Related Articles [Effects of stachyine on apoptosis in an Aβ25-35-induced PC12 cell model of Alzheimer's disease]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;40(7):1023-1028 Authors: Qu L, Huang J, Fan M, Hao Y, Yan J Abstract OBJECTIVE: To investigate the effects of stachydrine (STA) on apoptosis of Aβ25-35-induced PC12 cells mimicking Alzheimer's disease and explore the mechanisms. METHODS: The differential genes of STA...
Fri Jul 24, 2020 13:29
Related Articles Mannose shows antitumour properties against lung cancer via inhibiting proliferation, promoting cisplatin‑mediated apoptosis and reducing metastasis. Mol Med Rep. 2020 Jul 23;: Authors: Wang Y, Xie S, He B Abstract It has been reported that mannose exerts antitumour effects against certain types of cancer. The present study was designed to evaluate whether mannose exerted potential anticancer effects on A549 and H1299 non‑small...
Fri Jul 24, 2020 13:29
Related Articles A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy. Dalton Trans. 2020 Jul 23;: Authors: Cao S, Li X, Gao Y, Li F, Li K, Cao X, Dai Y, Mao L, Wang S, Tai X Abstract A bimetallic Cu(ii) complex as a novel antitumor chemodynamic therapy agent with glutathione (GSH) depletion properties is successfully synthesized and well characterized. In tumor cells, the Cu2+ ions of the complex...
Fri Jul 24, 2020 13:29
Related Articles Centaurea bruguierana inhibits cell proliferation, causes cell cycle arrest, and induces apoptosis in human MCF-7 breast carcinoma cells. Mol Biol Rep. 2020 Jul 22;: Authors: Nasr FA, Shahat AA, Alqahtani AS, Ahmed MZ, Qamar W, Al-Mishari AA, Almoqbil AN Abstract Centaurea bruguierana, of the Asteraceae family, has a long history of use in traditional medicines for the treatment of various ailments. However, the anticancer...
Fri Jul 24, 2020 13:29
Related Articles Natural compound Alternol as a novel therapeutic for prostate cancer treatment. Am J Clin Exp Urol. 2020;8(3):76-80 Authors: Xu H, Zhou Z, Li B Abstract Alternol is a monomeric compound purified from the fermentation of a microbial strain obtained from the bark of the yew tree. Recent studies have confirmed that it has specific anti-prostate cancer efficacy in vitro and in vivo. In in vitro cell culture experiments Alternol...
Fri Jul 24, 2020 13:29
Related Articles circ_0084927 promotes cervical carcinogenesis by sponging miR-1179 that suppresses CDK2, a cell cycle-related gene. Cancer Cell Int. 2020;20:333 Authors: Qu X, Zhu L, Song L, Liu S Abstract Background: Cervical cancer (CC) is a malignant tumor found in the lowermost part of the womb. Evolving studies on CC have reported that circRNA plays a crucial role in CC progression. In this study, we investigated the main function...
Fri Jul 24, 2020 13:29
Related Articles Apoptosis in Leukemic Cells Induced by Anti-proliferative Coumarin Isolated from the Stem Bark of Fraxinus rhynchophylla. J Microbiol Biotechnol. 2020 Jul 20;: Authors: Lee BZ, Lee IS, Pham CH, Jeong SK, Lee S, Hong K, Yoo HM Abstract Esculetin 6-O-β-D-arabinofuranosyl-(1→6)-β-D-glucopyranoside (EAG) is a coumarin glycoside isolated from the stem bark of Fraxinus rhynchophylla. This study scrutinized the anti-proliferative...
Fri Jul 24, 2020 13:29
Related Articles Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease. Stem Cell Res Ther. 2020 Jul 22;11(1):304 Authors: Amorim RM, Clark KC, Walker NJ, Kumar P, Herout K, Borjesson DL, Wang A Abstract BACKGROUND: Canine inflammatory brain disease (IBD) is a severe inflammatory disorder characterized by infiltration of activated immune cell subsets into the...
