Related ArticlesTraumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity. Transfusion. 2020 May 22;: Authors: Dyer MR, Plautz WE, Ragni MV, Alexander W, Haldeman S, Sperry JL, Guyette FX, Zuckerbraun BS, Rollins-Raval MA, Raval JS, Neal MD, A TACTIC Publication Abstract BACKGROUND: Increases in plasma von Willebrand Factor (VWF) levels, accompanied by decreases in the metalloprotease ADAMTS13,...
Sat May 23, 2020 14:34
Related ArticlesOutcomes of Patients with Borderline Resectable Pancreatic Cancer Treated with Combination Chemotherapy. J Gastrointest Cancer. 2020 May 21;: Authors: Templeton S, Moser M, Wall C, Shaw J, Chalchal H, Luo Y, Zaidi A, Ahmed S Abstract BACKGROUND: Patients with borderline resectable pancreatic cancer are at high risk of incomplete resection with upfront surgery. Currently, no standard induction chemotherapy regimen exists for these patients....
Sat May 23, 2020 14:34
Related ArticlesDevelopment and Testing of an Adjuvant Radiotherapy Decision Aid for Older Women Diagnosed with Stage I Breast Cancer: A Pilot Study. Cureus. 2020 Apr 16;12(4):e7690 Authors: Neve M, Henry-Noel N, Mehta R, Trudeau M, Menjak I, Szumacher E Abstract Background Whole breast irradiation therapy (WBRT), accelerated partial breast irradiation (APBI), and omission of radiotherapy (ORT) are options for women aged 65 years and older with low-risk...
Sat May 23, 2020 14:34
Related ArticlesLong Non-Coding RNA TTN-AS1 Serves as a Competing Endogenous RNA of miR-195 to Facilitate Clear Cell Renal Cell Carcinoma Progression. Cancer Manag Res. 2020;12:3091-3097 Authors: Lin K, Chen H, Su C, Zhu H, Lai C, Shi Y Abstract Introduction: Clear cell renal cell carcinoma (ccRCC) is an aggressive human malignancy. Long non-coding RNAs (lncRNAs) are critical regulators in many malignant tumors, including ccRCC. The aim of this study...
Sat May 23, 2020 14:34
Related ArticlesEconomic Evaluation of Single versus Combination Immuno-Oncology Therapies: Application of a Novel Modelling Approach in Metastatic Melanoma. Clinicoecon Outcomes Res. 2020;12:241-252 Authors: Gibson EJ, Begum N, Koblbauer I, Dranitsaris G, Liew D, McEwan P, Yuan Y, Juarez-Garcia A, Tyas D, Pritchard C Abstract Background: Existing economic model frameworks may not adequately capture the atypical treatment response patterns in immuno-oncology...
Sat May 23, 2020 14:34
Related ArticlesAdded value of contrast-enhanced mammography (CEM) in staging of malignant breast lesions-a feasibility study. World J Surg Oncol. 2020 May 21;18(1):100 Authors: Åhsberg K, Gardfjell A, Nimeus E, Rasmussen R, Behmer C, Zackrisson S, Ryden L Abstract OBJECTIVES: The aim of this feasibility study was to evaluate the added value of contrast-enhanced mammography (CEM) in preoperative staging of malignant breast lesions, beyond standard assessment...
Sat May 23, 2020 14:34
Related ArticlesCold-Atmospheric Plasma Induces Tumor Cell Death in Preclinical In Vivo and In Vitro Models of Human Cholangiocarcinoma. Cancers (Basel). 2020 May 19;12(5): Authors: Vaquero J, Judée F, Vallette M, Decauchy H, Arbelaiz A, Aoudjehane L, Scatton O, Gonzalez-Sanchez E, Merabtene F, Augustin J, Housset C, Dufour T, Fouassier L Abstract Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for...
