IJMS, Vol. 21, Pages 5262: Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery International Journal of Molecular Sciences doi: 10.3390/ijms21155262 Authors: Qingxin Li CongBao Kang Small-molecule drugs are organic compounds affecting molecular pathways by targeting important proteins. These compounds have a low molecular weight, making them penetrate cells easily. Small-molecule drugs can be developed from leads derived from rational drug design...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5261: A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21155261 Authors: Ahmed M. Darwesh Wesam Bassiouni Adeniyi Michael Adebesin Abdul Sattar Mohammad John R. Falck John M. Seubert While survival rates have markedly improved following cardiac ischemia-reperfusion (IR) injury, the resulting heart...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5258: The Long-Lasting Protective Effect of HGF in Cardiomyoblasts Exposed to Doxorubicin Requires a Positive Feed-Forward Loop Mediated by Erk1,2-Timp1-Stat3 International Journal of Molecular Sciences doi: 10.3390/ijms21155258 Authors: Simona Gallo Martina Spilinga Elena Casanova Alessandro Bonzano Carla Boccaccio Paolo Maria Comoglio Tiziana Crepaldi Previous studies showed that the hepatocyte growth factor (HGF)–Met receptor axis plays...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5259: Tethering Innate Surface Receptors on Dendritic Cells: A New Avenue for Immune Tolerance Induction? International Journal of Molecular Sciences doi: 10.3390/ijms21155259 Authors: Lucille Lamendour Nora Deluce-Kakwata-Nkor Caroline Mouline Valérie Gouilleux-Gruart Florence Velge-Roussel Dendritic cells (DCs) play a key role in immunity and are highly potent at presenting antigens and orienting the immune response. Depending on the environmental signals,...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5257: Exploring IDP–Ligand Interactions: tau K18 as A Test Case International Journal of Molecular Sciences doi: 10.3390/ijms21155257 Authors: Darius Vagrys James Davidson Ijen Chen Roderick E. Hubbard Ben Davis Over the past decade intrinsically disordered proteins (IDPs) have emerged as a biologically important class of proteins, many of which are of therapeutic relevance. Here, we investigated the interactions between a model IDP system, tau K18, and...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5260: Adaptive Traits to Improve Durum Wheat Yield in Drought and Crown Rot Environments International Journal of Molecular Sciences doi: 10.3390/ijms21155260 Authors: Samir Alahmad Yichen Kang Eric Dinglasan Elisabetta Mazzucotelli Kai P. Voss-Fels Jason A. Able Jack Christopher Filippo M. Bassi Lee T. Hickey Durum wheat (Triticum turgidum L. ssp. durum) production can experience significant yield losses due to crown rot (CR) disease. Losses...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5255: Distant Metastasis in Colorectal Cancer Patients—Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review International Journal of Molecular Sciences doi: 10.3390/ijms21155255 Authors: Stanislav Filip Veronika Vymetalkova Jiri Petera Ludmila Vodickova Ondrej Kubecek Stanislav John Filip Cecka Marketa Krupova Monika Manethova Klara Cervena Pavel Vodicka Colorectal cancer (CRC) remains a serious...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5256: Atherosclerotic Pre-Conditioning Affects the Paracrine Role of Circulating Angiogenic Cells Ex-Vivo International Journal of Molecular Sciences doi: 10.3390/ijms21155256 Authors: Sara Eslava-Alcon Mª Jesús Extremera-García Ismael Sanchez-Gomar Lucía Beltrán-Camacho Antonio Rosal-Vela Javier Muñoz Nuria Ibarz Jose Angel Alonso-Piñero Marta Rojas-Torres Margarita Jiménez-Palomares Almudena González-Rovira Rosario Conejero Esther...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5254: Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis International Journal of Molecular Sciences doi: 10.3390/ijms21155254 Authors: Hiroki Nishikawa Hirayuki Enomoto Shuhei Nishiguchi Hiroko Iijima Sarcopenia in patients with liver cirrhosis (LC) has been attracting much attention these days because of the close linkage to adverse outcomes. LC can be related to secondary sarcopenia due to protein metabolic disorders and energy metabolic disorders....
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5253: Identification of Long-Distance Transmissible mRNA between Scion and Rootstock in Cucurbit Seedling Heterografts International Journal of Molecular Sciences doi: 10.3390/ijms21155253 Authors: Liu Xiang Li Wang Lu Liu Gao Zhang : Grafting has been widely used to improve plant growth and tolerance in crop production, as well as for clarifying systemic mRNA signaling from donor to recipient tissues in organ-to-organ communication....
