Biomedicines, Vol. 8, Pages 245: Mechanisms Underlying Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia Biomedicines doi: 10.3390/biomedicines8080245 Authors: Eguchi Minami Kuzume Chi FLT3-ITD and FLT3-TKD mutations were observed in approximately 20 and 10% of acute myeloid leukemia (AML) cases, respectively. FLT3 inhibitors such as midostaurin, gilteritinib and quizartinib show excellent response rates in patients with FLT3-mutated AML, but its duration of response...
Fri Jul 24, 2020 03:00
Biomedicines, Vol. 8, Pages 244: Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria Biomedicines doi: 10.3390/biomedicines8080244 Authors: Insun Park Linda K. Johnson Allaura Cox Brian R. Branchford Jorge Di Paola Erez M. Bublil Tomas Majtan Severely elevated plasma homocysteine and methionine lead to thromboembolic events and strokes in homocystinuric (HCU) patients. Mouse models of HCU failed to exhibit...
Fri Jul 24, 2020 03:00
Biomedicines, Vol. 8, Pages 243: The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia Biomedicines doi: 10.3390/biomedicines8080243 Authors: Joanna Rog Anna Błażewicz Dariusz Juchnowicz Agnieszka Ludwiczuk Ewa Stelmach Małgorzata Kozioł Michal Karakula Przemysław Niziński Hanna Karakula-Juchnowicz A growing body of evidence confirms abnormal fatty acid (FAs) metabolism in the pathophysiology of schizophrenia. Omega-3 polyunsaturated...
Fri Jul 24, 2020 03:00
Biomedicines, Vol. 8, Pages 242: Induction of Cell Death in the Human Acute Lymphoblastic Leukemia Cell Line Reh by Infection with Rotavirus Isolate Wt1-5 Biomedicines doi: 10.3390/biomedicines8080242 Authors: Rafael Guerrero Carlos Guerrero Orlando Acosta Cancer is a major health problem that poses a great challenge to health care systems worldwide. Tools for cancer treatment have rapidly advanced in recent years, resulting in therapeutic strategies which are alternative and complementary...
Fri Jul 24, 2020 03:00
Biomimetics, Vol. 5, Pages 35: How to Build a Biological Machine Using Engineering Materials and Methods Biomimetics doi: 10.3390/biomimetics5030035 Authors: Alex Ellery We present work in 3D printing electric motors from basic materials as the key to building a self-replicating machine to colonise the Moon. First, we explore the nature of the biological realm to ascertain its essence, particularly in relation to the origin of life when the inanimate became animate. We take an expansive...
Sun Jul 26, 2020 03:00
Biomolecules, Vol. 10, Pages 1110: Precision Medicine for Lysosomal Disorders Biomolecules doi: 10.3390/biom10081110 Authors: Filippo Pinto e Vairo Diana Rojas Málaga Francyne Kubaski Carolina Fischinger Moura de Souza Fabiano de Oliveira Poswar Guilherme Baldo Roberto Giugliani Precision medicine (PM) is an emerging approach for disease treatment and prevention that accounts for the individual variability in the genes, environment, and lifestyle of each person. Lysosomal...
Sun Jul 26, 2020 03:00
Biomolecules, Vol. 10, Pages 1109: Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosystemic Responses? Biomolecules doi: 10.3390/biom10081109 Authors: Barillé-Nion Lohard Juin : The imbalance between BCL-2 homologues and pro-death counterparts frequently noted in cancer cells endows them with a cell autonomous survival advantage. To eradicate ectopic cells, inhibitors of these homologues (BH3 mimetics) were...
Sat Jul 25, 2020 03:00
Biomolecules, Vol. 10, Pages 1108: Biological Activity of Humulus Lupulus (L.) Essential Oil and Its Main Components Against Sitophilus granarius (L.) Biomolecules doi: 10.3390/biom10081108 Authors: Paventi de Acutis De Cristofaro Pistillo Germinara Rotundo Besides its use in the brewing industry, hop cones appear as a powerful source of biologically active compounds, already checked for their putative anticancer, antimicrobial, and other bioactivities. Conversely,...