Sat May 23, 2020 14:34
Related ArticlesChanges in colorectal cancer incidence in seven high-income countries: a population-based study. Lancet Gastroenterol Hepatol. 2019 07;4(7):511-518 Authors: Araghi M, Soerjomataram I, Bardot A, Ferlay J, Cabasag CJ, Morrison DS, De P, Tervonen H, Walsh PM, Bucher O, Engholm G, Jackson C, McClure C, Woods RR, Saint-Jacques N, Morgan E, Ransom D, Thursfield V, Møller B, Leonfellner S, Guren MG, Bray F, Arnold M Abstract BACKGROUND: The...
Sat May 23, 2020 14:34
Hypopharyngeal-Esophageal Impedance-pH Monitoring Profiles of Laryngopharyngeal Reflux Patients. Laryngoscope. 2020 May 21;: Authors: Lechien JR, Bobin F, Dapri G, Eisendrath P, Salem C, Mouawad F, Horoi M, Thill MP, Dequanter D, Rodriguez A, Muls V, Saussez S Abstract OBJECTIVES/HYPOTHESIS: To investigate the profile of patients with laryngopharyngeal reflux (LPR) at hypopharyngeal-esophageal multichannel intraluminal impedance-pH (HEMII-pH) monitoring...
Fri May 22, 2020 14:25
CELLector: Genomics-Guided Selection of Cancer In Vitro Models. Cell Syst. 2020 May 20;10(5):424-432.e6 Authors: Najgebauer H, Yang M, Francies HE, Pacini C, Stronach EA, Garnett MJ, Saez-Rodriguez J, Iorio F Abstract Selecting appropriate cancer models is a key prerequisite for maximizing translational potential and clinical relevance of in vitro oncology studies. We developed CELLector: an R package and R Shiny application allowing researchers to select...
Fri May 22, 2020 14:25
Fighting cancer in coronavirus disease era: organization of work in medical oncology departments in Emilia Romagna region of Italy. Future Oncol. 2020 May 21;: Authors: Brandes AA, Ardizzoni A, Artioli F, Cappuzzo F, Cavanna L, Frassineti GL, Frassoldati A, Leonardi F, Longo G, Maestri A, Tassinari D, Franceschi E, Nunno VD, Pinto C Abstract Aim: To assess which and when measures were applied to reduce coronavirus disease (COVID-19) spreads have been...
Fri May 22, 2020 14:25
Pulmonary nodules precision localization techniques. Future Oncol. 2020 May 21;: Authors: Nardini M, Dunning J Abstract The advent of helical high-resolution CT scanners, the application of screening programs and the follow-up of patient with oncological history, led to an increasing number of diagnosis of small pulmonary nodule (less than 10 mm in maximum diameter), partially solid nodule or completely ground glass ones. Their management is controversial....
Fri May 22, 2020 14:25
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials. NPJ Breast Cancer. 2020;6:15 Authors: Hudeček J, Voorwerk L, van Seijen M, Nederlof I, de Maaker M, van den Berg J, van de Vijver KK, Sikorska K, Adams S, Demaria S, Viale G, Nielsen TO, Badve SS, Michiels S, Symmans WF, Sotiriou C, Rimm DL, Hewitt SM, Denkert C, Loibl S, Loi S, Bartlett JMS, Pruneri G, Dillon DA, Cheang MCU, Tutt A, Hall JA, Kos Z,...
Fri May 22, 2020 14:25
Types of human papillomavirus observed in hospital-based population. Indian J Med Microbiol. 2019 Oct-Dec;37(4):557-562 Authors: Wagh P, Kulkarni P, Kerkar S, Tongaonkar H, Deodhar K, Rekhi B, Salvi V, Chaudhari H, Warke H, Mania-Pramanik J Abstract Background and Objectives: Human papillomavirus (HPV) is the causative agent of cervical cancer, a major cause of cancer mortality in Indian women. The current study was undertaken to add information to the...
Fri May 22, 2020 14:25
Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study. Cancer. 2020 May 21;: Authors: Poort H, de Rooij BH, Uno H, Weng S, Ezendam NPM, van de Poll-Franse L, Wright AA Abstract BACKGROUND: Fatigue is a common and distressing symptom for patients with gynecologic cancers. Few studies have empirically examined whether it spontaneously resolves. This study was aimed at identifying longitudinal patterns...
