Related Articles Unforeseen N2 Disease after Negative Endosonography Findings with or without Confirmatory Mediastinoscopy in Resectable Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. J Thorac Oncol. 2019 06;14(6):979-992 Authors: Bousema JE, van Dorp M, Noyez VJJM, Dijkgraaf MGW, Annema JT, van den Broek FJC Abstract INTRODUCTION: Confirmatory mediastinoscopy after negative endosonography findings is advised by the guidelines...
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Publication date: Available online 21 July 2020Source: Journal of Surgical EducationAuthor(s): James Ashcroft, Aimee Wilkinson, Mansoor Khan
Publication date: Available online 21 July 2020Source: Journal of Surgical EducationAuthor(s): Benjamin Young, Andrew Pouw, Amanda Redfern, Fei Cai, Jessica Chow
Publication date: Available online 21 July 2020Source: Journal of Surgical EducationAuthor(s): Karen J Dickinson, Brian J Dunkin, Barbara L Bass, Aman B Ali, J. Joseph Nguyen-Lee, Stephanie Zajac
Publication date: Available online 21 July 2020Source: Journal of Surgical EducationAuthor(s): Mohamed S. Baloul, Vicky J.-H. Yeh, Fareeda Mukhtar, Dhanya Ramachandran, David R. Farley, Mariela Rivera
Publication date: Available online 21 July 2020Source: Journal of Surgical EducationAuthor(s): Oday Obaid, Jason Zimmermann, Guillermo Ares
Publication date: Available online 21 July 2020Source: Journal of Surgical EducationAuthor(s): Anna B. Newcomb, Margaret Duval, Sharon L Bachman, Denise Mohess, Jonathan Dort, Muneera R. Kapadia
Publication date: Available online 21 July 2020Source: Journal of Surgical EducationAuthor(s): Peter J. Abraham, Mackenzie N. Abraham, Britney L. Corey, Brenessa Lindeman, Herbert Chen
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Presented here is a protocol to discover the overexpressed driver genes maintaining the established cancer stem-like cells derived from colorectal HT29 cells. RNAseq with available bioinformatics was performed to investigate and screen gene expression networks for elucidating a potential mechanism involved in the survival of targeted tumor cells.
This work presents a protocol to administrate Spanish Curriculum-Based Measures for the early detection of reading, math, and writing difficulties. These tools could help practitioners and applied researchers working in the context of the Response to Intervention model.
This study investigated the biomechanical characteristics of the lower extremity kinematic variables between the initial and terminal phase of 5 km treadmill running. The lower-limb kinematic data of 10 runners were collected using a three-dimensional motion capture system on a treadmill at the initial phase (0.5 km) and the terminal phase (5 km), respectively.
New routes for the synthesis of nitrogen-containing heterocycles utilizing cercosporin as a metal-free photocatalyst were developed.
We present a freely available workflow built for rapid exploration and accurate analysis of cellular bodies in specific cell compartments in fluorescence microscopy images. This user-friendly workflow is designed on the open-source software Icy and also uses ImageJ functionalities. The pipeline is affordable without knowledge in image analysis.
This method demonstrates use of the northern hybridization technique to detect miRNAs from total RNA extract.
Recombinant BDNF containing an Avi sequence (BDNFAvi) is produced in HEK293 cells in a cost-effective manner and is purified by affinity chromatography. BDNFavi is then directly mono-biotinylated with the enzyme BirA in a tube. BDNFavi and mono-biotinylated BDNFavi retain their biological activity when compared to commercially available BDNF.
This paper reports that the addition of Y-27632 to TIVA medium can significantly increase the yield of melanocytes from adult skin tissues.
The article describes quantification of 1) the size and number of focal adhesions and 2) cell shape index and its distribution from confocal images of the confluent monolayers of MCF7 cells.
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Specific inhalation challenge (SIC) is the reference standard for the diagnosis of occupational asthma. Current guidelines for identifying late asthmatic reactions are not evidence based.ObjectivesTo identify the fall in forced expiratory volume in 1 s (FEV1) required following SIC to exceed the 95% CI for control days, factors which influence this and to show how this can be applied in routine practice using a statistical method based on the pooled SD for FEV1 from three control days.MethodsFifty...
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Related Articles Nuclei detection in hepatocellular carcinoma and dysplastic liver nodules in histopathology images using bootstrap regression. Histol Histopathol. 2020 Jul 21;:18240 Authors: Kalinathan L, Kathavarayan RS, Kanmani M, Dinakaran N Abstract Hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm of the liver representing the fifth most common malignancy worldwide. This tumor is more common in men than women,...
