Antibiotics, Vol. 9, Pages 408: Kinetic Fingerprinting Links Bacteria-Phage Interactions with Emergent Dynamics: Rapid Depletion of Klebsiella pneumoniae Indicates Phage Synergy Antibiotics doi: 10.3390/antibiotics9070408 Authors: Holger Loessner Insea Schlattmeier Marie Anders-Maurer Isabelle Bekeredjian-Ding Christine Rohde Johannes Wittmann Cornelia Pokalyuk Oleg Krut Christel Kamp The specific temporal evolution of bacterial and phage population sizes, in...
Tue Jul 14, 2020 03:00
Antibiotics, Vol. 9, Pages 409: The Variability of Thymol and Carvacrol Contents Reveals the Level of Antibacterial Activity of the Essential Oils from Different Accessions of Oliveria decumbens Antibiotics doi: 10.3390/antibiotics9070409 Authors: Tahereh Khoshbakht Akbar Karami Aminallah Tahmasebi Filippo Maggi Oliveria decumbens (Apiaceae) is an aromatic herb traditionally employed in the Persian medicine for the treatment of infectious and gastrointestinal disorders. In the...
Tue Jul 14, 2020 03:00
Antibiotics, Vol. 9, Pages 407: Substandard Quality of the Antimicrobials Sold in the Street Markets in Haiti Antibiotics doi: 10.3390/antibiotics9070407 Authors: Théodule Jean-Baptiste John F. Carpenter Kevin Dahl Wellington Derameau Rosemela Veillard John Redford Jacquet Pierre Ludens Osselyn Albert Figueras This pilot study was conducted to analyze the quality of the antimicrobials sold in the street markets in Port-au-Prince, Haiti. A total of 258 packs containing...
Tue Jul 14, 2020 03:00
Antioxidants, Vol. 9, Pages 615: Glutathione S-Transferase Rescues Motor Neuronal Toxicity in Fly Model of Amyotrophic Lateral Sclerosis Antioxidants doi: 10.3390/antiox9070615 Authors: Sun Joo Cha Yeo Jeong Han Hyun-Jun Choi Hyung-Jun Kim Kiyoung Kim Transactive response DNA-binding protein-43 (TDP-43) is involved in the pathology of familial and sporadic amyotrophic lateral sclerosis (ALS). TDP-43-mediated ALS models in mice, Drosophila melanogaster, and zebrafish exhibit...
Tue Jul 14, 2020 03:00
Antioxidants, Vol. 9, Pages 616: Reduction of Protein Bound Methionine Sulfoxide by a Periplasmic Dimethyl Sulfoxide Reductase Antioxidants doi: 10.3390/antiox9070616 Authors: Tarrago Grosse Lemaire Faure Tribout Siponen Kojadinovic-Sirinelli Pignol Arnoux Sabaty In proteins, methionine (Met) can be oxidized into Met sulfoxide (MetO). The ubiquitous methionine sulfoxide reductases (Msr) A and B are thiol-oxidoreductases reducing MetO. Reversible Met...
Tue Jul 14, 2020 03:00
Atmosphere, Vol. 11, Pages 744: Use of Electronic UV Dosimeters in Measuring Personal UV Exposures and Public Health Education Atmosphere doi: 10.3390/atmos11070744 Authors: Martin W. Allen Neil Swift Kathryn M. Nield Ben Liley Richard L. McKenzie The performance limits of electronic ultraviolet (EUV) dosimeters, which use AlGaN Schottky photodiodes as the ultraviolet radiation (UVR) sensing element to measure personal erythemally weighted UVR exposures, were investigated...
Tue Jul 14, 2020 03:00
Atmosphere, Vol. 11, Pages 747: Modelling the Present Global Terrestrial Climatic Response Due to a Chicxulub-Type Asteroid Impact Atmosphere doi: 10.3390/atmos11070747 Authors: Víctor M. Mendoza Blanca Mendoza René Garduño Marni Pazos A Chicxulub-like asteroid event occurs, on average, approximately every ~27 to 200 million years. Therefore, such an event could happen presently. Here, we simulate the climatic anomalies it may cause with respect to the current conditions, assuming...
