Related ArticlesGuidelines of clinical practice for the management of swallowing disorders and recent dysphonia in the context of the COVID-19 pandemic. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 May;137(3):173-175 Authors: Mattei A, Amy de la Bretèque B, Crestani S, Crevier-Buchman L, Galant C, Hans S, Julien-Laferrière A, Lagier A, Lobryeau C, Marmouset F, Robert D, Woisard V, Giovanni A, French Society of Otorhinolaryngology, Head, Neck Surgery (SFORL), French...
Sat May 23, 2020 13:12
Miller Fisher Variant of Guillain-Barré Syndrome in a Child. J Pediatr Neurosci. 2020 Jan-Mar;15(1):60-62 Authors: Mane SS, Nagesh U, Sathe VT, Janadhanan J Abstract Miller Fisher syndrome (MFS), a rare form of Guillain-Barré Syndrome, presents with the classical triad of ophthalmoplegia, areflexia, and ataxia. We describe the case of a 7-year-old boy who presented with diplopia, speech difficulty, dysphagia, gait disturbance, and difficulty in eyeball...
Fri May 22, 2020 16:48
MicroRNA-345 functions as a tumor suppressor via targeting ZEB2 in oral squamous cell carcinoma. Arch Oral Biol. 2020 Apr 24;116:104732 Authors: Wu J, Cao J, Li X, Wu B, Zhang S Abstract OBJECTIVE: The objective of this study was to explore the role of miRNAs in OSCC and to identify potential novel biomarkers or therapeutic agents in OSCC treatment. DESIGN: Microarray analysis and quantitative reverse transcription polymerase chain reaction...
Sun May 24, 2020 13:37
SNHG7 is a lncRNA oncogene controlled by Insulin-like Growth Factor signaling through a negative feedback loop to tightly regulate proliferation. Sci Rep. 2020 May 22;10(1):8583 Authors: Boone DN, Warburton A, Som S, Lee AV Abstract Evidence suggests Insulin-like growth factor 1 (IGF1) signaling is involved in the initiation and progression of a subset of breast cancers by inducing cell proliferation and survival. Although the signaling cascade following...
Sun May 24, 2020 13:37
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells. Oncogene. 2020 May 23;: Authors: Lloyd RL, Wijnhoven PWG, Ramos-Montoya A, Wilson Z, Illuzzi G, Falenta K, Jones GN, James N, Chabbert CD, Stott J, Dean E, Lau A, Young LA Abstract The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits...
Sun May 24, 2020 13:37
Loss of Spry1 reduces growth of BRAFV600-mutant cutaneous melanoma and improves response to targeted therapy. Cell Death Dis. 2020 May 22;11(5):392 Authors: Montico B, Colizzi F, Giurato G, Rizzo A, Salvati A, Baboci L, Benedetti D, Pivetta E, Covre A, Bo MD, Weisz A, Steffan A, Maio M, Sigalotti L, Fratta E Abstract Mitogen-activated protein kinase (MAPK) pathway activation is a central step in BRAFV600-mutant cutaneous melanoma (CM) pathogenesis....
Sun May 24, 2020 13:37
Related ArticlesPreclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer. Cancers (Basel). 2020 May 18;12(5): Authors: Rai R, Gong Essel K, Mangiaracina Benbrook D, Garland J, Daniel Zhao Y, Chandra V Abstract Sulforaphane exerts anti-cancer activity against multiple cancer types. Our objective was to evaluate utility of sulforaphane for endometrial cancer therapy. Sulforaphane...
Sun May 24, 2020 13:37
Related ArticlesNew Treatments in Renal Cancer: The AhR Ligands. Int J Mol Sci. 2020 May 18;21(10): Authors: Itkin B, Breen A, Turyanska L, Sandes EO, Bradshaw TD, Loaiza-Perez AI Abstract Kidney cancer rapidly acquires resistance to antiangiogenic agents, such as sunitinib, developing an aggressive migratory phenotype (facilitated by c-Metsignal transduction). The Aryl hydrocarbon receptor (AhR) has recently been postulated as a molecular target...
