Abstract Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and...
Tue Jul 14, 2020 16:14
New Findings What is the topic of this review? Biomedical research at the Antarctic Concordia Station. What advances does it highlight? Findings in psychology, neuroscience, sleep, cardiovascular physiology and immune system, relevant in ICE environments and spaceflight. Abstract Extended stays in isolated, confined and extreme (ICE) environments like Antarctica, are associated with a whole set of psychological and physiological challenges for the crew. As such, winter‐over...
Tue Jul 14, 2020 17:19
At Makassed Hospital’s open-bay intensive care unit (ICU), enhanced terminal disinfection (ETD) using hydrogen peroxide (H2O2) was performed without a predefined schedule in extensively-drug-resistant Acinetobact...
Tue Jul 14, 2020 03:00
The prevalence of extended beta-lactamase producing Enterobacteriaceae (ESBL-E) has been constantly increasing over the last few decades. These microorganisms that have acquired broad antibiotic resistance are...
Tue Jul 14, 2020 03:00
Long-term care facilities (LTCFs) are an important reservoir of multidrug-resistant organisms (MDROs). Colonization of LTCF residents by MDROs is generally higher in Italy compared to other European countries....
Mon Jul 13, 2020 03:00
Chemosensors in the mouse stomach. Most chemosensors had higher expression in the antrum versus corpus, except for CD36, GNAT2, ghrelin, and GOAT. Chemosensors for fatty acids (FFAR4, CD36), protein (GPR93) and the sweet and umami taste receptor subunit (T1R3) were co‐expressed with ghrelin. Abstract Background The ability of the gut to detect nutrients is critical to the regulation of gut hormone secretion, food intake, and postprandial blood glucose control. Ingested nutrients are...
Tue Jul 14, 2020 18:23
More than eight in ten of the world’s 1.65 million adolescents living with human immunodeficiency virus (ALHIV) live in sub-Saharan Africa (SSA). Suboptimal adherence to antiretroviral therapy (ART) and poor v...
Tue Jul 14, 2020 03:00
Abstract Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and...
Tue Jul 14, 2020 16:17
Key points The relationship between spatiotemporal gait asymmetry and walking energetics is currently under debate. The split‐belt treadmill paradigm has been used to study adaptation of spatiotemporal gait parameters in relation to energetics, but it remains unclear why people reduce asymmetry in step lengths, but prefer asymmetry in step times. In this study we characterized the effects of step time asymmetry and step length asymmetry on energy cost during steady‐state walking on a split‐belt...
Tue Jul 14, 2020 17:19
Leaving in its wake more than 12 million infections, over 550,000 deaths, and an economic toll in the trillions of dollars to date, the SARS-CoV-2 pandemic has devastated the most vulnerable in our society — adults 65 years of age or older, persons with underlying conditions, and the economically…
Tue Jul 14, 2020 03:00
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019 (Covid-19). The urgent need for vaccines prompted an international response, with more than 120 candidate…
Tue Jul 14, 2020 03:00
To describe indications for injection augmentation (IA), endoscopic repair (ER) and conservative methods for the management of type 1 laryngeal cleft (LC1) and propose a management algorithm. We also aimed to ...
Tue Jul 14, 2020 03:00
The regulation of gliogenesis is a fundamental process for nervous system development, as the appropriate glial number and identity is required for a functional nervous system. To investigate the molecular mechanisms involved in gliogenesis, we used C. elegans as a model and identified the function of the proneural gene lin-32/Atoh1 in gliogenesis. We found that lin-32 functions during embryonic development to negatively regulate the number of AMsh glia. The ectopic AMsh cells at least partially...
Tue Jul 14, 2020 23:04
Bigenic expression relationships are conventionally defined based on metrics such as Pearson or Spearman correlation that cannot typically detect latent, non-linear dependencies or require the relationship to be monotonic. Further, the combination of intrinsic and extrinsic noise as well as embedded relationships between sample sub-populations reduces the probability of extracting biologically relevant edges during the construction of gene co-expression networks (GCNs). In this report, we address...
