Cancers, Vol. 12, Pages 2050: Resectable IIIA-N2 Non-Small-Cell Lung Cancer (NSCLC): In Search for the Proper Treatment Cancers doi: 10.3390/cancers12082050 Authors: Brascia De Iaco Schiavone Panza Signore Geronimo Sampietro Montrone Galetta Marulli Locally advanced non-small cell lung cancer accounts for one third of non-small cell lung cancer (NSCLC) at the time of initial diagnosis and presents with a wide range of clinical and pathological heterogeneity....
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2053: Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53’s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption Cancers doi: 10.3390/cancers12082053 Authors: Yu-Chu Wang Jau-Ling Huang Ka-Wo Lee Hsing-Han Lu Yuan-Jen Lin Long-Fong Chen Chung-Sheng Wang Yun-Chiao Cheng Zih-Ting Zeng Pei-Yi Chu Chang-Shen Lin Arecoline is the principal alkaloid in the...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2049: TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy Cancers doi: 10.3390/cancers12082049 Authors: Francesco Graziano Nicholas W. Fischer Irene Bagaloni Maria Di Bartolomeo Sara Lonardi Bruno Vincenzi Giuseppe Perrone Lorenzo Fornaro Elena Ongaro Giuseppe Aprile Renato Bisonni Michele Prisciandaro David Malkin Jean Gariépy...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2047: The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP/TAZ and TGF Signaling Cancers doi: 10.3390/cancers12082047 Authors: Pseftogas Xanthopoulos Poutahidis Ainali Dafou Panteris Kern Varelas Hardas Gonidas Tsingotjidou Hatzivassiliou Mosialos Downregulation of the cylindromatosis (CYLD) tumor suppressor has been associated with breast cancer development...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2046: Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome Cancers doi: 10.3390/cancers12082046 Authors: Izzi Davis Naba The extracellular matrix (ECM) is a master regulator of all cellular functions and a major component of the tumor microenvironment. We previously defined the "matrisome" as the ensemble of genes encoding ECM proteins and proteins modulating ECM structure or function. While compositional and biomechanical changes...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2043: TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas Cancers doi: 10.3390/cancers12082043 Authors: Mario Mischkulnig Barbara Kiesel Daniela Lötsch Thomas Roetzer Martin Borkovec Lisa I. Wadiura Petra A. Mercea Florian J. Jaklin Shawn Hervey-Jumper Karl Roessler Mitchel S. Berger Georg Widhalm Friedrich Erhart...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2045: Early Change in the Plasma Levels of Circulating Soluble Immune Checkpoint Proteins in Patients with Unresectable Hepatocellular Carcinoma Treated by Lenvatinib or Transcatheter Arterial Chemoembolization Cancers doi: 10.3390/cancers12082045 Authors: Odagiri Hai Thuy Dong Suoh Kotani Hagihara Uchida-Kobayashi Tamori Enomoto Kawada Immune checkpoint inhibitors, combined with anti-angiogenic agents or locoregional treatments...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2048: Telomeres and Telomerase in the Development of Liver Cancer Cancers doi: 10.3390/cancers12082048 Authors: in der Stroth Tharehalli Günes Lechel Liver cancer is one of the most common cancer types worldwide and the fourth leading cause of cancer-related death. Liver carcinoma is distinguished by a high heterogeneity in pathogenesis, histopathology and biological behavior. Dysregulated signaling pathways and various gene mutations are frequent...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2041: Ultra-Short Circulating Tumor DNA (usctDNA) in Plasma and Saliva of Non-Small Cell Lung Cancer (NSCLC) Patients Cancers doi: 10.3390/cancers12082041 Authors: Feng Li Fang Wei Wei-Lun Huang Chien-Chung Lin Liang Li Macy M. Shen Qingxiang Yan Wei Liao David Chia Michael Tu Jason H. Tang Ziding Feng Yong Kim Wu-Chou Su David T. W. Wong Mutations identified in the epidermal growth factor receptor (EGFR) predict sensitivity...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2040: MicroRNAs in Rectal Cancer: Functional Significance and Promising Therapeutic Value Cancers doi: 10.3390/cancers12082040 Authors: Imedio Cristóbal Rubio Santos Rojo García-Foncillas It is well-known that microRNAs (miRNAs) are critical mediators of initiation and disease progression in many human cancers. Rectal cancer is a highly prevalent tumor, accounting for around one third of newly diagnosed colorectal cancers. The usefulness of...