Antibiotics, Vol. 9, Pages 264: whISOBAXTM Inhibits Bacterial Pathogenesis and Enhances the Effect of Antibiotics Antibiotics doi: 10.3390/antibiotics9050264 Authors: Reuven Rasooly Hwang-Yong Choi Paula Do Gianluca Morroni Lucia Brescini Oscar Cirioni Andrea Giacometti Emmanouil Apostolidis As bacteria are becoming more resistant to commonly used antibiotics, alternative therapies are being sought. whISOBAX (WH) is a witch hazel extract that is highly stable (tested...
Tue May 19, 2020 03:00
Antibiotics, Vol. 9, Pages 263: Community-Acquired and Healthcare-Associated Sepsis: Characteristics and in-Hospital Mortality in Italy Antibiotics doi: 10.3390/antibiotics9050263 Authors: Gabriella Di Giuseppe Maria Mitidieri Federica Cantore Concetta P. Pelullo Maria Pavia Background: The main aim of the study was to analyse characteristics of sepsis according to the setting of occurrence and to identify predictors of sepsis-related in-hospital mortality. Methods: 544 medical...
Tue May 19, 2020 03:00
Antioxidants, Vol. 9, Pages 440: Bioavailability of Epigallocatechin Gallate Administered With Different Nutritional Strategies in Healthy Volunteers Antioxidants doi: 10.3390/antiox9050440 Authors: Fernández Almeida Toledano Pizarro Lozano Tapia Gómez Roig De la Torre Fornell García Algar The flavanol epigallocatechin gallate (EGCG) is being tested for the treatment of several diseases in humans. However, its bioavailability and pharmacokinetic profile needs...
Tue May 19, 2020 03:00
Arts, Vol. 9, Pages 60: The Torah Ark of Arthur Szyk Arts doi: 10.3390/arts9020060 Authors: Nashman Fraiman This paper discusses the design and symbolism of a hitherto unpublished work by the artist Arthur Szyk (1894–1951), an ark for the Torah which he designed for the Forest Hills Jewish Center of Queens, New York, and which was dedicated in 1949. The Torah Ark is the central focus of all synagogue worship. Szyk’s ark is unique in its multiplicity of symbols and...
Tue May 19, 2020 03:00
Atmosphere, Vol. 11, Pages 522: Air Pollution Sources’ Contribution to PM2.5 Concentration in the Northeastern Part of the Czech Republic Atmosphere doi: 10.3390/atmos11050522 Authors: Radim Seibert Irina Nikolova Vladimíra Volná Blanka Krejčí Daniel Hladký This article focuses on the source apportionment of air pollution in a specific northeastern part of the Czech Republic. The research area, located around the city of Třinec, is significantly affected by a complex spectrum...
Tue May 19, 2020 03:00
Atmosphere, Vol. 11, Pages 523: Nanoparticle Number Concentration in the Air in Relation to the Time of the Year and Time of the Day Atmosphere doi: 10.3390/atmos11050523 Authors: Jáchym Brzezina Klaudia Köbölová Vladimír Adamec The paper analyzes suspended particles number concentrations of 61 size fractions (184 nm to 17,165 nm) in the air at a traffic location. The average course of the individual fractions was analyzed at various intervals – daily, weekly, monthly...
Tue May 19, 2020 03:00
Atmosphere, Vol. 11, Pages 521: Tidal Wave-Driven Variability in the Mars Ionosphere-Thermosphere System Atmosphere doi: 10.3390/atmos11050521 Authors: Thaller Andersson Pilinski Thiemann Withers Elrod Fang González-Galindo Bougher Jenkins : In order to further evaluate the behavior of ionospheric variations at Mars, we investigate the Martian ionosphere-thermosphere (IT) perturbations associated with non-migrating thermal tides using over four years...
Tue May 19, 2020 03:00
Biology, Vol. 9, Pages 104: The Utility of Genomic and Transcriptomic Data in the Construction of Proxy Protein Sequence Databases for Unsequenced Tree Nuts Biology doi: 10.3390/biology9050104 Authors: Pirone-Davies McFarland Parker Adachi Croley As the apparent incidence of tree nut allergies rises, the development of MS methods that accurately identify tree nuts in food is critical. However, analyses are limited by few available tree nut protein sequences. We assess...
Tue May 19, 2020 03:00
Biology, Vol. 9, Pages 103: Clinical Features of Parkinson’s Disease: The Evolution of Critical Symptoms Biology doi: 10.3390/biology9050103 Authors: Csaba Váradi Parkinson’s disease (PD) is a multi-attribute neurodegenerative disorder combining motor and nonmotor symptoms without well-defined diagnostic clinical markers. The presence of primary motor features (bradykinesia, rest tremor, rigidity and loss of postural reflexes) are the most characteristic signs of PD that are...
