Mon Jul 20, 2020 11:35
Background Mailed reminders to promote colorectal cancer (CRC) screening by fecal immunochemical testing (FIT) have been shown to be effective in the Medicaid population, in which screening is underused. However, little is known regarding the cost‐effectiveness of these interventions, with or without an included FIT kit. METHODS The authors conducted a cost‐effectiveness analysis of a randomized controlled trial that compared the effectiveness of a reminder + FIT intervention versus a reminder‐only...
Mon Jul 20, 2020 11:35
British Journal of Cancer, Published online: 21 July 2020; doi:10.1038/s41416-020-0990-8Increasing operational and scientific efficiency in clinical trials
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British Journal of Cancer, Published online: 21 July 2020; doi:10.1038/s41416-020-0997-1Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer
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Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Eduardo Castañon, Alvaro Sanchez-Arraez, Felipe Alvarez-Manceñido, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas
Mon Jul 20, 2020 14:44
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Sarah J. Kitson, Cemsel Bafligil, Neil A.J. Ryan, Fiona Lalloo, Emma R. Woodward, Richard D. Clayton, Richard J. Edmondson, James Bolton, Emma J. Crosbie, Gareth D. Evans
Mon Jul 20, 2020 14:44
Publication date: Available online 20 July 2020Source: European Journal of Surgical OncologyAuthor(s): Shih-Ping Cheng, Jie-Jen Lee, Ming-Nan Chien, Chi-Yu Kuo, Jie-Yang Jhuang, Chien-Liang Liu
Mon Jul 20, 2020 13:43
Abstract Survivors of childhood cancer treated with cranial irradiation are at risk of cerebrovascular disease (CVD), but the risks beyond age 50 are unknown.13,457 survivors of childhood cancer included in the population‐based British Childhood Cancer Survivor Study cohort were linked to Hospital Episode Statistics data for England. Risk of CVD related hospitalisation was quantified by standardised hospitalisation ratios (SHR), absolute excess risks (AER), and cumulative incidence. Overall, 315...
Sun Jul 19, 2020 18:33
Abstract This study aimed to analyze the risk of hematologic malignancies (HM) associated with the use of G‐CSF with chemotherapy for BC. Using the French National Health Data System, we examined the HM risks in patients diagnosed with an incident breast cancer between 2007 and 2015, who received chemotherapy for BC. Main outcomes were acute myeloid leukemia (AML), Myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), multiple myeloma (MM), Hodgkin lymphoma or non–Hodgkin lymphoma...
Sun Jul 19, 2020 18:31
ABSTRACT Evidence is mounting to indicate that cancer patients may have more likelihood of having coronavirus disease 2019 (COVID‐19) but lack consistency. A robust estimate is urgently needed to convey appropriate information to the society and the public, in the time of ongoing COVID‐19 pandemic. We performed a systematic review and meta‐analysis through a comprehensive literature search in major databases in English and Chinese, and two investigators conducted publication selection and data extraction...
Sun Jul 19, 2020 18:30
Abstract In a previous phase II study (THERAPY), cetuximab and trastuzumab combination, as second‐line after progression with gemcitabine, showed disease stabilization in 27% of 33 patients with pancreatic carcinoma. In the present phase II multicenter study, we assessed the efficacy and tolerance of gemcitabine, trastuzumab plus erlotinib as first‐line treatment of metastatic pancreatic cancer. The primary endpoint was disease control rate (DCR, RECIST v.1); secondary endpoints were progression‐free...
Sun Jul 19, 2020 18:30
Abstract Chimeric antigen receptor T (CART) cells targeting CD19 have shown promising results in the treatment of chronic lymphocytic leukemia (CLL). However, efficacy seems to be inferior compared to diffuse large B‐cell lymphoma or acute lymphoblastic leukemia. Impaired T cell fitness of CLL patients may be involved in treatment failure. Less‐differentiated naïve‐like T cells play an important role in CART expansion and long‐term persistence in vivo . These cells are sparse in CLL patients. Therefore,...
Sun Jul 19, 2020 18:30
Abstract Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy‐corrected mortality rates of corpus uteri cancer, overall and stratified by age, stage, and histologic subtype. Using data from nationwide Danish registries, we calculated uncorrected and hysterectomy‐corrected age‐standardized mortality rates...
