Abstract Background Necrotizing sialometaplasia (NSM) is an extremely rare benign lesion with an uncertain pathogenesis. The differential diagnosis of this lesion is challenging due to little familiarity with this entity and histologic similarity with carcinomas, especially mucoepidermoid carcinoma (MEC). The purpose of this study is to raise awareness about NSM, which is often overlooked or misdiagnosed as malignancy in a small...
Tue Jul 14, 2020 03:00
Abstract The genomes of present-day humans outside Africa originated almost entirely from a single out-migration ~ 50,000–70,000 years ago, followed by mixture with Neanderthals contributing ~ 2% to all non-Africans. However, the details of this initial migration remain poorly understood because no ancient DNA analyses are available from this key time period, and interpretation of present-day autosomal data is complicated due to subsequent population movements/reshaping. One locus,...
Tue Jul 14, 2020 03:00
Abstract Liquid–liquid phase separation is an important mechanism by which eukaryotic cells functionally organize their intracellular content and has been related to cell malignancy and neurodegenerative diseases. These cells also undergo ATP-driven mechanical fluctuations, yet the effect of these fluctuations on the liquid–liquid phase separation remains poorly understood. Here, we employ high-resolution microscopy and atomic force microscopy of live Jurkat T cells to characterize...
Tue Jul 14, 2020 03:00
Background. Circulating long noncoding RNAs (lncRNAs) have been demonstrated to serve as diagnostic biomarkers for various cancers. We aimed to elucidate the diagnostic efficacy of eight serum lncRNAs HULC, MALAT1, Linc00152, PTENP1, PTTG3P, SPRY4-IT1, UBE2CP3, and UCA1 and their combinations for the diagnosis of hepatocellular carcinoma (HCC). Methods. A total of 129 patients with HCC, 49 patients with liver cirrhosis, 27 patients with chronic hepatitis B, and 93 healthy controls were enrolled in...
Tue Jul 14, 2020 09:50
Abstract Splenosis is defined as the growth of ectopic splenic tissue, due to its direct seeding, usually seen after traumatic or surgical procedures to the spleen. It often occurs on highly vascularized surfaces such as the omentum or the mesentery, and grows in sessile form, supplied by adjacent vessels. Intestinal splenosis with endoluminal extension is extremely rare. We present a case of intestinal splenosis with endoluminal growth in a 14-year-old boy that provoked a small...
Tue Jul 14, 2020 03:00
Abstract Pulmonary diseases and injury lead to structural and functional changes in the lung parenchyma and airways, often resulting in measurable sound transmission changes on the chest wall surface. Additionally, noninvasive imaging of externally driven mechanical wave motion in the chest (e.g., using magnetic resonance elastography) can provide information about lung stiffness and other structural property changes which may be of diagnostic value. In the present study, a comprehensive...
Tue Jul 14, 2020 03:00
ObjectivesSuicide is a leading cause of death in the working-age population. We investigated suicide mortality among diagnostic medical radiation workers in relation to their demographic and occupational factors in South Korea.MethodsThe study population consisted of all diagnostic medical radiation workers enrolled in the National Dosimetry Registry from 1996 to 2011. The registry data were linked with mortality data through the end of 2017. We calculated age-standardised suicide rates, standardised...
Tue Jul 14, 2020 19:00
Publication date: Available online 13 July 2020Source: Academic RadiologyAuthor(s): Elana B. Smith, Petra Lewis, Thad Benefield, Tara M. Catanzano, Muhammad J. Khan, Eric Nyberg, Sheryl Jordan
Tue Jul 14, 2020 19:43
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17194-5Eyewitness errors contribute to wrongful convictions. Here, the authors present a lineup procedure that reveals the structure of eyewitness memory, reduces decision bias, and measures performance of individual witnesses.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17331-0Here, Brasil et al. investigate mother to child Zika virus (ZIKV) transmission rates in a large longitudinal cohort of pregnant ZIKV-positive women with their infants followed from the time of maternal infection through birth and onwards, finding high in utero transmission rates that do not predict clinical outcomes, suggesting follow-up of children with antenatal ZIKV exposure is necessary.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17206-4Transposable elements are a potential source of transcriptional regulators, but how these sequences contribute to oncogenesis remains poorly understood. Here, the authors identify endogenous retroviruses (ERVs) with acute myeloid leukemia (AML)-associated enhancer chromatin signatures, and provide evidence that ERV activation provides an additional layer of gene regulation in AML.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17366-3Microbial ammonia oxidation is important in marine nutrient cycling and greenhouse gas dynamics, but the responses to ocean warming are unclear. Here coast to open ocean incubations show that projected year 2100 temperatures might be too hot for these microbes in oligotrophic regions to handle, but may facilitate oxidation rates in coastal waters.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17231-3A systematic time-resolved study can provide key insights on selective carbon dioxide electro-reduction. Here, the authors report operando seconds-resolved X-ray absorption spectroscopy to uncover the chemical state evolution of working catalysts in a carbon dioxide electroreduction process.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17083-xSpatial information in the tumour microenvironment may be exploited to optimise diagnosis, prognosis and therapy. Here, the authors develop a spatial analytics computational and systems pathology platform (SpAn) based on highly multiplexed antibody imaging on colorectal cancer samples to infer emergent network biology and predict 5-year risk of recurrence.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17277-3Gene tandem amplifications can drive bacterial evolution. Here, Belikova et al. identify copy number variations of lipoprotein-encoding genes in Staphylococcus aureus clinical isolates, and show that the loci expand and contract during bacterial growth in vitro and in mice, leading to changes in immunostimulatory capacity.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17147-yThe regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer cell migration.
