IJMS, Vol. 21, Pages 5301: Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs) International Journal of Molecular Sciences doi: 10.3390/ijms21155301 Authors: Tiffany J. Rios-Fuller Melanie Mahe Beth Walters Dounia Abbadi Sandra Pérez-Baos Abhilash Gadi John J. Andrews Olga Katsara C. Theresa Vincent Robert J. Schneider Non-communicable diseases (NCDs) are medical conditions that, by definition, are...
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5300: Transcriptional Inhibition of Sp-IAG by Crustacean Female Sex Hormone in the Mud Crab, Scylla paramamosain International Journal of Molecular Sciences doi: 10.3390/ijms21155300 Authors: Jiang Lu Wang Ye In crustaceans, the regulation of sex differentiation is mediated by insulin-like androgenic hormone (IAG) and crustacean female sex hormone (CFSH). CFSH is reported to inhibit IAG gene (Sp-IAG) expression in the mud crab Scylla paramamosain, but...
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5299: Discrimination between G/C Binding Sites by Olivomycin A Is Determined by Kinetics of the Drug-DNA Interaction International Journal of Molecular Sciences doi: 10.3390/ijms21155299 Authors: Artemy D. Beniaminov Galina V. Chashchina Mikhail A. Livshits Olga I. Kechko Vladimir A. Mitkevich Olga K. Mamaeva Anna N. Tevyashova Alexander A. Shtil Anna K. Shchyolkina Dmitry N. Kaluzhny Olivomycin A (OA) exerts its cytotoxic potency due to...
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5298: Heat Shock Protein 70 as a Double Agent Acting Inside and Outside the Cell: Insights into Autoimmunity International Journal of Molecular Sciences doi: 10.3390/ijms21155298 Authors: Stefan Tukaj Heat shock proteins (Hsp) are a diverse group of constitutive and/or stress-induced molecules that are categorized into several classes on the basis of their molecular weight. Mammalian Hsp have been mostly regarded as intracellular chaperones that mediate a range of...
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5297: Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases International Journal of Molecular Sciences doi: 10.3390/ijms21155297 Authors: Antonietta Fazio Eric Owusu Obeng Isabella Rusciano Maria Vittoria Marvi Matteo Zoli Sara Mongiorgi Giulia Ramazzotti Matilde Yung Follo James A. McCubrey Lucio Cocco Lucia Manzoli Stefano Ratti An increasing number of reports suggests a significant involvement...
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5296: Peroxisome Proliferator-Activated Receptor Beta/Delta Agonist Suppresses Inflammation and Promotes Neovascularization International Journal of Molecular Sciences doi: 10.3390/ijms21155296 Authors: Yutaro Tobita Takeshi Arima Yuji Nakano Masaaki Uchiyama Akira Shimizu Hiroshi Takahashi The effects of peroxisome proliferator-activated receptor (PPAR)β/δ ophthalmic solution were investigated in a rat corneal alkali burn model....
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5294: VEGF-A in Cardiomyocytes and Heart Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21155294 Authors: Mariantonia Braile Simone Marcella Leonardo Cristinziano Maria Rosaria Galdiero Luca Modestino Anne Lise Ferrara Gilda Varricchi Giancarlo Marone Stefania Loffredo The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is the key mediator of angiogenesis. Angiogenesis, the formation...
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5293: An In Vitro Model of Mast Cell Recruitment and Activation by Breast Cancer Cells Supports Anti-Tumoral Responses International Journal of Molecular Sciences doi: 10.3390/ijms21155293 Authors: Angélica Aponte-López Jennifer Enciso Samira Muñoz-Cruz Ezequiel M. Fuentes-Pananá Breast cancer (BrC) affects millions of women yearly. Mast cells (MCs) are common components of breast tumors with documented agonistic and antagonistic roles in tumor progression....
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5295: The Functional Roles and Applications of Immunoglobulins in Neurodegenerative Disease International Journal of Molecular Sciences doi: 10.3390/ijms21155295 Authors: Kyu-Young Sim Kyeong Chan Im Sung-Gyoo Park Natural autoantibodies, immunoglobulins (Igs) that target self-proteins, are common in the plasma of healthy individuals; some of the autoantibodies play pathogenic roles in systemic or tissue-specific autoimmune diseases, such as rheumatoid arthritis...
Sun Jul 26, 2020 03:00
IJMS, Vol. 21, Pages 5292: Halophytic Hordeum brevisubulatum HbHAK1 Facilitates Potassium Retention and Contributes to Salt Tolerance International Journal of Molecular Sciences doi: 10.3390/ijms21155292 Authors: Haiwen Zhang Wen Xiao Wenwen Yu Ying Jiang Ruifen Li Potassium retention under saline conditions has emerged as an important determinant for salt tolerance in plants. Halophytic Hordeum brevisubulatum evolves better strategies to retain K+ to improve high-salt tolerance....
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5289: Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis International Journal of Molecular Sciences doi: 10.3390/ijms21155289 Authors: Meurer Öhlmann Bonilla Valentin-Weigand Beineke Hennig-Pauka Schwerk Schroten Baums Köckritz-Blickwede de Buhr Streptococcus suis is a zoonotic agent causing meningitis in pigs and humans. Neutrophils, as the first line of defense against S....
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5291: Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective International Journal of Molecular Sciences doi: 10.3390/ijms21155291 Authors: Gonçalo S. Clemente Aren van Waarde Inês F. Antunes Alexander Dömling Philip H. Elsinga Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of hepatic ureogenic...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5288: ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155288 Authors: Scremin Agostini Leparulo Pozzan Greotti Fasolato Abstract: Senile plaques, the hallmarks of Alzheimer's Disease (AD), are generated by the deposition of amyloid-beta (Aβ), the proteolytic product of amyloid precursor protein (APP), by β and γ-secretase....
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5290: TETRALEC, Artificial Tetrameric Lectins: A Tool to Screen Ligand and Pathogen Interactions International Journal of Molecular Sciences doi: 10.3390/ijms21155290 Authors: Achilli Monteiro Serna Mayer-Lambertz Thépaut Roy Ebel Reichardt Lepenies Fieschi Vivès C-type lectin receptor (CLR)/carbohydrate recognition occurs through low affinity interactions. Nature compensates that weakness by multivalent display of the lectin...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5287: Metabolic Response of the Yeast Candida utilis During Enrichment in Selenium International Journal of Molecular Sciences doi: 10.3390/ijms21155287 Authors: Marek Kieliszek Katarzyna Bierla Javier Jiménez-Lamana Anna Maria Kot Jaime Alcántara-Durán Kamil Piwowarek Stanisław Błażejak Joanna Szpunar Selenium (Se) was found to inhibit the growth of the yeast Candida utilis ATCC 9950. Cells cultured in 30 mg selenite/L supplemented medium could...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5286: HSP90 Inhibition and Modulation of the Proteome: Therapeutical Implications for Idiopathic Pulmonary Fibrosis (IPF) International Journal of Molecular Sciences doi: 10.3390/ijms21155286 Authors: Ruben Manuel Luciano Colunga Biancatelli Pavel Solopov Betsy Gregory John D. Catravas Idiopathic Pulmonary fibrosis (IPF) is a catastrophic disease with poor outcomes and limited pharmacological approaches. Heat shock protein 90 (HSP90) has been recently involved...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5285: Phospholipid Signaling Is a Component of the Salicylic Acid Response in Plant Cell Suspension Cultures International Journal of Molecular Sciences doi: 10.3390/ijms21155285 Authors: Beatriz A. Rodas-Junco Geovanny I. Nic-Can Armando Muñoz-Sánchez S. M. Teresa Hernández-Sotomayor Salicylic acid (SA) is an important signaling molecule involved in plant defense. While many proteins play essential roles in SA signaling, increasing evidence shows that responses...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5284: Shade Effects on Peanut Yield Associate with Physiological and Expressional Regulation on Photosynthesis and Sucrose Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms21155284 Authors: Chen Zhang Zeng Wang Huang Wang Wang Zhang Intercropping improves land utilization with more crops grown together; however, shorter crops in intercropping experience stress, being shaded by the taller crops. Systematic changes...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5283: Inorganic Phosphate in the Pathogenesis of Pregnancy-Related Complications International Journal of Molecular Sciences doi: 10.3390/ijms21155283 Authors: Ana Correia-Branco Monica P. Rincon Leonardo M. Pereira Mary C. Wallingford Inorganic phosphate (Pi) is an essential nutrient that fulfills critical roles in human health. It enables skeletal ossification, supports cellular structure and organelle function, and serves key biochemical roles in energetics...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5278: Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting International Journal of Molecular Sciences doi: 10.3390/ijms21155278 Authors: Joana Vieira de Vieira de Castro Céline S. Gonçalves Adília Hormigo Bruno M. Costa The discovery of glioblastoma stem cells (GSCs) in the 2000s revolutionized the cancer research field, raising new questions regarding the putative cell(s) of origin of this tumor...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5282: Identification and Characterization of Glycoproteins and Their Responsive Patterns upon Ethylene Stimulation in the Rubber Latex International Journal of Molecular Sciences doi: 10.3390/ijms21155282 Authors: Li Yu Boxuan Yuan Lingling Wang Yong Sun Guohua Ding Ousmane Ahmat Souleymane Xueyan Zhang Quanliang Xie Xuchu Wang Natural rubber is an important industrial material, which is obtained from the only commercially cultivated rubber...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5280: Predicting In Vitro Neurotoxicity Induced by Nanoparticles Using Machine Learning International Journal of Molecular Sciences doi: 10.3390/ijms21155280 Authors: Furxhi Murphy The practice of non-testing approaches in nanoparticles hazard assessment is necessary to identify and classify potential risks in a cost effective and timely manner. Machine learning techniques have been applied in the field of nanotoxicology with encouraging results. A neurotoxicity...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5281: The Role of microRNAs in Organismal and Skin Aging International Journal of Molecular Sciences doi: 10.3390/ijms21155281 Authors: Gerasymchuk Cherkasova Kovalchuk Kovalchuk The aging process starts directly after birth and lasts for the entire lifespan; it manifests itself with a decline in an organism’s ability to adapt and is linked to the development of age-related diseases that eventually lead to premature death. This review aims...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5279: Sickle Cell Disease: A Paradigm for Venous Thrombosis Pathophysiology International Journal of Molecular Sciences doi: 10.3390/ijms21155279 Authors: Maria A. Lizarralde-Iragorri Arun S. Shet Venous thromboembolism (VTE) is an important cause of vascular morbidity and mortality. Many risk factors have been identified for venous thrombosis that lead to alterations in blood flow, activate the vascular endothelium, and increase the propensity for blood coagulation....
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5277: Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX International Journal of Molecular Sciences doi: 10.3390/ijms21155277 Authors: Katarina Koruza A. Briana Murray Brian P. Mahon Jesse B. Hopkins Wolfgang Knecht Robert McKenna S. Zoë Fisher Upregulation of carbonic anhydrase IX (CA IX) is associated with several aggressive forms of cancer and promotes metastasis. CA IX is normally constitutively expressed at low levels in...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5276: Increased Oxidative Phosphorylation is Required for Stemness Maintenance in Liver Cancer Stem Cells from Hepatocellular Carcinoma Cell Line HCCLM3 Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155276 Authors: Liu Luo Li Liu Ju Song Cancer stem cells (CSCs) are considered to be the main cause of tumor recurrence, metastasis, and an unfavorable prognosis. Energy metabolism is closely associated with cell stemness. However,...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5275: Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies International Journal of Molecular Sciences doi: 10.3390/ijms21155275 Authors: Margherita Di Costanzo Laura Carucci Roberto Berni Canani Giacomo Biasucci The increasing prevalence and severity of pediatric food allergies (FA) demands innovative preventive and therapeutic strategies. Emerging evidence suggests a pivotal role for the gut microbiome in modulating susceptibility...
