Background Studies have reported racial disparities in access to and use of multiple myeloma (MM) treatments between African American (AA) and White patients. Although AA patients demonstrate longer disease‐specific survival, this has not uniformly translated into improved survival over time. The association between race and treatment patterns and survival outcomes was analyzed using data from the Connect MM Registry. Methods The Connect MM Registry is a large US, multicenter, prospective...
Fri Jul 24, 2020 17:04
Background Neoadjuvant chemotherapy (NAC) has been used in patients with advanced head and neck cancers (HNCs) with the intent of downstaging tumors and suppressing distant metastases. However, to the authors' knowledge, the perioperative impact of NAC has not been systematically explored in patients with HNC. The objective of the current study was to compare perioperative outcomes with surgery upfront compared with patients treated with NAC. Methods Between March 1, 2016, and March 31, 2019,...
Fri Jul 24, 2020 17:04
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British Journal of Cancer, Published online: 27 July 2020; doi:10.1038/s41416-020-0999-zWhole-exome sequencing of long-term, never relapse exceptional responders of trastuzumab-treated HER2+ metastatic breast cancer
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British Journal of Cancer, Published online: 27 July 2020; doi:10.1038/s41416-020-1009-1The significance of highlighting the oestrogen receptor low category in breast cancer
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British Journal of Cancer, Published online: 27 July 2020; doi:10.1038/s41416-020-0994-4Intratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives
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Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon Jul 20, 2020 10:00
Abstract Advanced clear cell carcinomas originating from both ovaries and kidneys with cancerous peritonitis have poor prognoses. Murine double‐minute 2 is a potential therapeutic target for clear cell ovarian carcinomas with wild‐type TP53 . Herein, we characterized the anti‐angiogenic and antitumor effects of the Murine double‐minute 2 inhibitors, DS‐3032b and DS‐5272, in six clear cell ovarian carcinoma cell lines and two clear cell renal carcinoma cell lines, as well as in clear cell ovarian...
Sat Jul 25, 2020 18:19
Abstract Malignant pleural effusion (MPE) and paramalignant pleural effusion (PPE) remain debilitating complication in lung cancer patients with poor prognosis and limited treatment options. The role of vascular endothelial cells had not been explored in pleural environment of lung cancer. By integrating MPE and PPE as malignant associated pleural fluid (MAPF), current study aimed to evaluate MAPF on cell proliferation, migration, and angiogenesis of human umbilical vein endothelial cell (HUVEC)....
Fri Jul 24, 2020 13:14
Abstract Purpose Lung cancer (LC) has a significant impact on patients’ health-related quality of life (HRQoL). We investigate the correlations between pre-radiation therapy HRQoL and survival. Materials and methods A prospective, intention-to-treat, multicentre study of 437 patients with LC recruited at the radiation oncology departments...
Sat Jul 25, 2020 03:02
Acute ST‐segment elevation myocardial infarction (STEMI) is the most lethal coronary heart disease with vascular endothelium dysfunction and inflammation in the disease development process. Endothelial cell‐specific molecule 1 (ESM‐1) and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) are important for the diagnosis and characterization of STEMI. To date, no studies have reported the correlation between ESM‐1 and Lp‐PLA2 levels in patients with STEMI, which may be an important predictor of the...
Sat Jul 25, 2020 11:39
Purpose: SMARCA4 mutations are among the most common recurrent alterations in NSCLC, but the relationship to other genomic abnormalities and clinical impact has not been established. Experimental Design: To characterize SMARCA4 alterations in NSCLC, we analyzed the genomic, protein expression, and clinical outcome data of patients with SMARCA4 alterations treated at Memorial Sloan Kettering. Results: In 4813 tumors from patients with NSCLC, we identified 8% (n= 407) patients with SMARCA4-mutant lung...
Fri Jul 24, 2020 16:30
Background: In both the IMpassion 130 trial in the metastatic setting and in Keynote 522 in the neoadjuvant setting, triple negative breast cancer (TNBC) patients showed benefit from PD-1 axis immunotherapy. Here, we assess PD-L1 expression on both tumor and immune cells using quantitative immunofluorescence to assess association with benefit from neoadjuvant durvalumab concurrent with chemotherapy in TNBC. Methods: Pre-treatment core needle biopsies (n=69) were obtained from patients who participated...
