Τρίτη 21 Απριλίου 2020

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Effect of Noise Exposure on 1,382 Metallurgical Workers in Periodic Audiometric Evaluation: A Cohort Study
Introduction: Noise-induced hearing loss is the most preventable cause of auditory impairment. Periodic audiometric evaluations are essential to monitor the hearing health of noise-exposed workers. Objective: To compare the evolution of audiometric thresholds in the initial three evaluations at frequencies of 3, 4, and 6 kHz in groups of workers exposed or not to noise. Methods: In this historical cohort study, audiometric evaluations were obtained from male workers between 18 and 40 years of age...
AUD : Last 20 articles
21h
Relations between Creaky Voice and Vocal Symptoms of Fatigue
Background: The use of a creaky voice in speech has become more common. Laryngeal findings relate creaky voice with strong adductive tension in the glottis, and thus it may be expected to be related to an increased risk of vocal fatigue. Methods: The present study investigated the relation of creaky voice use and vocal symptoms in 104 Finnish female university students (mean age 24.3 years, SD 6.3 years). They had no known pathology of voice or hearing. The participants were recorded while reading...
FPL : Last 10 articles
21h
Preliminary Presentation of Metastatic Non-Small Cell Carcinoma of the Lung as Atraumatic Avulsion Fracture of the Lesser Trochanter
Traumatic avulsion fractures of the lesser trochanter are usually seen along with fractures of the proximal femur and with young adolescents involved in high-intensity sporting injuries. Atraumatic isolated lesser trochanter avulsion in adults are most commonly associated with malignancy. We describe a case of a female in her sixties who was previously fit and healthy with no systemic illness and no history of trauma presenting with groin pain. The X-ray demonstrated an isolated lesser trochanter...
CRO : Last 20 articles
23h
Incidental Accumulation of Fluciclovine in Neuroendocrine Tumour in a Patient with Oncological Duplicity
18F-fluciclovine is a PET radiopharmaceutical used for the detection of recurrent prostate cancer in adult men after primary curative treatment with suspicion of recurrence based on elevated prostate-specific antigen level. Several incidental uptakes of 18F-fluciclovine in other tumour types have been described in the literature so far – in breast cancer, hepatocellular carcinoma, and malignant melanoma. Our case report presents a patient with oncological duplicity (prostate gland carcinoma and newly...
CRO : Last 20 articles
23h
Brownish and Indurated Plaques With Yellowish Papules: Answer
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Retiform Purpura After Percutaneous Angioplasty: Challenge
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Role of BIOCHIP Indirect Immunofluorescence Test in Cutaneous Vesiculobullous Diseases
Abstract: BIOCHIP mosaics for indirect immunofluorescence in cutaneous vesiculobullous diseases provide antibody profiles in a single run and can be an alternative to performing multistep assays. There is scanty data regarding their utility. BIOCHIP tests performed over 4 years were compared with biopsy and/or direct immunofluorescence (DIF). Of 209 BIOCHIP tests, 108 were positive. Pemphigus vulgaris and Bullous pemphigoid were the commonest. Dsg3 was the commonest positive substrate in pemphigus...
The American Journal of Dermatopathology - Current Issue
23h
TTF-1 Positivity in Merkel Cell Carcinoma: The Chosen Clone Matters
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Erythema Nodosum, Early Stage—A Subcutaneous Variant of Leukocytoclastic Vasculitis? Clinicopathological Correlation in a Series of 13 Patients
Abstract: Erythema nodosum (EN) is considered to represent a septal panniculitis. In a period from January 2000 until June 2018, we clinically and histopathologically investigated 124 patients with EN, 13 (10.5%) of them in an early stage demonstrating features of a leukocytoclastic vasculitis (LCV) around postcapillary venules of the subcutaneous fat. Three of these patients presented with EN on the lower legs and Sweet syndrome on the head/neck, arms, or trunk. 19.3% and 70.2% of patients demonstrated...
The American Journal of Dermatopathology - Current Issue
23h
A Fatal Infection With Subtle and Nonspecific Signs and Symptoms: Answer
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Measurement of Tumor Thickness in Cutaneous Squamous Cell Carcinomas: Do the Different Methods Provide Better Prognostic Data?
Abstract: Cutaneous squamous cell carcinoma (cSCC) is the second most common cause of nonmelanoma skin cancers. Although it has a relatively low mortality rate, it may be locally destructive and potentially metastasize. Tumor thickness of the primary lesion is one important parameter associated with biologic behavior. Such measurement is currently performed in different ways depending on the anatomic location and subspecialty (eg, skin vs. head and neck vs. gynecologic pathology). Furthermore,...
The American Journal of Dermatopathology - Current Issue
23h
Adnexotropism as a Histopathological Clue for the Diagnosis of Primary Cutaneous CD4+ Small/Medium-Sized T-Cell Lymphoproliferative Disorder
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Rapid BRAF Mutation Testing in Pigmented Melanomas
Abstract: BRAF mutations are present in ∼40%–60% of melanomas, and targeted therapy in advanced-stage melanoma is associated with improvement in overall and progression-free survival. Accordingly, BRAF mutation determination is standard-of-care in metastatic melanoma, and a rapid, accurate assay is desirable. Melanin can present unique challenges due to inhibition of the polymerase chain reaction. The novel cartridge-based Idylla platform offers rapid molecular oncology testing; however, a formal...