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Related Articles An automated assessment system of limits of detection and quantitation in gradient high-performance liquid chromatography with ultraviolet detection. J Chromatogr A. 2020 Jun 21;1621:461077 Authors: Kotani A, Hakamata H, Hayashi Y Abstract A previous paper of this series of study put forward a basic model of an automated system for predicting detection limits and showed its application to a simple example of isocratic high-performance...
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Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveWe investigated factors affecting the disability assessment Longshi scale, and differences between the Longshi and Barthel scales, as well as modified Rankin scale (mRS), to determine whether the Longshi scale is superior to the other scales.MethodsThis cross-sectional study included 721 participants with disability. We performed the t-test, analysis of variance, Pearson’s correlation test, and multiple linear regression...
Wed Jul 22, 2020 15:10
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveTo explore concomitant neuroimaging and genetic alterations in patients with schizophrenia with or without auditory verbal hallucinations (AVHs), and to discuss the use of pattern recognition techniques in the development of an objective index that may improve diagnostic accuracy and treatment outcomes for schizophrenia.MethodsThe pilot study included patients with schizophrenia with AVHs (SCH-AVH group) and without...
Wed Jul 22, 2020 13:29
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectivePro-gastrin releasing peptide (ProGRP) plays an oncogenic role in small cell lung cancer (SCLC). The anti-ProGRP(31-98) monoclonal antibody D-D3 can selectively accumulate in SCLC xenografts in nude mice. This study evaluated the effectiveness of a new pretargeting procedure for the early diagnosis of SCLC.MethodsD-D3 was radiolabeled with technetium-99m (99mTc) using a three-step pretargeting method. Mice with SCLC...
Tue Jul 21, 2020 15:33
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveCardiovascular autonomic neuropathy is highly prevalent in patients with end-stage renal disease (ESRD), and it has a high fatality rate. This study aimed to determine whether peritoneal dialysis (PD) improves cardiovascular autonomic function (CAF) and decreases protein-bound uremic toxin (indoxyl sulfate [IS], p-cresyl sulfate [PCS]) levels.MethodsIS and PCS levels, and parameters of CAF (heart rate response to deep...
Tue Jul 21, 2020 15:33
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveTo investigate the association of body mass index (BMI) with multivessel coronary artery disease in patients with myocardial infarction.MethodsThis study was performed in 1566 patients with myocardial infarction in the Department of Cardiology, Affiliated Hospital of Jining Medical University, China. Independent and dependent variables were BMI measured at baseline and multivessel coronary artery disease, respectively....
Tue Jul 21, 2020 15:33
Journal of International Medical Research, Volume 48, Issue 7, July 2020. Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection with a mortality rate as high as 30% to 50%. However, the incidence rate of NF after liposuction is extremely low. In the current case report, we describe a woman with NF who developed multiple organ dysfunction syndrome (MODS) after fat acquisition. The aim of this paper is to summarize the management of these patients. After debridement and drainage,...
Tue Jul 21, 2020 15:33
Journal of International Medical Research, Volume 48, Issue 7, July 2020. We herein report two cases of primary adrenal insufficiency (AI) associated with antiphospholipid syndrome (APS). In both patients, the main finding that led to the diagnosis was hyponatraemia. The major difference between the two cases was the time at which AI evolved during the course of APS. In the first patient, AI developed acutely along with other presenting features of APS. In the second patient, the AI was unmasked...
Tue Jul 21, 2020 15:33
Journal of International Medical Research, Volume 48, Issue 7, July 2020. AimsPrevious studies suggest that small intestinal bacterial overgrowth (SIBO) is associated with type 2 diabetes. However, few studies have evaluated the association between SIBO and beta-cell function in type 2 diabetes. The aim of this study was to evaluate whether beta-cell function was associated with SIBO.Materials and methodsOne hundred four patients with type 2 diabetes were included in this study. Based on the presence...
Tue Jul 21, 2020 14:35
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveThis prospective study was designed to develop and internally validate an accurate prognostic nomogram model with which to predict the adverse outcomes of preterm preeclampsia.MethodsPregnant women with preeclampsia were divided into the adverse outcome group and the no adverse outcome group. The Kaplan–Meier method, univariate Cox regression analysis, and calculation of the concordance index (C-index) were applied...
