Papillary renal cell carcinoma (PRCC) is one of the most common histological subtypes of renal cell carcinoma. Type 1 and type 2 PRCC are reported to be clinically and biologically distinct. However, little is known about immune infiltration and the expression patterns of immune-related genes in these two histologic subtypes, thereby limiting the development of immunotherapy for PRCC. Thus, we analyzed the expression of 22 immune cells in type 1 and type 2 PRCC tissues by combining The Cancer Genome...
Sun Jul 26, 2020 10:05
Background. Spinal manipulation (SM) has been widely recognized and used with success in health care fields for spinal joint dysfunction and pain. SM is a procedure that involves small amplitude manipulative thrusts performed with speed. These forces are complex three-dimensional (3-D) forces delivered to create forces and moments at the joint of interest to cause joint movements. The aim of this study was to conduct a 3-dimensional analysis of the magnitude and direction of the forces transmitted...
Sun Jul 26, 2020 09:50
Background. Birth preparedness and complication readiness (BP/CR) concept is based on the premise that preparing for birth and being ready for complications reduce all three phases of delay to a bad obstetric outcome. Objectives. To determine the knowledge of BP/CR with its determinants and BP/CR index among pregnant women in Abakaliki, southeast Nigeria. Methods. A cross-sectional survey was done between 1st March 2019 and 31st July 2019 among 450 randomly selected antenatal attendees at Mile Four...
Sun Jul 26, 2020 09:50
Knockdown of Annexin A7 (ANXA7) or C-Jun N-terminal kinase (JNK) inhibits the proliferation, migration, invasion, and lymphatic adhesion of hepatocellular carcinoma (HCC) cells, suggesting that ANXA7 and JNK signaling pathways contribute to HCC growth and lymph node metastasis (LNM). While the intervening molecular pathways are largely unknown, emerging evidence suggests that long noncoding RNAs (lncRNAs) participate in ANXA7 and JNK signaling. To identify potential therapeutic targets for HCC, we...
Sun Jul 26, 2020 09:50
Objective. This pilot study is aimed at investigating the mechanical characteristics of a cast-wrapped fractured forearm and performing a clinical comparative study of our own developed 3D-printed orthopedic cast. Methods. An integrated finite element (FE) model including a forearm and a 3D-printed cast wrapping the forearm was created. The distal radial ulna in this model was cut through to mimic the bone fracture. A 400 N force and 1 Nm rotation moment, which were much larger than the loading conditions...
Sun Jul 26, 2020 08:35
RRM2B gene encodes ribonucleoside-diphosphate reductase subunit M2 B, the p53-inducible small subunit (p53R2) of ribonucleotide reductase (RNR), an enzyme catalyzing dNTP synthesis for mitochondrial DNA. Defects in this gene may cause severe mitochondrial disease affecting mainly the nervous system. This study is aimed at examining the effect of deleterious nonsynonymous SNP (nsSNP) on the structure of the RRM2B protein, using a variety of prediction tools followed by a molecular modeling analysis....
Sun Jul 26, 2020 08:35
Sat Jul 25, 2020 18:05
Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. Methods. The OTP website version of 19.11 was accessed in...
Sat Jul 25, 2020 17:50
Noninvasive Prenatal Testing (NIPT) has advanced the detection of fetal chromosomal aneuploidy by analyzing cell-free DNA in peripheral maternal blood. The statistic -test that it utilizes, which measures the deviation of each chromosome dosage from its negative control, is now widely accepted in clinical practice. However, when a chromosome has loss and gain regions which offset each other in the -score calculation, merely using the -test for the result tends to be erroneous. To improve the performance...
Sat Jul 25, 2020 16:20
Objective. A DNA intercalating agent reversibly stacks between the adjacent base pairs of DNA and thus is expected to exhibit preferential localization in the tumorous lesions as tumors are associated with enhanced DNA replication. Therefore, radiolabeled DNA intercalators are supposed to have potential to be used in targeted tumor therapy. Working in this direction, an attempt was made to radiolabel 9-aminoacridine, a DNA intercalator, with 177Lu, one of the most useful therapeutic radionuclides,...
