Related Articles pH-sensing in skin tumors: methods to study the involvement of GPCRs, acid-sensing ion channels and transient receptor potential vanilloid channels. Exp Dermatol. 2020 Jul 13;: Authors: Stolwijk J, Sauer L, Ackermann K, Nassios A, Aung T, Haerteis S, Bäumner A, Wegener J, Schreml S Abstract Solid tumors exhibit an inversed pH-gradient with increased intracellular pH (pHi ) and decreased extracellular pH (pHe ). This inside-out...
Tue Jul 14, 2020 14:59
Related Articles Pancreatic Neuroendocrine Neoplasms and Gastrointestinal Stromal Tumors: A Single-Institution Experience of a Rare Association and Review of the Literature. Pancreas. 2020 Jul 09;: Authors: Milanetto AC, Pacciani S, Fassan M, Pasquali C Abstract OBJECTIVE: Pancreatic neuroendocrine neoplasms (pNENs) and gastrointestinal stromal tumors (GISTs) represent rare neoplasms. Nonsyndromic cases of pNENs associated with a synchronous...
Tue Jul 14, 2020 14:59
Related Articles Medullary Pancreatic Carcinoma Due to Somatic POLE Mutation: A Distinctive Pancreatic Carcinoma With Marked Long-Term Survival. Pancreas. 2020 Jul 09;: Authors: Kryklyva V, Ter Linden E, Kroeze LI, de Voer RM, van der Kolk BM, Stommel MWJ, Hermans JJ, Luchini C, Wood LD, Hruban RH, Nagtegaal ID, Ligtenberg MJL, Brosens LAA Abstract Medullary pancreatic carcinoma (MPC) is a rare histological variant of pancreatic ductal adenocarcinoma...
Tue Jul 14, 2020 14:59
Related Articles Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review. Arch Iran Med. 2020 Jul 01;23(7):488-497 Authors: Alipour S, Eskandari A, Johar FM, Furuya S Abstract BACKGROUND: Phyllodes tumor (PT) is a rare tumor of the breast, which may occur during pregnancy or lactation. Several studies have reviewed and discussed PT occurring in pregnancy, gathering up to 14 patients. We performed a thorough systematic...
Tue Jul 14, 2020 14:59
Related Articles Liver transplantation in the treatment of unresectable hepatic metastasis from neuroendocrine tumors. J Gastrointest Oncol. 2020 Jun;11(3):601-608 Authors: Kim J, Zimmerman MA, Hong JC Abstract Neuroendocrine tumors (NET) are rare neoplasms with generally indolent growth behavior. The liver is the most common site of NET metastasis. The NET metastatic spread to the liver are usually multiple tumors involving bilateral hemilivers....
Tue Jul 14, 2020 13:57
Related Articles Inherited syndromes involving pancreatic neuroendocrine tumors. J Gastrointest Oncol. 2020 Jun;11(3):559-566 Authors: Geurts JL Abstract Inherited syndromes are important to recognize in the setting of a pancreatic neuroendocrine tumor (PNET) as there are significant implications for the patient's medical management and opportunity for early detection of subsequent manifestations. Although most PNETs are sporadic, approximately...
Tue Jul 14, 2020 13:57
Related Articles Surgical management and hyperthermic intraperitoneal chemotherapy for locally advanced colorectal cancer. J Gastrointest Oncol. 2020 Jun;11(3):508-512 Authors: Tan G, Wong J Abstract Locally advanced colorectal cancers (CRC) pose several management challenges, including local recurrence and the development of peritoneal metastases (PM). These recurrences are associated with a poor prognosis and onerous complications. In selected...
Tue Jul 14, 2020 13:57
Related Articles Solid pseudopapillary tumor of the pancreas: a rare entity in children. Pan Afr Med J. 2020;35:137 Authors: Berrada G, Belaaroussi S, Chbani K, Salam S, Laoudiyi D, Ouzidane L, Kebir AE, Guebessi NB, Benayad S, Mernissi F, Karkouri M, Anis S, Zemmouri MA Abstract Solid pseudopapillary tumors (SPTs) constitute 0.2 to 2.7% of non-endocrine primary tumors of the pancreas and comprise the majority (70%) of pediatric pancreatic neoplasms....
