Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17493-xAt Li-garnet interface, the poor interfacial wettability due to Li2CO3 passivation causes large resistance and unstable contact. Here the authors propose a Li2CO3-affiliative mechanism for air-accessible interface engineering of garnet electrolyte with superior wettability via facile liquid metal painting.
Fri Jul 24, 2020 03:00
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17530-9Current light-inducible Cre-loxP systems have minimal capacity for deep tissue penetration. Here, the authors present a far-red light-induced split Cre-loxP system for in vivo genome engineering.
Fri Jul 24, 2020 03:00
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17307-0Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.
Fri Jul 24, 2020 03:00
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17443-7During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is relieved by binding of RPA to the lagging-strand template.
Fri Jul 24, 2020 03:00
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17495-9SARS-CoV-2 expresses a 2′-O RNA methyltransferase (MTase) that is involved in the viral RNA cap formation and therefore a target for antiviral therapy. Here the authors provide the structure of nsp10-nsp16 with the panMTase inhibitor sinefungin and report that the development of MTase inhibitor therapies that target multiple coronoaviruses is feasible.
Fri Jul 24, 2020 03:00
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17486-wIt is unclear how the T-tubule structure of skeletal muscle, which regulates coordinated muscle contraction, forms. Here, the authors develop a four-dimensional quantitative model for T-tubule formation in zebrafish, based on live imaging, proposing a dynamic endocytic capture model.
Fri Jul 24, 2020 03:00
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17519-4Implementations of quantum walks on ion trap quantum computers have been so far limited to the analogue simulation approach. Here, the authors implement a quantum-circuit-based discrete quantum walk in one-dimensional position space, realizing a Dirac cellular automaton with tunable mass parameter.
Fri Jul 24, 2020 03:00
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17498-6Wild teas are considered as valuable resource for studying domestication and breeding. Here, Zhang et al. report genome of wild tea DASZ and transcriptome of 217 accessions, which clarify pedigree of Chinese tea cultivars and show tea may not have undergone long-term artificial directional selection on flavor-related metabolites.
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