Cancers, Vol. 12, Pages 2007: Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients Cancers doi: 10.3390/cancers12082007 Authors: Martínez Villarreal Gantchev Lagacé Barolet Sasseville Ødum Charli-Joseph Hernández Salazar Litvinov Hypopigmented mycosis fungoides (HMF) is a form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of extranodal non-Hodgkin’s lymphomas. HMF has a unique...
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 2005: Clinical and Pre-Clinical Evidence of Carbonic Anhydrase IX in Pancreatic Cancer and Its High Expression in Pre-Cancerous Lesions Cancers doi: 10.3390/cancers12082005 Authors: Sabina Strapcova Martina Takacova Lucia Csaderova Paola Martinelli Lubomira Lukacikova Viliam Gal Juraj Kopacek Eliska Svastova Hypoxia is a common phenomenon that occurs in most solid tumors. Regardless of tumor origin, the evolution of a hypoxia-adapted phenotype...
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 2002: Targeting STAT3 and STAT5 in Cancer Cancers doi: 10.3390/cancers12082002 Authors: Elvin D. de Araujo György M. Keserű Patrick T. Gunning Richard Moriggl Insights into the mutational landscape of the human cancer genome coding regions defined about 140 distinct cancer driver genes in 2013, which approximately doubled to 300 in 2018 following advances in systems cancer biology studies [...]
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 2003: Methylation Patterns and Chromatin Accessibility in Neuroendocrine Lung Cancer Cancers doi: 10.3390/cancers12082003 Authors: Elsa Arbajian Mattias Aine Anna Karlsson Johan Vallon-Christersson Hans Brunnström Josef Davidsson Sofie Mohlin Maria Planck Johan Staaf Lung cancer is the worldwide leading cause of death from cancer. Epigenetic modifications such as methylation and changes in chromatin accessibility are major gene regulatory...
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 2004: Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression Cancers doi: 10.3390/cancers12082004 Authors: María Alejandra Parigiani Anett Ketscher Sylvia Timme Peter Bronsert Manuel Schlimpert Bernd Kammerer Arnaud Jacquel Paul Chaintreuil Thomas Reinheckel Background: Cathepsin L (Ctsl) is a cysteine protease mainly located within the endosomal/lysosomal cell compartment....
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 2006: Ex Vivo Models Simulating the Bone Marrow Environment and Predicting Response to Therapy in Multiple Myeloma Cancers doi: 10.3390/cancers12082006 Authors: Konstantinos Papadimitriou Ioannis V. Kostopoulos Anastasia Tsopanidou Nikolaos Orologas-Stavrou Efstathios Kastritis Ourania Tsitsilonis Meletios A. Dimopoulos Evangelos Terpos Multiple myeloma (MM) remains incurable despite the abundance of novel drugs. As it has been previously...
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 2000: Discovery of Prognostic Markers for Early-Stage High-Grade Serous Ovarian Cancer by Maldi-Imaging Cancers doi: 10.3390/cancers12082000 Authors: Hagen Kulbe Oliver Klein Zhiyang Wu Eliane T. Taube Wanja Kassuhn David Horst Silvia Darb-Esfahani Paul Jank Salem Abobaker Frauke Ringel Andreas du Bois Florian Heitz Jalid Sehouli Elena I. Braicu With regard to relapse and survival, early-stage high-grade serous ovarian (HGSOC)...
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 2001: Genomic Alterations and Their Implications on Survival in Nonmetastatic Colorectal Cancer: Status Quo and Future Perspectives Cancers doi: 10.3390/cancers12082001 Authors: Reetu Mukherji John L. Marshall Andreas Seeber The selection of treatment according to genomic alterations is a standard approach in metastatic colorectal cancer but is only starting to have an impact in the earlier stages of the disease. The status if genes like KRAS, BRAF, and...
Wed Jul 22, 2020 03:00
Cancers, Vol. 12, Pages 1999: Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells Cancers doi: 10.3390/cancers12081999 Authors: Cesarina Giallongo Daniele Tibullo Fabrizio Puglisi Alessandro Barbato Nunzio Vicario Daniela Cambria Nunziatina Laura Parrinello Alessandra Romano Concetta Conticello Stefano Forte Rosalba Parenti Angela Maria Amorini Giuseppe Lazzarino Giovanni Li Volti Giuseppe...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1760: Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP Cells doi: 10.3390/cells9081760 Authors: Elmallah Cogo Constantinescu Elifio-Esposito Abdelfattah Micheau Resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis represents the major hurdle to the clinical use of TRAIL or its derivatives....
