Publication date: Available online 18 May 2020Source: New BiotechnologyAuthor(s): Rodrigo Andler, Cristian Valdés, Alvaro Díaz-Barrera, Alexander Steinbüchel
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Special report: How the coronavirus pandemic started, where it’s headed, and how scientists are fighting back -- Read more on ScientificAmerican.com
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Publication date: Available online 19 May 2020Source: Free Radical Biology and MedicineAuthor(s): Luke Carroll, Kelly Gardiner, Marta Ignasiak, Jeppe Holmehave, Shingo Shimodaira, Thomas Breitenbach, Michio Iwaoka, Peter R. Ogilby, David I. Pattison, Michael J. Davies
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Publication date: Available online 18 May 2020Source: Free Radical Biology and MedicineAuthor(s): Ashok Agarwal, Saradha Baskaran, Manesh Kumar Panner Selvam, Renata Finelli, Catalina Barbarosie, Kathy Amy Robert, Concetta Iovine, Kruyanshi Master, Ralf Henkel
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Cancers, Vol. 12, Pages 1285: Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children Cancers doi: 10.3390/cancers12051285 Authors: Marion K. Mateos Morten Tulstrup Michael CJ Quinn Ruta Tuckuviene Glenn M. Marshall Ramneek Gupta Chelsea Mayoh Benjamin O. Wolthers Pasquale M. Barbaro Ellen Ruud Rosemary Sutton...
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Cancers, Vol. 12, Pages 1286: Spectrum of Germline BRCA1 and BRCA2 Variants Identified in 2351 Ovarian and Breast Cancer Patients Referring to a Reference Cancer Hospital of Rome Cancers doi: 10.3390/cancers12051286 Authors: Concetta Santonocito Roberta Rizza Ida Paris Laura De Marchis Carmela Paolillo Giordana Tiberi Giovanni Scambia Ettore Capoluongo Pathogenic variants (PVs) carriers in BRCA1 or BRCA2 are associated with an elevated lifetime risk of...
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Cancers, Vol. 12, Pages 1287: Older Cancer Patients during the COVID-19 Epidemic: Practice Proposal of the International Geriatric Radiotherapy Group Cancers doi: 10.3390/cancers12051287 Authors: Nam P. Nguyen Vincent Vinh-Hung Brigitta Baumert Alice Zamagni Meritxell Arenas Micaela Motta Pedro Carlos Lara Arthur Sun Myint Marta Bonet Tiberiu Popescu Te Vuong Gokula Kumar Appalanaido Lurdes Trigo Ulf Karlsson Juliette Thariat ...
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While we're stuck indoors, it's a great time to get into cooking and baking. Our Science of Cooking series explains how to make foods such as sourdough bread, hand-pulled noodles and kimchi, and the theory behind the recipes
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Oral mucosal pigmentation induced by vandetanib therapy: First clinicopathological characterization.
Related ArticlesOral mucosal pigmentation induced by vandetanib therapy: First clinicopathological characterization. Oral Oncol. 2020 May 14;:104747 Authors: Vigarios E, Maret D, Herbaut-Barres B, Zerdoud S, Sibaud V PMID: 32418862 [PubMed - as supplied by publisher]
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Abstract Purpose In patients undergoing chemoradiation for esophageal squamous cell carcinoma (ESCC), the extent of elective nodal irradiation (ENI) is still discussed controversially. This study aimed to analyze patterns of lymph node metastases and their correlation with the primary tumor using 18F‑fludeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans. ...
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Abstract Purpose For many decades, endometrial cancer (EC) has been considered as a homogenous tumor entity with good prognosis. The currently valid risk stratification considers clinical and pathological factors. Treatment recommendations differ considerably from country to country. Materials and methods The Cancer Genome Atlas (TCGA) Research Network has...
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Background: Dominant mutations in MYO7A may lead to nonsyndromic deafness DFNA11. A p.R206C variant in MYO7A has previously been reported in a small deaf family from Taiwan but with ambiguous pathogenicity and inheritance pattern. Aims/Objectives: Our study aims to clarify the pathogenicity of this variant by clinical characterization and genetic analysis of a separate autosomal dominant deaf family harboring this variant in mainland China. Materials and Methods: Auditory features of hearing loss...
