Related Articles Management of loco-regionally advanced squamous laryngeal cancer in elderly patients. Eur Arch Otorhinolaryngol. 2020 Jul 12;: Authors: Cavalieri S, Orlandi E, Ivaldi E, Bergamini C, Alfieri S, Iacovelli NA, Ingargiola R, Resteghini C, Platini F, Apollonio G, Beninato T, Incandela F, Fontanella W, Bresciani L, Giannini L, Piazza C, Licitra L, Locati LD Abstract PURPOSE: To describe the management and outcomes of loco-regionally...
Tue Jul 14, 2020 16:24
Background. The aim of our study was to investigate whether serum cholinesterase (ChE) levels were associated with inflammatory bowel disease (IBD). Materials and Methods. We conducted a retrospective case-control study to clarify the relationship between serum ChE levels and IBD that included 142 patients with ulcerative colitis (UC), 60 patients with Crohn’s disease (CD), and 264 healthy controls (HCs). We used ROC curves to evaluate the diagnostic value of serum ChE levels for IBD. Results. Substantially...
Tue Jul 14, 2020 14:50
Condition: Acute Myeloid LeukemiaIntervention: Drug: XY0206Sponsors: Shijiazhuang Yiling Pharmaceutical Co. Ltd; Proswell Medical CorporationNot yet recruiting
Tue Jul 14, 2020 16:10
Condition: Cancer of the Head and NeckInterventions: Drug: INCAGN01876; Drug: INCMGA00012; Biological: DPV-001Sponsor: Providence Health & ServicesNot yet recruiting
Tue Jul 14, 2020 16:10
Publication date: Available online 14 July 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Nikhil Gogna, A.S. Johal, Pratik k. Sharma
Tue Jul 14, 2020 16:01
Background Chronic rhinosinusitis (CRS) is a spectrum of complex inflammatory conditions of the sinonasal mucosa. Identification of biomarkers that enable classification and improved delineation among CRS endotypes is of increasing interest. However, the extent to which less invasive sampling methods identify genuine tissue inflammatory patterns is not well understood. The aim of this study was to investigate mucosal swab and cytobrush sampling as less invasive proxies for tissue transcription levels...
Mon Jul 13, 2020 21:24
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Arysta LifeScience Benelux submitted a request to the competent national authority in Greece to modify the existing maximum residue levels (MRLs) for the active substance triclopyr in kiwi fruits. The data submitted in support of the request were found to be sufficient to derive an MRL proposal for kiwi fruits. Adequate analytical methods for enforcement are available to control the residues of triclopyr in the plant...
Mon Jul 13, 2020 21:04
Related Articles Determining pain in patients with voice disorders: a qualitative study. Logoped Phoniatr Vocol. 2020 Jul 13;:1-8 Authors: Tohidast SA, Mansuri B, Bagheri R, Azimi H Abstract AIM: The present study aimed to determine pain in patients with voice disorders (PWVDs). PATIENTS AND METHODS: A total number of 28 patients with a range of voice disorders and without any other diseases participated in the study. To gain maximum...
Tue Jul 14, 2020 15:39
Lasting modulation of human cortical swallowing motor pathways following thermal tongue stimulation.
Related Articles Lasting modulation of human cortical swallowing motor pathways following thermal tongue stimulation. Neurogastroenterol Motil. 2020 Jul 12;:e13938 Authors: Magara J, Watanabe M, Tsujimura T, Hamdy S, Inoue M Abstract BACKGROUND: Thermal tactile oropharyngeal stimulation has been clinically used to facilitate swallowing initiation in dysphagic patients. We previously demonstrated that thermal stimulation applied to the oral cavity...
Tue Jul 14, 2020 15:39
Related Articles Re-initiation of Oral Food Intake Following Enteral Nutrition Alters Oral and Gut Microbiota Communities. Front Cell Infect Microbiol. 2019;9:434 Authors: Katagiri S, Shiba T, Tohara H, Yamaguchi K, Hara K, Nakagawa K, Komatsu K, Watanabe K, Ohsugi Y, Maekawa S, Iwata T Abstract Stroke is associated with multiple forms of disability, including dysphagia. Post-stroke dysphagia increases the risks of pneumonia and mortality and...
Tue Jul 14, 2020 15:39
Abstract 49,XXXXY was previously associated with profound to severe intellectual deficits. However, prior research papers on the cognitive profiles of this population were confounded by small samples sizes, wide age spreads, and incomplete histories of testosterone replacement therapy. This study is the first comprehensive, international investigation of the neurocognitive aspects of 49,XXXXY, and the potential effects of biological treatment on this profile. Sixty‐seven boys from infancy to 11 years...