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1758: The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer Cells doi: 10.3390/cells9081758 Authors: Anitha Chellamuthu Steven G. Gray 5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs. Moreover, this modification...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1757: Engineering the Bridge between Innate and Adaptive Immunity for Cancer Immunotherapy: Focus on γδ T and NK Cells Cells doi: 10.3390/cells9081757 Authors: Fabio Morandi Mahboubeh Yazdanifar Claudia Cocco Alice Bertaina Irma Airoldi Most studies on genetic engineering technologies for cancer immunotherapy based on allogeneic donors have focused on adaptive immunity. However, the main limitation of such approaches is that they can lead to severe graft-versus-host...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1756: DNC4mC-Deep: Identification and Analysis of DNA N4-Methylcytosine Sites Based on Different Encoding Schemes By Using Deep Learning Cells doi: 10.3390/cells9081756 Authors: Abdul Wahab Omid Mahmoudi Jeehong Kim Kil To Chong N4-methylcytosine as one kind of modification of DNA has a critical role which alters genetic performance such as protein interactions, conformation, stability in DNA as well as the regulation of gene expression same cell developmental...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1753: Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages Cells doi: 10.3390/cells9081753 Authors: Bhakta Prasad Gaire Chi-Ho Lee Wondong Kim Arjun Sapkota Do Yup Lee Ji Woong Choi The pathogenesis of psoriasis, an immune-mediated chronic skin barrier disease, is not fully understood yet. Here, we identified lysophosphatidic acid (LPA) receptor 5 (LPA5)-mediated...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1759: Effects of Adult Müller Cells and Their Conditioned Media on the Survival of Stem Cell-Derived Retinal Ganglion Cells Cells doi: 10.3390/cells9081759 Authors: Xandra Pereiro Adam M. Miltner Anna La Torre Elena Vecino Retinal neurons, particularly retinal ganglion cells (RGCs), are susceptible to the degenerative damage caused by different inherited conditions and environmental insults, leading to irreversible vision loss and, ultimately, blindness....
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1749: Polyamines and Their Biosynthesis/Catabolism Genes are Differentially Modulated in Response to Heat Versus Cold Stress in Tomato Leaves (Solanum lycopersicum L.) Cells doi: 10.3390/cells9081749 Authors: Rakesh K. Upadhyay Tahira Fatima Avtar K. Handa Autar K. Mattoo Polyamines (PAs) regulate growth in plants and modulate the whole plant life cycle. They have been associated with different abiotic and biotic stresses, but little is known about the molecular...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1754: RTH-149 Cell Line, a Useful Tool to Decipher Molecular Mechanisms Related to Fish Nutrition Cells doi: 10.3390/cells9081754 Authors: Guillaume Morin Karine Pinel Karine Dias Iban Seiliez Florian Beaumatin Nowadays, aquaculture provides more than 50% of fish consumed worldwide but faces new issues that challenge its sustainability. One of them relies on the replacement of fish meal (FM) in aquaculture feeds by other protein sources without deeply...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1751: Biological and Medical Importance of Cellular Heterogeneity Deciphered by Single-Cell RNA Sequencing Cells doi: 10.3390/cells9081751 Authors: Rishikesh Kumar Gupta Jacek Kuznicki The present review discusses recent progress in single-cell RNA sequencing (scRNA-seq), which can describe cellular heterogeneity in various organs, bodily fluids, and pathologies (e.g., cancer and Alzheimer’s disease). We outline scRNA-seq techniques that are suitable...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1752: miRTil: An Extensive Repository for Nile Tilapia microRNA Next Generation Sequencing Data Cells doi: 10.3390/cells9081752 Authors: Luiz Augusto Bovolenta Danillo Pinhal Marcio Luis Acencio Arthur Casulli de Oliveira Simon Moxon Cesar Martins Ney Lemke Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1750: Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes Cells doi: 10.3390/cells9081750 Authors: Parimah Ahmadi Philip Hartjen Matin Kohsar Silke Kummer Stefan Schmiedel Jan-Hendrik Bockmann Anahita Fathi Samuel Huber Friedrich Haag Julian Schulze zur Wiesch The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1755: Fibroblast Growth Factor—14 Acts as Tumor Suppressor in Lung Adenocarcinomas Cells doi: 10.3390/cells9081755 Authors: Kati Turkowski Frederik Herzberg Stefan Günther David Brunn Andreas Weigert Michael Meister Thomas Muley Mark Kriegsmann Marc A. Schneider Hauke Winter Michael Thomas Friedrich Grimminger Werner Seeger Soni Savai Pullamsetti Rajkumar Savai Investigation of the molecular dynamics in lung cancer is crucial...
Wed Jul 22, 2020 03:00
Cells, Vol. 9, Pages 1748: Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H2S/Cav3.2 Signaling in Mice Cells doi: 10.3390/cells9081748 Authors: Shiori Hiramoto Maho Tsubota Kaoru Yamaguchi Kyoko Okazaki Aya Sakaegi Yuki Toriyama Junichi Tanaka Fumiko Sekiguchi Hiroyasu Ishikura Hidenori Wake Masahiro Nishibori Huy Du Nguyen Takuya Okada Naoki Toyooka Atsufumi Kawabata Cystitis-related bladder...