Sun Jul 19, 2020 18:30
Abstract Data from population‐based cancer registries (PBCR) are critical for planning, monitoring and evaluation of cancer control programmes, but are frequently underutilised by key stakeholders. As part of the ongoing partnership of the International Agency for Research on Cancer (IARC) and the WHO Eastern Mediterranean Regional Office (EMRO) in cancer surveillance, we designed a cancer registry survey to assess the level of involvement of PBCR in national cancer control planning across the region....
Sun Jul 19, 2020 18:29
Abstract Inflammation is considered to play a pivotal role in the pathogenesis of cancer, and observational studies have reported a relationship between circulating inflammation markers and the risk of prostate cancer. Using summary data of >140,000 individuals, two‐sample Mendelian randomization (MR) analyses were performed to evaluate whether circulating levels of 27 cytokines and growth factors have a causal effect on the risk of developing prostate cancer. Genetically predicted elevated levels...
Sun Jul 19, 2020 18:29
Abstract In recent year, inhibitors of the BET bromodomain proteins, such as BRD4 inhibitors, have demonstrated robust antitumor activity. JQ‐1, a representative small molecular BRD4 inhibitor, is also effective to block PD‐1/PD‐L1 signaling by significantly decreasing the PD‐L1 expression on tumor cells. However, toxicity of BRD4 inhibitors on lymphoid and hematopoietic tissues limits their clinical usage. In this research, we designed and studied an immunogenic BRD4 inhibitor, SZU‐119, by coupling...
Sun Jul 19, 2020 18:29
ABSTRACT Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are...
Sun Jul 19, 2020 18:29
Abstract The analysis of tumor cells or tumor cell products obtained from blood or other body fluids (“liquid biopsy”) provides a broad range of opportunities in the field of oncology. Clinical application areas include early detection of cancer or tumor recurrence, individual risk assessment and therapy monitoring. Liquid biopsy allows to portray the entire disease as tumor cells or tumor cell products are released from all metastatic or primary tumor sites, providing comprehensive and real‐time...
Sun Jul 19, 2020 18:28
Abstract Currently, all European countries offer some form of breast cancer screening. Nevertheless, disparities exist in the status of implementation, attendance, and the extent of opportunistic screening. As a result, breast cancer screening has not yet reached its full potential. We examined how many breast cancer deaths could be prevented if all European countries would biennially screen all women aged 50‐69 for breast cancer. We calculated the number of breast cancer deaths already prevented...
Sun Jul 19, 2020 18:28
Telomeres play a key role in chromosomal maintenance and stability. To date, few studies have investigated the association of leukocyte telomere length with risk of cancer incidence and allcause mortality in a large prospective cohort, particularly of the Asian population. Relative telomere lengths in genomic DNA from peripheral blood samples were quantified using a validated quantitative real‐time PCR among 26,540 middle‐aged or older Chinese adults. Hazard ratios (HRs) and 95% confidence intervals...
Sun Jul 19, 2020 18:28
Abstract Salicylidene acylhydrazide group synthetic compounds ME0053, ME005 and ME0192 are known for their iron chelating properties and due to these properties they are primarily used for blocking the bacterial type 3 secretory virulence system. On the other side, targeting the metabolic pathways of iron can provide new tools for cancer prognosis and treatment. Therefore, in this study, considering their iron chelating function, the effects of the compounds ME0053, ME0055 and...
Mon Jul 20, 2020 03:00
Abstract Background Patients diagnosed with primary central nervous system lymphoma (PCNSL) often face dismal outcomes due to the limited availability of therapeutic options. PCNSL cells frequently have deregulated B-cell receptor (BCR) signaling, but clinical responses to its inhibition using ibrutinib have been brief. In this regard, blocking nuclear export by using selinexor, which covalently binds to XPO1, can also inhibit BCR signaling....
Mon Jul 20, 2020 03:00
Abstract Neoadjuvant therapy is a common form of treatment in locally advanced breast cancer (LABC) patients. Besides some guidelines for grading regression, a standardized general scheme is not yet available. The aim of our study was to compare the prognostic impact of different regression grading systems, namely the TR/NR, Chevallier, Sataloff, Denkert-Sinn, Miller-Payne, NSABP-B18, Residual Disease in Breast and Nodes and Residual Cancer Burden (RCB) on disease-free (DFS) and...
Mon Jul 20, 2020 03:00
Publication date: Available online 20 July 2020Source: Surgical Oncology Clinics of North AmericaAuthor(s): Amanda R. Stram, Kenneth A. Kesler
Mon Jul 20, 2020 13:25
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