Antibiotics, Vol. 9, Pages 158: What Resources do NHS Commissioning Organisations Use to Support Antimicrobial Stewardship in Primary Care in England? Antibiotics doi: 10.3390/antibiotics9040158 Authors: Allison Lecky Beech Ashiru-Oredope Costelloe Owens McNulty Professional education and public engagement are fundamental components of any antimicrobial stewardship (AMS) strategy. The National Institute for Health and Care Excellence (NICE), Public Health England...
Thu Apr 02, 2020 03:00
Antibiotics, Vol. 9, Pages 157: Deep Functional Profiling Facilitates the Evaluation of the Antibacterial Potential of the Antibiotic Amicoumacin Antibiotics doi: 10.3390/antibiotics9040157 Authors: Stanislav S. Terekhov Anton S. Nazarov Yuliana A. Mokrushina Margarita N. Baranova Nadezhda A. Potapova Maja V. Malakhova Elena N. Ilina Ivan V. Smirnov Alexander G. Gabibov The global spread of antibiotic resistance is forcing the scientific community to find new...
Thu Apr 02, 2020 03:00
Antibiotics, Vol. 9, Pages 156: Genotypic and Phenotypic Evaluation of Biofilm Production and Antimicrobial Resistance in Staphylococcus aureus Isolated from Milk, North West Province, South Africa Antibiotics doi: 10.3390/antibiotics9040156 Authors: Marie Ebob Agbortabot Bissong Collins Njie Ateba Background: Biofilm formation in S. aureus may reduce the rate of penetration of antibiotics, thereby complicating treatment of infections caused by these bacteria. The aim of this study...
Thu Apr 02, 2020 03:00
Antioxidants, Vol. 9, Pages 296: PCSK9 Regulates Nox2-Mediated Platelet Activation via CD36 Receptor in Patients with Atrial Fibrillation Antioxidants doi: 10.3390/antiox9040296 Authors: Cammisotto Pastori Nocella Bartimoccia Castellani Marchese Scavalli Ettorre Viceconte Violi Pignatelli Carnevale Background: High levels of proprotein convertase subtilisin/kexin 9 (PCSK9) is predictive of cardiovascular events (CVEs) in atrial fibrillation...
Thu Apr 02, 2020 03:00
Antioxidants, Vol. 9, Pages 297: Management of Traumatic Brain Injury: From Present to Future Antioxidants doi: 10.3390/antiox9040297 Authors: Rosalia Crupi Marika Cordaro Salvatore Cuzzocrea Daniela Impellizzeri TBI (traumatic brain injury) is a major cause of death among youth in industrialized societies. Brain damage following traumatic injury is a result of direct and indirect mechanisms; indirect or secondary injury involves the initiation of an acute inflammatory response,...
Thu Apr 02, 2020 03:00
Atmosphere, Vol. 11, Pages 350: A New Land-Use Dataset for the Weather Research and Forecasting (WRF) Model Atmosphere doi: 10.3390/atmos11040350 Authors: Li Zhang Mamtimin Fan Ju The USGS (United States Geological Survey) land-use data used in the Weather Research and Forecasting (WRF) model have become obsolete as they are unable to accurately represent actual underlying surface features. Therefore, this study developed a new multi-satellite remote-sensing land-use...
Thu Apr 02, 2020 03:00
Atmosphere, Vol. 11, Pages 349: Tropospheric Dust and Associated Atmospheric Circulations over the Mediterranean Region with Focus on Romania’s Territory Atmosphere doi: 10.3390/atmos11040349 Authors: Țîmpu Sfîcă Dobri Cazacu Nita Birsan The aim of this study is to assess the distribution of dust over the Mediterranean region, with a special focus on the territory of Romania. Two parameters are analyzed—Dust Load (DL) and Aerosol Optical Depth (AOD), the...