Tue Jul 14, 2020 13:57
Related Articles Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications. Front Immunol. 2020;11:991 Authors: Yshii L, Bost C, Liblau R Abstract Paraneoplastic cerebellar degeneration (PCD) is a rare immune-mediated disease that develops mostly in the setting of neoplasia and offers a unique prospect to explore the interplay between tumor immunity and autoimmunity. In PCD, the deleterious adaptive immune response...
Tue Jul 14, 2020 13:57
Related Articles Clinical application of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration in the diagnosis of submucosal nasopharyngeal carcinoma. Endosc Ultrasound. 2020 Jul 09;: Authors: Zhang ZM, Zhou LX, Bao Y, Zhao R, Chen X, Liu WS, Wang RL, Hu SZ, Li SP Abstract Background and Objectives: Submucosal nasopharyngeal carcinoma (NPC) is a rare type, which is usually difficult to obtain tissue samples. We aimed to...
Tue Jul 14, 2020 13:57
Related Articles An Update on Gastroenteropancreatic Neuroendocrine Neoplasms: From Mysteries to Paradigm Shifts. Arch Med Res. 2020 Jul 09;: Authors: Ramírez-Rentería C, Ferreira-Hermosillo A, Marrero-Rodríguez D, Taniguchi-Ponciano K, Melgar-Manzanilla V, Mercado M Abstract Although neuroendocrine neoplasms (NEN) were once thought to be rare and mostly "benign" diseases, they are now being redefined in light of recently discovered molecular...
Tue Jul 14, 2020 13:57
Related Articles Recurrent Leiomyosarcoma of the Small Bowel: A Case Series. Anticancer Res. 2020 Jul;40(7):4199-4204 Authors: Ferrari C, DI Domenico S, Mascherini M, Santoliquido M, Mastracci L, DE Cian F Abstract BACKGROUND/AIM: Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours...
Tue Jul 14, 2020 13:57
Related Articles Synchronous Primary Pancreatic Ductal Carcinoma and Colonic Adenocarcinoma Present in a Patient With History of Skin Squamous Cell Carcinoma. Anticancer Res. 2020 Jul;40(7):4029-4032 Authors: Cao C, Parikh P, Moezardalan K, Anantharaman A, Azarm A, Lai J Abstract The synchronous diagnosis of two or more primary malignancies in a patient is overall rare. This is a case report of a 70-year-old female with a history of skin squamous...
Tue Jul 14, 2020 13:57
Related Articles Rapid Improvement in Gemcitabine-associated Thrombotic Microangiopathy After a Single Dose of Eculizumab: Case Report and Review of the Literature. Anticancer Res. 2020 Jul;40(7):3995-4000 Authors: Burns ST, Damon L, Akagi N, Laszik Z, Ko AH Abstract We present here the case of a 39-year-old man with metastatic pancreatic carcinoma receiving chemotherapy with the combination of gemcitabine and nab-paclitaxel as part of a clinical...
Tue Jul 14, 2020 13:57
Related Articles Russell Body Gastroesophagitis Concurrent With Barrett's Esophagus. Anticancer Res. 2020 Jul;40(7):3991-3994 Authors: Arshi J, Nguyen J, Yin F Abstract BACKGROUND: Russell body gastroesophagitis is a rare entity characterized by the accumulation of immunoglobulins within the cytoplasm of plasma cells. CASE REPORT: Here, we present the case of a 41-year-old male with history of gastroesophageal reflux disease who presented...
Tue Jul 14, 2020 13:57
Related Articles Risk and impact of invasive fungal infections in patients with multiple myeloma. Ann Hematol. 2020 Aug;99(8):1813-1822 Authors: Tsai CK, Liu YC, Kuan AS, Lee KL, Yeh CM, Lee YT, Hsiao LT, Ko PS, Wang HY, Chen PM, Liu JH, Hong YC, Liu CJ, Gau JP Abstract Infection is associated with great morbidity and mortality in patients with multiple myeloma (MM), but evidence for invasive fungal infections (IFIs) is lacking. We aimed to...
