The clinical outcomes of medical therapies in chronic rhinosinusitis is independent of microbiomic outcomes: a double-blinded, randomised placebo-controlled trial. Rhinology. 2020 Jul 21;: Authors: Cherian LM, Bassiouni A, Cooksley CM, Vreugde S, Wormald PJ, Psaltis AJ Abstract BACKGROUND: Oral and topical corticosteroids, and antibiotics form the mainstay medical treatment of chronic rhinosinusitis (CRS). Clinical outcomes vary depending on...
Leukotriene receptor antagonist addition to intranasal steroid: systematic review and meta-analysis.
Leukotriene receptor antagonist addition to intranasal steroid: systematic review and meta-analysis. Rhinology. 2020 Jul 21;: Authors: Seresirikachorn K, Mullol J, Limitlaohaphan K, Asvapoositkul V, Snidvongs K Abstract BACKGROUND: Intranasal corticosteroids (INCS) and leukotriene receptor antagonist (LTRA) have different mechanisms of action. The combination of INCS and LTRA (INCS+LTRA) are utilized to control the allergic rhinitis (AR) symptoms....
Endotypes of chronic rhinosinusitis with nasal polyps with and without NSAID - intolerance. Rhinology. 2020 Jul 21;: Authors: Steiner UC, Bischoff S, Valaperti A, Ikenberg K, Starzyk J, Bucher S, Bachmann LM, Soyka MB Abstract BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2-dominated inflammatory disease of the upper air- ways. A subgroup of patients with CRSwNP suffer from intolerance to nonsteroidal anti-inflammatory...
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An Invited Commentary on "The efficacy and safety of low dialysate sodium levels for patients with maintenance hemodialysis: a systematic review and metanalysis" (Int J Surg 2020; Epub ahead of Print). Int J Surg. 2020 Jul 18;: Authors: Ain QU, Majeed N PMID: 32693154 [PubMed - as supplied by publisher]
An Invited Commentary on "Four interventions for pediatric femoral shaft fractures: network meta-analysis of randomized trials" (Int J Surg 2020; Epub ahead of Print). Int J Surg. 2020 Jul 18;: Authors: Wang L, Cheng F PMID: 32693153 [PubMed - as supplied by publisher]
Invited commentary on original article: Comparison of three different bone graft methods for single segment lumbar tuberculosis: A retrospective single-center cohort study. Int J Surg. 2020 Jul 18;: Authors: Ain QU, Majeed N PMID: 32693152 [PubMed - as supplied by publisher]
Surgical activity during the Covid-19 pandemic: results for 112 patients in a French tertiary care center, a quality improvement study. Int J Surg. 2020 Jul 18;: Authors: Philouze P, Cortet M, Quatrone D, Céruse P, Aubrun F, Dubernard G, Mabrut JY, Delignette MC, Mohkam K Abstract BACKGROUND: After the emergence of Covid-19 in China, Hubei Province, the epidemic quickly spread to Europe. France was quickly hit and our institution was one...
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25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/07/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Background. Pediatric patients show an impressive capacity of cardiac regeneration. In contrast, severely deteriorated adult hearts do usually not recover. Since cardiac remodeling—involving the expression of fetal genes—is regarded as an adaptation to stress, we compared hearts of adult patients suffering from dilated cardiomyopathy (DCM) with remodeling of cultured neonatal (NRC) as well as adult (ARC) rat cardiomyocytes and the developing postnatal myocardium. Methods. NRC and ARC were stimulated...
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Related Articles Nuclei detection in hepatocellular carcinoma and dysplastic liver nodules in histopathology images using bootstrap regression. Histol Histopathol. 2020 Jul 21;:18240 Authors: Kalinathan L, Kathavarayan RS, Kanmani M, Dinakaran N Abstract Hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm of the liver representing the fifth most common malignancy worldwide. This tumor is more common in men than women,...
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Related Articles Glioblastoma treatment guidelines: Consensus by the Spanish Society of Neurosurgery Tumor Section. Neurocirugia (Astur). 2020 Jul 17;: Authors: Tejada Solís S, Plans Ahicart G, Iglesias Lozano I, de Quintana Schmidt C, Fernández Coello A, Hostalot Panisello C, Ley Urzaiz L, García Romero JC, Díez Valle R, González Sánchez J, Duque S Abstract INTRODUCTION: Glioblastoma (GBM) treatment starts in most patients with surgery, either...