Sat Jul 25, 2020 03:00
Biomolecules, Vol. 10, Pages 1107: On the Detection and Functional Significance of the Protein–Protein Interactions of Mitochondrial Transport Proteins Biomolecules doi: 10.3390/biom10081107 Authors: Youjun Zhang Alisdair R. Fernie Protein–protein assemblies are highly prevalent in all living cells. Considerable evidence has recently accumulated suggesting that particularly transient association/dissociation of proteins represent an important means of regulation of metabolism....
Sat Jul 25, 2020 03:00
Biomolecules, Vol. 10, Pages 1106: Baru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16 Biomolecules doi: 10.3390/biom10081106 Authors: Leite de Araújo dos Santos da Rocha Agarrayua Ávila Carollo Silva Estevinho de Picoli Souza dos Santos Fruits are sources of bioactive compounds that are responsible for several biological...
Sat Jul 25, 2020 03:00
Biomolecules, Vol. 10, Pages 1105: Role of Antioxidants in Alleviating Bisphenol A Toxicity Biomolecules doi: 10.3390/biom10081105 Authors: Amjad Rahman Pang Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function,...
Sat Jul 25, 2020 03:00
Biomolecules, Vol. 10, Pages 1104: Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia Biomolecules doi: 10.3390/biom10081104 Authors: Maria A. Ivanova Arina D. Kokorina Polina D. Timofeeva Tatiana V. Karelina Polina A. Abushik Julia D. Stepanenko Dmitry A. Sibarov Sergei M. Antonov Pathological homocysteine (HCY) accumulation in the human plasma, known as hyperhomocysteinemia, exacerbates...
Fri Jul 24, 2020 03:00
Biomolecules, Vol. 10, Pages 1102: Fatty Acid Biosynthesis in Chromerids Biomolecules doi: 10.3390/biom10081102 Authors: Tomčala Michálek Schneedorferová Füssy Gruber Vancová Oborník Fatty acids are essential components of biological membranes, important for the maintenance of cellular structures, especially in organisms with complex life cycles like protozoan parasites. Apicomplexans are obligate parasites responsible for various deadly diseases of humans and...
Fri Jul 24, 2020 03:00
Biomolecules, Vol. 10, Pages 1103: The Effect of Resveratrol on Mitochondrial Function in Myoblasts of Patients with the Common m.3243A>G Mutation Biomolecules doi: 10.3390/biom10081103 Authors: Motlagh Scholle Schieffers Al-Robaiy Thaele Dehghani Lehmann Urban Zierz Mitochondrial function is essential for ATP-supply, especially in response to different cellular stressors. Increased mitochondrial biogenesis resulting from caloric restriction (CR) has been...
Fri Jul 24, 2020 03:00
Biomolecules, Vol. 10, Pages 1101: Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase Biomolecules doi: 10.3390/biom10081101 Authors: Victor Marin Andres Iturra Andres Opazo Bernd Schmidt Matthias Heydenreich Leandro Ortiz Verónica A. Jiménez Cristian Paz Candida species cause an opportunistic yeast infection called Candidiasis, which is responsible for more than 50,000...
Fri Jul 24, 2020 03:00
Biomolecules, Vol. 10, Pages 1100: AGC2 (Citrin) Deficiency—From Recognition of the Disease till Construction of Therapeutic Procedures Biomolecules doi: 10.3390/biom10081100 Authors: Takeyori Saheki Mitsuaki Moriyama Aki Funahashi Eishi Kuroda Can you imagine a disease in which intake of an excess amount of sugars or carbohydrates causes hyperammonemia? It is hard to imagine the intake causing hyperammonemia. AGC2 or citrin deficiency shows their symptoms following sugar/carbohydrates...