Tue Jul 14, 2020 23:04
Background and Objectives This study was performed to compare the use of methylene blue (MB) and rose bengal (RB) in antimicrobial photodynamic therapy (PDT) targeting Enterococcus faecalis (E. faecalis ) bacteria in planktonic and biofilm forms with potassium iodide (KI) potentiation. Study Design/Materials and Methods E. faecalis bacteria in planktonic form were exposed to antimicrobial PDT protocols activating MB and RB, with or without KI potentiation, following laser irradiation with...
Tue Jul 14, 2020 14:19
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02104
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01741
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01464
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01837
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00583
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01867
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01772
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01776
Tue Jul 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00209
Tue Jul 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05505
Tue Jul 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04277
Tue Jul 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07517
Tue Jul 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06554
Tue Jul 14, 2020 07:00
Data normalization and clustering are mandatory steps in gene expression and downstream analyses, respectively. However, user-friendly implementations of these methodologies are available exclusively under exp...
Tue Jul 14, 2020 03:00
Our objective was to develop and validate a virtual patient (VP) learning module to educate pediatric residents about antimicrobial stewardship (AMS) principles. A VP module on complicated pneumonia was develo...
Tue Jul 14, 2020 03:00
LaryngorhinootologieDOI: 10.1055/a-1209-3225 Einleitung Atemänderungen auf wiederholte kurze olfaktorische Reize werden als objektiver Indikator für die Intaktheit des Riechsystems eingesetzt. Bislang war nicht untersucht, ob sich olfaktorisch-induzierte Änderungen inspiratorischer und exspiratorischer Zeitparameter willentlich unterdrücken lassen. Das Gleiche gilt auch für Atemänderungen infolge schwacher CO2-Reize. Methodik 34 gesunde erwachsene Normosmiker wurden während...
Tue Jul 14, 2020 02:00
Abstract Past research has demonstrated that regular physical activity provides a myriad of physical, mental, and emotional benefits. The decision of whether to partake in physical activity (PA) or remain sedentary appears to be partially influenced by motivational and emotional systems. Research suggests left frontal alpha asymmetry is a neural marker of approach motivation. However, studies have not explored whether habitual levels of PA and sedentary behavior relate to this neurophysiological...
Tue Jul 14, 2020 16:50
Abstract The attentional biases toward body‐related information for individuals with weight concerns and eating disorders have been well documented. However, our knowledge of the attentional biases toward body‐related information for subjects with physical stature concerns is only at the beginning. And the research on the auditory attentional biases for individuals with physical stature concerns is rare. The identification of attentional biases may provide an impetus for interventions to reduce...
Mon Jul 13, 2020 20:55
Abstract The autonomic nervous system (ANS) has demonstrated utility for identifying alterations in emotion processing associated with common psychopathology, including depression and anxiety. To date though the majority of this ANS research has several limitations. Most studies have examined parasympathetic and sympathetic branches separately, requiring activity in the other branch be inferred. This is problematic as each branch may function independently. Composite indices such as cardiac autonomic...
Mon Jul 13, 2020 20:44
Abstract The neuroactive metabolites of the steroid hormones progesterone (P4) and testosterone (T) are GABAergic modulators that influence cognition, yet, the specific effect of P4 and T on brain network activity remains poorly understood. Here, we investigated if a fundamental oscillatory network activity pattern, often related to cognitive control, frontal midline theta (FMT) oscillations, are modulated by steroids hormones, P4 and T. We measured the concentration of P4 and T using salivary enzyme...
Mon Jul 13, 2020 20:38
Martin Blaser (Foto de Nick Romanenko)Uno no puede dejar de preguntarse si somos más frágiles biológicamente que las generaciones que nos precedieron. No se trata de que seamos más cobardes, decadentes, incapaces de prestar atención y perezosos, e incluso menos inteligentes -sea la inteligencia lo que sea y se mida como se mida. Aunque algo de eso haya. Pero los defectos del carácter y la cognición tienen las más de las veces un trasfondo biológico. Se aprecia el aumento de enfermedades que antes...
00:34
Abstract Background The coronavirus disease 2019 (COVID‐19) has become a global pandemic, with 10‐20% of severe cases and over 508,000 deaths worldwide. Objective This study aims to address the risk factors associated with the severity of COVID‐19 patients and the mortality of severe patients. Methods 289 hospitalized laboratory‐confirmed COVID‐19 patients were included in this study. Electronic medical records, including patient demographics, clinical manifestation, comorbidities,...
Tue Jul 14, 2020 12:16
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου