Low detection rate of conventional imaging and unspecific fluctuations of PSA can hamper early diagnosis of castration-resistant prostate cancer (CRPC). We thus assessed the value of PSMA-PET/CT in the detection of early CRPC (PSA ≤3 ng/mL). Methods: We identified 55 patients with early CRPC (PSA≤3 ng/mL) from our institutional database. PSMA-PET/CT and its CT component were interpreted independently by three blinded readers. Primary endpoint was the per-patient detection rate, secondary endpoints...
Sat May 23, 2020 00:43
Sat May 23, 2020 00:43
Proinflammatory macrophages are important mediators of inflammation following myocardial infarction and allograft injury following heart transplantation. The aim of this study was to image the recruitment of proinflammatory chemokine receptor 2+ (CCR2+) cells in multiple heart injury models. Methods: 64Cu-DOTA-ECL1i PET was used to image CCR2+ monocytes/macrophages in heart transplantation mouse model. Flow cytometry was performed to characterize CCR2+ cells. Autoradiography on human heart specimen...
Sat May 23, 2020 00:43
Background: Although radiation-induced mesenteritis or peritonitis can potentially exacerbate the risk of bowel obstruction, there are no data in the literature on the incidence of intestinal obstruction related to peptide receptor radionuclide therapy (PRRT). Methods: Records of all patients treated with 177Lu-Dotatate at Moffitt Cancer Center between 4/2018 and 10/2019 were evaluated. The number of patients who developed bowel obstruction within 3 months of a 177Lu-Dotatate treatment was...
Sat May 23, 2020 00:43
Immunotherapy agents are now entering the clinic in a wide array of malignancies and have provided a valuable addition to the therapeutic armamentarium. These agents enhance the global immune response by modulating the tumor microenvironment but can lead to unconventional patterns of response, challenging the conceptual framework that imaging is a robust surrogate for therapeutic efficacy. There is also increasing evidence that an effective anti-tumor response requires a systemic immune response...
Sat May 23, 2020 00:43
Trametinib (MEKINIST™) is an extremely potent allosteric inhibitor of MEK1/2 that has been approved for treatment of metastatic melanoma and anaplastic thyroid cancer in patients with confirmed BRAFV600E/K mutations. Though highly efficacious, adverse side effects including skin, gastrointestinal and hepatic toxicity, are dose limiting and can lead to treatment termination. Development of a non-invasive tool to visualize and quantify the delivery and distribution of trametinib (either as single agent...
Sat May 23, 2020 00:43
Rationale: Radiolabelled bisphosphonates such as 99mTc-DPD typically show intense uptake in skeletal metastases from metastatic castration resistant prostate cancer (mCRPC). Extensive bone involvement is regarded a risk factor for mCRPC patients treated with 223Ra-radiumdichloride (223Ra). Aim of this study was to quantify 99mTc-DPD uptake by means of SPECT/CT prior to 223Ra and compare results to the feasibility of treatment and overall survival (OS). Methods: 60 consecutive mCRPC patients were...
Sat May 23, 2020 00:43
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00566E, PaperXinyang Zhang, Jianan Wen, Lili Lian, Xianhong Ma, Xiyue Wang, Dawei LouAbstract 3D magnetic porous carbon (MPCK) was prepared with metal–organic framework (MOF) MIL-100(Fe) as carbon precursor using carbonisation and KOH activation strategies. Carbonisation and activation ensured that MPCK possessed excellent...The content of this RSS Feed (c) The Royal Society of Chemistry
Sat May 23, 2020 02:00
Analyst, 2020, Advance ArticleDOI: 10.1039/C9AN02355K, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takayo Moriuchi-Kawakami, Yuria Sekiguchi, Shintaro Hattori, Takahiro Otsuki, Keiichi Fujimori, Toshiyuki Moriuchi, Yoshiaki UrahamaThe proton spin–spin relaxation times (T2) of ion-selective electrode membranes with differences in the polymerization degree of the incorporated poly(vinyl chloride) (PVC) polymers were investigated.To...
Fri May 22, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00481B, PaperSara Guerrero, Esther Sánchez-Tirado, Gonzalo Martínez-García, Araceli González-Cortés, Paloma Yáñez-Sedeño, Jose M PingarronThis paper reports a dual electrochemical biosensor involving carboxylated- or neutravidin-functionalized magnetic microbeads and dual screen-printed carbon electrodes for the simultaneous determination of rheumatoid factor (RF) and anti-cyclic citrullinated peptide...The content of this RSS Feed (c) The Royal...
Fri May 22, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00624F, PaperAgueda Molinero-Fernández, Miguel Ángel López, Alberto EscarpaA novel on-chip electrochemical magneto-immunoassay for Procalcitonin (PCT) determination is proposed. The strategy implies the on-line performing of the biorecognition event and the detection onto thin film microfluidic gold electrodes...The content of this RSS Feed (c) The Royal Society of Chemistry
Fri May 22, 2020 02:00
Summary Background Lemierre syndrome is characterized by head/neck vein thrombosis and septic embolism usually complicating an acute oropharyngeal bacterial infection in adolescents and young adults. We described the course of Lemierre syndrome in the contemporary era. Methods In our individual‐level analysis of 712 patients (2000‐2017), we included cases described as Lemierre syndrome if these criteria were met: (i) primary site of bacterial infection in the head/neck; (ii) objectively...
Fri May 22, 2020 16:09
Background: PARP inhibitors (PARPis) are standard-of-care therapy for high-grade serous ovarian cancer (HGSOC). We investigated combining cediranib (antiangiogenic) with olaparib (PARPi) at emergence of PARPi resistance. Methods: The proof-of-concept EVOLVE study (NCT02681237) assessed cediranib-olaparib combination therapy after progression on a PARPi. Women with HGSOC and radiographic evidence of disease progression were enrolled into one of three cohorts: platinum sensitive after PARPi; platinum...
Fri May 22, 2020 16:29
Purpose:Genomic methods can identify homologous recombination deficiency (HRD). Rigorous evaluation of their outcome association to DNA damage response–targeted therapies like platinum in pancreatic ductal adenocarcinoma (PDAC) is essential in maximizing therapeutic outcome.Experimental Design:We evaluated progression-free survival (PFS) and overall survival (OS) of patients with advanced-stage PDAC, who had both germline- and somatic-targeted gene sequencing. Homologous recombination gene mutations...
Fri May 22, 2020 10:04
Background. Chronic illnesses have a negative impact on the quality of sleep; however, patients with chronic illness do not bring sleep issues while they are coming to a health institution for a follow-up. As a result, poor sleep quality among patients with chronic illness is often unrecognized and untreated, and it results to a negative impact on the prognosis of chronic illness. Methods. An institutional-based cross-sectional study design was employed from February 22, 2018, to April 6, 2018. The...
Fri May 22, 2020 18:35
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03864
Fri May 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02384
Fri May 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02742
Fri May 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03239
Fri May 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01325
Fri May 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01704
Fri May 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01978
Thu May 21, 2020 07:00
Abstract Statins have shown beneficial treatment as chemotherapy and target‐therapy for lung cancer. This study aims to investigate the effectiveness of statins in combination with epidermal growth factor receptor‐ tyrosine kinase inhibitors (EGFR‐TKIs) therapy on resistance and mortality of lung cancer patients. A population‐based cohort study was conducted using the Taiwan Cancer Registry database. From January 1, 2007, to December 31, 2012, a total of 792 non‐statins and 41 statins users had...
Fri May 22, 2020 13:03
Condition: Head and Neck Squamous Cell CarcinomaIntervention: Other: Camrelizumab and SBRTSponsors: Xingchen Peng; Jiangsu HengRui Medicine Co., Ltd.Recruiting
Sat May 23, 2020 02:23
Condition: Esophageal CancerInterventions: Other: Injection of indocyanine green (ICG)dye; Device: Near-Infrared Image-Guided; Procedure: Sentinel Lymph Node (SNL) mappingSponsor: Memorial Sloan Kettering Cancer CenterRecruiting
Sat May 23, 2020 02:23
Facial Plast SurgDOI: 10.1055/s-0040-1709710The temporal region is challenging to treat due to its thin skin, which has the propensity toward showing irregularities. The literature on temporal hollowing augmentation suggests placing the filler either into the subcutaneous space or within the temporalis muscle. However, these techniques have been based upon opinion rather than supporting anatomical and clinical data. We introduce a novel injection technique to avoid complications and achieve lasting...
Fri May 22, 2020 02:00
Although clozapine treatment is often discontinued due to limited efficacy or low tolerability, there is a lack of guidelines and evidence on treatment options after discontinuation of clozapine in patients with schizophrenia. Persistence has proven to be an adequate indicator for treatment effectiveness in patients with schizophrenia. The aim of this study was, therefore, to compare persistence of antipsychotic use between antipsychotic treatment options in patients after stopping clozapine treatment....