Tue Jul 14, 2020 03:00
Atmosphere, Vol. 11, Pages 745: Climatological Large-Scale Circulation Patterns over The Middle Americas Region Atmosphere doi: 10.3390/atmos11070745 Authors: Carlos A. Ochoa-Moya Yoel A. Cala-Pérez Yanet Díaz-Esteban Christopher L. Castro Paulina Ordoñez-Peréz Arturo I. Quintanar In this study, twenty large-scale circulation patterns are identified to generate a synoptic classification of Weather Types (WT) over a region that comprises Mexico, the Intra-Americas Seas,...
Tue Jul 14, 2020 03:00
Atmosphere, Vol. 11, Pages 746: Variations in Ozone Concentration over the Mid-Latitude Region Revealed by Ozonesonde Observations in Pohang, South Korea Atmosphere doi: 10.3390/atmos11070746 Authors: Daegeun Shin Seungjoo Song Sang-Boom Ryoo Sang-Sam Lee Ozone absorbs harmful UV rays at high elevations but acts as a pollutant gas in the lower atmosphere. It is necessary to monitor both the vertical profile and the total column ozone. In this study, variations in the ozone concentration...
Tue Jul 14, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 116: The Combined Effect of Exercise and Behavioral Therapy for Depression and Anxiety: Systematic Review and Meta-Analysis Behavioral Sciences doi: 10.3390/bs10070116 Authors: Kelsey Bourbeau Terence Moriarty Akeisha Ayanniyi Micah Zuhl Behavioral therapy (BT) and exercise are efficacious treatments for depression and anxiety when employed separately. The combination of BT and exercise (BT+Ex) may augment improvements but the combined effect...
Tue Jul 14, 2020 03:00
Beverages, Vol. 6, Pages 45: Pulsed Light: Challenges of a Non-Thermal Sanitation Technology in the Winemaking Industry Beverages doi: 10.3390/beverages6030045 Authors: Aitana Santamera Carlos Escott Iris Loira Juan Manuel del Fresno Carmen González Antonio Morata Pulsed light is an emerging non-thermal technology viable for foodstuff sanitation. The sanitation is produced through the use of high energy pulses during ultra-short periods of time (ns to µs). The...
Tue Jul 14, 2020 03:00
Bioengineering, Vol. 7, Pages 74: Economic Perspectives of Biogas Production via Anaerobic Digestion
Bioengineering, Vol. 7, Pages 74: Economic Perspectives of Biogas Production via Anaerobic Digestion Bioengineering doi: 10.3390/bioengineering7030074 Authors: Arpit H. Bhatt Ling Tao As the demand for utilizing environment-friendly and sustainable energy sources is increasing, the adoption of waste-to-energy technologies has started gaining attention. Producing biogas via anaerobic digestion (AD) is promising and well-established; however, this process in many circumstances is unable...
Tue Jul 14, 2020 03:00
Biomedicines, Vol. 8, Pages 213: Fluorescent Labeling of Helminth Extracellular Vesicles Using an In Vivo Whole Organism Approach Biomedicines doi: 10.3390/biomedicines8070213 Authors: Anders T. Boysen Bradley Whitehead Allan Stensballe Anna Carnerup Tommy Nylander Peter Nejsum In the last two decades, extracellular vesicles (EVs) from the three domains of life, Archaea, Bacteria and Eukaryotes, have gained increasing scientific attention. As such, the role of EVs in host-pathogen...
Tue Jul 14, 2020 03:00
Biomedicines, Vol. 8, Pages 212: Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis Biomedicines doi: 10.3390/biomedicines8070212 Authors: Deborah Rudin Maurice Schmutz Noëmi Johanna Roos Jamal Bouitbir Stephan Krähenbühl Metamizole is an analgesic, whose pharmacological and toxicological properties are attributed to N-methyl-aminoantipyrine (MAA), its major metabolite. In the presence of heme iron, MAA...