Sun May 24, 2020 13:37
Related ArticlesSynthesis, characterization and cytotoxic activity of binuclear copper(II)-complexes with some S-isoalkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-isopropyl derivative of thiosalicylic acid. J Inorg Biochem. 2020 Apr 30;208:111078 Authors: Dimitrijević J, Arsenijević AN, Milovanović MZ, Arsenijević NN, Milovanović JZ, Stanković AS, Bukonjić AM, Tomović DL, Ratković ZR, Potočňák I, Samoľová E, Radić...
Sat May 23, 2020 13:21
Related ArticlesROS: Trichothecenes' handy weapon? Food Chem Toxicol. 2020 May 19;:111438 Authors: Ren Z, He H, Zuo Z, Xu Z, Wei Z, Deng J Abstract Trichothecenes are a class of toxic secondary metabolites produced by filamentous fungi such as Fusarium, which pose a threat to human and animal health. Among them, T-2 toxin and deoxynivalenol (DON) have attracted the most attention because of their extensive pollution and strong toxicity. Accumulated...
Sat May 23, 2020 13:21
Related ArticlesIdentification of Hub Genes in Atypical Teratoid/Rhabdoid Tumor by Bioinformatics Analyses. J Mol Neurosci. 2020 May 21;: Authors: Pan X, Liu W, Chai Y, Hu L, Wang J, Zhang Y Abstract Atypical teratoid/rhabdoid tumor (ATRT) is a devastating intracranial tumor in children. Currently, its molecular mechanisms cannot be studied effectively because patient samples are limited, and many factors are involved in its pathogenesis. In this...
Sat May 23, 2020 13:21
Related ArticlesActive Monomer RTR-1 Derived from the Root of Rhodomyrtus t omentosa Induces Apoptosis in Gastric Carcinoma Cells by Inducing ER Stress and Inhibiting the STAT3 Signaling Pathway. Cancer Manag Res. 2020;12:3117-3129 Authors: Zhang X, Cheng J, He P, Zhu J, Chen Z, Miao S, Wang G, Jiang J, Wang Y Abstract Purpose: Rhodomyrtus tomentosa, a flowering plant from the Myrtaceae family, is considered an antitumour substance with versatile...
Sat May 23, 2020 13:21
Related ArticlesInhibition of Aurora Kinase A by Alisertib Reduces Cell Proliferation and Induces Apoptosis and Autophagy in HuH-6 Human Hepatoblastoma Cells. Onco Targets Ther. 2020;13:3953-3963 Authors: Tan J, Xu W, Lei L, Liu H, Wang H, Cao X, Xu M Abstract Purpose: Aurora kinase A (AURKA), which belongs to the serine/threonine protein kinase family, has been identified as a key driver of the genesis and progression of diverse tumors. The aim...
Sat May 23, 2020 13:21
Related ArticlesThe Anti-Breast Cancer Effect and Mechanism of Glimepiride-Metformin Adduct. Onco Targets Ther. 2020;13:3777-3788 Authors: Long L, Hu X, Li X, Zhou D, Shi Y, Wang L, Zeng H, Yu X, Zhou W Abstract Background: Compound adduct is a eutectic crystal formed by non-covalent bonds of two compounds or multiple compounds with water. Emerging evidence suggests that adduct could be different from the simple physical mixture of the individual...
Sat May 23, 2020 13:21
Related ArticlesHigh ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma. Drug Des Devel Ther. 2020;14:1717-1727 Authors: Xie GF, Zhao LD, Chen Q, Tang DX, Chen QY, Lu HF, Cai JR, Chen Z Abstract Purpose: Oral squamous cell carcinoma (OSCC) is a common malignancy of the oral cavity. As the survival rate of OSCC patients is low, it is crucial to explore new markers...