Thu Apr 02, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 71: The Role of Family Relationships in Eating Disorders in Adolescents: A Narrative Review Behavioral Sciences doi: 10.3390/bs10040071 Authors: Michela Erriu Silvia Cimino Luca Cerniglia Background: Adolescents’ eating disorders have been explored through various conceptual and empirical models. Only recently, scientific literature in this area has more specifically investigated the role of relationships, with particular attention...
Thu Apr 02, 2020 03:00
Biology, Vol. 9, Pages 70: Is it Time to Rethink Our Weight Loss Paradigms? Biology doi: 10.3390/biology9040070 Authors: Gentil Viana Naves Boscolo Del Vecchio Coswig Loenneke Barbosa de Lira Strategies aiming to promote weight loss usually include anything that results in an increase in energy expenditure (exercise) or a decrease in energy intake (diet). However, the probability of losing weight is low and the probability of sustained weight loss is even lower....
Thu Apr 02, 2020 03:00
Biology, Vol. 9, Pages 69: Isolation and Identification of Fusarium spp., the Causal Agents of Onion (Allium cepa) Basal Rot in Northeastern Israel Biology doi: 10.3390/biology9040069 Authors: Ben Kalman Dekel Abraham Shaul Graph Rafael Perl-Treves Yael Meller Harel Ofir Degani Over the past decade, there have been accumulating reports from farmers and field extension personnel on the increasing incidence and spread of onion (Allium cepa) bulb basal rot in northern Israel....
Thu Apr 02, 2020 03:00
Biomolecules, Vol. 10, Pages 540: Highly Modular Protein Micropatterning Sheds Light on the Role of Clathrin-Mediated Endocytosis for the Quantitative Analysis of Protein-Protein Interactions in Live Cells Biomolecules doi: 10.3390/biom10040540 Authors: Lanzerstorfer Müller Gordiyenko Weghuber Niemeyer Protein micropatterning is a powerful tool for spatial arrangement of transmembrane and intracellular proteins in living cells. The restriction of one interaction partner...
Thu Apr 02, 2020 03:00
Biomolecules, Vol. 10, Pages 541: CD147 is a Novel Interaction Partner of Integrin αMβ2 Mediating Leukocyte and Platelet Adhesion Biomolecules doi: 10.3390/biom10040541 Authors: Heinzmann Noethel Ungern-Sternberg Mitroulis Gawaz Chavakis May Seizer Surface receptor-mediated adhesion is a fundamental step in the recruitment of leukocytes and platelets, as well as platelet–leukocyte interactions. The surface receptor CD147 is crucially involved in...
Thu Apr 02, 2020 03:00
Biomolecules, Vol. 10, Pages 538: Biotechnological Interventions for Ginsenosides Production Biomolecules doi: 10.3390/biom10040538 Authors: Gantait Mitra Chen Ginsenosides are secondary metabolites that belong to the triterpenoid or saponin group. These occupy a unique place in the pharmaceutical sector, associated with the manufacturing of medicines and dietary supplements. These valuable secondary metabolites are predominantly used for the treatment of nervous and cardiac...
Thu Apr 02, 2020 03:00
Biomolecules, Vol. 10, Pages 539: Actinoporins: From the Structure and Function to the Generation of Biotechnological and Therapeutic Tools Biomolecules doi: 10.3390/biom10040539 Authors: Santos Ramírez-Carreto Beatriz Miranda-Zaragoza Claudia Rodríguez-Almazán Actinoporins (APs) are a family of pore-forming toxins (PFTs) from sea anemones. These biomolecules exhibit the ability to exist as soluble monomers within an aqueous medium or as constitutively open oligomers in biological...
Thu Apr 02, 2020 03:00
Biomolecules, Vol. 10, Pages 537: Efficient Construction of Atomic-Resolution Models of Non-Sulfated Chondroitin Glycosaminoglycan Using Molecular Dynamics Data Biomolecules doi: 10.3390/biom10040537 Authors: Elizabeth K. Whitmore Gabriel Vesenka Hanna Sihler Olgun Guvench Glycosaminoglycans (GAGs) are linear, structurally diverse, conformationally complex carbohydrate polymers that may contain up to 200 monosaccharides. These characteristics present a challenge for studying...