Fri Jul 24, 2020 16:30
Galectins are an endogenous family of β-galactoside-binding proteins that play complex and multifaceted roles at various stages of cancer progression, including modulation of tumor cell proliferation, signaling, adhesion, migration, invasion, epithelial-mesenchymal transition, angiogenesis and immune escape. Recently, galectins have been implicated as major therapeutic determinants that confer sensitivity or resistance to a wide range of anticancer modalities including chemotherapy, radiotherapy,...
Fri Jul 24, 2020 16:30
Publication date: September 2020Source: European Journal of Cancer, Volume 137Author(s): Enrico Franceschi, Alicia Tosoni, Stefania Bartolini, Santino Minichillo, Antonella Mura, Sofia Asioli, Daniela Bartolini, Marina Gardiman, Marco Gessi, Claudio Ghimenton, Felice Giangaspero, Giovanni Lanza, Gianluca Marucci, Mariangela Novello, Enrico M. Silini, Elena Zunarelli, Alexandro Paccapelo, Alba A. Brandes
Sun Jul 26, 2020 20:01
Publication date: Available online 25 July 2020Source: European Journal of CancerAuthor(s): Nicolas Delanoy, Anne-Claire Hardy-Bessard, Eleni Efstathiou, Sylvestre Le Moulec, Umberto Basso, Alison Birtle, Alastair Thomson, Michael Krainer, Aline Guillot, Ugo De Giorgi, Ali Hasbini, Gedske Daugaard, Amit Bahl, Simon Chowdhury, Orazio Caffo, Philippe Beuzeboc, Dominique Spaeth, Jean-Christophe Eymard, Aude Fléchon, Jerome Alexandre
Sat Jul 25, 2020 18:49
Publication date: September 2020Source: European Journal of Cancer, Volume 137Author(s): Angela C. Hirbe, Vanessa Eulo, Chang I. Moon, Jingqin Luo, Stephanie Myles, Mahesh Seetharam, Jacqui Toeniskoetter, Tammy Kershner, Sasha Haarberg, Mark Agulnik, Varun Monga, Mohammad Milhem, Amanda Parkes, Steven Robinson, Scott Okuno, Steven Attia, Brian A. Van Tine
Fri Jul 24, 2020 16:43
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Roberto Iacovelli, Chiara Ciccarese, Emilio Bria, Sergio Bracarda, Camillo Porta, Giuseppe Procopio, Giampaolo Tortora
Fri Jul 24, 2020 16:43
Publication date: Available online 25 July 2020Source: European Journal of Surgical OncologyAuthor(s): Rachel H.S. Park, Grace R.S. Lim, Jania J.Y. Wu, Ye-Xin Koh, Jin-Yao Teo, Peng-Chung Cheow, Chung-Yip Chan, London L.P.J. Ooi, Alexander Y.F. Chung, Brian K.P. Goh
Sat Jul 25, 2020 17:45
Publication date: Available online 25 July 2020Source: European Journal of Surgical OncologyAuthor(s): Zhifang Zheng, Xiaojie Wang, Ying Huang, Xingrong Lu, Zhekun Huang, Pan Chi
Sat Jul 25, 2020 17:45
Publication date: Available online 25 July 2020Source: European Journal of Surgical OncologyAuthor(s): Byoung Hyuck Kim, Kyubo Kim, Jin-Young Jang, Wooil Kwon, Hongbeom Kim, Kyung-Hun Lee, Do-Youn Oh, Haeryoung Kim, Kyung Bun Lee, Eui Kyu Chie
Sat Jul 25, 2020 17:45
Publication date: Available online 25 July 2020Source: European Journal of Surgical OncologyAuthor(s): E.G.M. Steenhuis, I.J.H. Schoenaker, J.W.B. de Groot, H.B. Fiebrich, J.C. de Graaf, R.M. Brohet, J.D. van Dijk, H.L. van Westreenen, P.D. Siersema, W.H. de Vos tot Nederveen Cappel
Sat Jul 25, 2020 17:45
Publication date: Available online 24 July 2020Source: European Journal of Surgical OncologyAuthor(s): Ben Shofty, Oz Haim, Matias Costa, Alon Kashanian, Shai Shtrozberg, Zvi Ram, Rachel Grossman
Sat Jul 25, 2020 17:45
Publication date: Available online 24 July 2020Source: European Journal of Surgical OncologyAuthor(s): Chunlin Chen, Ziyu Fang, Qianqing Wang, Weili Li, Pengfei Li, Li Wang, Shan Kang, Bin Zhu, Zhong Lin, Xiaohong Wang, Lu Wang, Huijian Fan, Xiaonong Bin, Jinghe Lang, Ping Liu
Sat Jul 25, 2020 17:45
Publication date: Available online 24 July 2020Source: European Journal of Surgical OncologyAuthor(s): Melissa N.N. Arron, Elisabeth J. Lier, Johannes H.W. de Wilt, Martijn W.J. Stommel, Harry van Goor, Richard P.G. ten Broek
Sat Jul 25, 2020 17:45
Thu Jul 23, 2020 03:00
Thu Jul 23, 2020 03:00
On 13 March 2020, Israel’s government declared closure of all schools. Schools fully reopened on 17 May 2020. Ten days later, a major outbreak of coronavirus disease (COVID-19) occurred in a high school. The first case was registered on 26 May, the second on 27 May. They were not epidemiologically linked. Testing of the complete school community revealed 153 students (attack rate: 13.2%) and 25 staff members (attack rate: 16.6%) who were COVID-19 positive.
