Related Articles The Movember Prostate Cancer Landscape Analysis: an assessment of unmet research needs. Nat Rev Urol. 2020 Jul 22;: Authors: Kouspou MM, Fong JE, Brew N, Hsiao STF, Davidson SL, Choyke PL, Crispino T, Jain S, Jenster GW, Knudsen BS, Millar JL, Mittmann N, Ryan CJ, Tombal B, Buzza M Abstract Prostate cancer is a heterogeneous cancer with widely varying levels of morbidity and mortality. Approaches to prostate cancer screening,...
Fri Jul 24, 2020 14:24
Related Articles Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options. Cell Death Dis. 2020 Jul 22;11(7):556 Authors: Wu X, Luo Q, Liu Z Abstract MCL1 is an important antiapoptotic member of the BCL-2 family that is distinguishable from other family members based on its relatively short half-life. Emerging studies have revealed the crucial role of MCL1 in the...
Fri Jul 24, 2020 14:24
Related Articles Mesothelioma Biomarkers: A Review Highlighting Contributions from the Early Detection Research Network. Cancer Epidemiol Biomarkers Prev. 2020 Jul 22;: Authors: Pass HI, Alimi M, Carbone M, Yang H, Goparaju CM Abstract BACKGROUND: Malignant Pleural Mesothelioma (MPM) is an asbestos related neoplasm which can only be treated successfully when correctly diagnosed and treated in early stages. The asbestos exposed population serves...
Fri Jul 24, 2020 14:24
Related Articles Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy. Cancer Discov. 2020 Jul 22;: Authors: Nowicki TS, Farrell C, Morselli M, Rubbi L, Campbell KM, Macabali MH, Berent-Maoz B, Comin-Anduix B, Pellegrini M, Ribas A Abstract Transgenic T-cell receptor (TCR) adoptive cell therapies recognizing tumor antigens are associated with robust initial...
Fri Jul 24, 2020 14:24
Related Articles A Systematic Literature Review of Animal-Assisted Interventions in Oncology (Part II): Theoretical Mechanisms and Frameworks. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420943269 Authors: Holder TRN, Gruen ME, Roberts DL, Somers T, Bozkurt A Abstract Animal-assisted interventions (AAIs) can improve patients' quality of life as complementary medical treatments. Part I of this 2-paper systematic review focused on the methods and...
Fri Jul 24, 2020 14:24
Related Articles Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Eµ-TCL1 Transgenic Mouse Model. Cancers (Basel). 2020 Jul 20;12(7): Authors: Koch M, Reinartz S, Saggau J, Knittel G, Rosen N, Fedorchenko O, Thelen L, Barthel R, Reinart N, Seeger-Nukpezah T, Reinhardt HC, Hallek M, Nguyen PH Abstract The Eµ-TCL1 transgenic mouse model represents the most widely and extensively used animal model...
Fri Jul 24, 2020 14:24
Related Articles The immune landscape and response to immune checkpoint blockade therapy in lymphoma. Blood. 2020 02 20;135(8):523-533 Authors: Kline J, Godfrey J, Ansell SM Abstract The clinical development of effective cancer immunotherapies, along with advances in genomic analysis, has led to the identification of tumor environmental features that predict for sensitivity to immune checkpoint blockade therapy (CBT). Early-phase clinical trial...
Fri Jul 24, 2020 14:24
Related Articles Coagulative function assessed preoperatively via the clot formation and lysis assay as a prognostic factor for blood loss in adolescents undergoing posterior spinal fusion for idiopathic scoliosis. Paediatr Anaesth. 2019 11;29(11):1136-1145 Authors: Fernandez AM, Neustadt JB, Hahn GV, Nguyen ATH, Amankwah EK, Goldenberg NA Abstract BACKGROUND: Posterior spinal fusion for adolescent idiopathic scoliosis is a complex surgery...
Fri Jul 24, 2020 14:24
Related Articles Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer. Cell Rep. 2019 05 14;27(7):1967-1978.e4 Authors: Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C, Owen J, Gordon P, Male V, Cheung A, Noor F, Barber P, Marlow R, Francesch-Domenech E, Fruhwirth G, Squadrito M, Vojnovic B, Tutt A, Festy F, De Palma M, Ng T Abstract Lymphatic vasculature...
Fri Jul 24, 2020 14:24
Related Articles Cabozantinib Versus Mitoxantrone-prednisone in Symptomatic Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 3 Trial with a Primary Pain Endpoint. Eur Urol. 2019 06;75(6):929-937 Authors: Basch EM, Scholz M, de Bono JS, Vogelzang N, de Souza P, Marx G, Vaishampayan U, George S, Schwarz JK, Antonarakis ES, O'Sullivan JM, Kalebasty AR, Chi KN, Dreicer R, Hutson TE, Dueck AC, Bennett AV, Dayan E, Mangeshkar M, Holland J, Weitzman...
Fri Jul 24, 2020 14:24
Association of spontaneous cerebrospinal fluid rhinorrhea with transverse venous sinus stenosis: a retrospective matched case-control study. Int Forum Allergy Rhinol. 2020 Jul 23;: Authors: Bedarida V, Labeyrie MA, Eliezer M, Saint-Maurice JP, Jourdaine C, Gargalas S, Herman P, Houdart E, Verillaud B Abstract BACKGROUND: A significant proportion of spontaneous cerebrospinal fluid (sCSF) leaks are associated with idiopathic intracranial hypertension...
Fri Jul 24, 2020 14:17
Related Articles Different guidelines for pre-exposure prophylaxis (PrEP) eligibility estimate HIV risk differently: an incidence study in a cohort of HIV-negative men who have sex with men, Portugal, 2014-2018. Euro Surveill. 2020 Jul;25(28): Authors: Meireles P, Plankey M, Rocha M, Brito J, Mendão L, Barros H Abstract IntroductionGuidelines for pre-exposure prophylaxis (PrEP) provide criteria to identify individuals at higher risk of HIV infection....
Fri Jul 24, 2020 14:01
Related Articles SARS-CoV-2 IgG seroprevalence in blood donors located in three different federal states, Germany, March to June 2020. Euro Surveill. 2020 Jul;25(28): Authors: Fischer B, Knabbe C, Vollmer T Abstract Most cases of coronavirus disease 2019 are mild or asymptomatic. Therefore, many cases remain unrecorded. We determined seroprevalence of IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 3,186...
Fri Jul 24, 2020 14:01
Related Articles Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2. Euro Surveill. 2020 Jul;25(28): Authors: Zheng Z, Monteil VM, Maurer-Stroh S, Yew CW, Leong C, Mohd-Ismail NK, Cheyyatraivendran Arularasu S, Chow VTK, Lin RTP, Mirazimi A, Hong W, Tan YJ Abstract BackgroundA novel coronavirus, SARS-CoV-2, which emerged at the end of 2019 and causes COVID-19, has resulted in worldwide...
Fri Jul 24, 2020 14:01
Related Articles Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020. Euro Surveill. 2020 Jul;25(28): Authors: Harvala H, Mehew J, Robb ML, Ijaz S, Dicks S, Patel M, Watkins N, Simmonds P, Brooks T, Johnson R, Gopal R, Roberts DJ, Zambon M, NHS Blood and Transplant Convalescent Plasma Testing Group Abstract Serological reactivity was analysed in plasma from 436 individuals...
Fri Jul 24, 2020 14:01
Related Articles All-cause excess mortality observed by age group and regions in the first wave of the COVID-19 pandemic in England. Euro Surveill. 2020 Jul;25(28): Authors: Sinnathamby MA, Whitaker H, Coughlan L, Lopez Bernal J, Ramsay M, Andrews N Abstract England has experienced one of the highest excess in all-cause mortality in Europe during the current COVID-19 pandemic. As COVID-19 emerged, the excess in all-cause mortality rapidly increased,...
Fri Jul 24, 2020 14:01
Publication date: Available online 23 July 2020Source: Journal of VoiceAuthor(s): João Marcos da Trindade Duarte, Glaucia Verena Sampaio de Souza, Marcia Simões-Zenari, Katia Nemr
Fri Jul 24, 2020 14:00
Related Articles The Role of Itch and Pain Modulation in the Prediction of Phototherapy Outcomes: A Prospective Cohort Study. J Dermatolog Treat. 2020 Jul 23;:1-17 Authors: Ramon M, Yakov S, Kuperman P, Granot M Abstract OBJECTIVES: Ability to predict which chronic itch patients will benefit from particular treatments is a challenge. Common features in itch and pain in respect to sensory elicitation, and mechanisms of processing including sensitization...
Fri Jul 24, 2020 13:50
Related Articles Patient-ready syringes containing 25 mg/mL methotrexate can be kept at temperature ranging from 4 °C to 37 °C for up to 12 weeks for use in psoriatic and rheumatologic conditions. J Dermatolog Treat. 2020 Jul 23;:1-19 Authors: Chularojanamontri L, Wongpraparut C, Silpa-Archa N, Chaiyabutr C, Pruksaeakanan C, Klinniyom A, Junnu S, Srisawat C Abstract Methotrexate (MTX) is a mainstay drug in the treatment of psoriatic and rheumatologic...
