IJERPH, Vol. 17, Pages 5043: The Influence of Racial Differences in the Demand for Healthcare in South Africa: A Case of Public Healthcare International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17145043 Authors: David Mhlanga Rufaro Garidzirai The study sought to analyse the influence of racial differences in the demand for public healthcare in South Africa, using the 2018 General Household Survey (GHS) data. This was completed to understand if race still...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4979: Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host–Guest Recognition International Journal of Molecular Sciences doi: 10.3390/ijms21144979 Authors: Can-Peng Li Yu-Xun Lu Cheng-Ting Zi Yu-Ting Zhao Hui Zhao Ya-Ping Zhang We reported for the first time that cationic pillar[6]arene (cPA6) could tightly bind to peptide polymer (MW~20–50 kDa), an artificial substrate for tyrosine (Tyr)...
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IJMS, Vol. 21, Pages 4978: The Potential of Insects as Alternative Sources of Chitin: An Overview on the Chemical Method of Extraction from Various Sources International Journal of Molecular Sciences doi: 10.3390/ijms21144978 Authors: Nurul Alyani Zainol Abidin Faridah Kormin Nurul Akhma Zainol Abidin Nor Aini Fatihah Mohamed Anuar Mohd Fadzelly Abu Bakar Chitin, being the second most abundant biopolymer after cellulose, has been gaining popularity since its initial discovery...
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IJMS, Vol. 21, Pages 4977: Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease International Journal of Molecular Sciences doi: 10.3390/ijms21144977 Authors: Alex Cleber Improta-Caria Carolina Kymie Vasques Nonaka Bruno Raphael Ribeiro Cavalcante Ricardo Augusto Leoni De Sousa Roque Aras Júnior Bruno Solano de Freitas Souza Alzheimer disease (AD) is one of the most common neurodegenerative...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4976: Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats International Journal of Molecular Sciences doi: 10.3390/ijms21144976 Authors: Kang Choi Jang Lee Kim Kim Jeong Kim Na Kim : We investigated the time-dependent deleterious ocular changes induced by urban particulate matter (UPM) in vitro and in vivo. UPM treatment decreased...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4971: The Smallest Isoform of Metridia longa Luciferase as a Fusion Partner for Hybrid Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21144971 Authors: Marina D. Larionova Svetlana V. Markova Nina V. Tikunova Eugene S. Vysotski Bioluminescent proteins are widely used as reporter molecules in various in vitro and in vivo assays. The smallest isoform of Metridia luciferase (MLuc7) is a highly active, naturally secreted enzyme which,...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4974: De Novo Assembly of the Asian Citrus Psyllid Diaphorina citri (Hemiptera: Psyllidae) Transcriptome across Developmental Stages International Journal of Molecular Sciences doi: 10.3390/ijms21144974 Authors: Yang Ou Guo Lü Guo Qiu Pan Asian citrus psyllid Diaphorina citri Kuwayama is an important economic pest of citrus, as it transmits Candidatus Liberibacter asiaticus, the causative agent of huanglongbing. In this study, we used RNA-seq...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4975: Punicalagin Ameliorates Lupus Nephritis via Inhibition of PAR2 International Journal of Molecular Sciences doi: 10.3390/ijms21144975 Authors: Seo Mun Park Jeon Kim Yoon Ko Jo Park Namkung Lee Lupus nephritis (LN) is the most frequent phenotype in patients with systemic lupus erythematosus (SLE) and has a high rate of progression to end-stage renal disease, in spite of intensive treatment and maintenance therapies. Recent...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4973: P2 Purinergic Signaling in the Distal Lung in Health and Disease International Journal of Molecular Sciences doi: 10.3390/ijms21144973 Authors: Eva Wirsching Michael Fauler Giorgio Fois Manfred Frick The distal lung provides an intricate structure for gas exchange in mammalian lungs. Efficient gas exchange depends on the functional integrity of lung alveoli. The cells in the alveolar tissue serve various functions to maintain alveolar structure, integrity...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4972: Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21144972 Authors: Laurel C. Chandler Imran H. Yusuf Michelle E. McClements Alun R. Barnard Robert E. MacLaren Kanmin Xue Effective treatment of retinal diseases with adeno-associated virus (AAV)-mediated gene therapy is highly dependent on the proportion...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4970: Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species International Journal of Molecular Sciences doi: 10.3390/ijms21144970 Authors: Juan Perdomo Carlos Quintana Ignacio González Inmaculada Hernández Sara Rubio Juan F. Loro Russel J. Reiter Francisco Estévez José Quintana Melatonin is present in all living organisms where it displays a diversity of physiological...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4969: Research Tools for the Functional Genomics of Plant miRNAs During Zygotic and Somatic Embryogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21144969 Authors: Wójcik During early plant embryogenesis, some of the most fundamental decisions on fate and identity are taken making it a fascinating process to study. It is no surprise that higher plant embryogenesis was intensively analysed during the last century, while somatic embryogenesis...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4968: Cloning and Functional Analysis of Dwarf Gene Mini Plant 1 (MNP1) in Medicago truncatula International Journal of Molecular Sciences doi: 10.3390/ijms21144968 Authors: Shiqi Guo Xiaojia Zhang Quanzi Bai Weiyue Zhao Yuegenwang Fang Shaoli Zhou Baolin Zhao Liangliang He Jianghua Chen Plant height is a vital agronomic trait that greatly determines crop yields because of the close relationship between plant height and lodging resistance....