Fri May 22, 2020 14:25
Urothelial carcinoma: the development of FGFR inhibitors in combination with immune checkpoint inhibitors. Expert Rev Anticancer Ther. 2020 May 21;: Authors: Qin Q, Patel V, Galsky MD Abstract INTRODUCTION: The recent approval of erdafitinib and the emergence of other potent and selective fibroblast growth factor receptor (FGFR) inhibitors (FGFRi's) are shifting the treatment paradigm for patients with advanced urothelial carcinoma (UC) harboring FGFR3...
Fri May 22, 2020 14:25
Are Cyclin-Dependent Kinase 4/6 Inhibitors Without Future in Neuroendocrine Tumors? Oncologist. 2020 May 20;: Authors: Pusceddu S, Corti F, Milione M, Centonze G, Prinzi N, Torchio M, de Braud F PMID: 32436279 [PubMed - as supplied by publisher]
Fri May 22, 2020 14:25
Investigating the appropriateness of different concordance measures in a time-to-event setting. Pharm Stat. 2020 May 21;: Authors: Caetano SJ, Pond G Abstract PURPOSE: Prediction models that assess a patient's risk of an event are used to inform treatment options and confirm screening tests. The concordance (c) statistic is one measure to validate the accuracy of these models, but has many extensions when applied to censored data. The purpose was to...
Fri May 22, 2020 14:25
Polycomb-like 2 regulates PRC2 components to affect proliferation in glioma cells. J Neurooncol. 2020 May 21;: Authors: Wang F, Gao Y, Lv Y, Wu Y, Guo Y, Du F, Wang S, Yu J, Cao X, Li PA Abstract INTRODUCTION: The Polycomb group (PcG) is an important family of transcriptional regulators that controls growth and tumorigenesis. The PcG mainly consists of two complexes, PRC1 and Polycomb Repressive Complex 2 (PRC2). Polycomb-like 2 (PCL2) is known to interact...
Fri May 22, 2020 14:25
Healthcare provider perspectives on pediatric cancer survivorship care plans: a single institution pilot study. Support Care Cancer. 2020 May 21;: Authors: Mann K, Wu YP, Pannier ST, Hacking C, Warner EL, Rosen S, Acharya A, Wright J, Gerdy C, Kirchhoff AC Abstract PURPOSE: Survivorship care plans (SCPs) are used to facilitate communication between oncology and primary care providers (PCPs) after cancer treatment and to assist cancer survivors with healthcare...
Fri May 22, 2020 14:25
Effects of Label Noise on Deep Learning-Based Skin Cancer Classification. Front Med (Lausanne). 2020;7:177 Authors: Hekler A, Kather JN, Krieghoff-Henning E, Utikal JS, Meier F, Gellrich FF, Upmeier Zu Belzen J, French L, Schlager JG, Ghoreschi K, Wilhelm T, Kutzner H, Berking C, Heppt MV, Haferkamp S, Sondermann W, Schadendorf D, Schilling B, Izar B, Maron R, Schmitt M, Fröhling S, Lipka DB, Brinker TJ Abstract Recent studies have shown that deep learning...
Fri May 22, 2020 14:25
CAR T Cells for Acute Myeloid Leukemia: State of the Art and Future Directions. Front Oncol. 2020;10:697 Authors: Mardiana S, Gill S Abstract Relapse after conventional chemotherapy remains a major problem in patients with myeloid malignancies such as acute myeloid leukemia (AML), and the major cause of death after diagnosis of AML is from relapsed disease. The only potentially curative treatment option currently available is allogeneic hematopoietic...
Fri May 22, 2020 14:25
Follow-Up of Head and Neck Cancer Survivors: Tipping the Balance of Intensity. Front Oncol. 2020;10:688 Authors: Szturz P, Van Laer C, Simon C, Van Gestel D, Bourhis J, Vermorken JB Abstract The traditional concept of post-treatment surveillance in head and neck cancer patients relies on examinations directed at early detection of disease recurrence and/or second primary tumors. They are usually provided by ear, nose and throat specialists with complementary...