Fri Jul 24, 2020 13:50
Related Articles Evaluation of Plasma Exeresis as a New Technique for Non Surgical Treatment of Dermatochalasis. J Dermatolog Treat. 2020 Jul 23;:1-20 Authors: Hassan AM, Rady AAE, Shalaby OE, Shafik HM, Shaker ESE Abstract Background: Dermatochalasis is frequently associated with tissue ageing and leads to multiple functional and cosmetic issues. There are several possible medical and surgical treatments available, such as blepharoplasty and...
Fri Jul 24, 2020 13:50
Related Articles Effect of oral administration of Triphala, a polyphenol-rich prebiotic, on scalp sebum in patients with scalp seborrhea A Randomized Clinical Trial. J Dermatolog Treat. 2020 Jul 23;:1-19 Authors: Zareie E, Mansouri P, Hosseini H, Sadeghpour O, Shirbeigi L, Hejazi S, Emtiazy M Abstract Background: Although there are various therapeutic options to control oily skin, they have potential side effects and limitations especially in...
Fri Jul 24, 2020 13:50
Related Articles Ostmann's Fat Pad-Does it Really Matter? Ann Otol Rhinol Laryngol. 2020 Jul 22;:3489420943219 Authors: Biadsee A, Fanadka F, Dagan O, Firas K, Nageris B Abstract OBJECTIVE: To compare the size of Ostmann's fat pad (OFP) between healthy ears and ears with chronic otitis media with cholestatoma (COMwC) using magnetic resonance imaging (MRI). METHODS: Twenty-six patients with unilateral COMwC underwent mastoidectomy....
Fri Jul 24, 2020 13:42
Related Articles Rationing Rotational Magnet Cochlear Implant Technology in a Single Payer Healthcare System. Ann Otol Rhinol Laryngol. 2020 Jul 22;:3489420943235 Authors: Pisa J, Andrews C, Hochman JB Abstract INTRODUCTION: In a publicly funded health care system, fiscally responsible management of any program is required. This is especially pertinent as evolving technology and associated incremental costs, places pressure on device availability...
Fri Jul 24, 2020 13:42
Hypoglossal Nerve Stimulation in a Rabbit Model of Obstructive Sleep Apnea Reduces Apneas and Improves Oxygenation. J Appl Physiol (1985). 2020 Jul 23;: Authors: Schiefer M, Gamble J, Baskin JP, Strohl KP Abstract Based on a prior anesthetized model, we developed an unanesthetized model to evaluate the effects of hypoglossal nerve stimulation (HNS) during sleep. We prepared three rabbits with injections of Hyaluronic Acid in the base of tongue...
Fri Jul 24, 2020 13:39
Obstructive sleep apnea in pulmonary fibrosis. Curr Opin Pulm Med. 2020 Jul 20;: Authors: Schiza SE, Bouloukaki I, Bolaki M, Antoniou KM Abstract PURPOSE OF REVIEW: In previous years, there was limited research related to the role of sleep in interstitial lung diseases (ILDs). Physicians treating ILD patients tended to focus mainly on the daily disabling symptoms overlooking the possible significant role of coexisting sleep disorders, such...
Fri Jul 24, 2020 13:39
Related Articles Effects of central apneas on sympathovagal balance and hemodynamics at night: impact of underlying systolic heart failure. Sleep Breath. 2020 Jul 22;: Authors: Spiesshoefer J, Hegerfeld N, Gerdes MF, Klemm S, Gorbachevski M, Radke R, Tuleta I, Passino C, Jiang X, Sciarrone P, Randerath W, Dreher M, Boentert M, Giannoni A Abstract BACKGROUND: Increased sympathetic drive is the key determinant of systolic heart failure progression,...
Fri Jul 24, 2020 13:39
Related Articles Weight loss in patients with obstructive sleep apnea: an interventional procedure. Sleep Breath. 2020 Jul 22;: Authors: Kawada T PMID: 32700286 [PubMed - as supplied by publisher]
Fri Jul 24, 2020 13:39
Related Articles Jejunal-Ileal Bypass and its Complications: Case Report and Review of the Literature. Cureus. 2020 Jul 19;12(7):e9276 Authors: Khan A, Syed A, Martin D Abstract Herein, we describe an interesting case of a patient who underwent a jejunal-ileal bypass (JIB). She presented to the hospital with gastrointestinal bleeding after which her hospital course was complicated by electrolyte abnormalities. She was a 76-year-old Caucasian...
Fri Jul 24, 2020 13:39
Related Articles Sleep Apnea and Heart. Sleep Med Res. 2019 Dec;10(2):67-74 Authors: Kwon Y, Logan J, Pusalavidyasagar S, Kasai T, Cheong CS, Lee CH Abstract Scientific investigations in the past few decades have supported the important role of sleep in various domains of health. Sleep apnea is a highly prevalent yet underdiagnosed sleep disorder representing a valid cardiovascular risk factor, particularly for hypertension. While several studies...