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5251: Signaling Modulations of miR-206-3p in Tooth Morphogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21155251 Authors: Sanjiv Neupane Yam Prasad Aryal Tae-Young Kim Chang-Yeol Yeon Chang-Hyeon An Ji-Youn Kim Hitoshi Yamamoto Youngkyun Lee Wern-Joo Sohn Jae-Young Kim MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that post-transcriptionally regulate gene expression in organisms. Most...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5252: The Role of the Bacterial Muramyl Dipeptide in the Regulation of GLP-1 and Glycemia International Journal of Molecular Sciences doi: 10.3390/ijms21155252 Authors: Laura Williams Amal Alshehri Bianca Robichaud Alison Cudmore Jeffrey Gagnon The host’s intestinal microbiota contributes to endocrine and metabolic responses, but a dysbiosis in this environment can lead to obesity and insulin resistance. Recent work has demonstrated a role for...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5249: Bovine Organospecific Microvascular Endothelial Cell Lines as New and Relevant In Vitro Models to Study Viral Infections International Journal of Molecular Sciences doi: 10.3390/ijms21155249 Authors: Anne-Claire Lagrée Fabienne Fasani Clotilde Rouxel Marine Pivet Marie Pourcelot Aurore Fablet Aurore Romey Grégory Caignard Damien Vitour Sandra Blaise-Boisseau Claudine Kieda Henri-Jean Boulouis Nadia Haddad Catherine Grillon ...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5247: Phylogenomic proof of Recurrent Demipolyploidization and Evolutionary Stalling of the “Triploid Bridge” in Arundo (Poaceae) International Journal of Molecular Sciences doi: 10.3390/ijms21155247 Authors: Wuhe Jike Mingai Li Nicola Zadra Enrico Barbaro Gaurav Sablok Giorgio Bertorelle Omar Rota-Stabelli Claudio Varotto Polyploidization is a frequent phenomenon in plants, which entails the increase from one generation to the next by multiples...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5250: Modulating the Crosstalk between the Tumor and Its Microenvironment Using RNA Interference: A Treatment Strategy for Hepatocellular Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21155250 Authors: Mariam Mroweh Thomas Decaens Patrice N Marche Zuzana Macek Jilkova Flora Clément Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with one of the highest mortality rates among solid cancers. It develops...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5248: Drug Discovery Targeting the Disorder-To-Order Transition Regions through the Conformational Diversity Mimicking and Statistical Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21155248 Authors: Insung Na Sungwoo Choi Seung Han Son Vladimir N. Uversky Chul Geun Kim Intrinsically disordered proteins exist as highly dynamic conformational ensembles of diverse forms. However, the majority of virtual screening only focuses on proteins...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5246: Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View International Journal of Molecular Sciences doi: 10.3390/ijms21155246 Authors: Wenwen Lan Sumin Liu Long Zhao Ying Su The Drosophila hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for Drosophila larval hematopoiesis,...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5245: β-Carbolines in Experiments on Laboratory Animals International Journal of Molecular Sciences doi: 10.3390/ijms21155245 Authors: Renata Zawirska-Wojtasiak Agnieszka Fedoruk-Wyszomirska Paulina Piechowska Sylwia Mildner-Szkudlarz Joanna Bajerska Elżbieta Wojtowicz Krzysztof Przygoński Dorota Gurda Wiktoria Kubicka Eliza Wyszko Some studies have ascribed a protective effect against neurodegenerative diseases to the β-carbolines...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5244: Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155244 Authors: Betina Schmidt Christian Ferreira Carlos Luan Alves Passos Jerson Lima Silva Eliane Fialho Breast cancer is the leading cause of cancer mortality in women worldwide. Conventional cancer treatment is costly and results in many side effects. Dietary bioactive compounds may be a potential...