Tue Jul 14, 2020 13:57
Related Articles Heparanase: A Potential Therapeutic Target in Sarcomas. Adv Exp Med Biol. 2020;1221:405-431 Authors: Cassinelli G, Lanzi C Abstract Sarcomas comprise a heterogeneous group of rare malignancies of mesenchymal origin including more than 70 subtypes. They may arise in muscle, bone, cartilage and other connective tissues. Their high histological and genetic heterogeneity makes diagnosis and treatment very challenging. Deregulation...
Tue Jul 14, 2020 13:57
Related Articles Posterior Mediastinal Mature Cystic Teratoma-Known But Rare Entity. Am J Med Sci. 2020 05;359(5):308-309 Authors: Feng Q, Xiao Y, Han F PMID: 32265011 [PubMed - indexed for MEDLINE]
Tue Jul 14, 2020 13:57
Related Articles Canine retrobulbar lipoma excision through a ventral transpalpebral anterior orbitotomy. Can Vet J. 2020 03;61(3):257-262 Authors: Charnock L, Doran B, Milley E, Preston T Abstract A 5-year-old spayed female German shepherd dog was referred for diagnostic evaluation and treatment of progressive exophthalmos, conjunctival hyperemia, and protrusion of the third eyelid of the left eye. Computed tomography revealed a retrobulbar...
Tue Jul 14, 2020 13:57
Related Articles Recurrent Spinal Intramedullary Arachnoid Cyst: Case Report and Literature Review. World Neurosurg. 2020 06;138:68-72 Authors: Ichinose T, Miyashita K, Tanaka S, Oikawa N, Oishi M, Nambu I, Kinoshita M, Nakada M Abstract BACKGROUND: Symptomatic intramedullary arachnoid cysts are rarely observed lesions, particularly in the pediatric age group. Treatment includes cyst fenestration or resection of the cyst wall, and recurrence...
Tue Jul 14, 2020 13:57
Related Articles Assessing thyroid cancer risk using polygenic risk scores. Proc Natl Acad Sci U S A. 2020 03 17;117(11):5997-6002 Authors: Liyanarachchi S, Gudmundsson J, Ferkingstad E, He H, Jonasson JG, Tragante V, Asselbergs FW, Xu L, Kiemeney LA, Netea-Maier RT, Mayordomo JI, Plantinga TS, Hjartarson H, Hrafnkelsson J, Sturgis EM, Brock P, Nabhan F, Thorleifsson G, Ringel MD, Stefansson K, de la Chapelle A Abstract Genome-wide association...
Tue Jul 14, 2020 13:57
Related Articles Recurring Primary Xanthomatous Hypophysitis Behaving Like Pituitary Adenoma: Additional Case and Literature Review. World Neurosurg. 2020 06;138:27-34 Authors: Mathkour M, Zeoli T, Werner C, Scullen T, Garces J, Keen J, Ware M Abstract BACKGROUND: Xanthomatous hypophysitis (XH) is the rarest histologic type of primary hypophysitis. It is nonlymphocytic and characterized by an infiltration of the pituitary gland by lipid-laden...
Tue Jul 14, 2020 13:57
Related Articles Presentation, Surgical Management, and Postoperative Outcome of a Fourth Ventricular Cavernous Malformation: Case Report and Review of Literature. World Neurosurg. 2020 05;137:78-83 Authors: Kaye J, Zeller S, Patel NV, Herschman Y, Jumah F, Nanda A Abstract BACKGROUND: Brainstem cavernous malformations (CMs) represent dangerous clinical entities associated with high rates of rebleeding and morbidity compared with those in other...