Tue Jul 14, 2020 03:00
Nature Communications, Published online: 14 July 2020; doi:10.1038/s41467-020-17265-7Increasing the non-locality of the exchange and correlation functional in DFT theory comes at a steep increase in computational cost. Here, the authors develop NeuralXC, a supervised machine learning approach to generate density functionals close to coupled-cluster level of accuracy yet computationally efficient.
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Pancreatic Divisum (PD) is the most common congenital variation of pancreatic duct anatomy, arising when embryological ventral and dorsal endodermal buds fail to fuse (“classic” PD) or only fuse partially (“incomplete” PD). Most patients with PD are asymptomatic, but a subgroup of patients can present with recurrent bouts of pancreatitis. While alcohol and gallstones are the common causes of acquired pancreatitis, PD is a congenital cause of pancreatitis. It is usually suspected in younger individuals...
Tue Jul 14, 2020 16:35
Publication date: Available online 14 July 2020Source: Magnetic Resonance ImagingAuthor(s): Hiroyuki Takashima, Mitsunori Yoshimoto, Izaya Ogon, Yoshinori Terashima, Rui Imamura, Yoshihiro Akatsuka, Noriyuki Iesato, Tsutomo Oshigiri, Tomonori Morita, Tsuneo Takebayashi, Makoto Emori, Atsushi Teramoto, Toshihiko Yamashita
Tue Jul 14, 2020 19:13
Publication date: Available online 13 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): P.A. Brennan, K. Shakib, S. Parmar, D. Dhariwal, R.S. Oeppen
Tue Jul 14, 2020 18:56
Publication date: Available online 13 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Sun, H.-w. Zhang, W.-b. Zhang, Y. Yu, G.-y. Yu, X. Peng
Tue Jul 14, 2020 18:56
Publication date: Available online 13 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): B.L. Hechler, N.S. Matthews
Tue Jul 14, 2020 18:56
Publication date: July 2020Source: British Journal of Oral and Maxillofacial Surgery, Volume 58, Issue 6Author(s):
Tue Jul 14, 2020 18:56
Publication date: July 2020Source: British Journal of Oral and Maxillofacial Surgery, Volume 58, Issue 6Author(s):
Tue Jul 14, 2020 18:56
Publication date: Available online 14 July 2020Source: American Journal of OtolaryngologyAuthor(s): Pablo Parente-Arias, Pilar Barreira-Fernandez, Ana Quintana-Sanjuas, Berta Patiño-Castiñeira
Tue Jul 14, 2020 18:46
Publication date: Available online 13 July 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Marzieh Mohamadi, Zahra Rojhani-Shirazi, Reza Assadsangabi, Abbas Rahimi-Jaberi
Tue Jul 14, 2020 18:42
Publication date: Available online 13 July 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Anne E. Palermo, Lawrence P. Cahalin, Kelsey L. Garcia, Mark S. Nash
Tue Jul 14, 2020 18:42
Publication date: Available online 14 July 2020Source: Journal of the American College of SurgeonsAuthor(s): Valerie W. Rusch, Steven D. Wexner
Tue Jul 14, 2020 18:40
Abstract Purpose Thyroid carcinoma is the most frequent endocrine malignancy with high occurrence of BRAFV600E mutations. Though targeted therapy by vemurafenib, a specific inhibitor for BRAFV600E, has achieved great advance in therapeutic landscape, resistance occurrence is still a clinical challenge. Here, we sought to elucidate the function of high mobility group box 1 (HMGB1) in vemurafenib resistance in thyroid cancer harboring BRAF...
Tue Jul 14, 2020 03:00
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Tue Jul 14, 2020 03:00
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