Tue Jul 14, 2020 12:01
Abstract Polydactyly and syndactyly are digital abnormalities in limb‐associated birth defects usually caused by genetic disorders. In this study, a five‐generation Chinese pedigree was found with triphalangeal thumb polysyndactyly syndrome (TPTPS), showing an autosomal dominant pattern of inheritance. We utilized linkage analysis and whole genome sequencing (WGS) for the genetic diagnosis of this pedigree. Linkage analysis was performed using a genome‐wide single nucleotide polymorphism (SNP) chip...
Tue Jul 14, 2020 11:55
Publication date: Available online 14 July 2020Source: Radiotherapy and OncologyAuthor(s): John Leung Franzcr
Tue Jul 14, 2020 15:26
Publication date: Available online 13 July 2020Source: Radiotherapy and OncologyAuthor(s): Kathy Han, Lucas Mendez, David D'Souza, Vikram Velker, Elizabeth Barnes, Michael F. Milosevic, Anthony Fyles, Sarah E Ferguson, Amandeep Taggar, Jennifer Croke, Elysia Donovan, Eric Leung
Tue Jul 14, 2020 15:26
Publication date: Available online 13 July 2020Source: Radiotherapy and OncologyAuthor(s): Francesco Cellini, Maria Antonietta Gambacorta, Gian Carlo Mattiucci, Vincenzo Valentini
Tue Jul 14, 2020 15:26
Publication date: Available online 13 July 2020Source: Radiotherapy and OncologyAuthor(s): Leila T. Tchelebi, Karyn Goodman
Tue Jul 14, 2020 15:26
The Journal of Antibiotics, Published online: 14 July 2020; doi:10.1038/s41429-020-0350-1Identification of an extensively drug-resistant Escherichia coli clinical strain harboring mcr-1 and blaNDM-1 in Korea
Tue Jul 14, 2020 03:00
Tue Jul 14, 2020 03:00
An 80-year-old Japanese male was treated with chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, and prednisolone, for non-Hodgkin lymphoma. Nine months after the chemotherapy, he was diagnosed with acute myeloid leukemia (AML) (M4) with translocation 8p11 and 22q13. The patient bone marrow indicated a remarkable degree of sea-blue histiocytosis. His disease was aggressive, and he died of the disease. Sea-blue histiocytes are macrophages harboring blue vacuoles and granular deposition,...
Tue Jul 14, 2020 13:19
Pulmonary tumor thrombotic microangiopathy (PTTM) is characterized by tumor cell microemboli with occlusive fibrointimal remodeling in small pulmonary vessels. Platelet-derived growth factor (PDGF) has been implicated in the development of PTTM, and fibroblast growth factor (FGF) promotes PDGF signaling via PDGF receptor β. We here describe a cancer patient who presented with dyspnea of uncertain etiology and whose condition worsened rapidly. A 68-year-old man with hypopharyngeal squamous cell carcinoma...
Tue Jul 14, 2020 13:16
The survival of patients with head and neck squamous cancer with locoregional recurrence is short if salvage surgery or radiation cannot be performed. Systemic chemotherapy based on platinum salts and cetuximab produces only partial and transient responses. Immune checkpoint inhibitors (i.e., nivolumab) lead to a low complete response rate of only about 10%, but in some cases the effects can be long-lasting. Intratumoral chemotherapy (ITC) has been proposed for patients with local recurrence of head...
Tue Jul 14, 2020 08:32
We here report on 2 cases of monostotic Paget’s disease of bone, one in the ilium and the other in the skull, including quantitative values obtained with bone single photon emission computed tomography/computed tomography (SPECT/CT), which were useful to evaluate the response to bisphosphonate treatment. The quantitative parameters determined with those findings were decreased, with the maximum standardized uptake value (SUV), peak SUV, mean SUV, metabolic bone volume, and total bone uptake in case...
Tue Jul 14, 2020 08:31
Related Articles Implications of head and neck restraint test repeatability for specification improvement. Traffic Inj Prev. 2019;20(6):588-594 Authors: Patalak JP, Harper MG, Stitzel JD Abstract Objective: Since 2005, National Association for Stock Car Auto Racing, Incorporated (NASCAR) drivers have been required to use a head and neck restraint system (HNR) that complies with SFI Foundation, Inc. (SFI) 38.1. The primary purpose of the HNR...
Tue Jul 14, 2020 15:08
ABSTRACT A wide range of biomaterials and tissue engineered scaffolds are being investigated to support and stimulate bone healing in animal models. Using phantoms and rat cadavers, we investigated the feasibility of using spatially offset Raman spectroscopy (SORS) to monitor changes in collagen concentration at levels similar to those expected to occur in‐vivo during bone regeneration (0 – 0.84 g/cm3). A partial least squares (PLS) regression model was developed to quantify collagen concentration...