Tue Jul 14, 2020 13:57
Related Articles A rare cause of vomiting in an adolescent: gastric Burkitt`s lymphoma. Turk J Pediatr. 2019;61(3):431-435 Authors: Altay D, Özcan A, Ünal E, Deniz K, Özkan KU, Patıroğlu T, Arslan D Abstract Altay D, Özcan A, Ünal E, Deniz K, Özkan KU, Patıroğlu T, Arslan D. A rare cause of vomiting in an adolescent: gastric Burkitt`s lymphoma. Turk J Pediatr 2019; 61: 431-435. Burkitt`s lymphoma, which is the most commonly diagnosed pediatric...
Tue Jul 14, 2020 13:57
Related Articles Autoinhibition can identify rare driver mutations and advise pharmacology. FASEB J. 2020 01;34(1):16-29 Authors: Nussinov R, Tsai CJ, Jang H Abstract Identification of protein mutations that drive cancer is a major challenge. A primary reason is that driver mutations are principally identified by their high frequency even though they can also be rare. Driver mutations can locate at functional (binding or active) sites. We dub...
Tue Jul 14, 2020 13:57
Related Articles A ring-calcified thymoma, mimicking pericardial cyst, precedes pure red cell aplasia for more than 10 years - A case-based overview of pathophysiology. Neth J Med. 2019 12;77(10):373-376 Authors: de Graaf MA, Hazelbag HM, Tim J, van Rossum AP, Vlasveld LT Abstract Pure red cell aplasia (PRCA) is a rare disease characterised by anaemia and low reticulocyte count, caused by absence of erythropoiesis in the bone marrow. This report...
Tue Jul 14, 2020 13:57
Related Articles Why Are Some Driver Mutations Rare? Trends Pharmacol Sci. 2019 12;40(12):919-929 Authors: Nussinov R, Tsai CJ, Jang H Abstract Understanding why driver mutations that promote cancer are sometimes rare is important for precision medicine since it would help in their identification. Driver mutations are largely discovered through their frequencies. Thus, rare mutations often escape detection. Unlike high-frequency drivers, low-frequency...
Tue Jul 14, 2020 13:57
Related Articles Alazami syndrome: the first case of papillary thyroid carcinoma. J Hum Genet. 2020 Jan;65(2):133-141 Authors: Ivanovski I, Caraffi SG, Magnani E, Rosato S, Pollazzon M, Matalonga L, Piana S, Nicoli D, Baldo C, Bernasconi S, Frasoldati A, Zuffardi O, Garavelli L Abstract Alazami syndrome (MIM#615071) is a rare developmental disorder caused by biallelic variants in the LARP7 gene. Hallmark features include short stature, global...
Tue Jul 14, 2020 13:57
Related Articles Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies. J Immunother Cancer. 2019 10 22;7(1):272 Authors: Xu-Monette ZY, Li J, Xia Y, Crossley B, Bremel RD, Miao Y, Xiao M, Snyder T, Manyam GC, Tan X, Zhang H, Visco C, Tzankov A, Dybkaer K, Bhagat G, Tam W, You H, Hsi ED, van Krieken JH, Huh J, Ponzoni M, Ferreri AJM, Møller MB, Piris MA,...
Tue Jul 14, 2020 13:57
Related Articles Aberrant left brachiocephalic vein is a contraindication for anterior cervicothoracic approach. J Orthop Surg (Hong Kong). 2019 Sep-Dec;27(3):2309499019879213 Authors: Ong EKS, Wong TS, Chung WH, Chiu CK, Saw A, Hasan MS, Chan CYW, Kwan MK Abstract Aberrant left brachiocephalic vein is a rare condition. Its occurrence in patients requiring anterior cervicothoracic approach for severe kyphoscoliosis has not been described....
Tue Jul 14, 2020 13:57
Related Articles Fatal adverse events in two thymoma patients treated with anti-PD-1 immune check point inhibitor and literature review. Lung Cancer. 2019 09;135:29-32 Authors: Konstantina T, Konstantinos R, Anastasios K, Anastasia M, Eleni L, Ioannis S, Sofia A, Dimitris M Abstract OBJECTIVES: Thymomas, as well as thymic carcinomas, are extremely rare tumors that arise from the thymus. The management of these tumors is primarily the complete...