Wed Jul 22, 2020 03:00
Diagnostics, Vol. 10, Pages 508: Exploring Anatomic Variants to Enhance Anatomy Teaching: Musculus Sternalis Diagnostics doi: 10.3390/diagnostics10080508 Authors: Andrew J. Petto David E. Zimmerman Elizabeth K. Johnson Lucas Gauthier James T. Menor Nicholas Wohkittel The opportunity to encounter and appreciate the range of human variation in anatomic structures—and its potential impact on related structures, function, and treatment—is one of the chief...
Wed Jul 22, 2020 03:00
Diagnostics, Vol. 10, Pages 509: Capillary-Driven Flow Microfluidics Combined with Smartphone Detection: An Emerging Tool for Point-of-Care Diagnostics Diagnostics doi: 10.3390/diagnostics10080509 Authors: Sammer-ul Hassan Aamira Tariq Zobia Noreen Ahmed Donia Syed Z. J. Zaidi Habib Bokhari Xunli Zhang Point-of-care (POC) or near-patient testing allows clinicians to accurately achieve real-time diagnostic results performed at or near to the patient site. The outlook...
Wed Jul 22, 2020 03:00
Diagnostics, Vol. 10, Pages 507: The Utility of Endoscopic Ultrasound Fine Needle Aspiration in Pancreatic Cystic Lesions Diagnosis Diagnostics doi: 10.3390/diagnostics10080507 Authors: Tawfik Khoury Anas Kadah Amir Mari Bahir Sirhan Mahmud Mahamid Wisam Sbeit The yield of biochemical analysis of pancreatic cysts fluid obtained via fine needle aspiration (FNA) is limited. We aimed to assess whether biochemical cyst analysis correlates with the endoscopic ultra-sonographic...
Wed Jul 22, 2020 03:00
Diagnostics, Vol. 10, Pages 506: X-Ray and CT Scan Based Prediction of Best Fit Tracheostomy Tube—A Pilot Study Diagnostics doi: 10.3390/diagnostics10080506 Authors: Mel Corbett Isobel Hughes John O’Shea Matthew G. Davey Jane Savage Joseph Hughes Fintan Wallis Tracheostomy is a commonly performed intervention in patients requiring ventilatory support. The insertion of inappropriately sized tracheostomy tubes carries a risk of decannulation, tissue damage, ventilatory...
Wed Jul 22, 2020 03:00
Diversity, Vol. 12, Pages 286: Rotating Arrays of Orchid Flowers: A Simple and Effective Method for Studying Pollination in Food Deceptive Plants Diversity doi: 10.3390/d12080286 Authors: Daniela Scaccabarozzi Andrea Galimberti Kingsley W. Dixon Salvatore Cozzolino Floral deception has been observed in several genera in angiosperms, but is most common in the Orchidaceae. Pollination mechanisms in food deceptive plants are often difficult to assess, as visitation frequency by...
Wed Jul 22, 2020 03:00
Foods, Vol. 9, Pages 970: Triacylglycerols and Fatty Acid Compositions of Cucumber, Tomato, Pumpkin, and Carrot Seed Oils by Ultra-Performance Convergence Chromatography Combined with Quadrupole Time-of-Flight Mass Spectrometry Foods doi: 10.3390/foods9080970 Authors: Yanfang Li Fanghao Yuan Yanbei Wu Yaqiong Zhang Boyan Gao Liangli Yu The triacylglycerol (TAG) compositions of cucumber, tomato, pumpkin, and carrot seed oils were analyzed using ultra-performance convergence...
Wed Jul 22, 2020 03:00
Foods, Vol. 9, Pages 971: Improving the Stability of Lycopene from Chemical Degradation in Model Beverage Emulsions: Impact of Hydrophilic Group Size of Emulsifier and Antioxidant Polarity Foods doi: 10.3390/foods9080971 Authors: Jinhyuk Kim Seung Jun Choi The chemical stability of the lipophilic bioactives encapsulated in emulsions can be influenced by emulsion droplet interfacial characteristics as well as by the ability of antioxidants incorporated in emulsion to prevent the degradation...
Wed Jul 22, 2020 03:00
Foods, Vol. 9, Pages 969: Using Multiple Sensory Profiling Methods to Gain Insight into Temporal Perceptions of Pea Protein-Based Formulated Foods Foods doi: 10.3390/foods9080969 Authors: Audrey Cosson Isabelle Souchon Julia Richard Nicolas Descamps Anne Saint-Eve The food industry is focused on creating plant-based foods that incorporate pea protein isolates. However, pea protein isolates are often described as having persistent beany, bitter, and astringent notes that can...