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High-Dose Prednisone for Treatment of Autoimmune Pancreatitis in a Patient with Coronavirus Disease 2019 (COVID-19) due to Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Am J Case Rep. 2020 Jul 21;21:e926475 Authors: Liaquat H, Shupp B, Kapoor S, Matin A Abstract BACKGROUND Autoimmune pancreatitis (AIP) is a rare, steroid-responsive disease of the pancreas. Concurrent treatment with immunosuppressants, including...
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Related Articles Radiation Dose Assessment to Family Members Taking Care of Non-Cancerous Thyroid Patients Treated with I-131 Therapy in Nuclear Medicine Department. Radiat Prot Dosimetry. 2020 Jul 21;: Authors: Kadhim AA, Sheikhzadeh P, Farzanefar S, Yavari S, Ay MR Abstract This study aimed to determine the effective doses of caregivers taking care of non-cancerous patients treated with iodine-131 (I-131). Patients (administered 185-1110 MBq...
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In order to change antibiotic prescribing behaviour, we need to understand the prescribing process. The aim of this study was to identify targets for antibiotic stewardship interventions in hospitals through a...
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Recombinant vs plasma-derived von Willebrand factor to prevent postpartum hemorrhage in von Willebrand disease. Blood Adv. 2020 Jul 28;4(14):3234-3238 Authors: Machin N, Ragni MV Abstract von Willebrand disease (VWD) is a congenital bleeding disorder characterized by deficient or defective von Willebrand factor (VWF). Among women with VWD, postpartum hemorrhage (PPH) is common. Treatment options at delivery include plasma-derived VWF (pdVWF)...
Comparison of Access to Novel Drugs for Lymphoma and Chronic Lymphocytic Leukemia Between India and the United States. JCO Glob Oncol. 2020 Jul;6:1124-1133 Authors: Sathyanarayanan V, Flowers CR, Iyer SP Abstract This review will compare and contrast the costs and access to novel drugs for treating chronic lymphocytic leukemia (CLL) and lymphoma in the United States and India during the last 5 years. Clinical outcomes for patients with hematologic...
Outcomes and Costs for Women After Breast Cancer: Preparing for Improved Survivorship of Medicare Beneficiaries. JCO Oncol Pract. 2020 Jul 21;:OP2000155 Authors: Yashkin AP, Greenup RA, Gorbunova G, Akushevich I, Oeffinger KC, Hwang ES Abstract PURPOSE: Increasing health care costs, longer life expectancy, improved breast cancer (BC) survival, and higher levels of complex comorbidities have important implications for future Medicare expenditures....
Related Articles Sickle cell disease perceptions of caregivers, adolescent, and adult patients: Barriers and facilitators to medical care adherence. J Adv Nurs. 2020 Jul 21;: Authors: Hoegy D, Guilloux R, Bleyzac N, Gauthier-Vasserot A, Cannas G, Bertrand Y, Hot A, Dussart C, Janoly-Dumenil A Abstract AIMS: To provide an understanding of medical care adherence factors as reported by caregivers, adolescent, and adult patients with sickle cell...
Related Articles A comprehensive review of economic evaluations of therapeutic drug monitoring interventions for cancer treatments. Br J Clin Pharmacol. 2020 Jul 21;: Authors: Vithanachchi DT, Maujean A, Downes MJ, Scuffham P Abstract Therapeutic drug monitoring (TDM) of cancer drugs has been shown to improve treatment effectiveness and safety. The aim of this paper was to comprehensively review economic evaluations of TDM interventions for...
Related Articles Tivozanib, a highly potent and selective inhibitor of VEGF receptor tyrosine kinases, for the treatment of metastatic renal cell carcinoma. Future Oncol. 2020 Jul 21;: Authors: Jacob A, Shook J, Hutson TE Abstract The VHL mutation-HIF upregulation-VEGF transcription sequence is the principal pathway in the development of renal cell carcinoma. Tyrosine kinase inhibitors target the VEGF receptors to inhibit further growth of renal...