Thu Apr 02, 2020 03:00
Biomolecules, Vol. 10, Pages 536: Bacopa monnieri and Their Bioactive Compounds Inferred Multi-Target Treatment Strategy for Neurological Diseases: A Cheminformatics and System Pharmacology Approach Biomolecules doi: 10.3390/biom10040536 Authors: Rajendran Jeyasri Pandiyan Muthuramalingam Vellaichami Suba Manikandan Ramesh Jen-Tsung Chen Neurological diseases (NDs), especially Alzheimer’s and Spinocerebellar ataxia (SCA), can severely cause biochemical abnormalities...
Thu Apr 02, 2020 03:00
Biosensors, Vol. 10, Pages 33: Electrochemical Sensing of Serotonin by a Modified MnO2-Graphene Electrode Biosensors doi: 10.3390/bios10040033 Authors: Nehru Chinnathambi Fazio Neri Leonardi Bonavita Neri The development of MnO2-graphene (MnO2-GR) composite by microwave irradiation method and its application as an electrode material for the selective determination of serotonin (SE), popularly known as “happy chemical”, is reported. Anchoring...
Thu Apr 02, 2020 03:00
Biosensors, Vol. 10, Pages 32: Electrochemical (Bio)Sensors for Pesticides Detection Using Screen-Printed Electrodes Biosensors doi: 10.3390/bios10040032 Authors: Beatriz Pérez-Fernández Agustín Costa-García Alfredo de la Escosura- Muñiz Pesticides are among the most important contaminants in food, leading to important global health problems. While conventional techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) have traditionally been utilized...
Thu Apr 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 209: Combined Effects of Ethnicity and Education on Burden of Depressive Symptoms over 24 Years in Middle-Aged and Older Adults in the United States Brain Sciences doi: 10.3390/brainsci10040209 Authors: Assari Ethnicity and educational attainment are among the major social determinants of depression in the general population. While high education credentials protect individuals against depressive symptoms, this protection may be weaker for ethnic minority...
Thu Apr 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 208: Epileptiform Neuronal Discharges Impair Astrocyte Syncytial Isopotentiality in Acute Hippocampal Slices Brain Sciences doi: 10.3390/brainsci10040208 Authors: Qi Wang Wei Wang Sydney Aten Conrad M. Kiyoshi Yixing Du Min Zhou Astrocyte syncytial isopotentiality is a physiological mechanism resulting from a strong electrical coupling among astrocytes. We have previously shown that syncytial isopotentiality exists as a system-wide feature...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 866: Integrative Radiogenomics Approach for Risk Assessment of Post-Operative Metastasis in Pathological T1 Renal Cell Carcinoma: A Pilot Retrospective Cohort Study Cancers doi: 10.3390/cancers12040866 Authors: Hye Won Lee Hwan-ho Cho Je-Gun Joung Hwang Gyun Jeon Byong Chang Jeong Seong Soo Jeon Hyun Moo Lee Do-Hyun Nam Woong-Yang Park Chan Kyo Kim Seong Il Seo Hyunjin Park Despite the increasing incidence of pathological stage...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 863: Mass Spectrometry Imaging Reveals Neutrophil Defensins as Additional Biomarkers for Anti-PD-(L)1 Immunotherapy Response in NSCLC Patients Cancers doi: 10.3390/cancers12040863 Authors: Eline Berghmans Julie Jacobs Christophe Deben Christophe Hermans Glenn Broeckx Evelien Smits Evelyne Maes Jo Raskin Patrick Pauwels Geert Baggerman (1) Background: Therapeutic blocking of the interaction between programmed death-1 (PD-1) with its ligand...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 862: Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK Cancers doi: 10.3390/cancers12040862 Authors: Nurbubu T. Moldogazieva Innokenty M. Mokhosoev Alexander A. Terentiev It has been long recognized that cancer cells reprogram their metabolism under hypoxia conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to meet elevated requirements in energy and nutrients for proliferation, migration,...