Tue Jul 14, 2020 13:57
Related Articles Genotyping, generation and proteomic profiling of the first human autosomal dominant osteopetrosis type II-specific induced pluripotent stem cells. Stem Cell Res Ther. 2019 08 14;10(1):251 Authors: Ou M, Li C, Tang D, Xue W, Xu Y, Zhu P, Li B, Xie J, Chen J, Sui W, Yin L, Dai Y Abstract BACKGROUND: Autosomal dominant osteopetrosis type II (ADO2) is a rare human genetic disease that has been broadly studied as an important...
Tue Jul 14, 2020 13:57
Related Articles A retrospective study: Clinicopathological and immunohistochemical analysis of 54 cases of tufted angioma. Indian J Dermatol Venereol Leprol. 2020 Jan-Feb;86(1):24-32 Authors: Su X, Liu Y, Liu Y, Ma C Abstract Background: Tufted angioma is a rare benign lesion with vascular proliferation. Aim: To retrospectively analyze the clinicopathological manifestations and immunohistochemical features of tufted angioma. ...
Tue Jul 14, 2020 13:57
Related Articles A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors. Cell Death Dis. 2019 07 23;10(7):529 Authors: Orienti I, Francescangeli F, De Angelis ML, Fecchi K, Bongiorno-Borbone L, Signore M, Peschiaroli A, Boe A, Bruselles A, Costantino A, Eramo A, Salvati V, Sette G, Contavalli P, Zolla L, Oki T, Kitamura T, Spada M, Giuliani A, Baiocchi M, La Torre F, Melino G, Tartaglia M, De...
Tue Jul 14, 2020 13:57
Related Articles Clinical spectrum, treatment and outcomes of uveal melanoma in a tertiary centre. Singapore Med J. 2019 Sep;60(9):474-478 Authors: Wong W, Sundar G, Chee C, Zhao PS, Rajagopalan R, Gopal L Abstract INTRODUCTION: We aimed to describe the clinical characteristics, diagnostic challenges, treatment patterns and outcomes of uveal melanoma (UM) in a tertiary care centre. METHODS: This is a retrospective case series of 11...
Tue Jul 14, 2020 13:57
Related Articles Live donor liver transplantation for type 1 tyrosinemia: An analysis of 15 patients. Pediatr Transplant. 2019 09;23(6):e13498 Authors: Karaca CA, Yilmaz C, Farajov R, Iakobadze Z, Aydogdu S, Kilic M Abstract Type 1 tyrosinemia is a rare metabolic disorder of the tyrosine degradation pathway. Due to the rarity of the disease, the best evidence literature offers is limited to guidelines based on expert opinions and optimal treatment...
Tue Jul 14, 2020 13:57
Related Articles The impact of imaging on the surgical management of biliary cystadenomas and cystadenocarcinomas; a systematic review. HPB (Oxford). 2019 10;21(10):1257-1267 Authors: Klompenhouwer AJ, Ten Cate DWG, Willemssen FEJA, Bramer WM, Doukas M, de Man RA, Ijzermans JNM Abstract BACKGROUND: Biliary Cystadenomas (BCA) are considered to be benign but may transform to Biliary Cystadenocarcinomas (BCAC). The aim of this systematic review...
Tue Jul 14, 2020 13:57
Related Articles Early presentation in ameloblastic fibroma. J Stomatol Oral Maxillofac Surg. 2020 Feb;121(1):95-97 Authors: Cieliszka C, Galmiche-Rolland L, Khonsari RH Abstract Ameloblastic fibroma are rare mixed tumors composed by both epithelial and mesenchymal tissues. They mostly affect the posterior mandibular sector in young adults. Here we report an atypical case affecting a very young patient in an unusual localization. We describe...
Tue Jul 14, 2020 13:57
Related Articles Thyrotoxicosis with concomitant thyroid cancer. Endocr Relat Cancer. 2019 07;26(7):R395-R413 Authors: Fu H, Cheng L, Jin Y, Chen L Abstract Thyrotoxicosis with concomitant thyroid cancer is rare and poorly recognized, which may result in delayed diagnosis, inappropriate treatment and even poor prognosis. To provide a comprehensive guidance for clinicians, the etiology, pathogenesis, diagnosis and treatment of this challenging...