Tue Jul 21, 2020 14:33
Journal of International Medical Research, Volume 48, Issue 7, July 2020. BackgroundFibrocalculous pancreatic diabetes (FCPD), an uncommon form of secondary diabetes, is caused by chronic nonalcoholic calcific pancreatitis and primarily occurs in tropical countries.ObjectiveTo present our first-hand experiences in the diagnosis and management of FCPD in two patients from a non-tropical location.Case reportTwo male Chinese patients (29 and 32 years old) presented with poor insulin function, negative...
Tue Jul 21, 2020 14:33
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveHaemophilia A and B are disorders caused by the lack of clotting factors VIII and IX, respectively. Repeated bleeding into the same joint leads to haemophilic arthropathy (HA). Interleukin (IL)-1β is responsible for the pro-inflammatory response and IL-37 is induced by IL-1β stimuli to have an anti-inflammatory response and prevent uncontrolled inflammation and tissue damage. Our objective was to investigate plasma...
Tue Jul 21, 2020 14:32
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveThe aim of the current study was to evaluate the value of plasma endostatin for predicting 30-day mortality of patients with acute kidney injury (AKI).MethodsPatients who underwent non-cardiac major surgery and developed AKI in the first 48 hours after admission to the intensive care unit were consecutively included. Concentrations of plasma neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys C), and...
Tue Jul 21, 2020 14:31
Journal of International Medical Research, Volume 48, Issue 7, July 2020. BackgroundSpontaneous hemopneumothorax (SHP) is defined as the accumulation of >400 mL of blood in the pleural cavity in association with spontaneous pneumothorax. This rare clinical disorder may be life-threatening.Case presentationA 71-year-old woman presented with a 1-month history of recurrent bloody stool, and electronic colonoscopy suggested a rectal mass. Laparoscopic radical resection of rectal cancer was performed....
Tue Jul 21, 2020 13:49
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveTo compare the effect of two prophylactic euvolemic fluid strategy regimens on the incidence of cerebral vasospasm and clinical outcomes in patients with aneurysmal subarachnoid hemorrhage (SAH).MethodsNinety-six patients with a basal intravenous intake of 15 mL/kg/day of Ringer’s lactate solution were included, and an additional 15 to 50 mL/kg/day Ringer’s lactate (RL-group) or hydroxyethyl starch 130/0.4 solution...
Tue Jul 21, 2020 11:10
Journal of International Medical Research, Volume 48, Issue 7, July 2020. Branchial cleft abnormality is a common congenital neck malformation in children, which is caused by the abnormal development of the gill sac or gill groove. It is mainly manifested as a cyst in the sinus tract and fistula in the neck, as well as branchio-oto-renal syndrome (BORS). As a rare autosomal dominant genetic disease, the typical manifestations of BORS are hearing loss, abnormal branchial cleft development and renal...
Tue Jul 21, 2020 10:31
Journal of International Medical Research, Volume 48, Issue 7, July 2020. ObjectiveTo investigate the expression of glycosphingolipids in serum and tissue from patients with cholangiocarcinoma compared with healthy controls.MethodsNanospray ionization-linear ion trap mass spectrometry (NSI-MSn) was used to demonstrate the comparative structural glycomics of glycosphingolipids in serum from patients with cholangiocarcinoma (n=15), compared with healthy controls (n = 15). GM2 expression in cholangiocarcinoma...
Tue Jul 21, 2020 07:50
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Related Articles Molecular Dynamics in Esophageal Adenocarcinoma: Who's in Control? Curr Cancer Drug Targets. 2020 Jul 19;: Authors: Dang T, Chai J Abstract Esophageal adenocarcinoma (EAC) is one of the fastest-growing cancers in the world. It occurs primarily due to the chronic gastroesophageal reflux disease (GERD), during which the esophageal epithelium is frequently exposed to the acidic fluid coming up from the stomach. This triggers gene...
Related Articles Tumor-induced Metabolism and T Cells Located in Tumor Environment. Curr Cancer Drug Targets. 2020 Jul 19;: Authors: Iranparast S, Tayebi S, Ahmadpour F, Yousefi B Abstract Several subtypes of T cells are located in a tumor environment, each of which supplies their energy using different metabolic mechanisms. Since the cancer cells require high levels of glucose, the conditions of food poverty in the tumor environment can cause...
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Conditions: Thyroid Cancer; ThyroidectomyIntervention: Behavioral: Use of a virtual reality headsetSponsor: Centre Francois BaclesseNot yet recruiting
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