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2039: Targeted Therapies in Advanced Biliary Tract Cancer: An Evolving Paradigm Cancers doi: 10.3390/cancers12082039 Authors: Sakti Chakrabarti Mandana Kamgar Amit Mahipal Biliary tract cancers (BTCs) are a heterogeneous group of adenocarcinomas that originate from the epithelial lining of the biliary tree. BTCs are characterized by presentation with advanced disease precluding curative surgery, rising global incidence, and a poor prognosis. Chemotherapy...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2042: Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis Cancers doi: 10.3390/cancers12082042 Authors: Taha Azad Reza Rezaei Abera Surendran Ragunath Singaravelu Stephen Boulton Jaahnavi Dave John C. Bell Carolina S. Ilkow The Hippo pathway plays a critical role in tissue and organ growth under normal physiological conditions, and its dysregulation in malignant growth has made it an attractive...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2036: The Role of Location of Tumor in the Prognosis of the Pancreatic Cancer Cancers doi: 10.3390/cancers12082036 Authors: Mirang Lee Wooil Kwon Hongbeom Kim Yoonhyeong Byun Youngmin Han Jae Seung Kang Yoo Jin Choi Jin-Young Jang Identification of prognostic factors is important to improve treatment outcomes in pancreatic cancer. This study aimed to investigate the effect of the location of pancreatic cancer on survival and to determine whether...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2037: Friend or Foe: S100 Proteins in Cancer Cancers doi: 10.3390/cancers12082037 Authors: Allgöwer Kretz Karstedt Wittau Henne-Bruns Lemke S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis, proliferation, apoptosis, differentiation, and inflammation. Although the complex network of S100 signalling is by far not fully...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2038: Impact of Host, Lifestyle and Environmental Factors in the Pathogenesis of MPN Cancers doi: 10.3390/cancers12082038 Authors: Gajalakshmi Ramanathan Brianna M Hoover Angela G Fleischman Philadelphia-negative myeloproliferative neoplasms (MPNs) occur when there is over-production of myeloid cells stemming from hematopoietic stem cells with constitutive activation of JAK/STAT signaling, with JAK2V617F being the most commonly occurring somatic driver mutation....
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2044: Real-World Outcomes of Patients with Refractory or Relapsed FLT3-ITD Acute Myeloid Leukemia: A Toulouse-Bordeaux DATAML Registry Study Cancers doi: 10.3390/cancers12082044 Authors: Dumas Bertoli Bérard Largeaud Bidet Delabesse Leguay Leroy Gadaud Rieu Vial Vergez Lechevalier Luquet Klein Sarry Grande Pigneux Récher Two recent phase 3 trials showed that outcomes for relapsed/refractory...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2035: Emerging Contribution of PancRNAs in Cancer Cancers doi: 10.3390/cancers12082035 Authors: Neri Mercatelli Ramona Palombo Maria Paola Paronetto “Cancer” includes a heterogeneous group of diseases characterized by abnormal growth beyond natural boundaries. Neoplastic transformation of cells is orchestrated by multiple molecular players, including oncogenic transcription factors, epigenetic modifiers, RNA binding proteins, and coding...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2034: Impact of Extraskeletal Metastases on Skeletal-Related Events in Metastatic Castration-Resistant Prostate Cancer with Bone Metastases Cancers doi: 10.3390/cancers12082034 Authors: Soraia Lobo-Martins Arlindo R. Ferreira André Mansinho Sandra Casimiro Kim Leitzel Suhail Ali Allan Lipton Luís Costa The therapeutic landscape of metastatic castration-resistant prostate cancer (mCRPC) has substantially evolved over the last decade. Nonetheless,...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2028: Primary Thromboprophylaxis in Ambulatory Pancreatic Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Cancers doi: 10.3390/cancers12082028 Authors: Corinne Frere Benjamin Crichi Barbara Bournet Cindy Canivet Nassim Ait Abdallah Louis Buscail Dominique Farge Patients with pancreatic cancer (PC) carry the highest risk of venous thromboembolism (VTE) amongst all cancer patients. Appropriate...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2027: Radiomic Texture and Shape Descriptors of the Rectal Environment on Post-Chemoradiation T2-Weighted MRI are Associated with Pathologic Tumor Stage Regression in Rectal Cancers: A Retrospective, Multi-Institution Study Cancers doi: 10.3390/cancers12082027 Authors: Charlems Alvarez-Jimenez Jacob T. Antunes Nitya Talasila Kaustav Bera Justin T. Brady Jayakrishna Gollamudi Eric Marderstein Matthew F. Kalady Andrei Purysko Joseph E. Willis...