Fri Jul 24, 2020 13:39
Related Articles Randomised, cOntrolled Multicentre trial of 26 weeks subcutaneous liraglutide (a glucagon-like peptide-1 receptor Agonist), with or without contiNuous positive airway pressure (CPAP), in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnoEa (OSA) (ROMANCE): study protocol assessing the effects of weight loss on the apnea-hypnoea index (AHI). BMJ Open. 2020 Jul 22;10(7):e038856 Authors: Sprung VS, Kemp GJ, Wilding JP, Adams...
Fri Jul 24, 2020 13:39
Related Articles An Interesting Breathing Pattern. Ann Am Thorac Soc. 2019 07;16(7):920-922 Authors: Jerkins EG, Sanapureddy P, Rodriguez OM PMID: 31259637 [PubMed - indexed for MEDLINE]
Fri Jul 24, 2020 13:39
Related Articles A Novel c.676_677insG PHOX2B Mutation in Congenital Central Hypoventilation Syndrome. J Clin Sleep Med. 2019 03 15;15(3):509-513 Authors: Ye G, Han D, Jiang Y, Wang Z, Zhou Y, Lin X, Chen W, Chen M, Xu J, Yang Y, Guo Q Abstract ABSTRACT: Paired-like homeobox (PHOX)2B is considered to be the causative gene of congenital central hypoventilation syndrome (CCHS), a dominant genetic disorder that results in abnormal central respiratory...
Fri Jul 24, 2020 13:39
Fri Jul 24, 2020 03:00
Diamond-Blackfan Anemia. Blood. 2020 Jul 23;: Authors: Da Costa LM, Leblanc TM, Narla M Abstract Diamond-Blackan anemia (DBA) is the first ribosomopathy described and one of the constitutional inherited bone marrow failure syndromes. Erythroblastopenia is the major characteristic feature of the disease, which is a model for ribosomal diseases, related to a heterozygous allelic variation in one of the 20 ribosomal protein (RP) genes of...
Fri Jul 24, 2020 13:29
DNA methylation variation in the brain of laying hens in relation to differential behavioral patterns. Comp Biochem Physiol Part D Genomics Proteomics. 2020 Jun 02;35:100700 Authors: Guerrero-Bosagna C, Pértille F, Gomez Y, Rezaei S, Gebhardt-Henrich SG, Vögeli S, Stratmann A, Voelkl B, Toscano MJ Abstract Domesticated animals are unique to investigate the contribution of genetic and non-genetic factors to specific phenotypes. Among non-genetic...
Fri Jul 24, 2020 13:29
Comprehensive analysis of the prognostic value and immune function of chemokine-CXC receptor family members in breast cancer. Int Immunopharmacol. 2020 Jul 20;87:106797 Authors: Lyu L, Zheng Y, Hong Y, Wang M, Deng Y, Wu Y, Xu P, Yang S, Wang S, Yao J, Zhang D, Guo Y, Lyu J, Dai Z Abstract Recently, immune checkpoint inhibitors (ICIs) have been successfully used for treating melanoma. Unfortunately, many breast cancer (BC) patients show...
Fri Jul 24, 2020 13:29
Anticancer property of ginsenoside Rh2 from ginseng. Eur J Med Chem. 2020 Jul 13;203:112627 Authors: Li X, Chu S, Lin M, Gao Y, Liu Y, Yang S, Zhou X, Zhang Y, Hu Y, Wang H, Chen N Abstract Ginseng has been used as a well-known traditional Chinese medicine since ancient times. Ginsenosides as its main active constituents possess a broad scope of pharmacological properties including stimulating immune function, enhancing cardiovascular...
Fri Jul 24, 2020 13:29
3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere. Chem Biol Interact. 2020 Jul 20;:109200 Authors: Kushwaha PP, Singh AK, Shuaib M, Prajapati KS, Vardhan PS, Gupta S, Kumar S Abstract Activation of Notch signaling is associated with tumor aggressiveness, poor clinical outcome and drug resistance in breast cancer patients. Targeting Notch signaling...
Fri Jul 24, 2020 13:29
Linker DNA and histone contributions in nucleosome binding by p53. J Biochem. 2020 Jul 23;: Authors: Nishimura M, Arimura Y, Nozawa K, Kurumizaka H Abstract The tumor suppressor protein p53 regulates various genes involved in cell-cycle arrest, apoptosis, and DNA repair in response to cellular stress, and apparently functions as a pioneer transcription factor. The pioneer transcription factors can bind nucleosomal DNA, where many transcription...
Fri Jul 24, 2020 13:29
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