Fri Jul 24, 2020 13:29
Related Articles Pulsatilla Saponin A Induces Apoptosis and Differentiation of Myeloma Cells. Anticancer Agents Med Chem. 2020 Jul 21;: Authors: Ye B, Zhou Y, Liu Y, Li X, Li T, Qi X Abstract OBJECTIVES: To investigate the performance of Pulsatilla saponin A (PsA) in multiple myeloma (MM) cells. METHODS: Proliferation, cell cycle analysis, apoptosis and TUNEL assays were conducted to detect the growth and apoptosis in MM cells....
Fri Jul 24, 2020 13:29
Related Articles Anti-Cancer Stem Cells Potentiality of an Anti-Malarial Agent Quinacrine: An Old Wine in a New Bottle. Anticancer Agents Med Chem. 2020 Jul 21;: Authors: Das B, Kundu CN Abstract Quinacrine (QC) is a tricyclic compound and a derivative of 9-aminoacridine. It has been widely used to treat malaria and other parasitic diseases since the last century. Interestingly, studies have revealed that it also displayed anticancer activities....
Fri Jul 24, 2020 13:29
Related Articles Combination of Salinomycin and AZD3463 Reveals Synergistic Effect on Reducing the Viability of T98G Glioblastoma Cells. Anticancer Agents Med Chem. 2020 Jul 21;: Authors: Asik A, Ay NPO, Bagca BG, Caglar HO, Gunduz C, Avci CB Abstract BACKGROUND: Salinomycin, an ionophore antibiotic, is known to be effective agent in reducing the viability of glioblastoma (GBM) cells. The combination of salinomycin with other chemotherapeutic...
Fri Jul 24, 2020 13:29
Related Articles Emulsifying Properties of an Homologous Series of Medium- and Long-chain D-Maltotriose Esters and their Impacts on the Viabilities of Selected Cell Lines. J Agric Food Chem. 2020 Jul 22;: Authors: Zhu JP, Ma YR, Teng Y, Chen J, Banwell MG, Lan P Abstract The development of functional as well as nutritional surfactants for the food industry remains a matter of great interest. In the present study, a series of 6''-O-acylmaltotriose...
Fri Jul 24, 2020 13:29
Related Articles ATM/miR-34a-5p axis regulates a p21-dependent senescence-apoptosis switch in non-small cell lung cancer: a Boolean model of G1/S checkpoint regulation. FEBS Lett. 2020 01;594(2):227-239 Authors: Gupta S, Silveira DA, Mombach JCM Abstract MicroRNA-34a-5p regulates the G1/S checkpoint in non-small cell lung cancer (NSCLC) cells. Forced expression of miR-34a-5p enhances p21 expression and promotes cellular senescence, whereas...
Fri Jul 24, 2020 13:29
Related Articles Exercise preconditioning attenuates hind limb unloading-induced gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in old rats. Exp Gerontol. 2019 07 15;122:34-41 Authors: Yoshihara T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H Abstract The mechanisms involved in unloading-induced skeletal muscle loss may be age-specific, and the evidence for exercise preconditioning-induced protection against disuse muscle...
Fri Jul 24, 2020 13:29
Related Articles Short- and Long-Term Outcomes of Laparoscopic Organ-Sparing Resection for Pancreatic Neuroendocrine Neoplasms. World J Surg. 2020 Jul 22;: Authors: Zhang RC, Ma J, Mou YP, Zhou YC, Jin WW, Lu C Abstract BACKGROUND: Pancreatic neuroendocrine neoplasms (PNENs) are rare neoplasms associated with a long life expectancy after resection. In this setting, patients may benefit from laparoscopic organ-sparing resection. Studies of laparoscopic...
Fri Jul 24, 2020 13:19
Related Articles Kigali Surgical Sepsis (KiSS) Score: A New Tool to Predict Outcomes in Surgical Patients with Sepsis in Low- and Middle-Income Settings. World J Surg. 2020 Jul 22;: Authors: Niyongombwa I, Sibomana I, Karenzi ID, Kiswezi A, Rickard J Abstract BACKGROUND: Sepsis is common in surgical patients, and its presence influences the outcomes in those to undergo surgery. Factors such as advanced age, presence of comorbidities and many...