Tue Jul 14, 2020 03:00
Biomedicines, Vol. 8, Pages 211: Specific and Non-Invasive Fluorescent Labelling of Extracellular Vesicles for Evaluation of Intracellular Processing by Intestinal Epithelial Cells Biomedicines doi: 10.3390/biomedicines8070211 Authors: Maria S. Hansen Ida S. E. Gadegaard Eva C. Arnspang Kristine Blans Lene N. Nejsum Jan T. Rasmussen The presence of extracellular vesicles (EVs) in milk has gained interest due to their capacity to modulate the infant’s intestinal...
Tue Jul 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1046: ProAKAP4 as Novel Molecular Marker of Sperm Quality in Ram: An Integrative Study in Fresh, Cooled and Cryopreserved Sperm Biomolecules doi: 10.3390/biom10071046 Authors: Marta F. Riesco Luis Anel-Lopez Marta Neila-Montero Cristina Palacin-Martinez Rafael Montes-Garrido Mercedes Alvarez Paulino de Paz Luis Anel To improve artificial insemination protocols in ovine species it is crucial to optimize sperm quality evaluation after preservation...
Tue Jul 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1045: Role of RadA and DNA Polymerases in Recombination-Associated DNA Synthesis in Hyperthermophilic Archaea Biomolecules doi: 10.3390/biom10071045 Authors: Gaëlle Hogrel Yang Lu Nicolas Alexandre Audrey Bossé Rémi Dulermo Sonoko Ishino Yoshizumi Ishino Didier Flament Among the three domains of life, the process of homologous recombination (HR) plays a central role in the repair of double-strand DNA breaks and the restart of stalled...
Tue Jul 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1043: Nematicidal Activity of Holigarna caustica (Dennst.) Oken Fruit Is Due to Linoleic Acid Biomolecules doi: 10.3390/biom10071043 Authors: Sujogya Kumar Panda Raju Das Anh Hung Mai Wim M. De Borggraeve Walter Luyten Holigarna caustica (Dennst.) Oken is used by the tribes of Northeast India for the treatment of intestinal problems. Therefore, the present study was undertaken to investigate the active principles of this plant responsible for...
Tue Jul 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1044: Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases Biomolecules doi: 10.3390/biom10071044 Authors: Valeria Lodde Giampaolo Murgia Elena Rita Simula Maristella Steri Matteo Floris Maria Laura Idda Immune responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled, autoimmune diseases can occur. Autoimmune diseases (ADs) are a family of disorders...
Tue Jul 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 449: Role of NAD+—Modulated Mitochondrial Free Radical Generation in Mechanisms of Acute Brain Injury Brain Sciences doi: 10.3390/brainsci10070449 Authors: Nina Klimova Adam Fearnow Tibor Kristian It is commonly accepted that mitochondria represent a major source of free radicals following acute brain injury or during the progression of neurodegenerative diseases. The levels of reactive oxygen species (ROS) in cells are determined by two opposing...
Tue Jul 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 450: Treatment of Dystonia Using Trihexyphenidyl in Costello Syndrome
Brain Sciences, Vol. 10, Pages 450: Treatment of Dystonia Using Trihexyphenidyl in Costello Syndrome Brain Sciences doi: 10.3390/brainsci10070450 Authors: Domenico M. Romeo Alessandro Specchia Alfonso Fasano Chiara Leoni Roberta Onesimo Claudia Brogna Stefania Veltri Giuseppe Zampino Costello syndrome (CS), a rare syndrome with multisystemic involvement inherited as a dominant trait, is characterized by developmental delay, coarse facial appearance, cardiac defects...
Tue Jul 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 447: Sex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammation Brain Sciences doi: 10.3390/brainsci10070447 Authors: Héctor González-Pardo Jorge L. Arias Eneritz Gómez-Lázaro Isabel López Taboada Nélida M. Conejo Sex differences have been reported in the susceptibility to early life stress and its neurobiological correlates in humans and experimental animals. However, most of the current...