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Cancers, Vol. 12, Pages 1284: Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response Cancers doi: 10.3390/cancers12051284 Authors: Natalia Trempolec Charline Degavre Bastien Doix Davide Brusa Cyril Corbet Olivier Feron For poorly immunogenic tumors such as mesothelioma there is an imperious need to understand why antigen-presenting cells such as dendritic cells...
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In order to estimate the tsunami hazard it is essential to reliably identify and differentiate tsunami deposits from other high-energy events like storms. Recently, the microtextural analysis of quartz grain surfaces was introduced as a method to differentiate between tsunami and other deposits. Using tsunami deposits sampled from a bank profile of the Tirua river (central Chile), an area that was significantly affected by the 2010 and 1960 Chile tsunamis, we tested the microtextural analysis method...
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To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation.; For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision-making and medical management. As known risk factors...
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We know a great deal about the genes used by the model pathogen Salmonella enterica serovar Typhimurium to cause disease, but less about global gene regulation. New tools for studying transcripts at the single nucleotide level now offer an unparalleled opportunity to understand the bacterial transcriptome, and expression of the small RNAs (sRNA) and coding genes responsible for the establishment of infection. Here, we define the transcriptomes of 18 mutants lacking virulence-related global regulatory...
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Phenotypic diversity is an important trait of bacterial populations and can enhance fitness of the existing genotype in a given environment. To characterize different subpopulations, several studies have analyzed differential gene expression using fluorescent reporters. These studies visualized either single or multiple genes within single cells using different fluorescent proteins. However, variable maturation and folding kinetics of different fluorophores complicate the study of dynamics of gene...
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The majority of patients with overweight and type 2 diabetes show insufficient levels of daily physical activity (PA) and usually are among the least likely to engage in or adhere to any form of generic PA. Active video games (exergames) may be a solution to motivate these individuals to overcome their sedentary lifestyle.; This systematic review was conducted to review the current evidence for the effectiveness of exergaming in overweight and type 2 diabetes mellitus and thus to evaluate the suitability...
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To evaluate the suitability of the Wii Fit Plus exergame as a tool to improve cardiorespiratory fitness in individuals with type 2 diabetes.; Experimental cross-sectional study.; Controlled laboratory.; Twelve type 2 diabetic patients (10 male and 2 female; age, 60.2 ± 7.7 years; body mass index, 30.9 ± 6.2 kg/m).; At baseline, all participants underwent an all-out cardiopulmonary exercise test on a treadmill to assess peak and average oxygen consumption (V[Combining Dot Above]O2peak and V[Combining...
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Reduction in hippocampal volume is a hallmark of schizophrenia and already present in the clinical high-risk state. Nevertheless, other subcortical structures, such as the thalamus, amygdala and pallidum can differentiate schizophrenia patients from controls. We studied the role of hippocampal and subcortical structures in clinical high-risk individuals from two cohorts. High-resolution T1-weighted structural MRI brain scans of a total of 91 clinical high-risk individuals and 64 healthy controls...
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There is evidence that exposure to social stress plays a crucial role in the onset and relapse of schizophrenia; however, the reaction of patients with schizophrenia spectrum disorder (SSD) to experimentally induced social stress is not yet fully understood.; Original research published between January 1993 and August 2015 was included in this systematic literature research. Social stress paradigms, reporting subjective responses to stress measures, plasma or saliva cortisol, or heart rate (HR) in...
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Objective: According to legal requirements coercive treatment must be limited to acts necessary for the protection of patients and cannot be used for institutional interests. Here, we aimed to test the hypothesis that opening psychiatric wards can reduce the number of aggressive assaults and of coercive treatment without increasing absconding rates. Methods: Numbers of absconding, coercive medication, fixation and special security actions were collected retrospectively and compared between phases...