Sat May 23, 2020 13:21
Related ArticlesCharacterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins. Sci Rep. 2020 May 21;10(1):8390 Authors: Cibis H, Biyanee A, Dörner W, Mootz HD, Klempnauer KH Abstract B-MYB, a highly conserved member of the MYB transcription factor family, is expressed ubiquitously in proliferating cells and plays key roles in important cell cycle-related processes, such as control of G2/M-phase transcription, cytokinesis,...
Sat May 23, 2020 13:21
Related ArticlesLOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway. Mol Cell Probes. 2020 May 18;:101598 Authors: Lin J, Fang Y, Tao M, Ma L, Cao Y, Li Y, Ji C, Yang J, Yang X Abstract LncRNA LOC285194 has been associated with the occurrence of psoriasis. However, the underlying mechanisms that lead to psoriasis remain unclear. In this study, the expression of LOC285194, miR-616, and GATA3 was determined...
Sat May 23, 2020 13:21
Related ArticlesPar-4 mediated Smad4 induction in PDAC cells restores canonical TGF-β/ Smad4 axis driving the cells towards lethal EMT. Eur J Cell Biol. 2020 May 11;:151076 Authors: Mohd Faheem M, Rasool RU, Ahmad SM, Jamwal VL, Chakraborty S, Katoch A, Gandhi SG, Bhagat M, Goswami A Abstract Deregulation of TGF-β signaling is intricately engrossed in the pathophysiology of pancreatic adenocarcinomas (PDACs). The role of TGF-β all through pancreatic...
Sat May 23, 2020 13:21
Related ArticlesTargeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. Cells. 2020 May 19;9(5): Authors: Johnson J, Chow Z, Napier D, Lee E, Weiss HL, Evers BM, Rychahou P Abstract Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and is characterized by poor survival. Radiotherapy plays an important role in treating TNBC. The purpose of this study was...
Sat May 23, 2020 13:21
Related ArticlesCold-Atmospheric Plasma Induces Tumor Cell Death in Preclinical In Vivo and In Vitro Models of Human Cholangiocarcinoma. Cancers (Basel). 2020 May 19;12(5): Authors: Vaquero J, Judée F, Vallette M, Decauchy H, Arbelaiz A, Aoudjehane L, Scatton O, Gonzalez-Sanchez E, Merabtene F, Augustin J, Housset C, Dufour T, Fouassier L Abstract Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option...
Sat May 23, 2020 13:21
Related ArticlesExo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins. Nucleic Acids Res. 2020 04 06;48(6):3053-3070 Authors: Morafraile EC, Bugallo A, Carreira R, Fernández M, Martín-Castellanos C, Blanco MG, Segurado M Abstract The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is...
Sat May 23, 2020 13:21
Related ArticlesPLK1 and EGFR targeted nanoparticle as a radiation sensitizer for non-small cell lung cancer. Cancer Lett. 2019 12 28;467:9-18 Authors: Reda M, Ngamcherdtrakul W, Gu S, Bejan DS, Siriwon N, Gray JW, Yantasee W Abstract Radiation sensitizers that can selectively act on cancer cells hold great promise to patients who receive radiation therapy. We developed a novel targeted therapy and radiation sensitizer for non-small cell lung cancer...
Sat May 23, 2020 13:21
Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma. Blood. 2020 May 21;: Authors: Gaydosik AM, Queen DS, Trager MH, Akilov OE, Geskin L, Fuschiotti P Abstract The signal transducer and activator of transcription 6 (STAT-6) is a critical up-stream mediator of IL-13 and IL-4 signaling and is constitutively activated in malignant lymphocytes from Sezary syndrome (SS) and mycosis fungoides (MF),...
Fri May 22, 2020 13:20
Nickel and zinc complexes of testosterone N4-substituted thiosemicarbazone: Selective cytotoxicity towards human colorectal carcinoma cell line HCT 116 and their cell death mechanisms. J Inorg Biochem. 2020 May 04;208:111097 Authors: Heng MP, Sim KS, Tan KW Abstract Two new Schiff base ligands (TE and TF) were prepared from conjugation of testosterone with 4-(4-ethylphenyl)-3-thiosemicarbazide and 4-(4-fluorophenyl)-3-thiosemicarbazide, respectively....