Tue Jul 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 448: Explaining Age at Autism Spectrum Diagnosis in Children with Migrant and Non-Migrant Background in Austria Brain Sciences doi: 10.3390/brainsci10070448 Authors: Patricia Garcia Primo Christoph Weber Manuel Posada de la Paz Johannes Fellinger Anna Dirmhirn Daniel Holzinger This study explored (i) differences in age at Autism Spectrum Disorder (ASD) diagnosis between children with and without a migrant background in the main diagnostic...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1902: ERBB2 mRNA Expression and Response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-Positive Breast Cancer Cancers doi: 10.3390/cancers12071902 Authors: Gaia Griguolo Fara Brasó-Maristany Blanca González-Farré Tomás Pascual Núria Chic Tamara Saurí Ronald Kates Oleg Gluz Débora Martínez Laia Paré Vassilena Tsvetkova David Pesantez Maria Vidal Barbara Adamo Montserrat Muñoz Patricia Galván Laura Barberá Miriam Cuatrecasas...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1901: Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential Cancers doi: 10.3390/cancers12071901 Authors: Fernandes Dsouza Pandya Kirtonia Tergaonkar Lee Garg Khattar Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide sequences in humans. Telomeres preserve chromosomal stability and genomic integrity. Telomere length shortens with every cell division in somatic cells,...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1900: Efficacy and Safety of the Combination of Pravastatin and Sorafenib for the Treatment of Advanced Hepatocellular Carcinoma (ESTAHEP Clinical Trial) Cancers doi: 10.3390/cancers12071900 Authors: Riaño Martín Varela Serrano Núñez Mínguez Rodrigues Perugorria Banales Arenas Pravastatin has demonstrated anti-tumor activity in preclinical and clinical studies. This multicentric randomized double-blind placebo-controlled phase...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1903: Inconsistent Intersample ALK FISH Results in Patients with Lung Cancer: Analysis of Potential Causes Cancers doi: 10.3390/cancers12071903 Authors: Tang Chen Hong Tang Toruner Wang Roy Chowdhuri Yin Jung Gu Routbort Zhang Khoury Medeiros ALK FISH analyses of multiple specimens occasionally yield inconsistent intersample results in lung cancer patients, posing clinical challenges requiring intensive analysis...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1897: Rapid and Sensitive Quantification of Osimertinib in Human Plasma Using a Fully Validated MALDI–IM–MS/MS Assay Cancers doi: 10.3390/cancers12071897 Authors: Margaux Fresnais André Roth Kathrin I. Foerster Dirk Jäger Stefan M. Pfister Walter E. Haefeli Jürgen Burhenne Rémi Longuespée The third-generation tyrosine kinase inhibitor (TKI), osimertinib, has revolutionized the treatment of patients with non-small cell lung carcinoma with epidermal...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1895: Combinatorial Nanomedicine Made of Squalenoyl-Gemcitabine and Edelfosine for the Treatment of Osteosarcoma Cancers doi: 10.3390/cancers12071895 Authors: Carlos Rodríguez-Nogales Haritz Moreno Carolina Zandueta Didier Desmaële Fernando Lecanda Patrick Couvreur María J. Blanco-Prieto Due to chemoresistance and a high propensity to form lung metastasis, survival rates in pediatric osteosarcoma (OS) are poor. With the aim to improve anticancer...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1898: The Ubiquitin Proteasome System in Hematological Malignancies: New Insight into Its Functional Role and Therapeutic Options Cancers doi: 10.3390/cancers12071898 Authors: Antonella Di Costanzo Nunzio Del Gaudio Lidio Conte Lucia Altucci The ubiquitin proteasome system (UPS) is the main cellular degradation machinery designed for controlling turnover of critical proteins involved in cancer pathogenesis, including hematological malignancies. UPS plays...