Thu Jul 23, 2020 03:00
Thu Jul 23, 2020 03:00
Introduction Viral hepatitis remains a significant threat to transfusion safety, although largely mitigated by donor screening. Aim Our objective was to estimate the past and present burden of transfusion transmission of all types of viral hepatitis (A to E) and to find undiagnosed infections with hepatitis C virus (HCV). Method We performed a retrospective cohort study using a database of the entire computerised transfusion experience of Sweden from 1968 to 2012 and linking...
Thu Jul 23, 2020 03:00
Future Oncology, Ahead of Print.
Thu Jul 23, 2020 14:39
Related Articles Pexidartinib: first approved systemic therapy for patients with tenosynovial giant cell tumor. Future Oncol. 2020 Jul 23;: Authors: Gelderblom H, de Sande MV Abstract Pexidartinib is an orally administered small molecule tyrosine kinase inhibitor. Phase III ENLIVEN study results provided clinical evidence for US FDA approval for treatment of adult patients with symptomatic tenosynovial giant cell tumor associated with severe...
Fri Jul 24, 2020 13:24
Abstract By growing research on the mechanisms and functions of microRNAs (miRNAs, miRs), the role of these non‐coding RNAs gained more attention in healthcare. Due to the remarkable regulatory role of miRNAs, any dysregulation in their expression causes cellular functional impairment. In recent years, it has become increasingly apparent that these small molecules contribute to development, cell differentiation, proliferation, apoptosis, and tumor growth. In many studies, the miR‐192 family has...
Fri Jul 24, 2020 17:59
ABSTRACT The human papillomavirus (HPV) vaccines may provide some level of cross‐protection against high‐risk HPV genotypes not directly targeted by the vaccines. We evaluated the long‐term health and economic impacts of routine HPV vaccination using either the nonavalent HPV vaccine or the bivalent HPV vaccine in the context of 48 Gavi‐eligible countries. We used a multi‐modeling approach to compare the bivalent with or without cross‐protection and the nonavalent HPV. The optimal, i.e., most cost‐effective,...
Fri Jul 24, 2020 19:41
Abstract Using GLOBOCAN estimates, we describe the estimated cancer incidence among adults aged 80 years or older at the regional and global level in 2018, reporting the number of new cancer cases, and the truncated age‐standardised incidence rates (per 100,000) for all cancer sites combined for this age group. We also presented the five most frequent cancers diagnosed by region and globally among females and males aged 65‐79 years old and 80 years or older. We, finally, estimated the number of...
Fri Jul 24, 2020 19:40
Fri Jul 24, 2020 19:40
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Mon Jul 20, 2020 10:00
Journal of Adolescent and Young Adult Oncology, Ahead of Print.
Mon Jul 20, 2020 10:00
Abstract Background To investigate the role of intensity-modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT) for the radiation treatment of thymoma cancer. Methods Twenty patients were retrospectively planned for IMPT [with (IMPT_R1 or IMPT_R2 according to the approach adopted) and without robust optimization]...
Sat Jul 25, 2020 16:35
Abstract Purpose To investigate the synergistic effect of glycolysis inhibition on therapy answer to tyrosine kinase inhibitors in renal carcinoma. Methods Primary cell cultures from 33 renal tumors including clear cell RCC (ccRCC), papillary RCC and the rare subtype chromophobe RCC as well as two metastases of ccRCC were obtained and...