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2033: Transcriptomic Profile of Lymphovascular Invasion, a Known Risk Factor of Pancreatic Ductal Adenocarcinoma Metastasis Cancers doi: 10.3390/cancers12082033 Authors: Hideo Takahashi Eriko Katsuta Li Yan Yoshihisa Tokumaru Matthew H.G. Katz Kazuaki Takabe Lymphovascular invasion (LVI) is an aggressive pathologic feature and considered a risk factor for distant metastasis. We hypothesized that pancreatic ductal adenocarcinomas (PDACs) with LVI...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2031: Histopathological Classification of Breast Cancer Images Using a Multi-Scale Input and Multi-Feature Network Cancers doi: 10.3390/cancers12082031 Authors: Taimoor Shakeel Sheikh Yonghee Lee Migyung Cho Diagnosis of pathologies using histopathological images can be time-consuming when many images with different magnification levels need to be analyzed. State-of-the-art computer vision and machine learning methods can help automate the diagnostic pathology...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2029: Colorectal Cancer and Bone Tissue: Fantastic Relations and Where to Find Them Cancers doi: 10.3390/cancers12082029 Authors: Isabella Gigante Valeria Tutino Valentina De Nunzio Maria Notarnicola Colorectal cancer (CRC) is the third most common cancer worldwide. There is a need for the early diagnosis of CRC for a better prognostic outcome. It is, therefore, crucial to understand the CRC pathogenesis in all its aspects. In many cases, one of the main...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2030: The Great War of Today: Modifications of CAR-T Cells to Effectively Combat Malignancies Cancers doi: 10.3390/cancers12082030 Authors: Andriy Zhylko Magdalena Winiarska Agnieszka Graczyk-Jarzynka Immunotherapy of cancer had its early beginnings in the times when the elements of the immune system were still poorly characterized. However, with the progress in molecular biology, it has become feasible to re-engineer T cells in order to eradicate tumour...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2032: Primary Driver Mutations in GTF2I Specific to the Development of Thymomas Cancers doi: 10.3390/cancers12082032 Authors: Rumi Higuchi Taichiro Goto Yosuke Hirotsu Yujiro Yokoyama Takahiro Nakagomi Sotaro Otake Kenji Amemiya Toshio Oyama Hitoshi Mochizuki Masao Omata Thymomas are rare mediastinal tumors that are difficult to treat and pose a major public health concern. Identifying mutations in target genes is vital for the development...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2026: Hepatocellular Carcinoma: Special Issue Highlights Cancers doi: 10.3390/cancers12082026 Authors: Medhavi Gupta Renuka V. Iyer [...]
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2025: MicroRNAs and Their Targetomes in Tumor-Immune Communication Cancers doi: 10.3390/cancers12082025 Authors: Sunglim Cho Jesse W. Tai Li-Fan Lu The development of cancer is a complex and dynamically regulated multiple-step process that involves many changes in gene expression. Over the last decade, microRNAs (miRNAs), a class of short regulatory non-coding RNAs, have emerged as key molecular effectors and regulators of tumorigenesis. While aberrant expression...
Fri Jul 24, 2020 03:00
Cells, Vol. 9, Pages 1781: Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action Cells doi: 10.3390/cells9081781 Authors: Catalán Julio-Kalajzić Niemeyer Cid Sepúlveda Lubiprostone, a 20-carbon synthetic fatty acid used for the treatment of constipation, is thought to act through an action on Cl- channel ClC-2. Short chain fatty acids (SCFAs) are produced and absorbed in the distal intestine. We explore whether...
Sun Jul 26, 2020 03:00
Cells, Vol. 9, Pages 1780: Derivation and Characterization of Immortalized Human Muscle Satellite Cell Clones from Muscular Dystrophy Patients and Healthy Individuals Cells doi: 10.3390/cells9081780 Authors: Jimmy Massenet Cyril Gitiaux Mélanie Magnan Sylvain Cuvellier Arnaud Hubas Patrick Nusbaum F Jeffrey Dilworth Isabelle Desguerre Bénédicte Chazaud In Duchenne muscular dystrophy (DMD) patients, absence of dystrophin causes muscle wasting by impacting both...
Sun Jul 26, 2020 03:00
Cells, Vol. 9, Pages 1779: Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia Cells doi: 10.3390/cells9081779 Authors: Salman Goudarzi Shannon E. Gilchrist Sassan Hafizi The Gas6–TAM (Tyro3, Axl, Mer) ligand–receptor system is believed to promote central nervous system (CNS) (re)myelination and glial cell development. An additional important function of Gas6–TAM signalling appears to be the regulation...