Tue May 19, 2020 03:00
Biology, Vol. 9, Pages 102: Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer? Biology doi: 10.3390/biology9050102 Authors: Danuta Kuzajewska Agata Wszołek Wojciech Żwierełło Lucyna Kirczuk Agnieszka Maruszewska An important direction of research in increasing the effectiveness of cancer therapies is the design of effective drug distribution systems in the body. The development of the new strategies is primarily...
Tue May 19, 2020 03:00
Biomedicines, Vol. 8, Pages 127: Organic Cation Transporters (OCTs) in EpiAirway™, A Cellular Model of Normal Human Bronchial Epithelium Biomedicines doi: 10.3390/biomedicines8050127 Authors: Amelia Barilli Rossana Visigalli Francesca Ferrari Maria Di Lascia Benedetta Riccardi Paola Puccini Valeria Dall’Asta Bianca Maria Rotoli Organic cation transporters (OCTs) and novel organic cation transporters (OCTNs) are responsible for drug delivery in the intestine and...
Tue May 19, 2020 03:00
Biomolecules, Vol. 10, Pages 787: A Comparison between Several Response Surface Methodology Designs and a Neural Network Model to Optimise the Oxidation Conditions of a Lignocellulosic Blend Biomolecules doi: 10.3390/biom10050787 Authors: López Fernández Pereira Díez Cara Martínez Sánchez In this paper, response surface methodology (RSM) designs and an artificial neural network (ANN) are used to obtain the optimal conditions for the oxy-combustion of a corn–rape...
Tue May 19, 2020 03:00
Biomolecules, Vol. 10, Pages 788: Different Impacts of MucR Binding to the babR and virB Promoters on Gene Expression in Brucella abortus 2308 Biomolecules doi: 10.3390/biom10050788 Authors: Borriello Russo Paradiso Riccardi Criscuolo Verde Marasco Pedone Galiero Baglivo The protein MucR from Brucella abortus has been described as a transcriptional regulator of many virulence genes. It is a member of the Ros/MucR family comprising proteins that control...
Tue May 19, 2020 03:00
Biomolecules, Vol. 10, Pages 786: Oral Administration of Liquiritigenin Confers Protection from Atopic Dermatitis through the Inhibition of T Cell Activation Biomolecules doi: 10.3390/biom10050786 Authors: Hyun-Su Lee Eun-Nam Kim Gil-Saeng Jeong While liquiritigenin, isolated from Spatholobus suberectus Dunn, is known to possess anti-inflammatory activities, it still remains to be known whether liquiritigenin has a suppressive effect on T cell activation and T cell-mediated disease....
Tue May 19, 2020 03:00
Biomolecules, Vol. 10, Pages 785: Green Synthesis of MnO Nanoparticles Using Abutilon indicum Leaf Extract for Biological, Photocatalytic, and Adsorption Activities Biomolecules doi: 10.3390/biom10050785 Authors: Shakeel Ahmad Khan Sammia Shahid Basma Shahid Urooj Fatima Saddam Akber Abbasi We report the synthesis of MnO nanoparticles (AI-MnO NAPs) using biological molecules of Abutilon indicum leaf extract. Further, they were evaluated for antibacterial and cytotoxicity...
Tue May 19, 2020 03:00
Biomolecules, Vol. 10, Pages 784: Exposure of Intestinal Epithelial Cells to 2′-Fucosyllactose and CpG Enhances Galectin Release and Instructs Dendritic Cells to Drive Th1 and Regulatory-Type Immune Development Biomolecules doi: 10.3390/biom10050784 Authors: Veronica Ayechu-Muruzabal Saskia A. Overbeek Atanaska I. Kostadinova Bernd Stahl Johan Garssen Belinda van’t Land Linette E.M. Willemsen Intestinal epithelial cells (IEC) release immunomodulatory galectins upon...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1288: Thioholgamide A, a New Anti-Proliferative Anti-Tumor Agent, Modulates Macrophage Polarization and Metabolism Cancers doi: 10.3390/cancers12051288 Authors: Charlotte Dahlem Wei Xiong Siow Maria Lopatniuk William K. F. Tse Sonja M. Kessler Susanne H. Kirsch Jessica Hoppstädter Angelika M. Vollmar Rolf Müller Andriy Luzhetskyy Karin Bartel Alexandra K. Kiemer Natural products represent powerful tools searching for novel anticancer...