BackgroundRoutine use of the Sequential Organ Failure Assessment (SOFA) score to prognosticate patients with sepsis is challenged by the requirement to perform numerous laboratory tests. The prognostic accuracy of the quick SOFA (qSOFA) without or with lactate criteria has not been prospectively investigated in low and middle income countries. We assessed the performance of simplified prognosis criteria using qSOFA-lactate criteria in the emergency department of a hospital with limited resources,...
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JCDD, Vol. 7, Pages 14: New Technique in Assessment of Heart Chambers Remodeling in Acquired Mitral Valve Defects Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7020014 Authors: Bokeria Makarenko Kosareva Objective: Analysis and presentation of the capabilities of the new ultrasound technique —the index of volume remodeling (IRV), which allows comprehensive assessing of pathological remodeling of the heart as an integrated functional anatomical...
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BackgroundBulbar involvement is a hallmark of amyotrophic lateral sclerosis (ALS), but surprisingly very few studies have addressed the frequency, pattern and clinical relevance of laryngeal involvement in the disease.MethodsTwenty-six patients with spinal-onset ALS underwent nasofibroscopy (NF), followed by laryngeal electromyography (LEMG). We also studied resting activity and motor unit potentials of the genioglossus and masseter muscles.ResultsTwenty-four patients presented neurogenic changes...
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Background and aimIt is unclear which patients with Fabry disease (FD) are at risk for progression of white matter lesions (WMLs) and brain infarctions and whether enzyme replacement therapy (ERT) changes this risk. The aim of this study was to determine the effect of ERT and clinical characteristics on progression of WMLs and infarctions on MRI in patients with FD.MethodsMRIs were assessed for WMLs (Fazekas scale), infarctions and basilar artery diameter (BAD). The effect of clinical characteristics...
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IntroductionAlthough symptomatic medicines constitute an important intervention in amyotrophic lateral sclerosis (ALS), few systematic investigations into drug management have been reported so far.1 Furthermore, symptomatic pharmacotherapy is constantly evolving with an increasing number of drugs being used. Therefore, more detailed information on drug prescription must be obtained to monitor the current standards of care, identify potential shortcomings in drug management and elucidate progress...
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In the 2010s, a small number of science fiction films and television series exploring the theme of the robot carer and how humans respond to them were released. This paper explores three works in this regard: the films Robot & Frank (dir. Jake Schreier, USA 2012), Big Hero 6 (dir. Don Hall/Chris Williams, USA 2014) and the television series Humans (UK/USA, Channel 4/AMC, 2015–2018). Examining these works with some of the ethical issues currently being discussed in the use of robot technology...
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IntroductionSurgical site infections (SSI) are common healthcare-associated infections resulting in substantial morbidity, mortality and hospital costs.1–4 However, no standard algorithm for SSI surveillance or outbreak detection exists, and traditional surveillance techniques may fail to provide timely identification of important SSI rate increases.5 6 We previously showed that standard Shewhart and exponentially weighted moving average statistical process control (SPC) charts have potential to...
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Abstract Neutrophil-to-lymphocyte ratio (NLR) has been recently reported to be a promising inflammatory marker to assess systemic inflammation in many disorders. However, there are only a few studies looking at NLR in patients with myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This study was thus undertaken to explore the relationship between NLR at diagnosis with inflammatory response and disease activity among MPO-AAV patients...
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Disseminated intravascular coagulation is a critical complication of advanced clear cell renal cell carcinoma, despite the rarity of the occurrence of disseminated intravascular coagulation in such tumors. The...
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Osteosarcoma is a common malignancy of bone that usually occurs in individuals in the age range of 0–24 years. Extraskeletal osteosarcoma is a rare tumor presentation which originates in non-bony tissues. Extr...
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Abstract Growing evidence has supported that the nucleus accumbens (NAc), especially its shell portion, has been involved in epileptogenesis. However, relevant studies on vivo human brain are quite limited. In this study, we investigated left mesial temporal lobe epilepsy (MTLE) related function connectivity (FC) changes of NAc subregions using resting-state functional magnetic resonance imaging. We calculated functional connectivity from two NAc subregions to both whole brain...