Tue Jul 14, 2020 13:57
Related Articles The Loss of Lymph Node Metastases After Neoadjuvant Chemotherapy in Patients With Cytology-proven Axillary Node-positive Primary Breast Cancer. Clin Breast Cancer. 2019 08;19(4):278-285 Authors: Namura M, Tsunoda H, Kobayashi D, Enokido K, Yoshida A, Watanabe T, Suzuki K, Nakamura S, Yamauchi H, Hayashi N Abstract BACKGROUND: Axillary lymph node (LN) dissection after neoadjuvant chemotherapy (NAC) still remains a standard treatment...
Tue Jul 14, 2020 13:57
Related Articles Dentinogenic ghost cell tumor - a rare case report. J Stomatol Oral Maxillofac Surg. 2020 Apr;121(2):186-188 Authors: Ravi B, Kamath G, Srivathsa S, Babshet M, Dayanarayana U PMID: 30858131 [PubMed - indexed for MEDLINE]
Tue Jul 14, 2020 13:57
Related Articles Pleomorphic hyalinizing angiectatic tumor in the oral cavity: Report of a rare case. J Stomatol Oral Maxillofac Surg. 2020 Apr;121(2):189-191 Authors: Kökoğlu K, Gülmez E, Çağlı S, Yüce I, Deniz K PMID: 30836193 [PubMed - indexed for MEDLINE]
Tue Jul 14, 2020 13:57
Related Articles Inflammatory myofibroblastic tumour of the jaw: A rare presentation. J Stomatol Oral Maxillofac Surg. 2020 Feb;121(1):90-94 Authors: Monteiro L, Alhassani M, Resende T, Albuquerque R Abstract Inflammatory Myofibroblastic Tumour (IMT) is a rare entity of unknown aetiology and pathogenesis. It was initially described in the lung, although there have been reported cases affecting extra-pulmonary sites. The aetiology of IMT remains...
Tue Jul 14, 2020 13:57
Related Articles How Recent Advances in Biology of Waldenström's Macroglobulinemia May Affect Therapy Strategy. Curr Oncol Rep. 2019 02 26;21(3):27 Authors: Baron M, Simon L, Poulain S, Leblond V Abstract PURPOSE OF REVIEW: Waldenström macroglobulinemia (WM) is a rare lymphoproliferative disorder. Up to now, therapeutic choice was not influenced by the biological characteristics of the disease. Here, we will review how recent advances in biology...
Tue Jul 14, 2020 13:57
Related Articles Management of Adrenocortical Carcinoma. Curr Oncol Rep. 2019 02 23;21(3):20 Authors: Jasim S, Habra MA Abstract PURPOSE OF REVIEW: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy typically with poor prognosis. This review aims to summarize the current knowledge regarding the clinical management of ACC. RECENT FINDINGS: Surgery remains the cornerstone for localized ACC management. In more advanced cases,...
Tue Jul 14, 2020 13:57
Related Articles Vulvar basal cell carcinoma: clinical features and treatment outcomes from a tertiary care centre. Singapore Med J. 2019 Sep;60(9):479-482 Authors: Namuduri RP, Lim TY, Yam PK, Gatsinga R, Lim-Tan SK, Chew SH, Koh MJ, Mansor S Abstract We retrospectively reviewed the clinical features, management and outcomes of patients diagnosed with basal cell carcinoma (BCC) of the vulva at the Gynaecological Cancer Centre, KK Women's and...
Tue Jul 14, 2020 13:57
Related Articles A rare presentation of stafne bone cyst. J Stomatol Oral Maxillofac Surg. 2020 Feb;121(1):80-83 Authors: Bayrak NB Abstract Stafne bone cysts (SBC) are defined as pseudocysts of the jaw in the literature. These lesions are typically localized at lingual cortical surface of the mandible and generally included normal salivary gland tissue; but they do not contain an epithelial lining. They may contain fat, muscle, connective...
Tue Jul 14, 2020 13:57
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