Sat Jul 25, 2020 15:50
Background. Rifampicin resistance (RR) is associated with mortality among tuberculosis (TB) patients coinfected with HIV. We compared the prevalence of RR among TB patients with and without HIV coinfection at the National Tuberculosis Treatment Center (NTTC) in Uganda, a TB/HIV high burdened country. We further determined associations of RR among TB/HIV-coinfected patients. Methods. In this secondary analysis, we included adult (≥18 years) bacteriologically confirmed TB patients that were enrolled...
Sat Jul 25, 2020 15:35
This study was aimed at building a computed tomography- (CT-) based radiomics approach for the differentiation of sarcomatoid renal cell carcinoma (SRCC) and clear cell renal cell carcinoma (CCRCC). It involved 29 SRCC and 99 CCRCC patient cases, and to each case, 1029 features were collected from each of the corticomedullary phase (CMP) and nephrographic phase (NP) image. Then, features were selected by using the least absolute shrinkage and selection operator regression method and the selected...
Sat Jul 25, 2020 09:50
The use of histone deacetylase (HDAC) inhibitor is a novel therapeutic strategy for cardiovascular disease. Studies have shown that many HDAC inhibitors have the ability to reduce the aortic remodeling in various animal models. We hypothesized that the HDAC inhibitor, MGCD0103 (MGCD), attenuates aortic remodeling in rats under pressure overload-induced by transverse aortic constriction (TAC). The aortic ring tension analysis was conducted using the thoracic aorta. Sections of the aorta were visualized...
Sat Jul 25, 2020 09:50
Recent studies have suggested that circular RNAs play an important role in the progression of various cancers. However, few studies have revealed the great value of circRNAs in the diagnosis and prognosis prediction of osteosarcoma (OS). In this study, we performed experiments with the human OS cell lines and the results showed that the expression of circHIPK3 in OS cell lines was significantly upregulated compared to that in the normal cell line. In addition, the results showed that circHIPK3 could...
Sat Jul 25, 2020 09:50
Background. Coffee has been the most commercialized food product and most widely consumed stimulant beverage in the world. It is a major source of caffeine which is the most bioactive component of coffee. Although both the United States Department of Agriculture and European Food Safety Authority consider daily intake of coffee which contains 400 mg of caffeine as safe for health, it causes different clinically significant pharmacokinetic interactions with many drugs. The aim of this work was to...
Sat Jul 25, 2020 09:20
Immunotherapy has been demonstrated as a promising strategy in controlling head and neck squamous cell carcinoma (HNSC). The AID/APOBEC family is well characterized as DNA mutator and considered to play critical roles in immune responses in HNSC. However, the expression pattern and deamination-dependent demethylation roles of AID/APOBECs in HNSC are unclear. In this study, the RNA-seq and DNA methylation profiles of HNSC from TCGA database and cell-based experiments were applied to analyze the relationships...
Sat Jul 25, 2020 08:05
Purpose. In our study, we aimed to screen the risk factors that affect overall survival (OS) and cancer-specific survival (CSS) in adult glioma patients and to develop and evaluate nomograms. Methods. Primary high-grade gliomas patients being retrieved from the surveillance, epidemiology and end results (SEER) database, between 2004 and 2015, then they randomly assigned to a training group and a validation group. Univariate and multivariate Cox analysis models were used to choose the variables significantly...
Sat Jul 25, 2020 08:05
Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins. This molecule, which was first described in tumors nearly two decades ago, has recently received much attention in tumor-related research because it regulates the expression of many tumor-associated molecules through posttranscriptional regulatory mechanisms, thereby affecting biological characteristics. It is suggested that HuR might be a novel therapeutic target and a marker for therapeutic response and prognostic assessment....
Fri Jul 24, 2020 17:20
Objective. Type 2 diabetic (T2D) male patients with low total testosterone (TT) levels are at an increasing risk of all-cause mortality. However, the levels of TT in male patients with latent autoimmune diabetes in adults (LADA) remain largely unknown. Research Design and Methods. This was a single-center, open, observational study. The inclusion criteria were male patients who were diagnosed with LADA, and sex, body mass index, C-peptide, and glycated hemoglobin (HbA1c) levels matched with those...