Sun Jul 26, 2020 03:00
Cells, Vol. 9, Pages 1778: The Role of Cutinsomes in Plant Cuticle Formation Cells doi: 10.3390/cells9081778 Authors: Dariusz Stępiński Maria Kwiatkowska Agnieszka Wojtczak Justyna Teresa Polit Eva Domínguez Antonio Heredia Katarzyna Popłońska The cuticle commonly appears as a continuous lipophilic layer located at the outer epidermal cell walls of land plants. Cutin and waxes are its main components. Two methods for cutin synthesis are considered in plants. One that...
Sat Jul 25, 2020 03:00
Cells, Vol. 9, Pages 1776: A Transposon Story: From TE Content to TE Dynamic Invasion of Drosophila Genomes Using the Single-Molecule Sequencing Technology from Oxford Nanopore Cells doi: 10.3390/cells9081776 Authors: Mourdas Mohamed Nguyet Thi-Minh Dang Yuki Ogyama Nelly Burlet Bruno Mugat Matthieu Boulesteix Vincent Mérel Philippe Veber Judit Salces-Ortiz Dany Severac Alain Pélisson Cristina Vieira François Sabot Marie Fablet Séverine Chambeyron...
Sat Jul 25, 2020 03:00
Cells, Vol. 9, Pages 1777: A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2 Cells doi: 10.3390/cells9081777 Authors: Nina-Naomi Kreis Andreas Ritter Frank Louwen Juping Yuan The outbreak of the coronavirus disease 2019 (COVID-19) pandemic has caused a global public health crisis. Viral infections may predispose pregnant women to a higher rate of pregnancy complications, including preterm births, miscarriage, and stillbirth. Despite...
Sat Jul 25, 2020 03:00
Cells, Vol. 9, Pages 1775: The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines Cells doi: 10.3390/cells9081775 Authors: Roxan F.C.P.A. Helderman Daan R. Löke Jan Verhoeff Hans M. Rodermond Gregor G.W. van Bochove Menno Boon Sanne van Kesteren Juan J. Garcia Vallejo H. Petra Kok Pieter J. Tanis Nicolaas A.P. Franken Johannes Crezee Arlene...
Sat Jul 25, 2020 03:00
Cells, Vol. 9, Pages 1774: The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore Cells doi: 10.3390/cells9081774 Authors: Yulia Baburina Irina Odinokova Olga Krestinina Decades of active research have shown that mitochondrial dysfunction, the associated oxidative stress, impaired anti-stress defense mechanisms, and the activation of the proapoptotic signaling...
Fri Jul 24, 2020 03:00
Cells, Vol. 9, Pages 1773: Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases Cells doi: 10.3390/cells9081773 Authors: Syed Sayeed Ahmad Khurshid Ahmad Eun Ju Lee Yong-Ho Lee Inho Choi Skeletal muscle is an essential tissue that attaches to bones and facilitates body movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an important role in skeletal myogenesis and is importantly associated with muscle mass...
Fri Jul 24, 2020 03:00
Cells, Vol. 9, Pages 1771: Does Siponimod Exert Direct Effects in the Central Nervous System? Cells doi: 10.3390/cells9081771 Authors: Kipp The modulation of the sphingosine 1-phosphate receptor is an approved treatment for relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes in lymph nodes. Different sphingosine 1-phosphate receptor subtypes are expressed in the brain and spinal cord, and their pharmacological effects may improve disease development...
Fri Jul 24, 2020 03:00
Cells, Vol. 9, Pages 1772: Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship Cells doi: 10.3390/cells9081772 Authors: Lucarini Parisio Branca Segnani Ippolito Pellegrini Antonioli Fornai Micheli Pacini Bernardini Blandizzi Ghelardini Di Cesare Mannelli The management of visceral pain is a major clinical problem in patients affected by gastrointestinal disorders. The poor knowledge...
Fri Jul 24, 2020 03:00
Cells, Vol. 9, Pages 1769: Fission Yeast Polarization: Modeling Cdc42 Oscillations, Symmetry Breaking, and Zones of Activation and Inhibition Cells doi: 10.3390/cells9081769 Authors: Bita Khalili Hailey D. Lovelace David M. Rutkowski Danielle Holz Dimitrios Vavylonis Cells polarize for growth, motion, or mating through regulation of membrane-bound small GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP exchange factors) and inhibitors (GAPs,...
Fri Jul 24, 2020 03:00
Cells, Vol. 9, Pages 1768: Signals Orchestrating Peripheral Nerve Repair Cells doi: 10.3390/cells9081768 Authors: Michela Rigoni Samuele Negro The peripheral nervous system has retained through evolution the capacity to repair and regenerate after assault from a variety of physical, chemical, or biological pathogens. Regeneration relies on the intrinsic abilities of peripheral neurons and on a permissive environment, and it is driven by an intense interplay among neurons, the glia,...
Fri Jul 24, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου