Paget’s disease of the breast is a rare intraepithelial malignancy involving the nipple–areola complex, often associated with an underlying in-situ or invasive carcinoma in the breast parenchyma. Most of the cases disease is usually limited to nipple–areola or surrounding periareolar skin. We are reporting a case of extensive Paget’s disease, involving entire breast skin and even part of abdominal wall skin without any underlining breast pathology, which is a rare presentation.
37m
A 68-year-old woman with a long history of relapsing chronic rhinosinusitis with nasal polyps (CRSwNP) underwent a complete reboot surgery and nasal biopsy prior to and after surgery. Remarkable improvement of symptoms and no signs of mucosal oedema and no complaints of initially worsening nasal functions were still present 12 months after reboot surgery. Biopsy demonstrated an outstanding reduction in eosinophilic infiltration and re-epithelisation of nasal mucosa with normal features after reboot...
37m
Abstract Stain NN08200 was isolated from the surface-sterilized stem of sugarcane grown in Guangxi province of China. The stain was Gram-negative, facultative anaerobic, non-spore-forming bacteria. The complete genome SNP-based phylogenetic analysis indicate that NN08200 is a member of the genus Pantoea ananatis. Here, we summarize the features of strain NN08200 and describe its complete genome. The genome contains a chromosome and two plasmids, in total 5,176,640 nucleotides with...
1h
Abstract As an important insect vector, Asian citrus psyllid (ACP), Diaphorina citri Kuwayama (Hemiptera: Liviidae) transmits the pathogen ‘Candidatus Liberibacter asiaticus’ (CLas) that is associated with citrus greening also known as Huanglongbing (HLB) disease. The bacterial endosymbionts have a potential role in shaping the host range of insect herbivores and their performance on different host plants, which might affect the endosymbiont distribution in insect populations....
15h
Abstract Streptococcus pyogenes or Group A Streptococcus (GAS) infections are the leading cause of bacterial tonsillopharyngitis. The bacterium can survive and persist within the human host for a long time as it is observed in up to 40% of the population who are considered as carriers. Recurrent tonsillopharyngitis is a particular problem in children which is caused either by relapses due to failed bacterial clearance or by reinfection. A prolonged survival in tonsillar crypts...
19h
The authors would like to correct the errors in the publication of the original article.
23h
Abstract Background Demand for pediatric cardiac computed tomography (CT) angiography is increasing due to recent advances that reduce the need for sedation and radiation exposure while enhancing diagnostic accuracy. This has resulted in the increasing use of cardiac CT angiography emergently during weekends and after hours. The unexpected demand for these services can be challenging, as most hospitals are not staffed to provide 24/7 pediatric...
1h
Abstract A global and systematic theoretical research on the singlet and triplet potential energy surfaces (PESs) of the CH2ClO2/CHCl2O2 with ClO reactions are done at the CCSD(T)//B3LYP level and accompanied with RRKM computations to forecast the mechanism and distribution of products. The simulation results revealed that, on the singlet PES, products P1 (CHClO + HO2 + Cl)/P1 (CCl2O + HO2 + Cl) from IM1 (CH2ClOOOCl)/IM1 (CHCl2OOOCl) are forecasted to the primary products of the...
1h
Abstract The green turtle (Chelonia mydas) is known to present an herbivorous diet as an adult; however, juveniles may have an omnivore habit, and these changes in food preference may affect the uptake and accumulation of pollutants, such as mercury (Hg). In order to better understand the influence of this ontogenetic shift on Hg accumulation, this study evaluates the concentrations of total mercury (THg), methyl mercury (MeHg), and stable isotopes of carbon and nitrogen (δ13C...
3h
Abstract This study was designed to assess the synergistic effects of nitrogen (N) and phosphorus (P) concentrations on oil content, fatty acid profile, and predicted fuel properties of Dunaliella salina. Axenic D. salina cells were grown in F/2 growth medium of salinity 34 ppt containing 33.6 g.l−1 ultramarine synthetic sea salt. Growth dry weight, cell count, and their relationship were measured, and oils were extracted by soaking following Soxhlet extraction. Growth dry weight...
3h
Abstract A novel composite material (nZVI/UiO-66) of nanoscale zero-valent iron (nZVI) with a functionalized metal-organic framework was synthesized by this study via a coprecipitation method, which was used for the efficient removal of U(VI) in the aqueous solution. The nZVI/UiO-66 had an excellent removal capacity of 404.86 mg g−1 with an initial U(VI) concentration of 80 mg L−1, 313 K and pH = 6. The transmission electron microscopy (TEM) revealed that nZVI particles were inhomogeneously...
4h
Abstract Imazalil (IMZ), a fungicide containing imidazole group, is extensively used for the prevention and treatment of fungal diseases in plants. Current study was performed to examine cyto-genotoxic potential of IMZ on Allium cepa roots by following Allium ana-telophase and single cell gel electrophoresis (comet) assays. The concentration which reduced the growth of the root tips of IMZ by 50% compared to the negative control group (EC50) was found to be 1 μg/mL by Allium root...
6h
Abstract This paper makes a first empirical attempt at estimating the effects of environmental regulation on air pollution, total factor productivity (TFP), and factor structure based on a quasi-natural experiment method using a novel dataset of 216 prefectural-level cities during the years 1998–2016 in China. Specifically, we are focused on the policy impact of the listed key environmental protection (KEP) prefectures which subject to more stringent environmental regulations than...
11h
Abstract Karst aquifers represent the most important renewable sources of drinking water. Because anthropogenic influences threaten the integrity of karst aquifers, it is important to determine the soil erosion and karst denudation rates. In order to study the complex signs of degradation processes of the karst, a paleodoline (paleo-polje) was selected near to the county seat Veszprém, Hungary. It was found that gamma radiation measurements can be a useful tool to detect the level...
13h
Abstract The development of human activities along the Atlantic coast is responsible for the chronic pollution of the environment with organic and inorganic contaminants. In recent years, environmental regulations such as the MSFD (2008/56/EC) and the OSPAR commission have been developed to preserve coastal environments, giving rise to studies in aquatic biomonitoring. One of them is to use biomarkers to observe the pollutants impact on coastal species such as the bivalve Mimachlamys...
15h
Abstract As part of the ChArMEx project (Chemistry-Aerosol Mediterranean Experiment, http://charmex.lsce.ipsl.fr), one year of continuous filter sampling was conducted from August 2012 to August 2013 at a rural (coastal) site in Algeria aiming to better document fine aerosol seasonal variability and chemical composition in the Southern part of the Mediterranean. Over 350 filters have been collected, weighted, and analyzed for the main ions and organic and elemental carbon. The...
19h
Abstract Silicon (Si) is an essential nutrient for rice, but its effects on the yield and quality of rice under heavy metal stress remain uncertain. In this study, two typical paddy soils (acidic and calcareous purple soils) in the western region of Chongqing were selected for field plot experiment, with the purpose of understanding the effects of Si implementation methods on grain yields and cadmium (Cd) uptake, transport, and accumulation in the grain of a hybrid rice (Oryza...
21h
Abstract In this study, phytoremediation potential of the Azolla filiculoides Lam. was examined for sodium dodecyl benzene sulfonate (SDBS) anionic surfactant. Furthermore, the effect of surfactant treatment on some physiological characteristics of Azolla was studied. The surfactant bioremoval efficiency was studied under variable conditions including treatment time, initial surfactant concentration, Azolla fresh weight, temperature, and pH. Results showed that surfactant removal...
21h
Abstract In Pakistan, rice is considered as the second staple food and provides livelihoods to the millions of the farm households. During recent years, rice production in Pakistan significantly decreased reportedly due to changes in climate and its induced risks. This study analyzed the incidence and severity of climate change and its induced risks in the rice-growing region of Pakistan and assessed farmers’ perception and attitude by employing risk matrix and Equally Likely Certainty...
23h
Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously expressed PAR-2. Endogenous PAR-2 activation...
2h
Modified tetrapyrroles are large macrocyclic compounds, consisting of diverse conjugation and metal chelation systems and imparting an array of colors to the biological structures that contain them. Tetrapyrroles represent some of the most complex small molecules synthesized by cells and are involved in many essential processes that are fundamental to life on Earth, including photosynthesis, respiration, and catalysis. These molecules are all derived from a common template through a series of enzyme-mediated...
2h
The structurally homologous Mtf1 and TFB2M proteins serve as transcription initiation factors of the mitochondrial RNA polymerases in Saccharomyces cerevisiae and humans, respectively. These transcription factors directly interact with the non-template strand of the transcription bubble to drive promoter melting. Given the key roles of Mtf1 and TFB2M in promoter-specific transcription initiation, it can be expected that the DNA-binding activity of the mitochondrial transcription factors is regulated...
2h
Ecdysteroids are the principal steroid hormones essential for insect development and physiology. In the last 18 years, several enzymes responsible for ecdysteroid biosynthesis encoded by Halloween genes were identified and genetically and biochemically characterized. However, the tertiary structures of these proteins have not yet been characterized. Here, we report the results of an integrated series of in silico, in vitro, and in vivo analyses of the Halloween GST protein Noppera-bo (Nobo). We determined...
2h
Hundreds of sterile alpha motif (SAM) domains have predicted structural similarities and are reported to bind proteins, lipids, or RNAs. However, the majority of these domains have not been analyzed functionally. Previously, we demonstrated that a SAM domain–containing protein, SAMD14, promotes SCF/proto-oncogene c-Kit (c-Kit) signaling, erythroid progenitor function, and erythrocyte regeneration. Deletion of a Samd14 enhancer (Samd14-Enh), occupied by GATA2 and SCL/TAL1 transcription factors, reduces...
2h
The dedicator of cytokinesis D (DOCK-D) family proteins are atypical guanine nucleotide exchange factors (GEFs) that regulate Rho GTPase activity. The family consists of Zizimin1 (DOCK9), Zizimin2 (DOCK11), and Zizimin3 (DOCK10). Functions of the DOCK-D family proteins are presently not well explored, and the role of the DOCK-D family in neuroinflammation is unknown. In this study, we generated three mouse lines in which DOCK9 (DOCK9-/-), DOCK10 (DOCK10-/-), or DOCK11 (DOCK11-/-) had been deleted...
2h
Serine protease 14 (Prss14)/epithin is a transmembrane serine protease that plays essential roles in tumor progression and metastasis and therefore represents a promising target for managing cancer. Prss14/epithin shedding may underlie its activity in cancer and may worsen outcomes; accordingly, a detailed understanding of the molecular mechanisms in Prss14/epithin shedding may inform the design of future cancer therapies. On the basis of our previous observation that an activator of protein kinase...
2h
A detailed understanding of the molecular pathways for amyloid-β (Aβ) peptide aggregation from monomers into amyloid fibrils, a hallmark of Alzheimer’s disease, is crucial for the development of diagnostic and therapeutic strategies. We investigate the molecular details of peptide fibrillization in vitro by perturbing this process through addition of differently charged metal ions. Here, we used a monovalent probe, the silver ion, that, similarly to divalent metal ions, binds to monomeric Aβ peptide...
2h
The large secretory glycoprotein, thyroglobulin, is the primary translation product of thyroid follicular cells. This difficult-to-fold protein is susceptible to structural alterations that disable export of the misfolded thyroglobulin from the endoplasmic reticulum (ER), which is a known cause of congenital hypothyroidism characterized by severe, chronic thyrocyte ER stress. Nevertheless, individuals with this disease commonly grow a goiter, indicating thyroid cell survival and adaptation. To model...
2h
Leukocyte recruitment is a universal feature of tissue inflammation and regulated by the interactions of chemokines with their G protein-coupled receptors (GPCRs). Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine ligands, including CC chemokine ligand 2 (CCL2), plays a central role in recruitment of monocytes in several inflammatory diseases. In this study, we used phosphoproteomics to conduct an unbiased characterization of the signaling network resulting from CCL2 activation...
2h
The ATPase SecA is an essential component of the bacterial Sec machinery, which transports proteins across the cytoplasmic membrane. Most SecA proteins contain a long C-terminal tail (CTT). In Escherichia coli, the CTT contains a structurally flexible linker domain and a small metal-binding domain (MBD). The MBD coordinates zinc via a conserved cysteine-containing motif and binds to SecB and ribosomes. In this study, we screened a high-density transposon library for mutants that affect the susceptibility...
2h
British Journal of Cancer, Published online: 03 April 2020; doi:10.1038/s41416-020-0790-1Real-world data on cervical cancer risk stratification by cytology and HPV genotype to inform the management of HPV-positive women in routine cervical screening
3h
British Journal of Cancer, Published online: 03 April 2020; doi:10.1038/s41416-020-0824-8Reversal of glucocorticoid resistance in paediatric acute lymphoblastic leukaemia is dependent on restoring BIM expression
3h
British Journal of Cancer, Published online: 03 April 2020; doi:10.1038/s41416-020-0825-7Chemotherapy exacerbates ovarian cancer cell migration and cancer stem cell-like characteristics through GLI1
3h
British Journal of Cancer, Published online: 03 April 2020; doi:10.1038/s41416-020-0818-6Associations between calcium and magnesium intake and the risk of incident oesophageal cancer: an analysis of the NIH-AARP Diet and Health Study prospective cohort
3h
British Journal of Cancer, Published online: 03 April 2020; doi:10.1038/s41416-020-0787-9Triage of HPV-positive women in Norway using cytology, HPV16/18 genotyping and HPV persistence
3h
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