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Inpatient suicide and absconding of inpatients at risk of self-endangering behaviour are important challenges for all medical disciplines, particularly psychiatry. Patients at risk are often admitted to locked wards in psychiatric hospitals to prevent absconding, suicide attempts, and death by suicide. However, there is insufficient evidence that treatment on locked wards can effectively prevent these outcomes. We did this study to compare hospitals without locked wards and hospitals with locked...
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Klotho, a protein mainly expressed in kidney and cerebral choroid plexus, is a powerful regulator of 1,25(OH)2D3 formation. Klotho-deficient mice (kl/kl) suffer from excessive plasma 1,25(OH)2D3-, Ca(2+)- and phosphate-concentrations, leading to severe soft tissue calcification and accelerated aging. NH4Cl treatment prevents tissue calcification and premature ageing without affecting 1,25(OH)2D3-formation. The present study explored the impact of excessive 1,25(OH)2D3 formation in NH4Cl-treated kl/kl-mice...
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The implication of neuroinflammation in schizophrenia, sustained by recent genetic evidence, represents one of the most exciting topics in schizophrenia research. Drugs which inhibit microglia activation, especially the classical tetracycline antibiotic minocycline are currently under investigation as alternative antipsychotics. However, recent studies demonstrated that microglia activation is not only a hallmark of neuroinflammation, but plays important roles during brain development. Inhibition...
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The predictive therapeutic value of brain derived neurotrophic factor (BDNF) and its changes associated with the use of specific antidepressants are still unclear. In this study, we examined BDNF as a peripheral and NAA as a central biomarker over the time course of antidepressant treatment to specify both of their roles in the response to the medication and clinical outcome.; We examined serum BDNF (ELISA kit) in a sample of 76 (47 female and 29 male) depressed patients in a naturalistic setting....
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Alzheimer's disease (AD) is an age-related neurodegenerative disease marked by a progressive cognitive decline. Metabolic impairments are common hallmarks of AD, and amyloid-β (Aβ) peptide and hyperphosphorylated tau protein--the two foremost histopathological signs of AD--have been implicated in mitochondrial dysfunction. Neurosteroids have recently shown promise in alleviating cognitive and neuronal sequelae of AD. The present study evaluates the impact of neurosteroids belonging to the sex hormone...
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Abstract Most of the ENT surgeries (tympanoplasty, rhinoplasty, ossiculoplasty, septoplasty) involve the reconstruction and the functional correction of the respective structures involved. Success of otorhinolaryngological surgeries depends on accurate measurements and precision in judgement. There is need to develop simple tools for measurements which are easy to procure, accurate and simple to handle. Every surgeon needs unique tools to accomplish such an outcome. In order to...
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Related ArticlesAn Innovative Assessment of the Dynamics of Facial Movements in Surgically Managed Unilateral Cleft Lip and Palate Using 4D Imaging. Cleft Palate Craniofac J. 2020 May 18;:1055665620924871 Authors: Gattani S, Ju X, Gillgrass T, Bell A, Ayoub A Abstract OBJECTIVE: Assess facial asymmetry during maximum smile in patients with surgically managed unilateral cleft lip and palate (UCLP), using a dynamic 3-dimensional (3D) imaging (4-dimensional)...
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Abstract Objectives The aim of this split-mouth, prospective controlled study was to compare the effects of two different interdental devices on clinical plaque elimination, gingival bleeding and patient acceptance and comfort. Materials and methods Thirty participants who had been diagnosed with gingivitis were included in the study. After professional oral...
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Publication date: Available online 19 May 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Camila Angulo, Asitha D.L. Jayawardena, Paul Caruso, Daniel Ramos, José A. Bonilla, Evelyn Zablah, Christopher J. Hartnick
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Publication date: Available online 19 May 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Alanna M. Windsor, Eleanor P. Kiell, Steven E. Sobol
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Zusammenfassung Hintergrund Der Stellenwert und die Sicherheit einer perkutanen Leberbiopsie (PLB) bei hirntoten Spendern vor Organentnahme sowie der Einfluss der PLB auf die Organallokation und die Kosten im Rahmen der Lebertransplantation (LT) in der Eurotransplant-Region (ET), werden weiterhin diskutiert. Material und Methoden Eine perkutane Leberbiopsie...
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