The The impact of a hospital antimicrobial stewardship was determined on antimicrobial-resistant, Clostridioides difficile rates and the amount of antimicrobial consumed in cancer patients.The intervention effect...
Tue May 19, 2020 03:00
An amendment to this paper has been published and can be accessed via the original article.
Mon May 18, 2020 03:00
We hypothesized that a selective neural electrical stimulation of radial and median nerves enables the activation of functional movements in the paralyzed hand of individuals with tetraplegia. Compared to prev...
Tue May 19, 2020 03:00
Apart from biomechanical alterations in movement patterns, it is known that movement limitations in persons with knee osteoarthritis (PwKOA) are related to an individual’s perception and belief regarding pain ...
Tue May 19, 2020 03:00
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 (COVID-19). SARS-CoV-2 causes viral pneumonia with additional extrapulmonary manifestations and major complications, including acute myocardial injury, arrhythmia, and shock mainly in elderly patients. Furthermore, patients with existing cardiovascular comorbidities, such as hypertension and...
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Related ArticlesRole of microRNA in inner ear stem cells and related research progress. Am J Stem Cells. 2020;9(2):16-24 Authors: Wu X, Zou S, Wu F, He Z, Kong W Abstract Deafness is one of the major global health problems that seriously affects the quality of human life. At present, there are no successful treatments for deafness caused by cochlear hair cell (HC) damage. The irreversibility of mammalian hearing impairment is that the inner ear's sensory...
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J Neurol Surg Rep 2020; 81: e33-e37DOI: 10.1055/s-0040-1710309Lumbar artery pseudoaneurysm is a rare adverse event that is presented in reports. It is associated with serious injuries such as in the retroperitoneal cavity and pelvis. Furthermore, infection and iatrogenic etiology were documented as well. This case report presents a patient with a chest stab wound and a fall from a 2-m height, which resulted in multiple spinal fractures that were treated surgically. However, he presented back with...
Tue May 19, 2020 02:00
Abstract Background Drug addiction is a chronically relapsing disorder in humans yet the underlying mechanism remained unclear. Recent studies suggested that histidine triad nucleotide binding protein1 (HINT1) may play significant roles in diverse neuropsychiatric diseases including drug addiction. Methods In the current study, we used different batches of...
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Abstract Topiramate, an antiepileptic drug, has been found to be useful for the treatment of aggression in clinical populations. Most preclinical studies related to Topiramate have been focused exclusively on the quantitative aspects of the aggressive behavior between mice. However, there is still limited knowledge regarding the effects of Topiramate on neuronal mechanisms occurring in aggressive mice. The present work aims to understand further the effects of the antiepileptic...
Tue May 19, 2020 03:00
Epidemiological studies suggested that determinants for antibiotic resistance have originated in aquaculture. Recently, the integrated agriculture-aquaculture system has been implemented, where fish are raised...
Tue May 19, 2020 03:00
Surgical site infections are a leading cause of morbidity and mortality after caesarean section, especially in Low and Middle Income Countries. We hypothesized that a combined infection prevention and control ...
Tue May 19, 2020 03:00
Treatment of pandrug-resistant isolates often necessitates combination therapy. Checkerboard synergy and time-killing assay tests were performed to evaluate the benefits of a triple combination with meropenem,...
Tue May 19, 2020 03:00
Tue May 19, 2020 03:00
Multidrug-resistant organisms (MDROs) have emerged as an important cause of poor prognoses of patients in the intensive care unit (ICU). This study aimed to establish an easy-to-use nomogram for predicting the...
Tue May 19, 2020 03:00
Journal of Neurotrauma, Ahead of Print.
Mon May 18, 2020 10:00
Patients ≥65 years old with hereditary angioedema (HAE) due to C1-inhibitor (C1-INH) deficiency may have an altered response to treatment and be at higher risk for treatment-related adverse events (AEs) due to comorbidities and polypharmacy.
Tue May 19, 2020 03:00
Surgical Infections, Ahead of Print.
Tue May 19, 2020 10:00
Surgical Infections, Ahead of Print.
Mon May 18, 2020 10:00
Surgical Infections, Ahead of Print.
Mon May 18, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Tue May 19, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon May 18, 2020 10:00
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Mon May 18, 2020 10:00
The 7SK small nuclear RNA (7SKsnRNA) plays a key role in the regulation of RNA polymerase II by sequestrating and inhibiting the positive transcription elongation factor b (P-TEFb) in the 7SK ribonucleoprotein complex (7SKsnRNP), a process mediated by interaction with the protein HEXIM. P-TEFb is also an essential cellular factor recruited by the viral protein Tat to ensure the replication of the viral RNA in the infection cycle of the human immunodeficiency virus (HIV-1). Tat promotes the release...