Related Articles Patient preferences for locoregional therapy in early-stage breast cancer. Breast Cancer Res Treat. 2020 Jul 20;: Authors: Minami CA, King TA, Mittendorf EA Abstract PURPOSE: With an increasing emphasis on patient-centered care, clinicians in subspecialties such as breast surgery and radiation oncology that offer multiple therapeutic options with equivalent outcomes are under increasing pressure to aid patients with the decision-making...
Related Articles Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model. J Immunother Cancer. 2020 Jul;8(2): Authors: Lau SP, van Montfoort N, Kinderman P, Lukkes M, Klaase L, van Nimwegen M, van Gulijk M, Dumas J, Mustafa DAM, Lievense SLA, Groeneveldt C, Stadhouders R, Li Y, Stubbs A, Marijt KA, Vroman H, van der Burg SH, Aerts J, van Hall T, Dammeijer F, van Eijck...
Related Articles Media coverage of calls to rename low-risk cancers: a content analysis. BMJ Open. 2020 Jul 19;10(7):e038087 Authors: Nickel B, Moynihan R, Barratt A, Brito JP, McCaffery K Abstract OBJECTIVES: The use of more medicalised labels can increase both concern about illness and the desire for more invasive treatment. This study analyses the media's coverage of an Analysis article in The BMJ which generated a large amount of high-profile...
Related Articles Epidemiological realities of alcoholic liver disease: Global burden, research trends, and therapeutic promise. Gene Expr. 2020 Jul 20;: Authors: Xiao J, Wang F, Wong NK, Lv Y, Liu Y, Zhong J, Chen S, Li W, Koike K, Liu X, Wang H Abstract Globally, alcohol consumption contributes to more than 3 million deaths each year. While much of its ramifications is preventable, a coherent public health discourse on how to limit alcohol-related...
Related Articles Fertility-sparing treatment in early endometrial cancer: current state and future strategies. Obstet Gynecol Sci. 2020 Jul;63(4):417-431 Authors: Obermair A, Baxter E, Brennan DJ, McAlpine JN, Muellerer JJ, Amant F, van Gent MDJM, Coleman RL, Westin SN, Yates MS, Krakstad C, Janda M Abstract Endometrial cancer (EC) is the fifth most common cancer in women worldwide. Global estimates show rising incidence rates in both developed...
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Quantifying Vocal Power: Correlation of Whole-Body Anaerobic Power to Vocal Function Measures. J Speech Lang Hear Res. 2020 Jul 17;:1-12 Authors: Snell EN, Plexico LW, Weaver AJ, Sandage MJ Abstract Purpose The purpose of this preliminary study was to identify a vocal task that could be used as a clinical indicator of the vocal aptitude or vocal fitness required for vocally demanding occupations in a manner similar to that of the anaerobic...
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Related Articles Synthesis of a Unique Psammaplysin F Library and Functional Evaluation in Prostate Cancer Cells by Multiparametric Quantitative Single Cell Imaging. J Nat Prod. 2020 Jul 21;: Authors: Kumar R, Bidgood CL, Levrier C, Gunter JH, Nelson CC, Sadowski MC, Davis RA Abstract The spirooxepinisoxazoline alkaloid psammaplysin F (1) was selected as a scaffold for the generation of a unique screening library for both drug discovery...
Related Articles Long noncoding RNA NNT-AS1 functions as an oncogene in breast cancer via repressing ZFP36 expression. J Biol Regul Homeost Agents. 2020 May-Jun;34(3):795-805 Authors: Pan QH, Fan YH, Wang YZ, Li DM, Hu CE, Li RX Abstract Breast cancer is one of the most common cancers in women. This study focuses on the effects of Long non-coding RNAs (lncRNAs) NNT-AS1 on breast cancer cell growth and metastasis. Fifty-six pairs of breast...
Related Articles Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment. J Cell Physiol. 2020 Jul 20;: Authors: Zhang J, Si J, Gan L, Zhou R, Guo M, Zhang H Abstract Radiotherapy is one of the major modalities for malignancy treatment. High linear energy transfer (LET) charged-particle beams, like proton and carbon ions, exhibit favourable depth-dose distributions...
Related Articles Gint4.T-Modified DNA Tetrahedrons Loaded with Doxorubicin Inhibits Glioma Cell Proliferation by Targeting PDGFRβ. Nanoscale Res Lett. 2020 Jul 20;15(1):150 Authors: Wang F, Zhou Y, Cheng S, Lou J, Zhang X, He Q, Huang N, Cheng Y Abstract Glioma is one of the deadliest intrinsic brain tumours due to its invasive growth. The effect of glioma treatment is poor because of the presence of the blood-brain barrier and blood tumour...