The American Journal of Dermatopathology - Current Issue
23h
Skin-Colored Nodule on the Cutaneous Lip: Challenge
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Validation of Image Quality and Diagnostic Accuracy Using a Mobile Phone Camera Microscope Adaptor Compared With Glass Slide Review in Teledermatopathology
Abstract: New modalities of evaluating histopathology, such as whole-slide imaging, have been validated in the field of dermatopathology but are often unfeasible and unavailable in developing countries. Widely available across the globe, mobile phone camera technology represents a potential simple and inexpensive method of imaging histologic slides through the use of a mobile phone camera microscope adaptor. This study aims to validate the use of a commercially available adaptor in the diagnosis...
The American Journal of Dermatopathology - Current Issue
23h
BAP-1 Expression Status by Immunohistochemistry in Cellular Blue Nevus and Blue Nevus–like Melanoma
Abstract: The family of blue nevi includes the common blue nevus (BN), cellular blue nevus (CBN), and atypical BN, while melanomas with BN-like morphology can either arise in association with a blue nevus (MABN) or in the de novo setting mimicking cellular blue nevus (MMCBN). Recent molecular and immunohistochemical studies have demonstrated loss of BAP-1 in MABN/MMCBN but not in BN/CBN, suggesting that loss of BAP-1 correlates with a malignant phenotype in these lesions. In this study, we applied...
The American Journal of Dermatopathology - Current Issue
23h
Diffuse Dermal Angiomatosis: Report of a Classic Case With a Comment on the Pathophysiology Based on the Histologic Findings
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Skin-Colored Nodule on the Cutaneous Lip: Answer
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Localized Acral Sclerosing Langerhans Cell Histiocytosis: A New Form of Presentation of Cutaneous Langerhans Cell Histiocytosis
Abstract: Langerhans cell histiocytosis (LCH) is a rare proliferative disorder, more frequent in children, characterized by an abnormal accumulation of Langerhans cells admixed with eosinophils, lymphocytes, neutrophils, and macrophages. The clinical presentation is variable and depends on whether a single or multiple organs are affected. Skin lesions are common in LCH (40% of cases) and represent a frequent form of presentation (in up to 80% of cases). Cutaneous manifestations of LCH are highly...
The American Journal of Dermatopathology - Current Issue
23h
Retiform Purpura After Percutaneous Angioplasty: Answer
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Inflammatory Cells in Atypical Eruption of Lymphocyte Recovery Carry the Same Mutations as Neoplastic Myeloid Cells
Abstract: Cutaneous eruption of lymphocyte recovery (ELR) during bone marrow (BM) aplasia recovery after intensive chemotherapy has been reported in very few patients. The presence of skin rashes in patients with acute leukemia who are undergoing intensive chemotherapy and BM transplantation is a diagnostic challenge because of the clinical similarity between drug eruptions, infiltrates related to the relapse of the underlying disease, cutaneous graft-versus-host disease, and ELR. IDH1 mutations...
The American Journal of Dermatopathology - Current Issue
23h
Primary Subcutaneous Spindle Cell Synovial Sarcoma: First Reported Case
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
A Skin Plaque Preceding Systemic Relapse of Gamma-Delta Hepatosplenic T-Cell Lymphoma
Abstract: Hepatosplenic T-cell lymphoma (HSTL) is an uncommon, aggressive peripheral T-cell lymphoma with a dismal prognosis, usually expressing gamma-delta T-cell receptor on immunohistochemical study. We report the second instance in the literature of a solitary skin nodule heralding recurrence of HSTL. The patient was a 40-year-old man in apparent remission from HSTL, 4 years after chemotherapy and autologous bone marrow transplant. Biopsy of a flank lesion showed atypical lymphoid cells involving...
The American Journal of Dermatopathology - Current Issue
23h
A Fatal Infection With Subtle and Nonspecific Signs and Symptoms in a Neonate: Challenge
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Pattern of Cross-Reactivity Between Mycobacterial Immunohistochemical Stain and Normal Human Eosinophils: A Potential Pitfall in the Diagnosis of Cutaneous Mycobacterial Infections
Abstract: Cutaneous tuberculosis (CTB) is a challenging diagnosis that often requires tissue biopsy and the use of immunohistochemical (IHC) staining, among other special stains. The mycobacterium tuberculosis IHC stain is believed to be specific for mycobacteria and closely related organisms, without documented reactivity to normal human tissue. In this study, we document 4 cases of previously unreported cross-reactivity between the mycobacterium tuberculosis IHC polyclonal antibody and normal...
The American Journal of Dermatopathology - Current Issue
23h
Brownish and Indurated Plaques With Yellowish Papules: Challenge
No abstract available
The American Journal of Dermatopathology - Current Issue
23h
Multifocal Epithelioid Hemangioma of the Penis in a 4-Year-Old Child: A Case Report
Abstract: Epithelioid hemangioma (EH) is a rare benign vascular tumor which has wide morphological spectrum. In its typical forms, it is characterized histologically by lobular proliferation of vascular spaces lined by plump endothelial cells with variable inflammatory cell infiltrate in the background. They usually occur in middle-aged women and have predilection for the head and neck site, especially postauricular region. In this study, we report a case of a 4-year-old boy who presented with...
The American Journal of Dermatopathology - Current Issue
23h
Incidental Acantholysis in Hailey–Hailey Disease (Microscopic Nikolsky Sign): An Underappreciated Histologic Sign
Abstract: Identification of subtle disease-specific histologic changes may be of significant help in early diagnosis of acantholytic skin diseases. Hailey–Hailey disease (HHD) is an autosomal dominant genodermatosis characterized by vesiculoerosive lesions favoring the intertriginous areas. Histologically, HHD is characterized by full-thickness acantholysis of the spinous layer in association with dyskeratosis of individual keratinocytes; a pemphigus vulgaris-like suprabasal pattern of acantholysis...
The American Journal of Dermatopathology - Current Issue
23h

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