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 864: Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization Cancers doi: 10.3390/cancers12040864 Authors: Jarosław Króliczewski Sylwia Bartoszewska Magdalena Dudkowska Dorota Janiszewska Agnieszka Biernatowska David K. Crossman Karol Krzymiński Małgorzata Wysocka Anna Romanowska Maciej Baginski Michal Markuszewski Renata J. Ochocka James...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 865: [18F]FET-βAG-TOCA: The Design, Evaluation and Clinical Translation of a Fluorinated Octreotide Cancers doi: 10.3390/cancers12040865 Authors: Louis Allott Suraiya Dubash Eric O. Aboagye The success of Lutathera™ ([177Lu]Lu-DOTA-TATE) in the NETTER-1 clinical trial as a peptide receptor radionuclide therapy (PRRT) for somatostatin receptor expressing (SSTR) neuroendocrine tumours (NET) is likely to increase the demand for patient stratification...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 859: Comparative Analysis of Urine Fractions for Optimal Bladder Cancer Detection Using DNA Methylation Markers Cancers doi: 10.3390/cancers12040859 Authors: Anouk E. Hentschel Jakko A. Nieuwenhuijzen Judith Bosschieter Annina P. van Splunter Birgit I. Lissenberg-Witte J. Patrick van der Voorn Loes I. Segerink R. Jeroen A. van Moorselaar Renske D.M. Steenbergen DNA methylation analysis of full void urine and urine pellet seems promising...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 860: The Calcium-Sensing Receptor is A Marker and Potential Driver of Neuroendocrine Differentiation in Prostate Cancer Cancers doi: 10.3390/cancers12040860 Authors: Fanny Bery Mathilde Cancel Aurélie Chantôme Roseline Guibon Franck Bruyère François Rozet Karine Mahéo Gaëlle Fromont The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 861: Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells Cancers doi: 10.3390/cancers12040861 Authors: Elisabete Fernandes Rui Freitas Dylan Ferreira Janine Soares Rita Azevedo Cristiana Gaiteiro Andreia Peixoto Sara Oliveira Sofia Cotton Marta Relvas-Santos Luis Pedro Afonso Carlos Palmeira Maria José Oliveira Rita Ferreira André M. N. Silva Lúcio...
Thu Apr 02, 2020 03:00
Cancers, Vol. 12, Pages 858: Expression of CD44v6-Containing Isoforms Influences Cisplatin Response in Gastric Cancer Cells Cancers doi: 10.3390/cancers12040858 Authors: Carla Pereira Daniel Ferreira Nuno Mendes Pedro L. Granja Gabriela M. Almeida Carla Oliveira CD44v6-containing isoforms are frequently de novo expressed in gastric cancer (GC). Whether CD44v6 has a central role in GC transformation and/or progression, whether it conditions response to therapy or whether...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 872: Human Embryonic Stem Cell-Derived Wilson’s Disease Model for Screening Drug Efficacy Cells doi: 10.3390/cells9040872 Authors: Dongkyu Kim Su-Bin Kim Jung Lim Ryu Heesu Hong Jin-Hyuk Chang Tack-Jin Yoo Xiong Jin Han-Jin Park Choongseong Han Beom Hee Lee Jin-Ho Choi Han-Wook Yoo Jong-Hoon Kim Dong-Hun Woo Human pluripotent stem cells (hPSCs) including human embryonic stem cells (hESCs) and human-induced pluripotent stem cells...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 867: Short Histone H2A Variants: Small in Stature but not in Function Cells doi: 10.3390/cells9040867 Authors: Xuanzhao Jiang Tatiana A. Soboleva David J. Tremethick The dynamic packaging of DNA into chromatin regulates all aspects of genome function by altering the accessibility of DNA and by providing docking pads to proteins that copy, repair and express the genome. Different epigenetic-based mechanisms have been described that alter the way DNA is organised...