Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri May 22, 2020 09:22
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri May 22, 2020 09:18
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri May 22, 2020 09:14
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri May 22, 2020 09:11
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri May 22, 2020 09:09
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Fri May 22, 2020 09:05
Journal of Cutaneous Medicine and Surgery, Ahead of Print. BackgroundSystemic therapy for atopic dermatitis (AD) has been challenging with limited safe and efficacious long-term treatment options. In 2017, dupilumab was approved in the United States, Europe, and Canada as the first targeted therapy for patients with moderate-to-severe AD. Despite promising efficacy and safety results in clinical trials, our understanding of dupilumab in clinical practice remains limited with few studies outside clinical...
Fri May 22, 2020 09:00
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Thu May 21, 2020 09:51
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Thu May 21, 2020 06:14
Journal of Cutaneous Medicine and Surgery, Ahead of Print.
Thu May 21, 2020 06:13
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Esophageal squamous cell carcinoma is one of the leading aggressive malignancies with high mortality. Semaphorin 3F has been reported to be involved in lymphangiogenesis by interacting the vascular endothelial growth factor C/neuropilin 2 axis. This study aimed to assess the clinical and functional role of semaphorin 3F and preliminarily evaluate the relationship between semaphorin 3F and lymph node...
Fri May 22, 2020 13:45
Abstract Unicompartmental knee arthroplasty (UKA) which has many potential advantages compared with total knee arthroplasty (TKA) was widely used across the world in recent years. The introduction of the robot systems greatly makes up for the defects of the conventional UKA surgery such as higher complication rates and revision rates. MAKO system, a new image‐guided robot system relies on a preoperative computed tomography (CT) scan to assist in preoperative mapping and planning, offers an opportunity...
Sat May 23, 2020 11:15
X‐ray‐induced luminescence computed tomography (XLCT) is an emerging molecular imaging. Challenges in improving spatial resolution and reducing the scan time in a whole‐body field of view (FOV) still remain for practical in vivo applications. In this study, we present a novel XLCT technique capable of obtaining three‐dimensional (3D) images from a single snapshot. Specifically, a customed two‐planar‐mirror component is integrated into a cone beam XLCT imaging system to obtain multiple optical views...
Fri May 22, 2020 20:48
Abstract Toxoplasma gondii is an apicomplexan parasite that causes toxoplasmosis in the human body and commonly infects warm‐blooded organisms. Pathophysiology of its diseases is still an interesting issue to be studied since T. gondii can infect nearly all nucleated cells. Imaging techniques are crucial for studying its pathophysiology. In T. gondii‐ infected cells structural and biochemical alterations occurred. To study that modification, we use digital holotomography to investigate the structure...
Fri May 22, 2020 12:48
Abstract Purpose Obstructive sleep apnea syndrome is a clinical sleep disorder defined by total or partial airflow restraint during sleep that results in fragmented sleep and hypoxemia, impacting negatively with cognitive functioning. This review was conducted on studies investigating structural brain alteration and cognitive impairment in obstructive sleep apnea syndrome. ...
Sat May 23, 2020 03:00
Abstract Purpose We aimed to investigate the association between sleep disturbance and menstrual problems in female Chinese university students. Methods A convenience sample of 1006 female university students participated in this study. Sleep duration, sleep quality, and insomnia symptoms were assessed by the Pittsburgh Sleep Quality Index and the...
Sat May 23, 2020 03:00
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in December 2019 as the cause of a respiratory illness designated coronavirus disease 2019, or Covid-19. Several therapeutic agents have been evaluated for the treatment of Covid-19, but none…
Fri May 22, 2020 03:00
To rapidly communicate short reports of innovative responses to Covid-19 around the world, along with a range of current thinking on policy and strategy relevant to the pandemic, the Journal has initiated the Covid-19 Notes series. On March 15, 2020, leaders at New York–Presbyterian Columbia…
Fri May 22, 2020 03:00
Background Posterior nasal nerve (PNN) cryoablation has shown promise in improving rhinorrhea due to allergic and nonallergic rhinitis (NAR). Early case series have shown meaningful clinical improvement in 75‐80% of patients, but variables predicting PNN cryoablation success have not been studied. The purpose of this study was to evaluate whether disease features and ipratropium nasal spray response predicted rhinorrhea response after PNN cryoablation. Methods A multi‐institutional retrospective...
Fri May 22, 2020 17:49
Background Chronic rhinosinusitis with or without nasal polyps (CRSwNP/CRSsNP) seriously impairs health‐related quality of life (HRQoL). This analysis describes the impact of the exhalation delivery system with fluticasone (EDS‐FLU) on HRQoL, assessed by the 36‐item Short‐Form Health Survey version 2 (SF‐36v2), and on utilities, assessed via the Short‐Form 6‐Dimension (SF‐6D), in patients with CRSwNP. Methods Post hoc analysis of pooled randomized clinical trial data (NAVIGATE I and II; N...
Fri May 22, 2020 17:43
The Child Neurology Society collaborated with the Pediatric Epilepsy Research Consortium to issue an online statement April 6, 2020 of immediate recommendations to streamline diagnosis, treatment, and follow up of infantile spasms. The recommendations encourage use of telemedicine, outpatient over inpatient studies, and oral therapies as initial treatment. Each recommendation is earmarked as enduring if intended to outlast the pandemic, and limited if intended only during the duration of the pandemic....
Fri May 22, 2020 18:24
The neurodiagnostic criteria of Leigh syndrome have not yet been clearly redefined based on the expanding of molecular etiologies. We aimed to analyze twenty years of clinical, genetic, and magnetic resonance studies from our Leigh syndrome cohort to provide a detailed description of central nervous system lesions in Leigh syndrome and their biological evolution in view of their genetic and clinical findings. Our study adds new neurodiagnostic insights to the current knowledge of Leigh syndrome,...