Fri May 22, 2020 14:02
Abstract The global response to finding therapeutics for COVID‐19 is chaotic even if well intentioned. There is an opportunity, but more importantly, an obligation for the global clinical and quantitative pharmacology community to come together and use our state‐of‐the‐art tools and expertise to help society accelerate therapeutics to fight COVID‐19. This brief commentary is a call to action and highlights how the global pharmacology community should contribute to the COVID‐19 pandemic and prepare...
Fri May 22, 2020 13:08
Thorac Cardiovasc Surg Rep 2020; 09: e21-e23DOI: 10.1055/s-0040-1710321 Background Patients presenting with several cardiothoracic conditions that need to be addressed surgically require individual decision making as evidence remains inconclusive and combined surgical procedures carry an elevated perioperative risk. Case Description We present the case and management of a 73-year-old male with myocardial infarction due to three-vessel disease and left main stem stenosis, calcified...
Fri May 22, 2020 02:00
Thorac Cardiovasc Surg Rep 2020; 09: e24-e28DOI: 10.1055/s-0040-1710586 Background Traumatic injury of the trachea is rare, especially complete transection. Its operative revision requires an interdisciplinary approach. Case Description We hereby present a rare case of complete transection of the trachea by accident. To stabilize the patient and to allow for safe surgery, veno-venous extracorporeal support was initiated via the subclavian artery and the femoral vein. The patient...
Fri May 22, 2020 02:00
Abstract Accumulating evidence supports that Sirtuin 6 (SIRT6) may play a vital role in the pathogenesis of spinal cord injury. The current study was designed to investigate the specific effects of SIRT6 on spinal cord injury (SCI). HE and Nissl staining were performed for pathological analysis in SCI rats. SIRT6 expression was detected by RT-qPCR. CCK8 assay was applied for the detection of cell viability of LPS-injured PC12 cells....
Fri May 22, 2020 03:00
Abstract Intervertebral disc degeneration (IVDD) is considered to be the fundamental cause of the occurrence and development of lumbar disc herniation (LDH). The degeneration of IVDD is mainly caused by the participation of inflammatory factors. Thus, it is of great significance to analyze the pathogenesis of IVDD, which may guide clinical prevention and treatment of LDH. Our current study aims to identify the role of miR-495-3p in LDH and to further unravel the underlying mechanisms....
Fri May 22, 2020 03:00
Abstract Alzheimer’s disease (AD) is a serious neuropathologic disease characterized by aggregation of amyloid-β (Aβ) peptide. Aβ-mediated oxidative stress and neuroinflammation play crucial role in the development of AD. Engeletin is a flavononol glycoside that possesses anti-inflammatory effect. However, the effects of engeletin on AD have not been investigated. In the present study, we investigated the role of engeletin in AD using...
Fri May 22, 2020 03:00
Abstract Background Prospective renal donors are a select population of healthy individuals who have been thoroughly screened for significant comorbidities before they undergo multi‐detector computed tomography angiography and urography (MDCT). Purpose The aim of this study is to describe the anatomy of potential living renal donor subjects using MDCT over a 2‐year period. The primary objective is to identify the renal arterial anatomy variations, with a secondary objective of identifying...
Fri May 22, 2020 12:58
Summary Acute gastric volvulus is a rare surgical emergency which can lead to severe complications such as gastric ischaemia and perforation. Gastric volvulus is classified by the axis upon which the stomach rotates into organo‐axial and mesentero‐axial subtypes, with the former more common in adults. We present an uncommon case of recurrent adult mesentero‐axial gastric volvulus and describe the associated radiological findings.
Fri May 22, 2020 12:49
Abstract Introduction Balloon‐occluded retrograde transvenous obliteration (BRTO) is recommended for secondary prevention of gastric variceal bleeding in the American Association for the Study of Liver Disease (AASLD) guidelines, as an alternative to Transjugular intrahepatic portosystemic shunt (TIPS). However, there is significant heterogeneity in how BRTO is performed, including how and how long to occlude the outflow venous shunt amongst other variables such as variceal size, flow rate, agent...
Fri May 22, 2020 12:48
Fri May 22, 2020 13:19
Abstract In an earlier article, Gordon Drummond summarized ongoing changes in how statistics are being used in experimental physiology (Drummond, 2020). He described the near ubiquitous use of the P value, cautioning against declaring an analysis “statistically significant”. He mentioned alternative approaches including Bayesian and likelihood approaches. This article focusses on the latter approach although we will first have another look at that P value. Then the likelihood approach will be...
Fri May 22, 2020 13:17
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