Fri Jul 24, 2020 03:00
Biomolecules, Vol. 10, Pages 1099: From Mouse to Human: Comparative Analysis between Grey and White Matter by Synchrotron-Fourier Transformed Infrared Microspectroscopy Biomolecules doi: 10.3390/biom10081099 Authors: Paula Sanchez-Molina Martin Kreuzer Núria Benseny-Cases Tony Valente Beatriz Almolda Berta González Bernardo Castellano Alex Perálvarez-Marín Fourier Transform Infrared microspectroscopy (μFTIR) is a very useful method to analyze the biochemical...
Fri Jul 24, 2020 03:00
Biomolecules, Vol. 10, Pages 1097: Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations Biomolecules doi: 10.3390/biom10081097 Authors: Eric T. C. Wong Victor So Mike Guron Erich R. Kuechler Nawar Malhis Jennifer M. Bui Jörg Gsponer Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences....
Fri Jul 24, 2020 03:00
Biomolecules, Vol. 10, Pages 1098: Vanillic Acid Improves Comorbidity of Cancer and Obesity through STAT3 Regulation in High-Fat-Diet-Induced Obese and B16BL6 Melanoma-Injected Mice Biomolecules doi: 10.3390/biom10081098 Authors: Jinbong Park Seon Yeon Cho JongWook Kang Woo Yong Park Sujin Lee Yunu Jung Min-Woo Kang Hyun Jeong Kwak Jae-Young Um Obesity is known to be associated with risk and aggressiveness of cancer. Melanoma, the most lethal type of skin cancer,...
Fri Jul 24, 2020 03:00
Biosensors, Vol. 10, Pages 85: EMG-Centered Multisensory Based Technologies for Pattern Recognition in Rehabilitation: State of the Art and Challenges Biosensors doi: 10.3390/bios10080085 Authors: Chaoming Fang Bowei He Yixuan Wang Jin Cao Shuo Gao In the field of rehabilitation, the electromyography (EMG) signal plays an important role in interpreting patients’ intentions and physical conditions. Nevertheless, utilizing merely the EMG signal suffers from difficulty...
Sun Jul 26, 2020 03:00
Biosensors, Vol. 10, Pages 84: Electronic Nose as a Novel Method for Diagnosing Cancer: A Systematic Review Biosensors doi: 10.3390/bios10080084 Authors: Chiara Baldini Lucia Billeci Francesco Sansone Raffaele Conte Claudio Domenici Alessandro Tonacci Cancer is fast becoming the most important cause of death worldwide, its mortality being mostly caused by late or wrong diagnosis. Novel strategies have been developed to identify early signs of cancer in a minimally obtrusive...
Sat Jul 25, 2020 03:00
Brain Sciences, Vol. 10, Pages 482: CommunicationDoes Periodontal Tactile Input Uniquely Increase Cerebral Blood Flow in the Prefrontal Cortex? Brain Sciences doi: 10.3390/brainsci10080482 Authors: Takaharu Goto Nobuaki Higaki Takahiro Kishimoto Yoritoki Tomotake Tetsuo Ichikawa We previously studied the effect of peripheral sensory information from sensory periodontal ligament receptors on prefrontal cortex (PFC) activity. In the dental field, an alternative dental implant...
Sun Jul 26, 2020 03:00
Brain Sciences, Vol. 10, Pages 481: Evaluation of Risk Factors for Epilepsy in Pediatric Patients with Cerebral Palsy Brain Sciences doi: 10.3390/brainsci10080481 Authors: Małgorzata Sadowska Beata Sarecka-Hujar Ilona Kopyta Cerebral palsy (CP) is a set of etiologically diverse symptoms that change with the child’s age. It is one of the most frequent causes of motor disability in children. CP occurs at a frequency of 1.5 to 3.0 per 1000 live-born children. CP often coexists...