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Wafaa Al Rawi, Kamal Mustafa, Ashraf Abuobayda, Laila ObaidJournal of Clinical Neonatology 2020 9(2):143-145 Trisomy 13 (Patau syndrome) is third common trisomy and associated with multiple congenital anomalies including limb malformation like polydactyly. However, the presence of ectrodactyly or split-hand and/or foot malformation, a lobster claw-like appearance of the hand and/or foot, which may occur as an isolated entity or as part of a syndrome, in trisomy 13 is uncommon. This is a case...
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Raja M Thigha, Ahmad A Alzoani, Mufareh H M. Almazkary, Amal A Khormi, Rania H AlbarJournal of Clinical Neonatology 2020 9(2):98-110 Background: When hypoxia is the cause for neonatal encephalopathy, a clinical syndrome has been described known as hypoxic–ischemic encephalopathy (HIE). Aim of the Study: This study aimed to determine the magnitude of HIE occurrence, its short-term outcomes, and associated risk factors. Literature review was included for comparing our reported findings with other...
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Ali Almudeer, Jubara Alallah, Saad AlSaedi, Jasim Anabrees, Abdulhakiem Kattan, Zakariya AlSalam, Manal Asiri, Emad Khadawardi, Abdulrrahman AlMehery, Ibrahim Alhefzi, Abdulrrahman AlnemriJournal of Clinical Neonatology 2020 9(2):93-97
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Levent Korkmaz, Ahmet Ozdemir, Sabriye Korkut, Osman BastugJournal of Clinical Neonatology 2020 9(2):111-120 Background: While propranolol hydrochloride (PH) is being more widely used in adult patients, its administration in the neonatal period as well is progressively on the rise in our time. With the increasing use of PH in the neonatal age period, worries resulting from the potential adverse effects of the agent on vital organs, such as brain, in particular, have come to the fore. Such concerns...
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Arnab Banerjee, Geeta Ahlawat, Richa AggarwalJournal of Clinical Neonatology 2020 9(2):149-151 Craniosynostosis is a birth defect syndrome characterized by the premature closure of one or more of the fibrous joints between the bones of the skull. The most common among these craniosynostosis syndromes is Crouzon syndrome. Airway management in such patients becomes challenging and requires an experienced and calm anesthesiologist for expert management. We report a case of successful usage of i-gel™...
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N Nandhagopal, Uzma Firdaus, Syed Manazir Ali, Kamran AfzalJournal of Clinical Neonatology 2020 9(2):121-124 Background: Acute kidney injury (AKI) is a common and devastating medical condition. However, the true incidence of AKI around the world is not known. In newborns patients, AKI importance and dilemmas are even more pronounced, as a newborn's kidneys are more susceptible to hypoperfusion and have low glomerular filtration rate. Objective: The objective is to determine the incidence, risk...
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Amit Agrawal, Shilpa Pandya, Jyotsna ShrivastavaJournal of Clinical Neonatology 2020 9(2):138-142 Background: Neonatal hyperbilirubinemia (NNH) is an important cause of preventable brain damage among infants. Neurodevelopmental assessment and Brainstem-Evoked Response Audiometry (BERA) may help in the early identification and management of neurodevelopmental sequelae. Objectives: The objectives of this study were to find the association between neonatal peak serum bilirubin levels and the neurodevelopmental...
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Vibha Kariya, Manish Jain, Smita JategaonkarJournal of Clinical Neonatology 2020 9(2):125-131 Introduction: Perinatal asphyxia is among the three most common causes of neonatal deaths. Neonates with birth asphyxia suffer from hypoxic ischemic encephalopathy. They also develop multiorgan dysfunction including hepatic injury which leads to increase in liver enzymes in the blood. In this case control study, we studied the severity of liver dysfunction in term neonates with perinatal asphyxia as...