Fri Jul 24, 2020 13:19
Bone Conduction Vibration Vestibular Evoked Myogenic Potential (VEMP) Testing: Reliability in Children, Adolescents, and Young Adults. Ear Hear. 2020 Jul 17;: Authors: Greenwalt NL, Patterson JN, Rodriguez AI, Fitzpatrick D, Gordon KR, Janky KL Abstract OBJECTIVES: Bone conduction vibration (BCV) vestibular evoked myogenic potentials (VEMP) are clinically desirable in children for multiple reasons. However, no accepted standard exists...
Fri Jul 24, 2020 13:15
Related Articles Comparison of furosemide-loading cervical vestibular-evoked myogenic potentials with magnetic resonance imaging for the evaluation of endolymphatic hydrops. Acta Otolaryngol. 2020 Jul 23;:1-5 Authors: Shiraishi K, Ohira N, Kobayashi T, Sato M, Osaki Y, Doi K Abstract BACKGROUND: Furosemide-loading cervical vestibular-evoked myogenic potential (FVEMP), in which vestibular function is improved via diuretics-induced dehydration,...
Fri Jul 24, 2020 13:15
Related Articles Effects of MOPP Gear on SAM Medical Junctional Tourniquet Application: A Prospective, Randomized Control Trial. Mil Med. 2020 Jul 23;: Authors: Wagner EM, Naylor JF, Ahern BJ, Gendron BC, April MD, Schauer SG Abstract INTRODUCTION: Hemorrhage is the leading cause of preventable death on the battlefield, and hemostasis is particularly challenging to achieve at junctional sites such as the axillary or inguinal regions. Mission-oriented...
Fri Jul 24, 2020 13:14
Related Articles MHS Genesis Implementation: Strategies in Support of Successful EHR Conversion. Mil Med. 2020 Jul 23;: Authors: Woody Ii EW Abstract INTRODUCTION: The Military Health System (MHS) is implementing a new electronic health record (EHR) which will impact 9.5 million Department of Defense (DoD) beneficiaries and over 205,000 MHS employees globally. The scale and scope of this EHR rollout is unprecedented; however, lessons learned...
Fri Jul 24, 2020 13:14
Related Articles Tumor thrombus in abdominal aorta. Jpn J Clin Oncol. 2020 Jul 23;: Authors: Lai S, Diao T, Wang JY, Liu M PMID: 32700737 [PubMed - as supplied by publisher]
Fri Jul 24, 2020 13:11
Related Articles Effectiveness of doxorubicin-based and liposomal doxorubicin chemotherapies for patients with extra-abdominal desmoid-type fibromatosis: a systematic review. Jpn J Clin Oncol. 2020 Jul 23;: Authors: Shimizu K, Kawashima H, Kawai A, Yoshida M, Nishida Y Abstract OBJECTIVE: The treatment modality for desmoid-type fibromatosis has shifted from surgery to conservative treatment. The guideline committee for clinical care of extra-abdominal...
Fri Jul 24, 2020 13:11
Related Articles Effect of neoadjuvant chemotherapy on health-related quality of life in patients with muscle-invasive bladder cancer: results from JCOG0209, a randomized phase III study. Jpn J Clin Oncol. 2020 Jul 23;: Authors: Kitamura H, Hinotsu S, Tsukamoto T, Shibata T, Mizusawa J, Kobayashi T, Miyake M, Nishiyama N, Kojima T, Nishiyama H, Urologic Oncology Study Group of the Japan Clinical Oncology Group Abstract BACKGROUND: Although neoadjuvant...
Fri Jul 24, 2020 13:11
Related Articles Characteristics of primary and repeated recurrent retroperitoneal liposarcoma: outcomes after aggressive surgeries at a single institution. Jpn J Clin Oncol. 2020 Jul 23;: Authors: Ishii K, Yokoyama Y, Nishida Y, Koike H, Yamada S, Kodera Y, Sassa N, Gotoh M, Nagino M Abstract OBJECTIVE: This study sought to investigate the characteristics of primary and repeated recurrent retroperitoneal liposarcoma. METHODS: Patients...