Mon Jul 13, 2020 22:00
Stimulated Raman Scattering (SRS) is a fast chemical imaging technique with remarkable bio‐science applications. Cross Phase Modulation (XPM) is a ubiquitous non‐linear phenomenon that can create spurious background signals that render difficult a high‐contrast imaging in SRS measurements. The XPM‐induced signal is usually suppressed using high Numerical Aperture (NA) microscope objectives or condensers to collect the transmitted excitation beam. However, these high‐NA optics feature short working...
Mon Jul 13, 2020 18:14
Publication date: August 2020Source: Journal of Human Evolution, Volume 145Author(s): David Hérisson, Sylvain Soriano
Tue Jul 14, 2020 14:55
Publication date: Available online 14 July 2020Source: Clinical NeurophysiologyAuthor(s): T.W.P. Janssen, N. van Atteveldt, J. Oosterlaan
Tue Jul 14, 2020 14:55
Abstract Minipig skin is one of the most widely used non‐rodent animal skin models for dermatological research. A thorough characterization of minipig skin is essential for gaining deeper understanding of its structural and functional similarities with human skin. In this study, three‐dimensional (3‐D) in vivo images of minipig skin was obtained non‐invasively using a multimodal optical imaging system capable of acquiring two‐photon excited fluorescence (TPEF) and fluorescence lifetime imaging...
Mon Jul 13, 2020 20:48
Abstract Solid tumors exhibit an inversed pH‐gradient with increased intracellular pH (pHi) and decreased extracellular pH (pHe). This inside‐out pH‐gradient is generated via sodium/hydrogen antiporter 1, vacuolar‐type H+ ATPases, monocarboxylate transporters, (bi)carbonate (co)transporters, and carboanhydrases. Our knowledge on how pHe‐signals are sensed and what the respective receptors induce inside cells is scarce. Some pH‐sensitive receptors (GPR4, GPR65/TDAG8, GPR68/OGR1, GPR132/G2A, possibly...
Mon Jul 13, 2020 15:59
Objective To investigate if neurodegenerative biomarkers in cerebro‐spinal fluid (CSF) diffferentiate patients with suspected normal pressure hydrocephalus (NPH) who respond to CSF drainage from patients who do not respond. Methods Data of 62 consecutive patients who presented with MRI‐changes indicative of NPH were studied with regard to cognitive and gait functions before and after drainage of 40‐50 ml CSF. Additionally, S100, NSE, ß‐amyloid protein, tau‐protein, phospho‐tau were determined...
Mon Jul 13, 2020 21:00
Publication date: July–August 2020Source: Brachytherapy, Volume 19, Issue 4Author(s):
Tue Jul 14, 2020 14:19
Publication date: July–August 2020Source: Brachytherapy, Volume 19, Issue 4Author(s):
Tue Jul 14, 2020 14:19
Publication date: July–August 2020Source: Brachytherapy, Volume 19, Issue 4Author(s):
Tue Jul 14, 2020 14:19
Publication date: July–August 2020Source: Brachytherapy, Volume 19, Issue 4Author(s): Jenna M. Kahn, Drew Moghanaki
Tue Jul 14, 2020 14:19
A 70-year-old immunocompetent male in South Carolina was admitted secondary to altered mental status and headache without focal neurological deficits. Head CT was negative. Lumbar puncture (LP) revealed normal glucose, elevated protein, and lymphocytosis. Opening pressure was 15 cm of H20. CSF lateral flow assay was negative for cryptococcal antigen; CSF cultures showed no growth. The patient rapidly improved on acyclovir and was diagnosed with presumed viral meningitis, as viral PCR and fungal culture...
Tue Jul 14, 2020 09:20
Streptococcus constellatus is an oropharyngeal commensal Gram-positive coccus, frequently associated with the respiratory tract. S. constellatus is part of the Streptococcus anginosus or milleri group, which has traditionally been considered to have propensity to cause empyema and purulent abscesses, a property that is sometimes overlooked as the severity of infections it causes may have a varying degree. In this case, we present the case of a 54-year-old male with known liver cirrhosis who developed...
Tue Jul 14, 2020 04:20
Publication date: 1 December 2020Source: Talanta, Volume 220Author(s): Tianlin Ye, Zhipeng Huang, Zhenyu Zhu, Di Deng, Ren Zhang, Hui Chen, Jilie Kong
Tue Jul 14, 2020 14:01
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