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Hammam A H. Ali, Osayd Samer ZohudJournal of Clinical Neonatology 2020 9(2):146-148 In Palestine, antibody screening is done antenatally only for pregnant women who are Rh-D negative. However, we report the first hemolytic disease of the newborn (HDN) due to anti-e in Palestine, illustrating the importance of alloantibodies other than anti-D as a cause of HDN. A pregnant woman had e-antigen negative and her blood group was B positive developed alloantibody against her infant erythrocyte e-antigen...
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Raghav Taneja, Prerna Batra, Jagdish SadizaJournal of Clinical Neonatology 2020 9(2):132-137 Background: Early transfer of baby to mother in step down ward is an approach that can improve maternal satisfaction among parents of neonates admitted in NICU. Objective: To assess the satisfaction of mothers of neonates admitted in the neonatal step down ward of a public sector hospital. Methods: This cross sectional study was conducted in neonatal step down ward of a public sector hospital in North...
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Abubakar Sani Lugga, Nuraddeen Ibrahim, Amina Oiza Ibrahim, Sule Garba ParetJournal of Clinical Neonatology 2020 9(2):152-155 Pseudomonas aeruginosa sepsis is associated with high morbidity and mortality in the neonatal period. It is the most common cause of endogenous endophthalmitis which is a rare ophthalmic emergency that can result in complete blindness. Diagnosis can be a challenge in the neonate, hence the need for early ophthalmic consultation in babies presenting with fever, eye swelling,...
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Incidence of difficult endotracheal intubation ranges between 3 and 10%. Bougies have been recommended as an airway adjunct for difficult intubation, but reported success rates are variable. A new generation f...
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Innervation of the clavicle is complex and debated, with scarce data on the analgesic and clinical impact of regional anaesthesia after surgical repair of clavicle fracture.
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Publication date: Available online 21 April 2020Source: Journal of Controlled ReleaseAuthor(s): Eride Quarta, Veronica Chierici, Lisa Flammini, Massimiliano Tognolini, Elisabetta Barocelli, Anna Maria Cantoni, Gabriela Dujovny, Susana Ecenarro, Fabio Sonvico, Gaia Colombo, Alessandra Rossi, Ruggero Bettini, Paolo Colombo, Francesca Buttini
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Publication date: Available online 20 April 2020Source: Journal of Controlled ReleaseAuthor(s): Xiaoye Yang, Xiaoqun Shi, Yanan Zhang, Jiangkang Xu, Jianbo Ji, Lei Ye, Fan Yi, Guangxi Zhai
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Publication date: Available online 21 April 2020Source: The Journal of Emergency MedicineAuthor(s): Alexander M. Sidlak, Michael G. Abesamis, Joshua A. Shulman, Ryan T. Marino
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The hypothesis that the reactivity, and in particular the kinetic behavior, of complexes of classical diimine ligands based on pyridine donors could be reinterpreted, in terms of reactivity at the ligand rather than the metal center was proposed some forty years ago by the Gillard group in Cardiff. The model received considerable resistance from the traditional inorganic chemistry community and has not received great attention in the past twenty years. This review surveys the modern evidence that...
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Chemical inducers of dimerization (CIDs) have been developed to orchestrate protein dimerization and translocation. Here we present a novel photocleavable HaloTag- and SNAP-tag-reactive CID (MeNV-HaXS) with excellent selectivity and intracellular reactivity. Excitation at 360nm cleaves the methyl-6-nitroveratryl core of MeNV-HaXS. MeNV-HaXS covalently links HaloTag- and SNAP-tag fusion proteins, and enables targeting of selected membranes and intracellular organelles. MeNV-HaXS-mediated translocation...
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We study the finite-time effects in a quantum Otto cycle where a collective spin system is used as the working fluid. Starting from a simple one-qubit system we analyze the transition to the limit cycle in the case of a finite-time thermalization. If the system consists of a large sample of independent qubits interacting coherently with the heat bath, then the super-radiant equilibration is observed. We show that this phenomenon can boost the power of the engine. Mutual interaction of qubits in the...
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