Wed Jul 22, 2020 03:00
Foods, Vol. 9, Pages 968: Investigation of Raman Spectroscopy (with Fiber Optic Probe) and Chemometric Data Analysis for the Determination of Mineral Content in Aqueous Infant Formula Foods doi: 10.3390/foods9080968 Authors: Ming Zhao Saif Shaikh Renxi Kang Maria Markiewicz-Keszycka This study investigated the use of Raman spectroscopy (RS) and chemometrics for the determination of eight mineral elements (i.e., Ca, Mg, K, Na, Cu, Mn, Fe, and Zn) in aqueous infant formula (INF)....
Wed Jul 22, 2020 03:00
Foods, Vol. 9, Pages 967: Impact of Cooking on Bioactive Compounds and Antioxidant Activity of Pigmented Rice Cultivars Foods doi: 10.3390/foods9080967 Authors: Daniela Fracassetti Carola Pozzoli Sara Vitalini Antonio Tirelli Marcello Iriti Pigmented rice cultivars, namely Venere and Artemide, are a source of bioactive molecules, in particular phenolics, including anthocyanins, exerting a positive effect on cardiovascular systems thanks also to their antioxidant capacity....
Wed Jul 22, 2020 03:00
Foods, Vol. 9, Pages 966: Audiovisual Crossmodal Correspondence between Bubbles’ Size and Pouring Sounds’ Pitch in Carbonated Beverages Foods doi: 10.3390/foods9080966 Authors: Jérémy Roque Jérémie Lafraire Malika Auvray Visual and auditory carbonation have been separately documented as being two sensory markers of perceived freshness in beverages. The aim of the present study is to investigate the cross-modal interactions between these two dimensions of carbonation. Three experiments...
Wed Jul 22, 2020 03:00
GastrointestDisord, Vol. 2, Pages 212-235: Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients Gastrointestinal Disorders doi: 10.3390/gidisord2030022 Authors: Lampis Ghidini Ratti Mirchev Okuducu Valeri Hahne Circulating tumour DNAs and non-coding RNAs present in body fluids have been under investigation as tools for cancer diagnosis, disease monitoring, and prognosis for many years. These so-called...
Wed Jul 22, 2020 03:00
GastrointestDisord, Vol. 2, Pages 202-211: Should the Glu Be Ten or Twenty? An Update on the Ongoing Debate on Gluten Safety Limits for Patients with Celiac Disease Gastrointestinal Disorders doi: 10.3390/gidisord2030021 Authors: Spector Cohen Day Shaoul The only currently accepted and recommended treatment for individuals diagnosed with celiac disease (CD) is a strict life-long gluten-free diet (GFD). While the use of the GFD is well-established, strict adherence to diet is...
Wed Jul 22, 2020 03:00
Healthcare, Vol. 8, Pages 222: Guidelines for the Evaluation of Cardiorespiratory Physiotherapy in Stroke Patients Healthcare doi: 10.3390/healthcare8030222 Authors: Sung-Hyoun Cho Ki-Bok Choi Evaluation of stroke patients is prioritized over therapeutic interventions to restore cardiorespiratory capacity. This study aimed to develop a clinically applicable guideline to evaluate cardiorespiratory physiotherapy in stroke patients based on a literature review and a modified Delphi survey....
Wed Jul 22, 2020 03:00
Healthcare, Vol. 8, Pages 223: Impact of South Korea’s Comprehensive Nursing Service Policy on Nurse and Patient Outcomes Healthcare doi: 10.3390/healthcare8030223 Authors: Seon Heui Lee Soyoung Yu Miok Kim Hee Sun Kim In some Asian and African countries, caregivers of patients are permitted to reside in hospital rooms and support the daily tasks of patient care. To solve the various problems that this system could cause, the Korean government has established a comprehensive...
Wed Jul 22, 2020 03:00
Humanities, Vol. 9, Pages 68: The View from the Sea: The Power of a Blue Comparative Literature Humanities doi: 10.3390/h9030068 Authors: Katie Ritson This paper advocates for a blue comparative literature that uses the view from the sea to provide new axes for comparison. Roy Jacobsen’s De usynlige (The Unseen, 2013) and Sarah Moss’s Night Waking (2011) explore subsistence lives on small islands in the northern Atlantic at different moments in the past, when inhabitants...
Wed Jul 22, 2020 03:00
Humanities, Vol. 9, Pages 67: Learning an Inclusive Blue Humanities: Oceania and Academia through the Lens of Cinema Humanities doi: 10.3390/h9030067 Authors: James L. Smith Steve Mentz Hollywood films such as Pixar’s Moana (2016) and Warner Brothers’ Aquaman (2018) have drawn on the aesthetics and stories of the island cultures of Oceania to inform their narratives. In doing so, these works have both succeeded and failed to respect and engage with oceanic cultural...
Wed Jul 22, 2020 03:00
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