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 871: Ecklonia stolonifera Extract Suppresses Lipid Accumulation by Promoting Lipolysis and Adipose Browning in High-Fat Diet-Induced Obese Male Mice Cells doi: 10.3390/cells9040871 Authors: Heegu Jin Kippeum Lee Sungwoo Chei Hyun-Ji Oh Kang-Pyo Lee Boo-Yong Lee Obesity develops due to an energy imbalance and manifests as the storage of excess triglyceride (TG) in white adipose tissue (WAT). Recent studies have determined that edible natural materials...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 870: Diagnostic and Therapeutic Potential of TSPO Studies Regarding Neurodegenerative Diseases, Psychiatric Disorders, Alcohol Use Disorders, Traumatic Brain Injury, and Stroke: An Update Cells doi: 10.3390/cells9040870 Authors: Jasmina Dimitrova-Shumkovska Ljupcho Krstanoski Leo Veenman Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 868: Glycation Leads to Increased Polysialylation and Promotes the Metastatic Potential of Neuroblastoma Cells Cells doi: 10.3390/cells9040868 Authors: Maximilian Scheer Kaya Bork Frieder Simon Manimozhi Nagasundaram Rüdiger Horstkorte Vinayaga Srinivasan Gnanapragassam Neuroblastoma is the second most frequent extracranial tumor, affecting young children worldwide. One hallmark of tumors such as neuroblastomas, is the expression of polysialic acid,...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 869: High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells Cells doi: 10.3390/cells9040869 Authors: Marcella Brescia Josephine M. Janssen Jin Liu Manuel A.F.V. Gonçalves Duchenne muscular dystrophy (DMD) is a fatal X-linked muscle wasting disorder arising from mutations in the ~2.4 Mb dystrophin-encoding DMD gene. RNA-guided CRISPR-Cas9 nucleases (RGNs) are opening new DMD therapeutic...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 861: The Emerging Roles of Exosomes as EMT Regulators in Cancer Cells doi: 10.3390/cells9040861 Authors: Hyunwoo Kim Sungmin Lee Eunguk Shin Ki Moon Seong Young Woo Jin HyeSook Youn BuHyun Youn Epithelial–mesenchymal transition (EMT) causes epithelial cells to lose their polarity and adhesion property, and endows them with migratory and invasive properties to enable them to become mesenchymal stem cells. EMT occurs throughout embryonic...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 859: Failure to Down-Regulate miR-154 Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia Cells doi: 10.3390/cells9040859 Authors: Cho-Ming Chao Gianni Carraro Zvonimir A. Rako Johannes Kolck Jamschid Sedighi Volker Zimmermann Alena Moiseenko Jochen Wilhelm Brittany M. Young Lei Chong Jin Wu Adriana Contreras Parviz Minoo Guillermo...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 865: Revisiting the Role of Neurotrophic Factors in Inflammation Cells doi: 10.3390/cells9040865 Authors: Lucas Morel Olivia Domingues Jacques Zimmer Tatiana Michel The neurotrophic factors are well known for their implication in the growth and the survival of the central, sensory, enteric and parasympathetic nervous systems. Due to these properties, neurturin (NRTN) and Glial cell-derived neurotrophic factor (GDNF), which belong to the GDNF family ligands...
Thu Apr 02, 2020 03:00
Cells, Vol. 9, Pages 863: Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences
Cells, Vol. 9, Pages 863: Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences Cells doi: 10.3390/cells9040863 Authors: Kristin Eckel-Mahan Aleix Ribas Latre Mikhail G. Kolonin Adipose tissue (AT) is comprised of a diverse number of cell types, including adipocytes, stromal cells, endothelial cells, and infiltrating leukocytes. Adipose stromal cells (ASCs) are a mixed population containing adipose progenitor cells (APCs) as well as fibro-inflammatory precursors...
Thu Apr 02, 2020 03:00
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