Related Articles Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo. Bioorg Med Chem. 2020 Aug 15;28(16):115584 Authors: Tian N, Wu H, Zhang H, Yang D, Lv L, Yang Z, Zhang T, Quan D, Zhou L, Xie Y, Xu Y, Wei N, Zhang J, Chen M, Schmitz JC, Tian Y, Wu S Abstract Triple-negative breast cancer (TNBC), a subset of breast cancers, have poorer survival...
Related Articles An efficient method to isolate lemon derived extracellular vesicles for gastric cancer therapy. J Nanobiotechnology. 2020 Jul 20;18(1):100 Authors: Yang M, Liu X, Luo Q, Xu L, Chen F Abstract BACKGROUND: Plant-derived extracellular vesicles (PDEVs) have great potential for clinical applications. Ultracentrifugation, considered the gold standard method for the preparation of PDEVs, is efficacious but time-consuming and highly...
Related Articles Applications of miRNAs in cardiac development, disease progression and regeneration. Stem Cell Res Ther. 2019 11 21;10(1):336 Authors: Pang JKS, Phua QH, Soh BS Abstract Development of the complex human heart is tightly regulated at multiple levels, maintaining multipotency and proliferative state in the embryonic cardiovascular progenitors and thereafter suppressing progenitor characteristics to allow for terminal differentiation...
Related Articles Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking. Neuropharmacology. 2019 10;157:107679 Authors: Sakharkar AJ, Kyzar EJ, Gavin DP, Zhang H, Chen Y, Krishnan HR, Grayson DR, Pandey SC Abstract Binge drinking during adolescence increases the risk for neuropsychiatric disorders including alcoholism in adulthood. DNA methylation in post-mitotic neurons...
Related Articles Theaflavin and epigallocatechin-3-gallate synergistically induce apoptosis through inhibition of PI3K/Akt signaling upon depolymerizing microtubules in HeLa cells. J Cell Biochem. 2019 04;120(4):5987-6003 Authors: Chakrabarty S, Nag D, Ganguli A, Das A, Ghosh Dastidar D, Chakrabarti G Abstract Theaflavin (TF) and epigallocatechin-3-gallate (EGCG) both have been reported previously as microtubule depolymerizing agents that also...
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Variability in expert clinicians practices on use of motility investigations in diagnosing CIPO and ED. Abstract Background Chronic intestinal pseudo‐obstruction (CIPO) and enteric dysmotility (ED) are small intestinal motility disorders defined by radiological and manometric criteria. In the absence of consensus guidelines, we surveyed opinions on the diagnosis and management of CIPO and ED among experts from different countries. Methods A survey questionnaire was circulated electronically...
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Related Articles Comparative antidandruff efficacy of plant extracts prepared from conventional and supercritical fluid extraction method and chemical profiling using GCMS. J Dermatolog Treat. 2020 Jul 21;:1-22 Authors: Mishra RC, Kumari R, Yadav JP Abstract Background: To combat dandruff associated pathogens, supercritical fluid extraction (SFE) can be used as an alternative eco-friendly technique to obtain antimicrobial plant extracts over...
Related Articles A case of severe psoriatic erythroderma with COVID-19. J Dermatolog Treat. 2020 Jul 21;:1-11 Authors: Ghalamkarpour F, Pourani MR, Abdollahimajd F, Zargari O Abstract COVID-19 caused by the SARS-CoV-2, became pandemic very quickly. Management of severe dermatologic disorders in patients who require systemic immunosuppressive treatment is a major concern in COVID-19 pandemic era. Here we report a 45-year-old homeless addicted...
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Related Articles Study of anatomical variations of hepatic vasculature using multidetector computed tomography angiography. Surg Radiol Anat. 2020 Jul 20;: Authors: Anwar AS, Srikala J, Papalkar AS, Parveez MQ, Sharma A Abstract PURPOSE: Preoperative evaluation of the hepatic vasculature is necessary to minimize mortality and morbidity during various surgeries due to the complexity of liver anatomy. The purpose of our investigation is to...
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