Fri Jul 24, 2020 17:20
Gliomas are the most common primary tumors in the brain with poor prognosis. Previous studies have detected high expression of Cyclophilin A (CyPA) and CD147, respectively, in glioma. However, the correlation between their expressions and glioma prognosis remains unclear. Here, we investigated the expression of CyPA and CD147 in different types of glioma and characterized their relationships with clinical features, prognosis, and cell proliferation. Results showed that CyPA and CD147 expressions...
Fri Jul 24, 2020 17:05
The polarization of macrophages and its anti-inflammatory and proinflammatory properties play a significant role in host response after implant placement to determine the outcome of osseointegration and long-term survival. In the previous study, we immobilized an antimicrobial peptide, GL13K, onto titanium surfaces to provide immune regulation property. In the herein presented study, we aimed at investigating whether GL13K immobilized titanium surface could improve osteogenesis and reduce the inflammatory...
Fri Jul 24, 2020 17:05
Aquaporins are a large family of transmembrane channel proteins that facilitate the passive but highly selective transport of water and other small solutes across biological membranes. House dust mite (Dermatophagoides farinae) is the major source of household immunogens, and we have recently reported six cDNA sequence encoding aquaporins from this mite species. To better understand the structure and role of mite aquaporin, we constructed a tertiary structure for DerfAQP1 by homology modeling from...
Fri Jul 24, 2020 10:05
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Patients with severe mental illness (SMI) are at a higher risk for developing CVD and have a higher risk for harboring factors related to CVD. In addition to the effects of antipsychotic medications, unhealthy lifestyle factors, such as poor diet, inadequate physical activity, cigarette smoking, and sedentary behaviors, are known to be risk factors that may contribute to poor cardiovascular health in patients with...
Fri Jul 24, 2020 10:05
Purpose. To investigate the factors influencing brachial-ankle pulse wave velocity (baPWV) in an apparently healthy Chinese population, especially the associations between baPWV and indices of blood pressure (BP). Methods. A total of 1123 participants with no history of hypertension were enrolled in this study, and the baPWV and BP of all four limbs were measured along with other covariates. Correlation analyses and multivariate linear regression models were used to identify factors associated with...
Fri Jul 24, 2020 09:35
Background. Long noncoding RNAs (lncRNAs) act as competing endogenous RNAs for microRNAs in cancer metastasis. However, the roles of lncRNA-mediated competing endogenous RNA (ceRNA) networks for breast cancer (BC) are still unclear. Material and Methods. The expression profiles of mRNAs, lncRNAs, and miRNAs with BC were extracted from The Cancer Genome Atlas database. Weighted gene coexpression network analysis was conducted to extract differentially expressed mRNAs (DEmRNAs) that might be core genes....
Fri Jul 24, 2020 09:20
Protaryx Medical, a company based in Baltimore, Maryland, has developed a device to allow for more precise transseptal access to the left atrium during transcatheter procedures. The device provides three-dimensional control and steerability to take the guesswork out of transseptal access to the left atrium, and the company believes that this could improve physician convenience and reduce the chances of complications during such procedures. Transseptal access to the left atrium is required...
Fri Jul 24, 2020 23:11
Palliare, a company out of Galway, Ireland, won FDA clearance for its flagship product, the EVA15 insufflator and smoke evacuation system. The EVA15 combines two devices into a compact package that is designed for use in laparoscopic, endoscopic, endolumenal, and robotic procedures. Smoke is a common problem in all kinds of minimally invasive procedures that involve ablation, cauterization, and other kinds of tissue manipulation. Smoke makes it difficult to see the surgical scene,...
Fri Jul 24, 2020 22:51
Guide dogs can be incredibly helpful, letting blind people maintain a level of independence that would be difficult without their loyalty. However, guide dogs require a huge amount of training and, because they’re dogs, are not practical for every blind person. Now, a student at Loughborough University in England has designed a concept handheld device that can do some of the tasks of a guide dog. The electronic tool is called Theia and it features gyroscope-based technology to pull...