Sat Jul 25, 2020 03:00
Brain Sciences, Vol. 10, Pages 480: What Do We Know about Transcranial Direct Current Stimulation for Major Depression? Brain Sciences doi: 10.3390/brainsci10080480 Authors: Derrick Matthew Buchanan Philippe Robaey Amedeo D’Angiulli The interest in using non-invasive brain stimulation (NIBS) for the treatment of major depression (MD), including treatment resistant depression, is growing rapidly. The paper by Bennabi and Haffen (Brain Sci. 2018, 8) was an important step towards...
Sat Jul 25, 2020 03:00
Brain Sciences, Vol. 10, Pages 477: Pain Processing in Older Adults and Its Association with Prefrontal Characteristics Brain Sciences doi: 10.3390/brainsci10080477 Authors: Bunk Emch Koch Lautenbacher Zuidema Kunz Aging is known to affect nociceptive processing, e.g., the ability to inhibit pain. This study aims to investigate whether pain responses in older individuals are associated with prefrontal characteristics, namely (i) executive functioning performance...
Fri Jul 24, 2020 03:00
Brain Sciences, Vol. 10, Pages 478: Effects of Neuromuscular Electrical Stimulation (NMES) Plus Upper Cervical Spine Mobilization on Forward Head Posture and Swallowing Function in Stroke Patients with Dysphagia Brain Sciences doi: 10.3390/brainsci10080478 Authors: Yung Hyun Jeon Kyun Hee Cho Shin Jun Park After a stroke, forward head posture occurs, resulting in swallowing dysfunction. Neuromuscular electrical stimulation (NMES) combined with upper cervical spine mobilization...
Fri Jul 24, 2020 03:00
Brain Sciences, Vol. 10, Pages 476: MTHFR Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity Brain Sciences doi: 10.3390/brainsci10080476 Authors: Dana Simona Chita Anca Tudor Ruxandra Christodorescu Florina Nicoleta Buleu Raluca Sosdean Sanda Maria Deme Simona Mercea Adina Pop Moldovan Ana Pah Any Docu Axelerad Daniel Docu Axelerad Simona Ruxanda Dragan Background: Cardioembolic stroke (CES),...
Fri Jul 24, 2020 03:00
Brain Sciences, Vol. 10, Pages 479: The Neuropathological Diagnosis of Alzheimer’s Disease—The Challenges of Pathological Mimics and Concomitant Pathology Brain Sciences doi: 10.3390/brainsci10080479 Authors: King Bodi Troakes The definitive diagnosis of Alzheimer’s disease (AD) rests with post-mortem neuropathology despite the advent of more sensitive scanning and the search for reliable biomarkers. Even though the classic neuropathological features of AD have been...
Fri Jul 24, 2020 03:00
Cancers, Vol. 12, Pages 2061: Neoadjuvant Treatment Options in Soft Tissue Sarcomas Cancers doi: 10.3390/cancers12082061 Authors: Mateusz Jacek Spałek Katarzyna Kozak Anna Małgorzata Czarnecka Ewa Bartnik Aneta Borkowska Piotr Rutkowski Due to the heterogeneity of soft tissue sarcomas (STS), the choice of the proper perioperative treatment regimen is challenging. Neoadjuvant therapy has attracted increasing attention due to several advantages, particularly in patients...
Sun Jul 26, 2020 03:00
Cancers, Vol. 12, Pages 2062: Inhibitors of Ceramide- and Sphingosine-Metabolizing Enzymes as Sensitizers in Radiotherapy and Chemotherapy for Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12082062 Authors: Yoshiaki Yura Atsushi Masui Masakazu Hamada In the treatment of advanced head and neck squamous cell carcinoma (HNSCC), including oral SCC, radiotherapy is a commonly performed therapeutic modality. The combined use of radiotherapy with chemotherapy improves...
