British Journal of Cancer, Published online: 20 May 2020; doi:10.1038/s41416-020-0867-xNeoadjuvant modified FOLFIRINOX followed by postoperative gemcitabine in borderline resectable pancreatic adenocarcinoma: a Phase 2 study for clinical and biomarker analysis
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British Journal of Cancer, Published online: 20 May 2020; doi:10.1038/s41416-020-0888-5Association of tumour and stroma PD-1, PD-L1, CD3, CD4 and CD8 expression with DCB and OS to nivolumab treatment in NSCLC patients pre-treated with chemotherapy
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Bacterial infections are frequent triggers for diabetic ketoacidosis. In this context, delayed antibiotic treatment is associated with increased morbidity and mortality. Unnecessary administration of antimicro...
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This NICE guideline summary (BMJ 2012;344:1163, doi:10.1136/bmj.e3979) has now been superseded by a summary of updated guidance at www.bmj.com/content/369/bmj.m1565.
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In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per day. Less than 100 days later, the W...
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The objective of this study is to evaluate the efficiency of methylene blue removal using Oued Sebou sediments as an adsorbent. The presence of carboxyl functional group demonstrated by infrared (IR) analysis of the sediment favorized the methylene blue (MB) adsorption. Sediment collected from Oued Sebou could remove the most MB molecules at pH 8. The Freundlich model described suitably the adsorption process. The experimental measured enthalpy (ΔH) and entropy (ΔS°) are 118.1 kJ mol−1 and 395.2 J mol−1 K−1,...
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By using fixed-point index theory, we consider the existence of multiple positive solutions for a system of nonlinear Caputo-type fractional differential equations with the Riemann-Stieltjes boundary conditions.
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As an important component of universal sign language and the basis of other sign language learning, finger sign language is of great significance. This paper proposed a novel fingerspelling identification method for Chinese Sign Language via AlexNet-based transfer learning and Adam optimizer, which tested four different configurations of transfer learning. Besides, in the experiment, Adam algorithm was compared with stochastic gradient descent with momentum (SGDM) and root mean square propagation...
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We provide a technical assessment and critique of the existing literature via highlighting problems associated with conceptualization and technical improvement of agility practices. By presenting a narrative evaluation of the technical review, we underscore the nature of the SC hazard in addition to agility practices and furnish a synthesis for future studies. The purpose is to examine the relationship between identifying and ranking the elements affecting supply management for SC agility in compressed...
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Aim. There is an increasing interest in the application of BioACTIVE materials to achieve hard tissue formation and maintain pulp vitality. Mineral trioxide aggregate (MTA) and Biodentine® are BioACTIVE materials used for pulp capping. Recently, dental researchers have produced BioACTIVE glass-incorporated light-curable pulp capping material. The study is aimed at evaluating the subcutaneous connective tissue reactions to MTA, Biodentine®, ACTIVA BioACTIVE Base/Liner. These materials were placed...
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Background/Aim. Improving walking ability, especially the step-to-step transition control, is important in individuals after stroke. Although walking is a continuous skill, the discrete skills of gait, defined as movements with a clear beginning and end, may effectively modify walking performance. This pilot study shows the immediate effects of a discrete skill-based step training on ground reaction forces (GRFs) during gait in individuals with chronic hemiplegia following stroke. Methods. Twenty-two...
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Background. Neuromyelitis optica (NMO) and multiple sclerosis (MS) are often presenting with overlapping symptoms. The aim of this study was to determine whether and how NMO and MS differ regarding cerebral iron deposits in deep gray matter (DGM) and the correlation between iron deposition and clinical severity as well as to regional atrophy of the DGM. Methods. We analyzed 20 patients with NMO, 40 patients with a relapsing-remitting (RR) form of MS, and 20 healthy controls with 1.5T MRI. Quantitative...
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Background and Aims. Balloon-assisted enteroscopy (BAE) can be used to retrieve small intestinal foreign bodies (FBs). Here, we aimed at exploring the clinical usefulness of BAE for the retrieval of small intestinal FBs. Methods. We retrospectively reviewed the medical records of 34 patients who underwent BAE to retrieve small intestinal FBs at 3 tertiary referral centers between April 2005 and June 2017. Results. The retained materials included capsule endoscopes (CEs; [52.9%]), self-expandable...
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A few types of myeloproliferative neoplasms may be significant for Janus-associated kinase 2 mutation, JAK2 V617F, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. The prevalence of JAK2 mutation is low in the general population but higher in patients with myeloproliferative neoplasms. Some patients with JAK2 V617F-positive essential thrombocythemia are asymptomatic, but others may develop hemorrhagic or thromboembolic complications. Thromboembolism may occur in...
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Objective. To determine the prevalence of skin changes during pregnancy and to relate their occurrence to specific factors in a population of south Brazil. Methods. A cross-sectional analytical study was carried out with 1284 puerperal patients. A questionnaire about skin changes during pregnancy was developed and applied by the authors to all puerperal women admitted in a tertiary hospital in south Brazil. Results. The appearance of striae during pregnancy was reported by 633 women (49.5%) and had...
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Abstract Background The Doppler-derived renal resistive index (RRI) is emerging as a promising bedside tool for assessing renal perfusion and risk of developing acute kidney injury in critically ill patients. It is not known what level of ultrasonography competence is needed to obtain reliable RRI values. Objective The aim of this study was to...