Fri Jul 24, 2020 19:20
Publication date: Available online 23 July 2020Source: Medical Image AnalysisAuthor(s): Wei Shao, Tongxin Wang, Liang Sun, Tianhan Dong, Zhi Han, Zhi Huang, Jie Zhang, Daoqiang Zhang, Kun Huang
Fri Jul 24, 2020 18:48
Background Humic substances (HS) are compounds with a complicated structure, present in the humus soil layer, water, lake sediments, peat, brown coal and shales. Due to their similar physicochemical properties to DNA, they may have an adverse effect on the subsequent use of the isolated material. The main aim of this research was to examine the effect of HS on DNA isolation depending on the soil type and land use, taking into account the spectroscopic full characteristics of HS fractions. ...
Fri Jul 24, 2020 03:00
In birds the auditory system plays a key role in providing the sensory input used to discriminate between conspecific and heterospecific vocal signals. In those species that are known to learn their vocalizations, for example, songbirds, it is generally considered that this ability arises and is manifest in the forebrain, although there is no a priori reason why brainstem components of the auditory system could not also play an important part. To test this assumption, we used groups of normal reared...
Fri Jul 24, 2020 03:00
Lethal measures are widely adopted by local communities and governments to manage human-wildlife conflicts. Such measures lead to large scale decline of carnivore populations globally with trophic cascades on ecosystems and questionable impacts on human-wildlife conflicts. Mitigating human-carnivore conflicts through non-lethal measures will protect endangered predators and secure livelihoods. However, information on the effectiveness of such measures are extremely limited and hence cannot be applied...
Fri Jul 24, 2020 03:00
Objectives Medications with anticholinergic or sedative effects are frequently used by older people but can increase risk of falls and adverse events; however, less is known about their effect on movement behaviour. Here we examine the cross-sectional association between medication use and movement behaviour in older adults living in residential aged care. Materials and Methods Twenty-eight older adults living in residential...
Fri Jul 24, 2020 03:00
Publication date: Available online 25 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jaroslaw T. Hepel, Kara L. Leonard, Sandra Sha, Theresa A. Graves, Doreen L. Wiggins, Dean Mastras, Ann Pittier, Brown University Oncology Research Group, David E. Wazer
Sun Jul 26, 2020 15:06
Publication date: Available online 25 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Theodora A. Koulis, Alan M. Nichol, Pauline T. Truong, Caroline Speers, Lovedeep Gondara, Scott Tyldesley, Caroline Lohrisch, Lorna Weir, Robert A. Olson
Sun Jul 26, 2020 15:06
Publication date: Available online 24 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Matthew G. Parry, Julie Nossiter, Thomas E. Cowling, Arunan Sujenthiran, Brendan Berry, Paul Cathcart, Noel W. Clarke, Heather Payne, Jan van der Meulen, Ajay Aggarwal
Sat Jul 25, 2020 13:16
Publication date: Available online 23 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Nikhil T. Sebastian, Eric D. Miller, Xiangyu Yang, Dayssy Alexandra Diaz, Yubo Tan, Joshua Dowell, James Spain, Ali Rikabi, Eric Elliott, Michael Knopp, Terence M. Williams
Fri Jul 24, 2020 18:13
Publication date: Available online 23 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Abdallah S.R. Mohamed, Renjie He, Yao Ding, Jihong Wang, Joly Fahim, Baher Elgohari, Hesham Elhalawani, Andrew D. Kim, Hoda Ahmed, Jose A. Garcia, Jason M. Johnson, R. Jason Stafford, James A. Bankson, Mark S. Chambers, Vlad C. Sandulache, Clifton D. Fuller, Stephen Y. Lai
Fri Jul 24, 2020 18:13
Publication date: Available online 23 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Tomoki Kimura, Atsuya Takeda, Yuichiro Tsurugai, Reo Kawano, Yoshiko Doi, Yohei Oku, Kazunari Hioki, Hideharu Miura, Yasushi Nagata
Fri Jul 24, 2020 18:13
Publication date: Available online 23 July 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Michelle D. Tibbs, Minh-Phuong Huynh-Le, Roshan Karunamuni, Anny Reyes, Anna Christina Macari, Kathryn R. Tringale, Mia Salans, Anthony Yip, Eulanca Liu, Aaron Simon, Carrie R. McDonald, Jona A. Hattangadi-Gluth
Fri Jul 24, 2020 18:13
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