Fri May 22, 2020 14:25
MiR-200b Inhibits Tumor Growth and Chemoresistance via Targeting p70S6K1 in Lung Cancer. Front Oncol. 2020;10:643 Authors: Jin HF, Wang JF, Song TT, Zhang J, Wang L Abstract Downregulation of microRNA-200b (miR-200b) has been identified in a range of cancers, yet the specific mechanisms whereby it influences lung cancer growth require further exploration. We determined that lung cancer patient tumor samples exhibit decreased miR-200b expression, and...
Fri May 22, 2020 14:25
Impact of the ENSP eLearning platform on improving knowledge, attitudes and self-efficacy for treating tobacco dependence: An assessment across 15 European countries. Tob Induc Dis. 2020;18:40 Authors: Girvalaki C, Papadakis S, Mechili EA, Nikitara K, Demin A, Trofor AC, Lila A, Harutyunyan A, Saliaj A, Dimitrievska D, Lozano FR, Bakhturidze G, Ayesta J, Przewoźniak K, Cattaruzza MS, Zdraveska M, Lovše M, Kilibarda B, Stoyka O, Behrakis P, Bizel P, Starchenko P, Spahija...
Fri May 22, 2020 14:25
Surgical resection of early stage hepatocellular carcinoma: balancing tumor biology with the host liver. Chin Clin Oncol. 2020 May 14;: Authors: Ju MR, Yopp AC Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. In early stage HCC, current practice guidelines recommend surgical resection with 5-year overall survival (OS) rates approaching 60%. Due to heterogeneity of the patient population and underutilization...
Fri May 22, 2020 14:25
Systemic therapy for advanced hepatocellular carcinoma: targeted therapies. Chin Clin Oncol. 2020 May 14;: Authors: Tella SH, Kommalapati A, Mahipal A Abstract Therapeutic options for advanced, unresectable hepatocellular carcinoma (HCC) have changed dramatically over the last 3 years. While surgical resection, orthotropic liver transplantation, and localized therapeutic options such as ablation, radiation therapy, and embolization remain therapeutics...
Fri May 22, 2020 14:25
Related ArticlesCirculating cell-free nucleic acids as biomarkers in colorectal cancer screening and diagnosis - an update. Expert Rev Mol Diagn. 2019 06;19(6):477-498 Authors: Molnár B, Galamb O, Kalmár A, Barták BK, Nagy ZB, Tóth K, Tulassay Z, Igaz P, Dank M Abstract Introduction: Screening methods for one of the most frequently diagnosed malignancy, colorectal cancer (CRC), have limitations. Circulating cell-free nucleic acids (cfNA) hold clinical...
Fri May 22, 2020 14:25
Real world data in the era of Immune Checkpoint Inhibitors (ICIs): Increasing evidence and future applications in lung cancer. Cancer Treat Rev. 2020 May 16;87:102031 Authors: Pasello G, Pavan A, Attili I, Bortolami A, Bonanno L, Menis J, Conte P, Guarneri V Abstract Immune checkpoint inhibitors (ICIs) targeting programmed death 1 (PD-1) and PD-ligand 1 (PD-L1) quickly subverted the standard of treatment in Non-Small Cell Lung Cancer (NSCLC), where...
Sun May 24, 2020 13:08
Current concepts and future directions for hemato-oncologic diagnostics. Crit Rev Oncol Hematol. 2020 May 12;151:102977 Authors: Flach J, Shumilov E, Joncourt R, Porret N, Novak U, Pabst T, Bacher U Abstract At present, hemato-oncologic diagnostics is facing dynamic changes. This applies to the exploration and introduction of novel technologies such as next-generation sequencing or digital droplet PCR for myeloid and lymphatic malignancies in laboratory...
Sun May 24, 2020 13:08
Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act. Crit Rev Oncol Hematol. 2020 May 07;151:102963 Authors: Lubberts S, Meijer C, Demaria M, Gietema JA Abstract Treatment of testicular cancer (TC) has an exceptionally high success rate compared to other cancer types; even in case of metastasized disease, 80-90 % of TC patients can be cured. Consequently, attention has been drawn to a potential downside...