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1285: Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children Cancers doi: 10.3390/cancers12051285 Authors: Marion K. Mateos Morten Tulstrup Michael CJ Quinn Ruta Tuckuviene Glenn M. Marshall Ramneek Gupta Chelsea Mayoh Benjamin O. Wolthers Pasquale M. Barbaro Ellen Ruud Rosemary Sutton Pasi Huttunen...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1284: Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response Cancers doi: 10.3390/cancers12051284 Authors: Natalia Trempolec Charline Degavre Bastien Doix Davide Brusa Cyril Corbet Olivier Feron For poorly immunogenic tumors such as mesothelioma there is an imperious need to understand why antigen-presenting cells such as dendritic cells (DCs)...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1286: Spectrum of Germline BRCA1 and BRCA2 Variants Identified in 2351 Ovarian and Breast Cancer Patients Referring to a Reference Cancer Hospital of Rome Cancers doi: 10.3390/cancers12051286 Authors: Concetta Santonocito Roberta Rizza Ida Paris Laura De Marchis Carmela Paolillo Giordana Tiberi Giovanni Scambia Ettore Capoluongo Pathogenic variants (PVs) carriers in BRCA1 or BRCA2 are associated with an elevated lifetime risk of developing...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1287: Older Cancer Patients during the COVID-19 Epidemic: Practice Proposal of the International Geriatric Radiotherapy Group Cancers doi: 10.3390/cancers12051287 Authors: Nam P. Nguyen Vincent Vinh-Hung Brigitta Baumert Alice Zamagni Meritxell Arenas Micaela Motta Pedro Carlos Lara Arthur Sun Myint Marta Bonet Tiberiu Popescu Te Vuong Gokula Kumar Appalanaido Lurdes Trigo Ulf Karlsson Juliette Thariat The coronavirus...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1283: Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models Cancers doi: 10.3390/cancers12051283 Authors: Emma Polonio-Alcalá Sònia Palomeras Daniel Torres-Oteros Joana Relat Marta Planas Lidia Feliu Joaquim Ciurana Santiago Ruiz-Martínez Teresa Puig Epidermal growth factor receptor (EGFR) tyrosine kinases inhibitors (TKIs) are effective therapies for non-small...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1282: Circulating MicroRNAs Regulating DNA Damage Response and Responsiveness to Cisplatin in the Prognosis of Patients with Non-Small Cell Lung Cancer Treated with First-Line Platinum Chemotherapy Cancers doi: 10.3390/cancers12051282 Authors: Chara Papadaki Alexia Monastirioti Konstantinos Rounis Dimitrios Makrakis Konstantinos Kalbakis Christofors Nikolaou Dimitrios Mavroudis Sofia Agelaki The expression of microRNA (miR)-21, miR-128, miR-155,...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1280: Cold-Atmospheric Plasma Induces Tumor Cell Death in Preclinical In Vivo and In Vitro Models of Human Cholangiocarcinoma Cancers doi: 10.3390/cancers12051280 Authors: Javier Vaquero Florian Judée Marie Vallette Henri Decauchy Ander Arbelaiz Lynda Aoudjehane Olivier Scatton Ester Gonzalez-Sanchez Fatiha Merabtene Jérémy Augustin Chantal Housset Thierry Dufour Laura Fouassier Through the last decade, cold atmospheric plasma...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1279: Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines Cancers doi: 10.3390/cancers12051279 Authors: Stefan Schönberger Daniela Kraft Daniel Nettersheim Hubert Schorle Anna Casati Rogerio B. Craveiro Mahsa Mir Mohseni Gabriele Calaminus Dagmar Dilloo Outcome in high-risk patients with refractory or relapsed germ cell tumours (GCT) remains poor. Novel strategies enhancing...