Fri Jul 24, 2020 13:11
A 29-Year-Old Male with a Fatal Case of COVID-19 Acute Respiratory Distress Syndrome (CARDS) and Ventilator-Induced Lung Injury (VILI). Am J Case Rep. 2020 Jul 23;21:e926136 Authors: Deliwala SS, Ponnapalli A, Seedahmed E, Berrou M, Bachuwa G, Chandran A Abstract BACKGROUND COVID-19 patients that develop acute respiratory distress syndrome (ARDS) "CARDS" behave differently compared to patients with classic forms of ARDS. Recently 2 CARDS phenotypes...
Fri Jul 24, 2020 13:05
Related Articles A 73-Year-Old Man with a History of Hypertension and Ischemic Heart Disease Who Presented with Pain in the Right Flank as a Symptom of COVID-19 Pneumonia. Am J Case Rep. 2020 Jul 23;21:e925771 Authors: Veliyankodan Parambil J, Abdulrahman R, Al-Shokri S Abstract BACKGROUND Coronavirus disease 2019 (COVID-19) has been increasing all over the world. During the pandemic, a variety of presentations have been described. Nevertheless,...
Fri Jul 24, 2020 13:05
PSEUDOANEURYSM RESULTING IN REBLEEDING AFTER EVACUATION OF SPONTANEOUS INTRACEREBRAL HAEMORRHAGE - A CASE REPORT. World Neurosurg. 2020 Jul 20;: Authors: Jain S, Gopinathan A, Ng ZX, Ren Yang EW, Lwin S, Yeo TT, Yang M, Lim J, Hew CH, Chan B, Pang BC Abstract BACKGROUND: Spontaneous intracerebral haemorrhage (ICH) is a devastating cerebrovascular disease with high morbidity and mortality. Branching pattern of the lenticulostriate arteries from...
Fri Jul 24, 2020 13:03
Exchange cranioplasty using bioabsorbable hydroxyapatite and collagen complex after removal of an extensive frontal bone tumor in an infant. World Neurosurg. 2020 Jul 20;: Authors: Kono M, Miwa T, Sakamoto Y, Kishi K, Yoshida K Abstract BACKGROUND: Forehead reconstruction is challenging. Reconstruction of the innate curvature of the forehead is difficult and the forehead is an esthetically important part of the face. Although synthetic implants...
Fri Jul 24, 2020 13:03
Primary endoscopic management of apoplexy in a giant pituitary adenoma. World Neurosurg. 2020 Jul 20;: Authors: Romano A, Ganau M, Zaed I, Scibilia A, Oretti G, Chibbaro S Abstract Sellar lesions with large suprasellar extension represent a neurosurgical challenge because of their nature and anatomical complexity. The goal of the extended transphenoidal-transtuberculum approach is enlarging the transsphenoidal route superiorly and laterally...
Fri Jul 24, 2020 13:03
Endodermal cyst with a non- enhancing nodule in the quadrigeminal cistern developed in an octogenarian. World Neurosurg. 2020 Jul 20;: Authors: Miyashita K, Oikawa N, Kobayashi M, Aida Y, Kitabayashi T, Shimizu Y, Tohma Y Abstract BACKGROUND: Intracranial endodermal cysts are congenital lesions that generally develop in the cerebellopontine angle and ventral brainstem of the posterior fossa, while endodermal cysts in the quadrigeminal cistern...
Fri Jul 24, 2020 13:03
Supracerebellar approach for clival chordomas: A technical note. World Neurosurg. 2020 Jul 20;: Authors: Goel A, Vaja T, Shah A, Rai S, Hawaldar A, Lunawat A Abstract Conventional retrosigmoid and lateral supracerebellar approach was used for surgery in five select cases of large chordomas. The patients were treated during the period 2011 and 2019. Location of the tumor in the depth from surface, wide tumor extensions and intimate relationships...
Fri Jul 24, 2020 13:03
Afternoon Surgical Start Time is Associated with Higher Cost and Longer Length of Stay in Posterior Lumbar Fusion. World Neurosurg. 2020 Jul 20;: Authors: Neifert SN, Martini ML, Gal JS, Maron SZ, Rasouli JJ, Lamb CD, Rothrock RJ, McNeill IT, Grant LK, Genadry L, Cho SK, Caridi JM Abstract BACKGROUND/OBJECTIVE: Existing research about surgical start time is equivocal about associations between outcomes and late start times, and there is only...