Sat Jul 25, 2020 16:35
Abstract Purpose Bone metastasis is the result of complex crosstalk between tumor cells and bone marrow cells. Bone marrow adipocytes (BMAs) are the most abundant cell type in adult bone marrow. Therefore, we explore the effects of BMAs on bone metastasis in lung cancer. Methods RNA-seq was used to compare the mRNA expression level of...
Sat Jul 25, 2020 16:35
Abstract Purpose We herein present the results of the first Italian Association of Radiotherapy and Clinical Oncology (AIRO) survey regarding salvage external beam re-irradiation of local prostate cancer relapse named PROLAPSE. Methods A questionnaire with 12 items was administered to the 775 Italian radiation oncologist members of the...
Sat Jul 25, 2020 16:35
Abstract Purpose Pancreatic cancer is a lethal form of cancer that can be triggered by prolonged or acute inflammation of the pancreas. Inflammation have been shown to be regulated by a group of key protein molecules known as the inflammasomes. The NLRP3 inflammasome is the most studied inflammasome and have been strongly implicated to regulate cancer cell proliferation. Therefore, this study aimed to examine the regulation of...
Sat Jul 25, 2020 16:35
Abstract Purpose Pseudomyxoma peritonei (PMP) is a rare clinical malignancy syndrome characterized by the uncontrollable accumulation of copious mucinous ascites in the peritoneal cavity, resulting in “jelly belly”. The mechanism of tumor progression and mucin hypersecretion remains largely unknown, but GNAS mutation is a promising contributor. This review is to systemically summarize the biological background and variant features...
Sat Jul 25, 2020 16:35
Abstract Introduction Biliary tract cancers (BTC) are rare malignancies arising from biliary system. Systemic therapy is the cornerstone for stage IV disease, with poor overall survival (OS). Evidence is lacking about safety and efficacy of local ablative treatments, such as surgery and stereotactic body radiotherapy (SBRT) in the context of metastatic BTC (mBTC). ...
Sat Jul 25, 2020 16:35
Abstract Introduction Cholecystokinin type 2 receptor (CCK2R), which mediates the action of gastrin and cholecystokinin (CCK), has been demonstrated to promote the proliferation of colorectal cancer (CRC). A number of studies showed that CCK2R overexpressed in gastric cancer and pancreatic cancer but few in CRC. The correlation between CCK2R expression and clinicopathological characteristics is also not clear. ...
Sat Jul 25, 2020 16:35
Abstract Purpose Multiple lung lesions found in a single patient at the time of diagnosis often pose a diagnostic dilemma: are these lesions independent primary tumors (IPT) or the result of intrapulmonary metastases (IPM)? While traditional pathological methods sometimes have difficulty distinguishing IPM from IPT, modern molecular profiling based on next-generation sequencing techniques may provide a new strategy. ...
Sat Jul 25, 2020 16:35
Abstract Background Adjuvant chemotherapy could improve the prognosis of stage II–III non-small cell lung cancer (NSCLC). However, its influences on stage IB were controversial. The purpose of this study was to investigate whether patients with stage IB NSCLC could benefit from adjuvant chemotherapy. Methods Stage IB NSCLC in 2010–2015...
Sat Jul 25, 2020 16:35
Abstract Purpose We aimed to investigate the treatment effect of chemotherapy on ground-glass opacity (GGO)-featured lung adenocarcinoma radiologically and pathologically. Methods This retrospective study included patients who met the following criteria: (1) presence of lung GGO lesions before chemotherapy for other concurrent malignancies;...
Sat Jul 25, 2020 16:35
Abstract Purpose Cervical cancer metastasis results in poor prognosis and increased mortality, which is not separated from inflammatory reactions accumulated by prostaglandin E2 (PGE2). As a specific G-protein coupled PGE2 receptor, EP3 is demonstrated as a negative prognosticator of cervical malignancy. Now, we aimed to investigate the pathological mechanism of EP3 in modulating cervical cancer carcinogenesis. ...
Sat Jul 25, 2020 16:35
Abstract Objective This study aims to systematically review the application of artificial intelligence (AI) techniques in gastric cancer and to discuss the potential limitations and future directions of AI in gastric cancer. Methods A systematic review was performed that follows the Preferred Reporting Items for Systematic Reviews and...