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1896: Radiotherapy-Induced High Neutrophil-to-Lymphocyte Ratio is a Negative Prognostic Factor in Patients with Breast Cancer Cancers doi: 10.3390/cancers12071896 Authors: Chang Ik Yoon Dooreh Kim Sung Gwe Ahn Soong June Bae Chihwan Cha Soeun Park Seho Park Seung Il Kim Hye Sun Lee Ju Young Park Joon Jeong Radiotherapy (RT) is the standard of care following breast-conserving operation in breast cancer patients. The neutrophil-to-lymphocyte...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1894: Pre-Treatment T2-WI Based Radiomics Features for Prediction of Locally Advanced Rectal Cancer Non-Response to Neoadjuvant Chemoradiotherapy: A Preliminary Study Cancers doi: 10.3390/cancers12071894 Authors: Bianca Petresc Andrei Lebovici Cosmin Caraiani Diana Sorina Feier Florin Graur Mircea Marian Buruian Locally advanced rectal cancer (LARC) response to neoadjuvant chemoradiotherapy (nCRT) is very heterogeneous and up to 30% of patients...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1893: Periodontal Diseases as Putative Risk Factors for Head and Neck Cancer: Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers12071893 Authors: Divya Gopinath Rohit Kunnath Menon Sajesh K. Veettil Michael George Botelho Newell W. Johnson Whether “periodontal disease” can be considered as an independent risk factor for head and neck cancer (HNC) remains controversial. The aim of the current meta-analysis was to quantitatively...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1899: Impact of Chemotherapy in the Adjuvant Setting of Early Stage Uterine Leiomyosarcoma: A Systematic Review and Updated Meta-Analysis Cancers doi: 10.3390/cancers12071899 Authors: Alessandro Rizzo Margherita Nannini Annalisa Astolfi Valentina Indio Pierandrea De Iaco Anna Myriam Perrone Antonio De Leo Lorena Incorvaia Valerio Di Scioscio Maria Abbondanza Pantaleo Background: Although the use of adjuvant chemotherapy (AC) appears...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1891: Clinical, Hematologic, Biologic and Molecular Characteristics of Patients with Myeloproliferative Neoplasms and a Chronic Myelomonocytic Leukemia-Like Phenotype Cancers doi: 10.3390/cancers12071891 Authors: Sonja Heibl Bettina Gisslinger Eva Jäger Agnes Barna Michael Gurbisz Maike Stegemann Peter Bettelheim Sigrid Machherndl-Spandl Michael Pfeilstöcker Thomas Nösslinger Gökhan Uyanik Gregor Hoermann Reinhard Stauder Josef...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1892: Loss of Function SETD2 Mutations in Poorly Differentiated Metastases from Two Hürthle Cell Carcinomas of the Thyroid Cancers doi: 10.3390/cancers12071892 Authors: Valeria Pecce Antonella Verrienti Luana Abballe Raffaella Carletti Giorgio Grani Rosa Falcone Valeria Ramundo Cosimo Durante Cira Di Gioia Diego Russo Sebastiano Filetti Marialuisa Sponziello Hürthle cell carcinomas (HCC) are rare differentiated thyroid...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1889: Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives Cancers doi: 10.3390/cancers12071889 Authors: Ulrich T. Hacker Martin Bentler Dorota Kaniowska Michael Morgan Hildegard Büning Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1890: Identification of Novel microRNA Prognostic Markers Using Cascaded Wx, a Neural Network-Based Framework, in Lung Adenocarcinoma Patients Cancers doi: 10.3390/cancers12071890 Authors: Jeong Seon Kim Sang Hoon Chun Sungsoo Park Sieun Lee Sae Eun Kim Ji Hyung Hong Keunsoo Kang Yoon Ho Ko Young-Ho Ahn The evolution of next-generation sequencing technology has resulted in a generation of large amounts of cancer genomic data. Therefore,...
Tue Jul 14, 2020 03:00
Cancers, Vol. 12, Pages 1888: Relevance of Regulatory T Cells during Colorectal Cancer Development Cancers doi: 10.3390/cancers12071888 Authors: Jonadab E. Olguín Itzel Medina-Andrade Tonathiu Rodríguez Miriam Rodríguez-Sosa Luis I. Terrazas In recent years, there has been a significant increase in the study of own and foreign human factors favoring the development of different types of cancer, including genetic and environmental ones. However, the fact that the immune response...
Tue Jul 14, 2020 03:00
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