Fri May 22, 2020 13:20
Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest. Eur J Med Chem. 2020 May 06;200:112386 Authors: Shi Z, Li N, Chen C, Wang Y, Lei Z, Chen L, Sun J Abstract A series of phenylsulfonyfuroxan-based NO-releasing scopoletin derivatives were designed and synthesized in the study. All target compounds showed significantly improved antiproliferative activity against four cancer cell lines...
Fri May 22, 2020 13:20
Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents. Eur J Med Chem. 2020 May 11;199:112349 Authors: Zhang XH, Bo-Wang, Tao YY, Ma Q, Wang HJ, He ZX, Wu HP, Li YH, Zhao B, Ma LY, Liu HM Abstract In this paper, a series of thiosemicarbazone derivatives containing different aromatic heterocyclic groups were synthesized and the tridentate donor system of the lead compound was optimized. Most...
Fri May 22, 2020 13:20
Inhibiting effect of MicroRNA-3619-5p/PSMD10 axis on liver cancer cell growth in vivo and in vitro. Life Sci. 2020 May 08;:117632 Authors: Hao P, Yue F, Xian X, Ren Q, Cui H, Wang Y Abstract AIMS: Liver cancer is one of the leading causes of cancer death worldwide owing to its delayed diagnosis and absence of efficient treatment at advanced TNM stages. Increasing evidence demonstrated that microRNAs are implicated in tumorgenesis and cancer development...
Fri May 22, 2020 13:20
Antiangiogenic and antitumoral activity of LQFM126 prototype against B16F10 melanoma cells. Chem Biol Interact. 2020 May 11;325:109127 Authors: Garcia da Silva AC, Rodrigues BDS, Andrade WM, Marques Dos Santos TR, de Carvalho FS, Sanz G, Vaz BG, Lião LM, Menegatti R, Valadares MC Abstract Inhibition of mouse double minute 2 homolog (MDM2)-p53 interaction and reactivation of p53 signaling have been explored as effective anticancer therapeutic strategy....
Fri May 22, 2020 13:20
Anti-carcinogenic effects of Halofuginone on lung derived cancer cells. Cell Biol Int. 2020 May 21;: Authors: Demiroglu-Zergeroglu A, Turhal G, Topal H, Ceylan H, Donbaloglu F, Cerit KK, Odongo RR Abstract Malignant Mesothelioma is a rare but aggressive form of malignancy that is difficult to diagnose and is resistant to current chemotherapeutic treatment options. Molecular techniques have been used to investigate the mechanisms of action and the...
Fri May 22, 2020 13:20
Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth.
Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth. Chem Commun (Camb). 2020 May 21;: Authors: Zhan J, Zhong J, Ma S, Ma W, Wang Y, Yu Z, Cai Y, Huang W Abstract Herein we first report a dual-responsive peptide substrate (Comp. 1) for preparing self-assembled nanomaterials triggered by pH and legumain. The dual-responsive self-assembly of Comp. 1 in glioma cells enables its long retention time in lysosomes,...
Fri May 22, 2020 13:20
Interfering with retrotransposition by two types of CRISPR effectors: Cas12a and Cas13a. Cell Discov. 2020;6:30 Authors: Zhang N, Jing X, Liu Y, Chen M, Zhu X, Jiang J, Wang H, Li X, Hao P Abstract CRISPRs are a promising tool being explored in combating exogenous retroviral pathogens and in disabling endogenous retroviruses for organ transplantation. The Cas12a and Cas13a systems offer novel mechanisms of CRISPR actions that have not been evaluated...