Sat Jul 25, 2020 16:35
Abstract Purpose NSCLC is the most common type of lung cancers. The purpose of this study is to screen cancer-related mutations in early LUAD in China through NGS technology, determine their correlation with clinical characteristics and provide basis for treatment decisions. Methods In this study, we performed a 583 gene panel to detect...
Sat Jul 25, 2020 16:35
Abstract Purpose Lymphocyte activation gene-3 (LAG3) is an immunosuppressive checkpoint molecule expressed on T cells. The frequency and distribution of LAG3 expression in oesophageal adenocarcinoma (EAC) is unknown. Aim of the study was the evaluation and distribution of LAG3 on tumour infiltrating lymphocytes (TILs) and correlation with clinico-pathological and molecular data. ...
Sat Jul 25, 2020 16:35
Abstract With the development of antitumor therapies, different treatment methods including monotherapy and combined therapy have achieved clinical efficacy in advanced epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) patients. Exon 19 deletion (ex19del) and exon 21 L858R mutation are common sensitive subtypes of EGFR mutation. However, potential distinct mechanisms are found from several dimensions including molecular structures, biological...
Sat Jul 25, 2020 16:35
Cervical cancer is one of the most common cancers among females worldwide and advanced patients have extremely poor prognosis. However, adverse reactions and accumulating resistance to radiation therapy requir...
Sat Jul 25, 2020 03:00
Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles in carcinogenesis, as it has been document...
Sat Jul 25, 2020 03:00
The original version of this article unfortunately contained a mistake. All the authors first name and second name has been inadvertently interchanged. Now the authors name are corrected.
Sun Jul 26, 2020 03:00
Abstract Breast carcinoma with neuroendocrine differentiation, also known as neuroendocrine breast carcinoma (NEBC), includes a heterogeneous group of rare tumors, which account for 2–5% of all invasive breast carcinomas. Because of their low incidence, most of the current limited knowledge of these tumors derives from anecdotal case reports or small retrospective series. The diagnosis of NEBC is based on the presence of morphological features similar to gastrointestinal and...
Sat Jul 25, 2020 03:00
Abstract Oral therapies have highly modified cancer patient management and changed hospital practises. We introduce a specific Oral Therapy Centre and retrospectively review information prospectively recorded by co-ordination nurses (CNs) (the DICTO programme). We describe the roles played by CNs in the management of oral cancer therapies at Limoges Dupuytren Hospital between May 2015 and June 2018. All cancers, irrespective of stage or whether oral general chemotherapy or targeted...
Sat Jul 25, 2020 03:00
Abstract CREB signaling is known for several decades, but how it regulates both positive and negative regulators of cell proliferation is not well understood. On the other hand functions of major epigenetic repressors such as DNMT3B, EZH2 and CUL4B for their repressive epigenetic modifications on chromatin have also been well studied. However, there is very limited information available on how these repressors are regulated at their transcriptional level. Here, using computational...
Fri Jul 24, 2020 03:00
Abstract Background Few epidemiological studies of pediatric central nervous system (CNS) tumors have been performed using data from Southeast Asian national registries. Therefore, we aimed to examine data on CNS tumors from the first national childhood CNS tumor registry in Thailand. Methods Newly diagnosed children with benign and malignant primary...
Fri Jul 24, 2020 03:00
Publication date: Available online 23 July 2020Source: Practical Radiation OncologyAuthor(s): William G. Breen, Krishan R. Jethwa, Nathan Y. Yu, Grant M. Spears, William S. Harmsen, Robert C. Miller, Jonathan B. Ashman, William G. Rule, Terence T. Sio, Michelle A. Neben-Wittich, Michael G. Haddock, Amit Mahipal, Mark J. Truty, Christopher L. Hallemeier, Kenneth W. Merrell
Fri Jul 24, 2020 17:16
Fri Jul 24, 2020 15:58
Locally recurrent rectal cancer (LRRC) after surgery or external beam radiotherapy (EBRT) is a serious challenge for which no standard treatment is defined. In the present study, we investigated the feasibilit...
Sat Jul 25, 2020 03:00
Radiation therapy (RT) is an important component in the management of breast cancer. It is recommended that up to 80% of patients with breast cancer should receive RT as part of their treatment [1]. The standard of care for many years has been whole breast irradiation delivered with a long fractionated schedule over 5 to 6 weeks [2]. Hypofractionation (39-42.5 Gy in 13-16 fractions) has been shown in several randomised trials to be equally efficacious when compared with those treated with traditional...