Tue May 19, 2020 03:00
Cancers, Vol. 12, Pages 1281: Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion Cancers doi: 10.3390/cancers12051281 Authors: Candice Merle Noémie Thébault Sophie LeGuellec Jessica Baud Gaëlle Pérot Tom Lesluyes Lucile Delespaul Lydia Lartigue Frédéric Chibon Whole-genome doubling is the second most frequent genomic event, after TP53 alterations, in advanced solid tumors and is associated with...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1259: The Role of Caspase-2 in Regulating Cell Fate Cells doi: 10.3390/cells9051259 Authors: Vasanthy Vigneswara Zubair Ahmed Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family and has been implicated in both apoptotic and non-apoptotic signaling pathways, including tumor suppression, cell cycle regulation, and DNA repair. A myriad of signaling molecules is associated with the tight regulation of caspase-2 to mediate multiple...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1260: Dihydroartemisinin (DHA) Affects Microtubule Dynamics Through Reduction of Phospho-Translationally Controlled Tumour Protein (TCTP) Levels and Enhances the Antiproliferative Effect of Trastuzumab Emtansine (T-DM1) in Trastuzumab-Resistant Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Cell Lines Cells doi: 10.3390/cells9051260 Authors: Silvia D’Amico Ewa Krystyna Krasnowska Isabella Manni Gabriele Toietta Silvia Baldari Giulia...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1257: Contribution of a GATA4-Expressing Hematopoietic Progenitor Lineage to the Adult Mouse Endothelium Cells doi: 10.3390/cells9051257 Authors: Rita Carmona Sandra Díaz del Moral Silvia Barrena Ramón Muñoz-Chápuli Different sources have been claimed for the embryonic origin of the coronary endothelium. Recently, the potential of circulating cells as progenitors of the cardiac endothelium has also been suggested. In a previous study we have shown that circulating...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1255: Digital Spindle: A New Way to Explore Mitotic Functions by Whole Cell Data Collection and a Computational Approach Cells doi: 10.3390/cells9051255 Authors: Norio Yamashita Masahiko Morita Hideo Yokota Yuko Mimori-Kiyosue From cells to organisms, every living system is three-dimensional (3D), but the performance of fluorescence microscopy has been largely limited when attempting to obtain an overview of systems’ dynamic processes in three...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1256: Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E2 Activation in Human Podocytes Cells doi: 10.3390/cells9051256 Authors: Eva Mangelsen Michael Rothe Angela Schulz Aikaterini Kourpa Daniela Panáková Reinhold Kreutz Juliane Bolbrinker Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1258: Direct Inhibition of the Allergic Effector Response by Raw Cow’s Milk—An Extensive In Vitro Assessment Cells doi: 10.3390/cells9051258 Authors: Suzanne Abbring Bart R.J. Blokhuis Julie L. Miltenburg Kiri G.J. Romano Olmedo Johan Garssen Frank A. Redegeld Betty C.A.M. van Esch The mechanisms underlying the allergy-protective effects of raw cow’s milk are poorly understood. The current focus is mainly on the modulation of T cell responses....
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1251: Metabolic Adaptation during nab-Paclitaxel Resistance in Pancreatic Cancer Cell Lines Cells doi: 10.3390/cells9051251 Authors: Lukas M. Braun Simon Lagies Jessica Guenzle Stefan Fichtner-Feigl Uwe A. Wittel Bernd Kammerer Pancreatic ductal adenocarcinoma (PDAC) correlates with high mortality and is about to become one of the major reasons for cancer-related mortality in the next decades. One reason for that high mortality is the limited availability...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1254: Phosphodiesterase 4B: Master Regulator of Brain Signaling Cells doi: 10.3390/cells9051254 Authors: Amy J. Tibbo George S. Baillie Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targeting of individual isoforms to discrete brain locations and it is often the location...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1252: Disease-Specific Changes in Reelin Protein and mRNA in Neurodegenerative Diseases Cells doi: 10.3390/cells9051252 Authors: Laia Lidón Laura Urrea Franc Llorens Vanessa Gil Ignacio Alvarez Monica Diez-Fairen Miguel Aguilar Pau Pastor Inga Zerr Daniel Alcolea Alberto Lleó Enric Vidal Rosalina Gavín Ferrer Rio Reelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1250: Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction Cells doi: 10.3390/cells9051250 Authors: Ming-Che Liu Meng-Lin Chang Ya-Chun Wang Wei-Hung Chen Chien-Chih Wu Shauh-Der Yeh Erectile dysfunction (ED) is an inability to attain or maintain adequate penile erection for successful vaginal intercourse, leading to sexual and relationship dissatisfaction. To combat ED, various surgical and non-surgical approaches have been...
Tue May 19, 2020 03:00
Cells, Vol. 9, Pages 1253: Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer Cells doi: 10.3390/cells9051253 Authors: Jeremy Johnson Zeta Chow Dana Napier Eun Lee Heidi L. Weiss B. Mark Evers Piotr Rychahou Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and is characterized by poor survival. Radiotherapy plays an important role in treating TNBC. The purpose of this...
Tue May 19, 2020 03:00
Clean Technol., Vol. 2, Pages 170-183: Performance Ratio and Degradation Rate Analysis of 10-Year Field Exposed Residential Photovoltaic Installations in the UK and Ireland Clean Technologies doi: 10.3390/cleantechnol2020012 Authors: Mahmoud Dhimish As photovoltaic (PV) penetration of the power grid increases, accurate predictions of return on investment require accurate analysis of decreased operational power output over time. The degradation rate in PV module performance must be known...
Tue May 19, 2020 03:00
Diagnostics, Vol. 10, Pages 321: Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma Diagnostics doi: 10.3390/diagnostics10050321 Authors: Feiqian Wang Kazushi Numata Masayuki Nakano Mikiko Tanabe Makoto Chuma Hiromi Nihonmatsu Akito Nozaki Katsuaki Ogushi Wen Luo Litao Ruan Masahiro Okada Masako Otani Yoshiaki Inayama Shin Maeda We attempted to establish an ultrasound (US) imaging-diagnostic system for...
Tue May 19, 2020 03:00
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