Sun May 24, 2020 13:08
Treatment Variation in Older Adults With Differentiated Thyroid Cancer. J Surg Res. 2020 May 20;254:154-164 Authors: Sutton W, Canner JK, Segev DL, Zeiger MA, Mathur A Abstract BACKGROUND: The growth of the aging population coupled with the increasing incidence of thyroid cancer warrants a better understanding of thyroid cancer in older adults. We aimed to investigate the variation of treatment patterns and determine if the extent of surgery is associated...
Sun May 24, 2020 13:08
Impact of Sun Exposure and Tanning Patterns on Next-Generation Sequencing Mutations in Melanoma. J Surg Res. 2020 May 20;254:147-153 Authors: Loo K, Soliman I, Renzetti M, Li T, Wu H, Reddy S, Olszanski AJ, Farma JM Abstract BACKGROUND: For the past 30 y, the incidence rate of malignant melanoma has risen steadily. Ultraviolet radiation exposure has been identified as the most prevalent modifiable risk factor for melanoma. Here, next-generation sequencing...
Sun May 24, 2020 13:08
Uro-oncology in times of COVID-19: The available evidence and recommendations in the Indian scenario. Indian J Cancer. 2020 Apr-Jun;57(2):129-138 Authors: Narain TA, Gautam G, Seth A, Panwar VK, Rawal S, Dhar P, Talwar HS, Singh A, Jaipuria J, Mittal A Abstract The Corona Virus Disease-2019 (COVID-19), one of the most devastating pandemics ever, has left thousands of cancer patients to their fate. The future course of this pandemic is still an enigma,...
Sun May 24, 2020 13:08
Clinical Practice and Research in Cardio-Oncology: Finding the "Rosetta Stone" for Establishing Program Excellence in Cardio-oncology. J Cardiovasc Transl Res. 2020 May 22;: Authors: Adusumalli S, Alvarez-Cardona J, Khatana SM, Mitchell JD, Blaes AH, Casselli SJ, O'Quinn R, Lenihan DJ Abstract The burgeoning field of cardio-oncology (C-O) is now necessary for the delivery of excellent care for patients with cancer. Many factors have contributed to...
Sun May 24, 2020 13:08
Accelerated partial breast irradiation by brachytherapy: present evidence and future developments. Jpn J Clin Oncol. 2020 May 23;: Authors: Galalae R, Hannoun-Lévi JM Abstract Accelerated partial breast irradiation (APBI) delivers a short course of adjuvant RT after breast conserving surgery to only a limited part of the breast where the tumor was located. This procedure requires expertise, good communication, and close collaboration between specialized...
Sun May 24, 2020 13:08
Radiation-related caries: current diagnostic, prognostic, and management paradigms. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 May 19;: Authors: Palmier NR, Migliorati CA, Prado-Ribeiro AC, de Oliveira MCQ, Vechiato Filho AJ, de Goes MF, Brandão TB, Lopes MA, Santos-Silva AR Abstract OBJECTIVE AND STUDY DESIGN: This narrative review summarizes the current state of art of radiation-related caries (RC), an aggressive disease that affects approximately...
Sun May 24, 2020 13:08
Delving deeper into disparity: The impact of health literacy on the surgical care of breast cancer patients. Am J Surg. 2020 May 12;: Authors: Portelli Tremont JN, Downs-Canner S, Maduekwe U Abstract BACKGROUND: Breast surgical oncology is a unique field that involves complex cancer management and longstanding patient interactions with the healthcare system, making it potentially challenging for patients with low health literacy. The purpose of this...
Sun May 24, 2020 13:08
The use of complementary and alternative medicine (CAM) among cancer patients at a tertiary hospital in Malaysia. Complement Ther Med. 2020 May;50:102343 Authors: Hamed Abdalla MEA, Ali AM, Loong L Abstract PURPOSE: Complementary and alternative medicine (CAM) use among cancer patients is increasing over the years. Some types of CAM may interact with conventional cancer therapy or may cause serious adverse effects. This study was designed to determine...
Sun May 24, 2020 13:08
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