Fri Jul 24, 2020 13:03
A case of meningioma originating from the oculomotor nerve. World Neurosurg. 2020 Jul 20;: Authors: Doi K, Otani N, Hagita D, Horiuchi M, Takeuchi S, Toyooka T, Wada K, Hayashi M, Mori K Abstract A 22-year-old woman presented with a unique case of meningioma originating from the oculomotor nerve manifesting as periorbital pain and diplopia beginning 4 months previously. Oculomotor nerve schwannoma was suggested by several pre-treatment examinations....
Fri Jul 24, 2020 13:03
Neurosurgical Procedures and Safety During the COVID-19 Pandemic: A Case-Control Multi-Center Study.
Neurosurgical Procedures and Safety During the COVID-19 Pandemic: A Case-Control Multi-Center Study. World Neurosurg. 2020 Jul 20;: Authors: Bajunaid K, Alqurashi A, Alatar A, Alkutbi M, Alzahrani AH, Sabbagh AJ, Alobaid A, Barnawi A, Alferayan AA, Alkhani AM, Salamah AB, Sheikh BY, Alotaibi FE, Alabbas F, Farrash F, Al-Jehani HM, Alhabib H, Alnaami I, Altweijri I, Khoja I, Taha M, Alzahrani M, Bafaquh MS, Binmahfoodh M, Algahtany MA, Al-Rashed S, Raza SM, Elwatidy...
Fri Jul 24, 2020 13:03
Abstract The purpose of this illustrative pictorial series is to demonstrate the value of an image technique known as 3D Volume Rendering (3DVR) for the pre‐operative visualization and assessment of complex abdominal hernias. A small subset of complex abdominal hernia cases were selected from our early clinical experience with 3DVR to illustrate the value of visualizing standard 2D computed tomography (CT) data from a 3D perspective. For the surgeon , pre‐operative 3DVR can assist the holistic understanding...
Fri Jul 24, 2020 11:07
Abstract Introduction To correlate tumour grading and prognostic immunohistochemical markers of lung cancer with simultaneously acquired standardised uptake values (SUV) and apparent diffusion coefficient (ADC) derived from hybrid PET/MRI. Methods In this retrospective study, 55 consecutive patients (mean age 62.5 ± 9.2 years) with therapy‐naïve, histologically proven lung cancer were included. All patients underwent whole‐body PET/MRI using 18F‐flourdeoxyglucose (18F‐FDG) as a radiotracer....
Fri Jul 24, 2020 11:04
Mate choice is a taxonomically wide-spread phenomenon, mostly exerted by females although male mate choice occurs as well. While costs and benefits of choosiness have been well studied, the underlying mechanis...
Thu Jul 23, 2020 03:00
Adenocarcinoma is the most common malignant neoplasm involving breast tissue. In contrast to carcinomas, the other types of malignant neoplasms involving the breast are relatively uncommon. One of the examples of this rare entity is lymphoma. Traditionally, non-Hodgkin lymphomas (NHL) involving the breast are divided into primary lymphoma of the breast and systemic lymphoma, although the distinction could be challenging. Most of NHL involving breast tissue have B cell origin; T cell NHL represents...
Fri Jul 24, 2020 10:05
Abstract Much of our knowledge about the nineteenth-century natural history boom resides with the collectors themselves and their collections. We know much less about the conduct of the global trade that made collecting possible. That such a trade occurred in the face of significant obstacles of distance, variable prices, inadequate information, and diverse agents makes our knowledge deficit the more significant. William John Macleay, based in Sydney, built his significant natural...
Thu Jul 23, 2020 03:00
Abstract Purpose of Review Sickle cell disease (SCD) remains among the most common and severe monogenic disorders present in the world today. Although sickle cell pain has been traditionally characterized as nociceptive, a significant portion of sickle cell patients has reported neuropathic pain symptoms. Our review article will discuss clinical aspects of SCD-related neuropathic pain, epidemiology of neuropathic pain among individuals...
Fri Jul 24, 2020 03:00
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