Fri Jul 24, 2020 03:00
JCM, Vol. 9, Pages 2387: Combined Surgical and Orthodontic Treatments in Children with OSA: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9082387 Authors: Laura Templier Cecilia Rossi Manuel Miguez Javier De la Cruz Pérez Adrián Curto Alberto Albaladejo Manuel Lagravère Vich Obstructive sleep apnea (OSA) is a sleeping breathing disorder. In children, adenotonsillar hypertrophy remains the main anatomical risk factor of OSA. The aim of this study was...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2385: Renal Survival in Children with Glomerulonephritis with Crescents: A Pediatric Nephrology Research Consortium Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9082385 Authors: Joseph G. Maliakkal M. John Hicks Mini Michael David T. Selewski Katherine Twombley Michelle N. Rheault Meredith Seamon Jason M. Misurac Cheryl L. Tran Loretta Reyes Joseph T. Flynn Ali M. Onder Alexandru R. Constantinescu Vaishali Singh Cynthia...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2386: Is Basal Cell Carcinoma an Itchy Tumor? Clinical Characteristics of Itch in Basal Cell Carcinoma Journal of Clinical Medicine doi: 10.3390/jcm9082386 Authors: Iwona Chlebicka Aleksandra A Stefaniak Łukasz Matusiak Jacek C Szepietowski In common knowledge, basal cell carcinoma (BCC) is known to be asymptomatic, but in clinical practice, at least some patients complain of itching. The present study group comprised of 180 patients with histologically confirmed...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2381: Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease Journal of Clinical Medicine doi: 10.3390/jcm9082381 Authors: Chisato Saeki Tomoya Kanai Masanori Nakano Tsunekazu Oikawa Yuichi Torisu Masahiro Abo Masayuki Saruta Akihito Tsubota Osteosarcopenia and frailty have a negative health impact on an aging society. This cross-sectional study aimed to investigate the clinical characteristics and relationship...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2382: Volume of Lateral Geniculate Nucleus in Patients with Glaucoma in 7Tesla MRI Journal of Clinical Medicine doi: 10.3390/jcm9082382 Authors: Ewa Kosior-Jarecka Anna Pankowska Piotr Polit Andrzej Stępniewski Mark Roger Symms Paulina Kozioł Tomasz Żarnowski Radosław Pietura The aim of the study was to assess the volume of the lateral geniculate nucleus (LGN) in patients with open-angle glaucoma in 7Tesla MRI and to evaluate its relation to RNFL...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2383: Effectiveness, Timing and Procedural Aspects of Cognitive Behavioral Therapy after Deep Brain Stimulation for Therapy-Resistant Obsessive Compulsive Disorder: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9082383 Authors: Meltem Görmezoğlu Tim Bouwens van der Vlis Koen Schruers Linda Ackermans Mircea Polosan Albert F.G. Leentjens Background and aim: Deep brain stimulation (DBS) is an effective treatment for patients with severe...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2384: Skin Phototype Could Be a Risk Factor for Multiple Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm9082384 Authors: Patricia Urbaneja Isaac Hurtado-Guerrero Miguel Ángel Hernández Begoña Oliver-Martos Celia Oreja-Guevara Jesús Ortega-Pinazo Ana Alonso Francisco J Barón-López Laura Leyva Óscar Fernández María Jesús Pinto-Medel Environmental and genetic factors are assumed to be necessary for the development of multiple sclerosis...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2380: Exosome: A New Player in Translational Nanomedicine Journal of Clinical Medicine doi: 10.3390/jcm9082380 Authors: Aheget Tristán-Manzano Mazini Cortijo-Gutierrez Galindo-Moreno Herrera Martin Marchal Benabdellah Summary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2379: Retrospective Analysis of the Clinical Outcome in a Matched Case-Control Cohort of Polytrauma Patients Following an Osteosynthetic Flail Chest Stabilization Journal of Clinical Medicine doi: 10.3390/jcm9082379 Authors: Niemann Graef Tsitsilonis Stöckle Märdian Background: In polytrauma (PT) patients, osseous thoracic injuries are commonly observed. One of the most severe injuries is the flail chest where the rib cage is broken in such a way that...
Sun Jul 26, 2020 03:00
JCM, Vol. 9, Pages 2378: SMAD4 Overexpression in Patients with Sleep Apnoea May Be Associated with Cardiometabolic Comorbidities Journal of Clinical Medicine doi: 10.3390/jcm9082378 Authors: Elena Díaz-García Ana Jaureguizar Raquel Casitas Sara García-Tovar Begoña Sánchez-Sánchez Ester Zamarrón Eduardo López-Collazo Francisco García-Río Carolina Cubillos-Zapata Obstructive sleep apnoea (OSA) is associated with several diseases related to metabolic and cardiovascular...
Sat Jul 25, 2020 03:00
JCM, Vol. 9, Pages 2377: Enhance PARPi Application beyond BRCA-Mutant Breast Cancer (BC): Facts Are Facts Journal of Clinical Medicine doi: 10.3390/jcm9082377 Authors: Tania Di Raimo Francesco Angelini Breast cancer (BC) represents one of the three most common neoplasia and the principal worldwide leading cause of death among women [...]
Sat Jul 25, 2020 03:00
JCM, Vol. 9, Pages 2376: Temporal Trends and Risk Factors for Delayed Hospital Admission in Suspected Stroke Patients Journal of Clinical Medicine doi: 10.3390/jcm9082376 Authors: Moritz Kielkopf Thomas Meinel Johannes Kaesmacher Urs Fischer Marcel Arnold Mirjam Heldner David Seiffge Pasquale Mordasini Tomas Dobrocky Eike Piechowiak Jan Gralla Simon Jung (1) Background: The benefit of acute ischemic stroke (AIS) treatment declines with any time delay...
Sat Jul 25, 2020 03:00
JCM, Vol. 9, Pages 2375: Mentally Sick or Not—(Bio)Markers of Psychiatric Disorders Needed Journal of Clinical Medicine doi: 10.3390/jcm9082375 Authors: Napoleon Waszkiewicz Psychiatric disorders, also called mental illnesses or mental disorders, constitute a wide group of disorders including major depression disorder (MDD), bipolar disorder (BD), schizophrenia (SCZ) and other psychoses, anxiety disorders (ANX), substance-related disorders (SRD), dementia, developmental disorders e [...]
Sat Jul 25, 2020 03:00
JCM, Vol. 9, Pages 2374: Influences of Sex, Education, and Country of Birth on Clinical Presentations and Overall Outcomes of Interdisciplinary Pain Rehabilitation in Chronic Pain Patients: A Cohort Study from the Swedish Quality Registry for Pain Rehabilitation (SQRP) Journal of Clinical Medicine doi: 10.3390/jcm9082374 Authors: Gerdle Boersma Åsenlöf Stålnacke Larsson Ringqvist This study investigates the effects of sex, education, and country of birth on clinical...
Sat Jul 25, 2020 03:00
JCM, Vol. 9, Pages 2373: From Basic Science to Clinical Research to Develop New Solutions to Improve Diagnoses and Treatment of Bladder Cancer Patients Journal of Clinical Medicine doi: 10.3390/jcm9082373 Authors: Marco Moschini Bladder cancer (BCa) is the tenth most common form of cancer worldwide, with 549,000 new cases and 200,000 deaths estimated in 2018 [...]
Sat Jul 25, 2020 03:00
JCM, Vol. 9, Pages 2372: Imaging Bacteria with Radiolabelled Probes: Is It Feasible? Journal of Clinical Medicine doi: 10.3390/jcm9082372 Authors: Alberto Signore Vera Artiko Martina Conserva Guillermina Ferro-Flores Mick M. Welling Sanjay K. Jain Søren Hess Mike Sathekge Bacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be difficult and delayed as well as the identification of the etiological pathogen, necessary...
Sat Jul 25, 2020 03:00
JCM, Vol. 9, Pages 2371: The Combined Effect of Low-dose Atropine with Orthokeratology in Pediatric Myopia Control: Review of the Current Treatment Status for Myopia Journal of Clinical Medicine doi: 10.3390/jcm9082371 Authors: José-María Sánchez-González Concepción De-Hita-Cantalejo María-José Baustita-Llamas María Carmen Sánchez-González Raúl Capote-Puente Pediatric myopia has become a major international public health concern. The prevalence of myopia has undergone a significant...
Fri Jul 24, 2020 03:00
JCM, Vol. 9, Pages 2369: Head-to-Head Accuracy Comparison of Three Commercial COVID-19 IgM/IgG Serology Rapid Tests Journal of Clinical Medicine doi: 10.3390/jcm9082369 Authors: Andrey Cohen Meyer Torriani Yerly Mazza Calame Arm-Vernez Guessous Stringhini Roux-Lombard Fontao Agoritsas Stirnemann Reny Siegrist Eckerle Kaiser Vuilleumier Background: Comparative data of SARS-CoV-2 IgM/IgG serology rapid diagnostic...
Fri Jul 24, 2020 03:00
JCM, Vol. 9, Pages 2370: Attributable Mortality of Hip Fracture in Older Patients: A Retrospective Observational Study Journal of Clinical Medicine doi: 10.3390/jcm9082370 Authors: Lorène Zerah David Hajage Mathieu Raux Judith Cohen-Bittan Anthony Mézière Frédéric Khiami Yannick Le Manach Bruno Riou Jacques Boddaert Hip fracture (HF) in older patients is associated with a high six-month mortality rate. Several clinical conditions may affect outcome, including...
Fri Jul 24, 2020 03:00
JCM, Vol. 9, Pages 2365: Influence of Implant Connection, Abutment Design and Screw Insertion Torque on Implant-Abutment Misfit Journal of Clinical Medicine doi: 10.3390/jcm9082365 Authors: Jorge Vélez Jesús Peláez Carlos López-Suárez Rubén Agustín-Panadero Celia Tobar María J. Suárez Background: An accurate fit at the implant-abutment interface is an important factor to avoid biological and mechanical complications. The aim of this study was to evaluate the marginal misfit...
Fri Jul 24, 2020 03:00
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