Fri May 22, 2020 17:43
Objectives Alterations of the gut microbiome in Parkinson's disease (PD) have been repeatedly demonstrated. However, little is known about whether such alterations precede disease onset and how they relate to risk and prodromal markers of PD. We investigated associations of these features with gut microbiome composition. Methods Established risk and prodromal markers of PD as well as factors related to diet/lifestyle, bowel function and medication were studied in relation to bacterial α−/β‐diversity,...
Fri May 22, 2020 13:02
Abstract We report the case of isolation of Bordetella trematum from the respiratory tract of a patient with lung carcinoma. This gram-negative, opportunistic rod was firstly described in 1996. To date, only several strains of Bordetella trematum have been isolated and reported, mostly from skin and soft tissue infections. The patient was admitted to the ICU of the Pulmonary Department in incipient septic shock with respiratory failure. Intravenous fluid resuscitation and non-invasive...
Sat May 23, 2020 07:18
Abstract The aim of this study was to trace the dynamic changes of methicillin-resistant Staphylococcus aureus (MRSA) lineages in the local hospital in both the national and international context. We describe genotypic and phenotypic characterization of 62 non-duplicate MRSA isolates collected during 2010–2016 at University Hospital in Hradec Kralove, Czech Republic. The isolates were characterized by multilocus sequence typing (MLST), spa typing, and staphylococcal cassette...
Sat May 23, 2020 07:18
Abstract Garlic (Allium sativum L.) is a well-known spice widely utilised for its medicinal properties. There is an extensive record of the many beneficial health effects of garlic which can be traced back to as early as the ancient Egyptian era. One of the most studied properties of garlic is its ability to cure certain ailments caused by infections. In the 1940s, the antimicrobial activities exhibited by garlic were first reported to be due to allicin, a volatile compound...
Sat May 23, 2020 07:18
Abstract Schinzel– Giedion syndrome (SGS; OMIM 269150) is an ultra‐rare genetic disorder associated with a distinctive facial gestalt, congenital malformations, severe intellectual disability, and a progressive neurological course. The prognosis for SGS is poor, with survival beyond the first decade rare. Germline, de novo heterozygous variants in the SETBP1 gene cause SGS with the pathogenic variants associated with the SGS phenotype missense and confined to exon 4 of the gene, clustered in a...
Fri May 22, 2020 18:23
Abstract 3MC syndromes are rare heterogeneous autosomal recessive conditions previously designated as Mingarelli, Malpuech, Michels, and Carnevale syndromes, characterized by dysmorphic facial features, facial clefts, growth restriction, and intellectual disability. 3MC is secondary to mutations in the MASP1, MASP3, COLEC11 , and COLEC10 genes. The number of patients with 3MC syndrome with known mutations in the COLEC11 or MASP1 is, to date, less than 50. At the time this case presented (2015),...
Fri May 22, 2020 12:56
Background: Lung adenocarcinoma (LUAD) is one of the most common malignant tumors. How to effectively diagnose LUAD at an early stage and make an accurate judgement of the occurrence and progression of LUAD are still the focus of current research. Support vector machine (SVM) is one of the most effective methods for diagnosing LUAD of different stages. The study aimed to explore the dynamic change of differentially expressed genes (DEGs) in different stages of LUAD, and to assess the risk of LUAD...
Fri May 22, 2020 23:27
Hummingbirds in flight exhibit the highest mass-specific metabolic rate of all vertebrates. The bioenergetic requirements associated with sustained hovering flight raise the possibility of unique amino acid substitutions that would enhance aerobic metabolism. Here, we have identified a non-conservative substitution within the mitochondria-encoded cytochrome c oxidase subunit I (COI) that is fixed within hummingbirds, but not among other vertebrates. This unusual change is also rare among metazoans,...
Fri May 22, 2020 23:27
Influenza A virus (IAV) utilizes cap-snatching to obtain host capped small RNAs for priming viral mRNA synthesis, generating capped hybrid mRNAs for translation. Previous studies have been focusing on canonical cap-snatching, which occurs at the very 5' end of viral mRNAs. Here we discovered non-canonical cap-snatching, which generates capped hybrid mRNAs/noncoding RNAs mapped to the region ~300 nucleotides (nt) upstream of each mRNA 3' end, and to the 5' region, primarily starting at the second...
Fri May 22, 2020 18:18
64Cu-DOTATATE PET/CT imaging 1 hour (h) post-injection (p.i.) is excellent for lesion detection in patients with neuroendocrine neoplasms (NEN). We hypothesized that the imaging time window can be extended up to 3h p.i. without significant differences in the number of lesions detected. Methods From a prospective study, we compared, on a head-to-head basis, sets of 64Cu-DOTATATE PET/CT images from 35 patients with NEN scanned 1h and 3h p.i. of 200 MBq 64Cu-DOTATATE. The number of lesions on both scans...
Sat May 23, 2020 00:43
With the largest high-risk prostate cancer (PCa) cohort to date undergoing 68Ga-prostate-specific membrane antigen (PSMA) PET/CT primary staging, we aimed to 1) characterize the metastatic spread of PCa in relation to tumor 68Ga-PSMA-uptake and the D’Amico classification, and 2) compare 68Ga-PSMA PET/CT findings with radical prostatectomy (RP) with pelvic lymph node dissection (PLND) histopathology. Methods: A total of 691 consecutive newly diagnosed, biopsy-proven, treatment-naïve, D’Amico high-risk...
Sat May 23, 2020 00:43
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