Sun Jul 26, 2020 03:00
Cancers, Vol. 12, Pages 2060: The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies Cancers doi: 10.3390/cancers12082060 Authors: Federica Ungaro Silvia D’Alessio Silvio Danese Inflammation is a recognized hallmark of cancer that contributes to the development and progression of colorectal cancer (CRC). Anti-inflammatory drugs currently used for the treatment of CRC show many adverse side effects that prompted...
Sun Jul 26, 2020 03:00
Cancers, Vol. 12, Pages 2058: PKM2 Expression as Biomarker for Resistance to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Cancers doi: 10.3390/cancers12082058 Authors: Maria Sfakianaki Chara Papadaki Maria Tzardi Maria Trypaki Stavroula Manolakou Ippokratis Messaritakis Zenia Saridaki Elias Athanasakis Dimitrios Mavroudis John Tsiaoussis Nikolaos Gouvas John Souglakos The purpose of the current study is to investigate the prognostic significance...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2057: Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions Cancers doi: 10.3390/cancers12082057 Authors: Shweta Joshi Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer. The neuroblastoma cancer research has long been focused on the role of MYCN oncogene amplification and the contribution of other genetic...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2059: Prognostic Significance of CD105- and CD31-Assessed Microvessel Density in Paired Biopsies and Surgical Samples of Laryngeal Carcinoma Cancers doi: 10.3390/cancers12082059 Authors: Gino Marioni Leonardo Franz Giancarlo Ottaviano Giacomo Contro Giulia Tealdo Alessandro Carli Anna Chiara Frigo Piero Nicolai Lara Alessandrini Small pretreatment laryngeal biopsies may not fully represent a tumor’s biological profile. This study...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2054: PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies Cancers doi: 10.3390/cancers12082054 Authors: Elizabeth K. Lee Ursula A. Matulonis The use of PARP inhibitors (PARPi) is growing widely as FDA approvals have shifted its use from the recurrence setting to the frontline setting. In parallel, the population developing PARPi resistance is increasing. Here we review the role of PARP, DNA damage repair, and synthetic...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2056: The Impact of BRAF Mutation on the Recurrence of Papillary Thyroid Carcinoma: A Meta-Analysis Cancers doi: 10.3390/cancers12082056 Authors: Xin Li Hyungju Kwon Previous meta-analyses indicated that the BRAF V600E mutation was associated with an increased recurrence rate of papillary thyroid carcinoma (PTC). However, with recent publications of large cohort studies, the need for an updated meta-analysis increases. Therefore, we conducted a comprehensive...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2051: Interplay between Cellular Metabolism and the DNA Damage Response in Cancer Cancers doi: 10.3390/cancers12082051 Authors: Moretton Loizou Metabolism is a fundamental cellular process that can become harmful for cells by leading to DNA damage, for instance by an increase in oxidative stress or through the generation of toxic byproducts. To deal with such insults, cells have evolved sophisticated DNA damage response (DDR) pathways that allow for the maintenance...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2055: Statin Use Improves Overall Survival of Patients with Gastric Cancer after Surgery and Adjuvant Chemotherapy in Taiwan: A Nationwide Matched Cohort Study Cancers doi: 10.3390/cancers12082055 Authors: Pei-Rung Yang Ying-Ying Tsai Ko-Jung Chen Yao-Hsu Yang Wei-Tai Shih Background: Numerous studies have revealed that statins have antitumor effects in vivo and in vitro. However, few studies have explored the relationship between statin use and the...
Sat Jul 25, 2020 03:00
Cancers, Vol. 12, Pages 2052: Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish Cancers doi: 10.3390/cancers12082052 Authors: Silvia Giunco Manuela Zangrossi Francesca Dal Pozzolo Andrea Celeghin Giovanni Ballin Maria Raffaella Petrara Aamir Amin Francesco Argenton Miguel Godinho Ferreira Anita De Rossi Besides its canonical role in stabilizing telomeres, telomerase...
Sat Jul 25, 2020 03:00
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