Tue May 19, 2020 17:44
Modern crop breeding is in constant demand for new genetic diversity as part of the arms race with genetic gain. The elite gene pool has limited genetic variation and breeders are trying to introduce novelty from unadapted germplasm, landraces and wild relatives. For polygenic traits, currently available approaches to introgression are not ideal, as there is a demonstrable bias against exotic alleles during selection. Here, we propose a partitioned form of genomic selection, called Origin Specific...
Tue May 19, 2020 23:34
Linkage mapping has been widely used to identify quantitative trait loci (QTL) in many plants and usually requires a time-consuming and labor-intensive fine mapping process to find the causal gene underlying the QTL. Previously, we described QTG-Finder, a machine-learning algorithm to rationally prioritize candidate causal genes in QTLs. While it showed good performance, QTG-Finder could only be used in Arabidopsis and rice because of the limited number of known causal genes in other species. Here...
Tue May 19, 2020 23:34
Abstract Objectives This study aimed to evaluate the clinical effects of xenogeneic collagen matrix (XCM) in augmenting keratinized mucosa width (KMW) around dental implants. Materials and methods Articles that were published before or during April 2020 were electronically searched in four databases without any date or language restrictions and manually searched...
Tue May 19, 2020 03:00
Tue May 19, 2020 03:00
Abstract Objectives The aim of this split-mouth, prospective controlled study was to compare the effects of two different interdental devices on clinical plaque elimination, gingival bleeding and patient acceptance and comfort. Materials and methods Thirty participants who had been diagnosed with gingivitis were included in the study. After professional oral...
Tue May 19, 2020 03:00
Abstract Objectives The purpose of the present study was to analyze treatment outcome with a full-occlusion biofeedback (BFB) splint on sleep bruxism (SB) and TMD pain compared with treatment with an adjusted occlusal splint (AOS). Materials and methods Forty-one patients were randomly allocated to a test (BFB) or a control (AOS) group and monitored over...
Tue May 19, 2020 03:00
Purpose: Low dose computed tomography (CT) screening can reduce lung cancer mortality. However, CT screening has a false discovery rate of nearly 96%. We sought to assess if urine samples can be a source for DNA methylation-based detection of non-small cell lung cancer. Experimental Design: This nested case-control study of subjects with suspicious nodules on CT imaging obtained plasma and urine samples pre-operatively. Cases (n=74) had pathological confirmation of non-small cell lung cancer. Controls...
Tue May 19, 2020 16:30
CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas
Purpose: Cancer immunoediting shapes tumor progression by the selection of tumor cell variants that can evade immune recognition. Given the immune evasion and intra-tumor heterogeneity characteristic of gliomas, we hypothesized that CD8+ T-cells mediate immunoediting in these tumors. Experimental Design: We developed retrovirus-induced PDGF+Pten-/- murine gliomas and evaluated glioma progression and tumor immunogenicity in the absence of CD8+ T-cells by depleting this immune cell population. Furthermore,...
Tue May 19, 2020 16:30
Purpose: The cytokine interleukin 22 (IL-22) promotes tumor progression in murine models of colorectal cancer (CRC). However, the clinical significance of IL-22 in human CRC remains unclear. We sought to determine whether the IL-22 pathway is associated with prognosis in human CRC, and to identify mechanisms by which IL-22 can influence disease progression. Experimental Design: Transcriptomic data from stage II/III colon cancers in independent discovery (GSE39582 population-based cohort, N=566) and...
Tue May 19, 2020 16:30
British Journal of Cancer, Published online: 20 May 2020; doi:10.1038/s41416-020-0859-xFatal prostate cancer incidence trends in the United States and England by race, stage, and treatment
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British Journal of Cancer, Published online: 20 May 2020; doi:10.1038/s41416-020-0867-xNeoadjuvant modified FOLFIRINOX followed by postoperative gemcitabine in borderline resectable pancreatic adenocarcinoma: a Phase 2 study for clinical and biomarker analysis
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British Journal of Cancer, Published online: 20 May 2020; doi:10.1038/s41416-020-0888-5Association of tumour and stroma PD-1, PD-L1, CD3, CD4 and CD8 expression with DCB and OS to nivolumab treatment in NSCLC patients pre-treated with chemotherapy
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Abstract Lack of substantive research experiences and technical skills mentoring during undergraduate studies leaves many underrepresented minority (URM) students unprepared to apply to competitive graduate programs. As a part of our ongoing effort to increase the pipeline for the development and training of successful URM scientists in biomedical sciences with focus on reducing cancer health disparities, the Florida-California Cancer Research Education and Engagement (CaRE2)...
Tue May 19, 2020 03:00
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