Fri May 22, 2020 13:20
Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells. Biosci Biotechnol Biochem. 2020 May 20;:1-11 Authors: Zhang L, Wang Z, Kong D, Zhao X, Chen X, Chai W Abstract Pancreatic cancer (PC), highly malignant, is one of the most lethal cancers. Interferon-induced transmembrane protein 1 (IFITM1) has recently been regarded...
Fri May 22, 2020 13:20
Related ArticlesMutation in histone deacetylase clr6 promotes the survival of S. pombe cds1 null mutant in response to hydroxyurea. Mol Genet Genomics. 2020 May;295(3):695-703 Authors: Khan S, Ahamad N, Panigrahi L, Walworth N, Ahmed S Abstract Fission yeast Cds1 is responsible for the replication checkpoint activation and helps to protect replication fork collapse in response to hydroxyurea (HU). Here, we investigated the role of histone deacetylase...
Fri May 22, 2020 13:20
Unusual cause of seizure in a child: Intracranial calcified metastasis of osteosarcoma. Indian J Cancer. 2020 Apr-Jun;57(2):209-211 Authors: Ananthashayana VH, Jana M, Malapure SS, Gupta AK Abstract Intracranial parenchymal calcification has both benign and malignant etiologies. Calcifications by malignant etiologies are comparatively rare. Malignant calcification has numerous causes. Calcified brain metastasis from osteosarcoma is one such cause. We...
Sun May 24, 2020 13:35
Rare cancers in India: A road less travelled. Indian J Cancer. 2020 Apr-Jun;57(2):139-143 Authors: Darling HS, Rastogi S Abstract Globally, rare cancers as a group are commoner than any single common cancer. They represent an unmet medical need, and this issue gets further amplified in India due to various reasons, including the limited accessibility of healthcare system to the population at large. The scarce available data yet only represents the tip...
Sun May 24, 2020 13:35
Is the outcome after hepatectomy for transitional hepatocholangiocarcinoma different from that of hepatocellular carcinoma and mass-forming cholangiocarcinoma? A case-matched analysis. Updates Surg. 2020 May 22;: Authors: Gentile D, Donadon M, Di Tommaso L, Samà L, Franchi E, Costa G, Lleo A, Torzilli G Abstract Hepatocholangiocarcinoma (HCC-CC) is a rare malignancy containing features of both hepatocellular carcinoma (HCC) and mass-forming cholangiocarcinoma...
Sun May 24, 2020 13:35
Fine needle aspiration of thymic epithelial neoplasms and non-neoplastic lesions. Semin Diagn Pathol. 2020 May 15;: Authors: Illei PB, Shyu S Abstract Thymic epithelial neoplasms are rare as these tumors represent less than 1% of all human tumors. In addition, thymic hyperplasia and thymic cysts can also present as anterior or less often superior mediastinal masses. Fine needle aspirates and core biopsies of thymic epithelial neoplasms are rarely encountered...
Sun May 24, 2020 13:35
Related ArticlesThe Reconstruction after a Giant Phyllodes Tumor Resection Using a DIEP Flap. Plast Reconstr Surg Glob Open. 2020 Apr;8(4):e2760 Authors: Tsuruta Y, Karakawa R, Majima K, Yamamoto S, Shibata T, Yoshimatsu H, Miyashita H, Tanakura K, Yano T Abstract A phyllodes tumor of the breast is a rare neoplasm, accounting for 0.3%-1% of all breast cancers. The size is 4-5 cm on average but sometimes the tumor grows more and involves the entire breast....
Sat May 23, 2020 13:11
Related ArticlesDual roles of the sterol recognition region in Hedgehog protein modification. Commun Biol. 2020 May 21;3(1):250 Authors: Purohit R, Peng DS, Vielmas E, Ondrus AE Abstract Nature provides a number of mechanisms to encode dynamic information in biomolecules. In metazoans, there exist rare chemical modifications that occur in entirely unique regimes. One such example occurs in the Hedgehog (Hh) morphogens, proteins singular across all domains...
Sat May 23, 2020 13:11
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