Sat Jul 25, 2020 03:00
IJMS, Vol. 21, Pages 5270: Gingival Crevicular Fluid Peptidome Profiling in Healthy and in Periodontal Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21155270 Authors: Mariaimmacolata Preianò Rocco Savino Chiara Villella Corrado Pelaia Rosa Terracciano Given its intrinsic nature, gingival crevicular fluid (GCF) is an attractive source for the discovery of novel biomarkers of periodontal diseases. GCF contains antimicrobial peptides and small proteins...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5274: External and Genetic Conditions Determining Male Infertility International Journal of Molecular Sciences doi: 10.3390/ijms21155274 Authors: Piotr Kamiński Jędrzej Baszyński Izabela Jerzak Brendan P. Kavanagh Ewa Nowacka-Chiari Mateusz Polanin Marek Szymański Alina Woźniak Wojciech Kozera We explain environmental and genetic factors determining male genetic conditions and infertility and evaluate the significance of environmental stressors...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5269: The Janus Role of Adhesion in Chondrogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21155269 Authors: Ignasi Casanellas Anna Lagunas Yolanda Vida Ezequiel Pérez-Inestrosa José A. Andrades José Becerra Josep Samitier Tackling the first stages of the chondrogenic commitment is essential to drive chondrogenic differentiation to healthy hyaline cartilage and minimize hypertrophy. During chondrogenesis, the extracellular matrix...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5272: The Potential of Metabolomics in the Diagnosis of Thyroid Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21155272 Authors: Margarida Coelho Luis Raposo Brian J. Goodfellow Luigi Atzori John Jones Bruno Manadas Thyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5273: Detection of Salivary Small Extracellular Vesicles Associated Inflammatory Cytokines Gene Methylation in Gingivitis International Journal of Molecular Sciences doi: 10.3390/ijms21155273 Authors: Pingping Han Andrew Lai Carlos Salomon Sašo Ivanovski Salivary small extracellular vesicles (sEV) are emerging as a potential liquid biopsy for oral diseases. However, technical difficulties for salivary sEV isolation remain a challenge. Twelve participants...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5268: Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations International Journal of Molecular Sciences doi: 10.3390/ijms21155268 Authors: Katarzyna Bucholc Aleksandra Skrajna Kinga Adamska Xiao-Cui Yang Krzysztof Krajewski Jarosław Poznański Michał Dadlez Zbigniew Domiński Igor Zhukov FLICE-associated huge protein (FLASH), Yin...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5264: Aryl Hydrocarbon Receptor Connects Inflammation to Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21155264 Authors: Tiziana Guarnieri Aryl hydrocarbon receptor (AhR), an evolutionary conserved transcription factor, is a pleiotropic signal transductor. Thanks to its promiscuous ligand binding domain, during the evolution of eukaryotic cells its developmental functions were integrated with biosensor functions. Its activation by a multitude...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5265: New Methodology for the Identification of Metabolites of Saccharides and Cyclitols by Off-Line EC-MALDI-TOF-MS International Journal of Molecular Sciences doi: 10.3390/ijms21155265 Authors: Gulyaim Sagandykova Justyna Walczak-Skierska Fernanda Monedeiro Paweł Pomastowski Bogusław Buszewski A combination of electrochemistry (EC) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (off-line EC-MALDI-TOF-MS) was applied...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5271: Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant International Journal of Molecular Sciences doi: 10.3390/ijms21155271 Authors: Rachida Guennoun Progesterone has a broad spectrum of actions in the brain. Among these, the neuroprotective effects are well documented. Progesterone neural effects are mediated by multiple signaling pathways involving binding to specific receptors (intracellular progesterone receptors (PR); membrane-associated...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5266: Roles of Mitochondrial Sirtuins in Mitochondrial Function, Redox Homeostasis, Insulin Resistance and Type 2 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms21155266 Authors: Chih-Hao Wang Yau-Huei Wei Mitochondria are the metabolic hubs that process a number of reactions including tricarboxylic acid cycle, β-oxidation of fatty acids and part of the urea cycle and pyrimidine nucleotide biosynthesis. Mitochondrial dysfunction...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5267: Effects of Hydrogen Sulfide Donor NaHS on Porcine Vascular Wall-Mesenchymal Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21155267 Authors: Chiara Bernardini Debora La Mantia Salvatore Nesci Roberta Salaroli Cristina Algieri Alessandra Pagliarani Augusta Zannoni Monica Forni Hydrogen sulfide (H2S) is now considered not only for its toxicity, but also as an endogenously produced gas transmitter with multiple physiological...
Fri Jul 24, 2020 03:00
IJMS, Vol. 21, Pages 5263: An Overview of Different Strategies to Recreate the Physiological Environment in Experimental Erythropoiesis International Journal of Molecular Sciences doi: 10.3390/ijms21155263 Authors: Cécile Deleschaux Martina Moras Sophie D. Lefevre Mariano A. Ostuni Human erythropoiesis is a complex process leading to the production of mature, enucleated erythrocytes (RBCs). It occurs mainly at bone marrow (BM), where hematopoietic stem cells (HSCs) are engaged...
Fri Jul 24, 2020 03:00
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