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4967: The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis International Journal of Molecular Sciences doi: 10.3390/ijms21144967 Authors: Eunah Shin Ja Seung Koo The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4966: Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21144966 Authors: Shani Blumenreich Or B. Barav Bethan J. Jenkins Anthony H. Futerman The lysosome is a central player in the cell, acting as a clearing house for macromolecular degradation, but also plays a critical role in a variety of additional metabolic and regulatory processes. The lysosome has recently...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4965: EPA and DHA Fatty Acids Induce a Remodeling of Tumor Vasculature and Potentiate Docetaxel Activity International Journal of Molecular Sciences doi: 10.3390/ijms21144965 Authors: Caroline Goupille Sophie Vibet Philippe G. Frank Karine Mahéo n-3 long chain Polyunsaturated Fatty Acids (n-3 LCPUFA) have been shown to improve the efficacy of conventional chemotherapies used for breast cancer treatment. In addition to their reported ability to increase the...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4964: Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21144964 Authors: Elena Naumovska Germaine Aalderink Christian Wong Valencia Kinga Kosim Arnaud Nicolas Stephen Brown Paul Vulto Kai S. Erdmann Dorota Kurek Intestinal organoids have emerged as the new paradigm for modelling the healthy and diseased intestine with patient-relevant properties....
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4961: Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability International Journal of Molecular Sciences doi: 10.3390/ijms21144961 Authors: Guadalupe Elizabeth Jimenez-Gutierrez Ricardo Mondragon-Gonzalez Luz Adriana Soto-Ponce Wendy Lilián Gómez-Monsiváis Ian García-Aguirre Ruth Abigail Pacheco-Rivera Rocío Suárez-Sánchez Andrea Brancaccio Jonathan Javier Magaña Rita C.R. Perlingeiro Bulmaro Cisneros...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4962: The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy International Journal of Molecular Sciences doi: 10.3390/ijms21144962 Authors: Humna Bhagani Suzanne A. Nasser Ali Dakroub Ahmed F. El-Yazbi Assaad A. Eid Firas Kobeissy Gianfranco Pintus Ali H. Eid Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes....
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4963: Spiegelmer-Based Sandwich Assay for Cardiac Troponin I Detection International Journal of Molecular Sciences doi: 10.3390/ijms21144963 Authors: Zoltán János Tolnai Judit András Zsuzsanna Szeitner Krisztina Percze László Ferenc Simon Róbert E. Gyurcsányi Tamás Mészáros Two subunits of the ternary troponin complex, I and C, have cardiac muscle specific isoforms, and hence could be applied as highly-selective markers of acute coronary syndrome....
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4958: Activation of NOTCH1 by Shear Force Elicits Immediate Cytokine Expression in Human Chondrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21144958 Authors: Hao-Jen Cheng Wan-Ting Hsu Cheng-Nan Chen Chin Li Osteoarthritis is caused by overloading of joints and is characterized by inflammation-induced disruption of cartilage structure. Current treatment strategy aims to relieve inflammation and prevent further deterioration of joint...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4960: Structure of Nanotubes Self-Assembled from a Monoamide Organogelator International Journal of Molecular Sciences doi: 10.3390/ijms21144960 Authors: Samuel Zapién-Castillo Nancy P. Díaz-Zavala José A. Melo-Banda Duncan Schwaller Jean-Philippe Lamps Marc Schmutz Jérôme Combet Philippe J. Mésini Some organic compounds are known to self-assemble into nanotubes in solutions, but the packing of the molecules into the walls of the tubes is known...
Tue Jul 14, 2020 03:00
IJMS, Vol. 21, Pages 4959: Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage International Journal of Molecular Sciences doi: 10.3390/ijms21144959 Authors: Friedrich Barsch Tanja Niedermair Andreas Mamilos Volker H. Schmitt David Grevenstein Maximilian Babel Thomas Burgoyne Amelia Shoemark Christoph Brochhausen Cilia are cellular organelles that project from the cell....
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2231: Long-Term Outcomes of Patients with Unprotected Left Main Coronary Artery Disease Treated with Percutaneous Angioplasty versus Bypass Grafting: A Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine doi: 10.3390/jcm9072231 Authors: Bajraktari Zhubi-Bakija Ndrepepa Alfonso Elezi Rexhaj Bytyçi Bajraktari Poniku Henein Background and Aim: Treatment of patients with left main coronary artery disease (LMCA)...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2232: Delirium Post-Stroke: Short- and Long-Term Effect on Depression, Anxiety, Apathy and Aggression (Research Study—Part of PROPOLIS Study) Journal of Clinical Medicine doi: 10.3390/jcm9072232 Authors: Katarzyna Kowalska Jakub Droś Małgorzata Mazurek Paulina Pasińska Agnieszka Gorzkowska Aleksandra Klimkowicz-Mrowiec Background: Stroke patients are particularly vulnerable to delirium episodes, but very little is known about its subsequent adverse mental...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2237: Multimodality Imaging in the Diagnostic Work-Up of Endocarditis and Cardiac Implantable Electronic Device (CIED) Infection Journal of Clinical Medicine doi: 10.3390/jcm9072237 Authors: Nicola Galea Francesco Bandera Chiara Lauri Camillo Autore Andrea Laghi Paola Anna Erba Infective endocarditis (IE) is a serious cardiac condition, which includes a wide range of clinical presentations, with varying degrees of severity. The diagnosis is multifactorial...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2235: Injury of the Tibial Nutrient Artery Canal during External Fixation for Lower Extremity Fractures: A Computed Tomography Study Journal of Clinical Medicine doi: 10.3390/jcm9072235 Authors: Haidara Almansour Johann Jacoby Heiko Baumgartner Marie K. Reumann Konstantin Nikolaou Fabian Springer The tibial nutrient artery (TNA) is the major diaphyseal artery of the tibia supplying two thirds of the inner osseous cortex. Hence, iatrogenic injury of the...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2236: Comparison of a Significant Decline in the Glomerular Filtration Rate between Ileal Conduit and Ileal Neobladder Urinary Diversions after Radical Cystectomy: A Propensity Score-Matched Analysis Journal of Clinical Medicine doi: 10.3390/jcm9072236 Authors: Yu Hong Park Lee Hwang Kong Kim Urinary diversion after radical cystectomy is associated with a risk of renal function impairment. A significant decline in the glomerular filtration...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2233: Age-Related Risk Factors at the First Stroke Event Journal of Clinical Medicine doi: 10.3390/jcm9072233 Authors: Soto-Cámara González-Bernal González-Santos Aguilar-Parra Trigueros López-Liria (1) Background: Stroke is a multifactorial disease, which can affect individuals at any age. Risk factors (RFs) associated with the first stroke event have been well identified; however, the influence of these RFs on the patient´s age needs...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2234: Hereditary ATTR Amyloidosis in Austria: Prevalence and Epidemiological Hot Spots Journal of Clinical Medicine doi: 10.3390/jcm9072234 Authors: Michaela Auer-Grumbach Rene Rettl Klemens Ablasser Hermine Agis Christian Beetz Franz Duca Martin Gattermeier Franz Glaser Markus Hacker Renate Kain Birgit Kaufmann Gabor G. Kovacs Christian Lampl Neira Ljevakovic Jutta Nagele Gerhard Pölzl Stefan Quasthoff Bernadette Raimann...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2228: Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment Journal of Clinical Medicine doi: 10.3390/jcm9072228 Authors: Lazar Dinescu Costache Cutaneous squamous cell carcinoma (cSCC) is a common type of neoplasia, representing a terrible burden on patients’ life and clinical management. Although it seldom metastasizes, and most cases can be effectively treated with surgical intervention, once...