francesco Fisicaro Manuela Pennisi Rita Bella Mariagiovanna Cantone In the last years, there has been a significant growth in the literature exploring the pathophysiology of vascular cognitive impairment (VCI). As an “umbrella...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2974: Blockade of CDK7 Reverses Endocrine Therapy Resistance in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21082974 Authors: Yasmin M. Attia Samia A. Shouman Salama A. Salama Cristina Ivan Abdelrahman M. Elsayed Paola Amero Cristian Rodriguez-Aguayo Gabriel Lopez-Berestein Cyclin-dependent kinase (CDK)-7 inhibitors are emerging as promising drugs for the treatment of different types of cancer that show chemotherapy...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2976: Donor CYP3A5 Gene Polymorphism Alone Cannot Predict Tacrolimus Intrarenal Concentration in Renal Transplant Recipients International Journal of Molecular Sciences doi: 10.3390/ijms21082976 Authors: Mengyu Zhang Soichiro Tajima Tomohiro Shigematsu Rao Fu Hiroshi Noguchi Keizo Kaku Akihiro Tsuchimoto Yasuhiro Okabe Nobuaki Egashira Satohiro Masuda CYP3A5 gene polymorphism in recipients plays an important role in tacrolimus blood pharmacokinetics...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2971: Sulfur Deficiency Increases Phosphate Accumulation, Uptake, and Transport in Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms21082971 Authors: Alaa Allahham Satomi Kanno Liu Zhang Akiko Maruyama-Nakashita Recent studies have shown various metabolic and transcriptomic interactions between sulfur (S) and phosphorus (P) in plants. However, most studies have focused on the effects of phosphate (Pi) availability and P signaling...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2975: Intravenous Enzyme Replacement Therapy in Mucopolysaccharidoses: Clinical Effectiveness and Limitations International Journal of Molecular Sciences doi: 10.3390/ijms21082975 Authors: Parini Deodato The aim of this review is to summarize the evidence on efficacy, effectiveness and safety of intravenous enzyme replacement therapy (ERT) available for mucopolysaccharidoses (MPSs) I, II, IVA, VI and VII, gained in phase III clinical trials and in observational...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2978: Signal Deconvolution and Noise Factor Analysis Based on a Combination of Time–Frequency Analysis and Probabilistic Sparse Matrix Factorization International Journal of Molecular Sciences doi: 10.3390/ijms21082978 Authors: Yamada Kurotani Chikayama Kikuchi Nuclear magnetic resonance (NMR) spectroscopy is commonly used to characterize molecular complexity because it produces informative atomic-resolution data on the chemical structure and molecular...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2970: Ruthenium, Not Carbon Monoxide, Inhibits the Procoagulant Activity of Atheris, Echis, and Pseudonaja Venoms International Journal of Molecular Sciences doi: 10.3390/ijms21082970 Authors: Vance G. Nielsen The demonstration that carbon monoxide releasing molecules (CORMs) affect experimental systems by the release of carbon monoxide, and not via the interaction of the inactivated CORM, has been an accepted paradigm for decades. However, it has recently been documented...
Thu Apr 23, 2020 03:00
IJMS, Vol. 21, Pages 2968: Overcoming Intrinsic Doxorubicin Resistance in Melanoma by Anti-Angiogenic and Anti-Metastatic Effects of Liposomal Prednisolone Phosphate on Tumor Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms21082968 Authors: Emilia Licarete Valentin Florian Rauca Lavinia Luput Denise Drotar Ioana Stejerean Laura Patras Bogdan Dume Vlad Alexandru Toma Alina Porfire Claudia Gherman Alina Sesarman Manuela Banciu ...
Thu Apr 23, 2020 03:00
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