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Abstract Purpose Results from studies on the relationship between restless legs syndrome (RLS) and coronary artery disease (CAD) are conflicting. Some studies associate RLS with CAD by heart rate variability, blood pressure variability, and other autonomic, neuronal reasons, while other studies do not support these observations. The aim of this study was to investigate the prevalence of RLS in patients undergoing coronary angiography for...
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Planta MedDOI: 10.1055/a-1167-4284 Artemisia gmelinii (Artemisia iwayomogi) has been used in traditional medicine to cure various infectious diseases such as cholecystitis, hepatitis, and jaundice. In this study, the Artemisiae Iwayomogii Herba ethanol extract was investigated for the ability to inhibit growth of hepatocellular carcinoma and its underlying mechanism involved. The antiproliferative effect of Artemisiae Iwayomogii Herba ethanol extract was evaluated using cell viability...
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Planta MedDOI: 10.1055/a-1170-7785The pomegranate phenolics are reported to have cutaneous benefits and to be effective in treating skin disorders, including hyperpigmentation. In this context, a preparation method was developed by which to obtain phenolic-rich pomegranate peel extract. Sinapic acid was presented as the major pomegranate peel phenolics, followed by gallic and ellagic acids, and 4 additional phenolics. The extract exhibited strong antioxidant activity with an in vitro tyrosinase inhibitory...
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Abstract Bacteria are important soil components that function as both decomposers and plant symbionts and play a major role in plant–microbe interactions. However, little is known about the diversity of bacterial communities in the rhizosphere of the native invasive plant Echinochloa caudata. In this study, we used high-throughput sequencing to investigate bacterial communities in the rhizospheres of Echinochloa caudata collected from areas with differing degrees of invasion. We...
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Abstract Background Otosclerosis causes conductive, sensorineural and mixed hearing loss (CHL, SNHL, MHL) and tinnitus in young adults. It is best diagnosed on high-resolution CT (HRCT). Occasionally, patients presenting with SNHL and/or tinnitus may undergo temporal bone MRI as the first investigation. In this study, we have described the role of MRI as the first-line modality in the detection of previously undiagnosed otosclerosis....
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Latest Impact Factor: 7.786 The Official Journal of: American Thyroid Association® Read these new open access articles now: Thyroid Hormone Analogues: An Update Riccardo Zucchi Neurodevelopmental Outcomes at 42 Months After Thyroxine Supplementation in Infants Below 28 Weeks’ Gestation: A Randomized Controlled TrialSze May Ng, Mark A. Turner, and A. Michael Weindling A Prospective Mixed-Methods Study of Decision-Making on Surgery or Active Surveillance for Low-Risk Papillary Thyroid...
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Abstract Objectives This study aimed to evaluate the clinical effects of xenogeneic collagen matrix (XCM) in augmenting keratinized mucosa width (KMW) around dental implants. Materials and methods Articles that were published before or during April 2020 were electronically searched in four databases without any date or language restrictions and manually searched...
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Abstract Anatomical variations such as a non-recurrent laryngeal nerve (NRLN) are very rare (reported rates within 0.6–1% to the right side and only four cases to the left side) but they can lead to serious risk of nerve lesion during thyroidectomy. It is known that to prevent inferior laryngeal nerve lesions, it is mandatory to obtain a correct and wide exposure of the nerve during all kind of thyroid surgeries but in case of laryngeal nerve position anomalies, it is hard to...
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This NICE guideline summary (BMJ 2012;344:1163, doi:10.1136/bmj.e3979) has now been superseded by a summary of updated guidance at www.bmj.com/content/369/bmj.m1565.
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Abstract Sertraline pharmacokinetics is poorly understood and highly variable due to large between-subject variability with inconsistent reports for oral bioavailability. The study objective was to characterize sertraline pharmacokinetics by developing and validating a sertraline population pharmacokinetic (PK) model in healthy subjects using published clinical PK data. We carried a systematic literature search in PubMed in October 2015 and identified 27 pharmacokinetic studies...
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Abstract The pharmaceutical industry and regulatory agencies rely on dissolution similarity testing to make critical product performance decisions as part of drug product life cycle management. Accordingly, the application of mathematical approaches to evaluate dissolution profile similarity is described in regulatory guidance. However, the requirements (e.g., which time points, number of time points, %CV) to apply the widely known similarity factor f2 and other alternative...
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Abstract The present study demonstrates the solubility and dissolution of flufenamic acid (FLF)/β-cyclodextrin (β-CD)/Soluplus® supramolecular ternary inclusion complex. The binary and ternary inclusion complexes were prepared using solvent evaporation and the microwave irradiation method. The prepared inclusion complexes were evaluated for physicochemical characterization and anti-inflammatory activity using a murine paw edema mol. The phase solubility studies demonstrated...
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Acute laryngitis is a common disease with self-limiting nature. Since the leading cause is attributed to viral infections and thus self-limiting, many affected individuals do not seek professional medical help. However, because the major symptom of hoarseness imposes a substantial burden in everyday life, it might be speculated that web-based search interest on this condition follows incidence rates, with highest peaks during winter months. The aim of this study was to evaluate global public health-information...
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Laryngology is an expanding field with incorporation in resident training nationwide. However, the breadth of training in laryngology reported by residents has not been previously evaluated. This project assesses the variability in laryngology training among otolaryngology residents.
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TWIK-related potassium channel-1 (TREK-1) and Aquaporin 5 (AQP5) are involved in epithelial integrity and fluid transport, respectively. In this study, we aimed to compare physiological and gestational patterns of TREK-1 and AQP5 location and expression in rat larynx. Our secondary objective was to reveal the effect of estradiol (E2) and progesterone (PG) on these two biomolecules.
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