Abstract Dynamic magnetic resonance imaging (MRI) is a non-invasive method that can be used to increase the understanding of the pathomechanics of joints. Various types of real-time gradient echo sequences used for dynamic MRI acquisition of joints include balanced steady-state free precession sequence, radiofrequency-spoiled sequence, and ultra-fast gradient echo sequence. Due to their short repetition time and echo time, these sequences provide high temporal resolution, a good...
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Abstract Testicular trauma is common, usually trivial and rarely requires hospital attendance, but if it does, then imaging becomes essential as scrotal assessment may be difficult due to pain and/or scrotal disruption. Ultrasound (US) assumes a crucial role as other cross-sectional modalities have a limited use in the acute presentation. Despite the acceptable accuracy of conventional US techniques, there are limitations which hinder a thorough evaluation, critically the assessment...
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Abstract The enlargement of the bronchial arteries occurs in a multitude of congenital and acquired diseases and is responsible for the majority of cases of hemoptysis. In this review, we provide a simplified imaging approach to the evaluation of the bronchial arteries. We highlight the anatomy and function of the bronchial arteries, typical imaging findings, how to recognize bronchial artery dilatation, and its underlying causes. Contrast-enhanced computer tomography plays a...
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Abstract Adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma are relatively new classification entities which replace the now retired term, bronchoalveolar carcinoma (BAC). The radiographic appearance of these lesions ranges from pure, ground glass nodules to large, solid masses. A thorough understanding of the new classification is essential to radiologists who work with MDT colleagues to provide...
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Abstract Lymphoma in HIV-infected patients is AIDS defining. This is the second most common AIDS defining malignancy after Kaposi’s sarcoma. Development of lymphoma in HIV patients is related to immunosuppression and high viral load. Co-infection with other lymphotrophic viruses especially EBV is also strongly associated with development of lymphoma in HIV patients. Despite advances in HAART therapy, incidence of diffuse large B cell lymphoma in HIV-infected patients remains...
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Abstract Background Otosclerosis causes conductive, sensorineural and mixed hearing loss (CHL, SNHL, MHL) and tinnitus in young adults. It is best diagnosed on high-resolution CT (HRCT). Occasionally, patients presenting with SNHL and/or tinnitus may undergo temporal bone MRI as the first investigation. In this study, we have described the role of MRI as the first-line modality in the detection of previously undiagnosed otosclerosis....
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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
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Early data indicated that smokers may be less likely to be hospitalised with coronavirus, but broader analyses suggest smokers are actually at higher risk
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The coronavirus lockdown will see global carbon emissions fall by a fifth compared with last year, but this dramatic drop won't slow climate change
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Abstract Purpose Underlying mechanisms of the relationship between body fatness and colorectal cancer remain unclear. This study investigated associations of circulating metabolites with visceral (VFA), abdominal subcutaneous (SFA), and total fat area (TFA) in colorectal cancer patients. Methods Pre-surgery plasma samples from 212 patients (stage I–IV) from...
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A recent examination of older adults with cancer found accelerated losses in differing sarcopenia measures existed before and after a cancer diagnosis. (Source: CancerNetwork)
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Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/D0PP00098A, CommunicationKenzo Fujimoto, Kenta Ishida, Li Xue, Shigetaka NakamuraThe photo-cross-linkable ODN containing 3-cyanovinylcarbazole moiety by postmodified with click chemistry can photo-cross-linked to thymidine at −1 position or −2 position.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
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Photochem. Photobiol. Sci., 2020, Accepted ManuscriptDOI: 10.1039/D0PP00114G, PaperKelly A. D. F. Castro, Letícia D. Costa, Samuel Guieu, Juliana Biazzoto, Maria da Graça P. M. S. Neves, Maria Amparo Faustino, Roberto Santana da Silva, Augusto ToméThis work provides the first study about the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against...The content of this RSS Feed (c) The Royal Society...
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Photoprotection conferred by low level summer sunlight exposures against pro-inflammatory UVR insult
Photochem. Photobiol. Sci., 2020, Advance ArticleDOI: 10.1039/C9PP00452A, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.S. J. Felton, B. B. Shih, R. E. B. Watson, R. Kift, A. R. Webb, L. E. RhodesTanning (melanisation and epidermal thickening) is a photoprotective response to solar UVR exposure, but it has been unclear to what degree low-level exposures induce this, or whether this modifies the histological inflammatory response to UVR.To cite...
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The fungal cell-wall integrity signaling (CWIS) pathway regulates cellular response to environmental stress to enable wall repair and resumption of normal growth. This complex, interconnected, pathway has been only partially characterized in filamentous fungi. To better understand the dynamic cellular response to wall perturbation, a β-glucan synthase inhibitor (micafungin) was added to a growing A. nidulans shake-flask culture. From this flask, transcriptomic and phosphoproteomic data were acquired...
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Doctors have told The BMJ they are deeply concerned at the number of patients becoming infected with covid-19 in NHS hospitals in England and have called for more stringent infection control measures...
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bmj;369/may19_6/m2015/FAF1faThe Cardiff artist Nathan Wyburn created this collage during the covid-19 lockdown from hundreds of images sent to him by health workers.Wyburn put out a request on social...
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The coroner investigating the botched birth of a baby boy who died from hypoxia has strongly criticised the Healthcare Service Investigation Branch (HSIB) over its report on his death.Karen...
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Some have trumpeted the 4-aminoquinoline antimalarial drugs, chloroquine and hydroxychloroquinine, for the treatment of covid-19, based on the (literally) incredible results of efficacy in reported...
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Abstract Introduction Widespread use of effective antiretroviral therapy (ART) in people living with human immunodeficiency virus (PLHIV) infection has changed the prognosis of the disease from a fatal and debilitating one to a chronic manageable illness. ART leads to immune restoration, but immune functional levels seen in HIV-uninfected people are never achieved. The dynamics of immune suppression, chronic immune activation, and immune...
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by Dana Lau-Corona, Woo Kyun Bae, Lothar Hennighausen, David J. Waxman Sex differences in the incidence and progression of many liver diseases, including liver fibrosis and hepatocellular carcinoma, are associated with sex-biased hepatic expression of hundreds of genes. This sexual dimorphism is largely determined by the sex-specific pattern of pituitary growth hormone secretion, which controls a transcriptional regulatory network operative in the context of sex-biased and growth hormone-regulated...
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by Dominic Holland, Oleksandr Frei, Rahul Desikan, Chun-Chieh Fan, Alexey A. Shadrin, Olav B. Smeland, V. S. Sundar, Paul Thompson, Ole A. Andreassen, Anders M. Dale Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. SNP-heritability is proportional to the product of these quantities. We present a basic model, using detailed linkage...
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In-vivo accuracy of intraoral scans of complete mixed dentitions of patients in active treatment have not yet been investigated. The aim was to test the hypothesis that dimensional differences between intraora...
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Abstract Objective Despite their benefit for detecting primary tumors, data for normal 18F-fluoro-2-deoxy-d-glucose (FDG) uptake in the anal canal are insufficient. Here we used positron emission tomography–computed tomography (PET/CT) to determine the uptake of FDG in the normal adult anal canal (AC) and to evaluate its clinical significance compared with that of anal cancer. ...
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Abstract Background Although there is growing utilisation of intermediate care to improve the health and well-being of older adults with complex care needs, there is no international agreement on how it is defined, limiting comparability between studies and reducing the ability to scale effective interventions. Aim To identify and define the characteristics...
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Publication date: Available online 19 May 2020Source: The Journal of Emergency MedicineAuthor(s): Saurabh Bansal, Namrata Singhania, Manajyoti Yadav, Girish Singhania
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Publication date: Available online 19 May 2020Source: The Journal of Emergency MedicineAuthor(s): Winton Chong, Mohammed Hijazi, Mohammed Abdalrazig, Naishadh Patil
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Publication date: Available online 19 May 2020Source: The Journal of Emergency MedicineAuthor(s): Daniel Manzur-Sandoval, Guillermo Dueñas-Pérez, Edgar Ortiz-Brizuela, Pedro Valdez-Hernández, Jorge Oseguera-Moguel, José Luis Briseño-de la Cruz
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Publication date: Available online 18 May 2020Source: The Journal of Emergency MedicineAuthor(s): Engin Ozakin, Nazlı Ozcan Yazlamaz, Filiz Baloglu Kaya, Evvah M. Karakilic, Muzaffer Bilgin
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Abstract Vitamin D-dependent rickets type 1B (VDDR1B) is an autosomal semidominant genetic disorder caused by a deficiency in CYP2R1, which encodes vitamin D 25-hydroxylase, an enzyme that plays a crucial role in the conversion of vitamin D to 25-dihydroxyvitamin D3. VDDR1B is a severe form of rickets that occurs during infancy and which is responsive to 25-OH vitamin D supplementation. We studied three adult patients from a multi-consanguineous family with VDDR1B. They have been...
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Abstract Brain metastases (BM) represent the most common intracranial malignancy in adults. Limitations of existing prognostic models reduce their predictivity and clinical applicability. The aim of this study is to validate the cumulative intracranial tumour volume prognostic assessment (CITVPA) as a new prognostic score system for patients with BM treated by Stereotactic Radiosurgery (SRS). Between January 2001 and December 2015, 1894 patients underwent Gamma Knife SRS treatment....
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Several typos occurred during the production process and captions were misplaced. The corrected captions for Picture 1, Fig. 6-9 are below.
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