Sat Jul 25, 2020 03:00
Radiation therapy (RT) is the cornerstone of treatment for nasopharyngeal cancer (NPC). Using contemporary intensity-modulated radiation therapy (IMRT), dose escalation with tumor ablative intent, while sparing surrounding normal organs, is feasible. Thus, significantly high local control and survival rate, as well as reduced chronic toxicities, can be achieved.[1–3] How to further enhance the quality of care and long-term outcome is an issue worth studying.
Sat Jul 25, 2020 03:00
Despite striking improvements in the diagnosis and care of human cancer, treatment resistance remains to this day an issue in some hard-to-treat cancers. Chondrosarcomas (CSs) constitute the second most common primary bone tumor in adults [1]. Because these cartilaginous tumors exhibit resistance to chemotherapy and conventional radiation therapy, complete surgical resection still remains the primary treatment, with a 10-year survival rate comprised between 30% and 80% depending on the grade. A significant...
Fri Jul 24, 2020 03:00
Prostate cancer is the most common non-cutaneous malignancy in North American and European men [1–3]. For those who undergo curative-intent treatment, preferred options for localized prostate cancer include radical prostatectomy, external beam radiotherapy (EBRT) and brachytherapy [4] either alone or in combination with EBRT. Guidelines from the American Society of Clinical Oncology and Cancer Care Ontario recommend that brachytherapy be considered for the treatment of all appropriate prostate cancer...
Fri Jul 24, 2020 03:00
Thoracic re-irradiation for primary or metastatic intrathoracic lesions remains a challenge regarding the balance of a locally effective treatment and acceptable treatment related toxicities. Patients with primary lung tumors have a high risk of locoregional recurrence, a second primary lung cancer or thoracic metastases [1–3]. Besides patients with primary lung cancer, also patients with other primary tumors might require repeated treatment for intrathoracic metastases [4–7].
Fri Jul 24, 2020 03:00
Tumors of the head and neck region (HNSCC) are the sixth most common cancer worldwide with nearly 600.000 new cases every year [1]. HNSCC can be subdivided in two main etiologies with one being mostly driven by noxa (HPV neg.) and the other by infection with human Papillomavirus of high-risk genotypes (HPV pos.). While the incidence for HPV neg. appears to decline, a constant increase is observed for HPV pos. tumors [2].
Fri Jul 24, 2020 03:00
Recent rising use of immune checkpoint inhibitors (ICIs) in metastatic and recurrent cancers leverages their systemic activity to eradicate disseminated malignancies. For example, the current National Comprehensive Cancer Network (NCCN) guidelines (version 1.2019) for newly diagnosed metastatic melanoma to the brain recommend four treatment options: ipilimumab with nivolumab, nivolumab alone, pembrolizumab, or BRAF/MEK inhibitors.[1] Similarly, radiation therapy (RT) may be used for palliation or...
Fri Jul 24, 2020 03:00
Publication date: Available online 25 July 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Susana Pérez-Echagüen, Camilo José Sanz-Freire, José Luis Guinot-Rodríguez, Cristina Gutiérrez-Miguélez, Pilar Samper-Ots, Víctor González-Pérez, Elena Villafranca-Iturre, Ignasi Modolell, Santiago Pellejero-Pellejero, Mauricio Cambeiro-Vázquez, Gustavo Ossola-Lentati
Sun Jul 26, 2020 14:13
Neoadjuvant chemotherapy for gastric cancer. Has the time to decelerate the enthusiasm passed us by?
Publication date: Available online 25 July 2020Source: Seminars in OncologyAuthor(s): Stefano Rausei, Christina D. Bali, Georgios D. Lianos
Sun Jul 26, 2020 14:24
Abstract Purpose Based on the risk of locoregional recurrence (LRR), postmastectomy radiotherapy (PMRT) is recommended in T1-T2pN1 breast carcinoma (BC). We aimed to elucidate our institutional strategies underlying selection of these patients for PMRT. In the no-PMRT subset, we compared various lymph node (LN) staging systems’ abilities to predict 5‑year overall and locoregional-free survival (OS/LRFS). ...
Fri Jul 24, 2020 03:00
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