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2229: Impact of Galectin-3 Circulating Levels on Frailty in Elderly Patients with Systolic Heart Failure Journal of Clinical Medicine doi: 10.3390/jcm9072229 Authors: Komici Gnemmi Bencivenga Vitale Rengo Di Stefano Eleuteri Background: Heart Failure (HF), a leading cause of morbidity and mortality, represents a relevant trigger for the development of frailty in the elderly. Inflammation has been reported to play an important role in HF and...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2230: Kurarinone Inhibits HCoV-OC43 Infection by Impairing the Virus-Induced Autophagic Flux in MRC-5 Human Lung Cells Journal of Clinical Medicine doi: 10.3390/jcm9072230 Authors: Min Kim Jin Kwon Kurarinone is a prenylated flavonone isolated from the roots of Sophora flavescens. Among its known functions, kurarinone has both anti-apoptotic and anti-inflammatory properties. Coronaviruses (CoVs), including HCoV-OC43, SARS-CoV, MERS-CoV, and SARS-CoV-2,...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2227: Epidemiology and Clinical Presentation of Children Hospitalized with SARS-CoV-2 Infection in Suburbs of Paris Journal of Clinical Medicine doi: 10.3390/jcm9072227 Authors: Gaborieau Delestrain Bensaid Vizeneux Blanc Garraffo Georget Chalvon Garrec Laoudi Varon Rouget Pupin Abdel Aal Toulorge Ducrocq Barrey Pantalone Robert Joly-Sanchez Thach Masserot-Lureau Chahine Garcia-Roudaut...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2226: Clinical Characterization of the Frequent Exacerbator Phenotype in Asthma Journal of Clinical Medicine doi: 10.3390/jcm9072226 Authors: Andrea Elio Sprio Vitina Carriero Stefano Levra Carlotta Botto Francesca Bertolini Antonino Di Stefano Mauro Maniscalco Giorgio Ciprandi Fabio Luigi Massimo Ricciardolo Background: Asthma exacerbation is episodic worsening of respiratory symptoms in conjunction with the deterioration of lung function,...
Tue Jul 14, 2020 03:00
JCM, Vol. 9, Pages 2225: A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema Journal of Clinical Medicine doi: 10.3390/jcm9072225 Authors: Noemi Lois Evie Gardner Margaret McFarland David Armstrong Christine McNally Nuala Jane Lavery Christina Campbell Rita I Kirk Daiva Bajorunas Ann Dunne Anthony Cerami Michael Brines Purpose: Evaluating the effects of cibinetide in diabetic macular edema (DME). Methods: Phase...
Tue Jul 14, 2020 03:00
JFMK, Vol. 5, Pages 48: Perspective of Dose and Response for Individualized Physical Exercise and Training Prescription Journal of Functional Morphology and Kinesiology doi: 10.3390/jfmk5030048 Authors: Thomas Gronwald Alexander Törpel Fabian Herold Henning Budde Physical interventions are used to increase physical (sports) performance and considered as effective low-cost strategies in the fields of healthcare, disease or injury prevention, and medical treatment. In general,...
Tue Jul 14, 2020 03:00
JoF, Vol. 6, Pages 108: Modeling Approaches Reveal New Regulatory Networks in Aspergillus fumigatus Metabolism Journal of Fungi doi: 10.3390/jof6030108 Authors: Enzo Acerbi Marcela Hortova-Kohoutkova Tsokyi Choera Nancy Keller Jan Fric Fabio Stella Luigina Romani Teresa Zelante Systems biology approaches are extensively used to model and reverse-engineer gene regulatory networks from experimental data. Indoleamine 2,3-dioxygenases (IDOs)—belonging in the...
Tue Jul 14, 2020 03:00
Life, Vol. 10, Pages 112: UPLC-MS/MS Phytochemical Analysis of Two Croatian Cistus Species and Their Biological Activity Life doi: 10.3390/life10070112 Authors: Ivana Carev Ana Maravić Nada Ilić Vedrana Čikeš Čulić Olivera Politeo Zoran Zorić Mila Radan Aqueous extracts of two Cistus species wild growing in Croatia—Cistus creticus (CC) and Cistus salviifolius (CS)—have been assessed with UPLC-MS/MS, showing 43 different phytochemicals, with flavonol...
Tue Jul 14, 2020 03:00
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