Related ArticlesPersonalized neoantigen-based immunotherapy for advanced collecting duct carcinoma: case report. J Immunother Cancer. 2020 May;8(1): Authors: Zeng Y, Zhang W, Li Z, Zheng Y, Wang Y, Chen G, Qiu L, Ke K, Su X, Cai Z, Liu J, Liu X Abstract BACKGROUND: Collecting duct carcinoma (CDC) of the kidney is a rare and highly aggressive malignant tumor with the worst prognosis among all renal cancers. Nevertheless, the first-line treatments, including...
Sat May 23, 2020 13:11
Related ArticlesPreviously undiagnosed neuroendocrine tumour mimicking breast cancer metastasis to the orbit. BMJ Case Rep. 2020 May 20;13(5): Authors: Bacorn C, Kim E, Borowsky AD, Lin LK Abstract Metastatic neuroendocrine neoplasms to the breast are rare and histopathologic overlap with mammary carcinomas has led to misdiagnosis. We present a case of a middle-aged woman with diplopia and a right medial rectus mass. Metastatic breast cancer was initially...
Sat May 23, 2020 13:11
Related ArticlesCystic liver neoplams: A single centre experience and literature review. Cir Esp. 2020 May 18;: Authors: Marcacuzco Quinto AA, Nutu OA, Rodríguez Gil Y, Manrique A, Calvo Pulido J, García-Sesma Perez-Fuentes Á, Loinaz Segurola C, Jiménez Romero C, Justo Alonso I Abstract INTRODUCTION: The hepatic cystic tumour is a very rare neoplasm, representing about 5% of all cystic liver neoplasms. The preoperative diagnosis is difficult and can...
Sat May 23, 2020 13:11
Related ArticlesClival Chordoma in an Adolescent: A Perspective from Primary Care. Korean J Fam Med. 2020 May 22;: Authors: Miptah HN, Badlishah-Sham SF, Hashim H, Ramli AS Abstract Clival chordoma is a rare malignant tumor of the brain that typically occurs in older adults. It has a high local recurrence rate and is hence associated with poor prognosis. Here, we report a case of an adolescent who presented with a 1-month history of worsening headache...
Sat May 23, 2020 13:11
Related ArticlesSkin involvement as the presenting sign of a male breast cancer. Dermatol Online J. 2020 Feb 15;26(2): Authors: Alouani I, Zerrouki N, Bouziane M, Dikhaye S, Zizi N Abstract Male breast cancer is a rare disease with an unknown etiopathogenesis. We report a case of a 50-year-old man with a breast cancer revealed by skin involvement.PMID: 32239900 [PubMed - indexed for MEDLINE]
Sat May 23, 2020 13:11
Related ArticlesAdult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene. Dermatol Online J. 2020 Feb 15;26(2): Authors: Alomran H, Kanitakis J Abstract Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare dermatosis initially described as 'comedo nevus' and renamed 'PEODDN'; it has also been referred to as linear eccrine nevus with comedones, porokeratotic eccrine ostial and...
Sat May 23, 2020 13:11
Related ArticlesViolaceous nodules in an HIV-positive man. Dermatol Online J. 2020 Feb 15;26(2): Authors: Scott BL, Dominguez AR, Nguyen KD Abstract Plasmablastic lymphoma (PBL) is a rare and aggressive malignancy associated with immunosuppression and the oncogenic effects of the Epstein-Barr virus (EBV). We present an HIV-positive man with PBL that presented as ulcers and violaceous exophytic nodules on the legs. The clinical features, histologic appearance,...
Sat May 23, 2020 13:11
Related ArticlesThe complex genetic landscape of familial MDS and AML reveals pathogenic germline variants. Nat Commun. 2020 02 25;11(1):1044 Authors: Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N, Wang J, Tummala H, Al Seraihi AFH, Alnajar J, Bewicke-Copley F, Armes H, Barnett M, Bloor A, Bödör C, Bowen D, Fenaux P, Green A, Hallahan A, Hjorth-Hansen H, Hossain U, Killick S, Lawson S, Layton M, Male AM, Marsh J, Mehta P, Mous...
Sat May 23, 2020 13:11
Related ArticlesPrecision medicine in gastrointestinal stromal tumors. Discov Med. 2019 Nov-Dec;28(155):267-276 Authors: Florou V, Trent JC, Wilky BA Abstract Gastrointestinal stromal tumors (GISTs) are rare soft tissue sarcomas of the gastrointestinal tract, with most carrying conserved driver mutations in the tyrosine kinase receptors KIT or PDGFRα. The use of targeted therapy against these mutations in GISTs is one of the most successful examples...
Sat May 23, 2020 13:11
Related ArticlesActivating BRAF mutation in sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: two case reports and review of the literature. J Med Case Rep. 2019 Dec 28;13(1):385 Authors: Sukumar JS, Sukumar S, Purohit D, Welch BJ, Balani J, Yan S, Hathiramani SS Abstract BACKGROUND: Sclerosing mucoepidermoid carcinoma with eosinophilia is a rare form of thyroid carcinoma. The underlying molecular mechanisms of sclerosing...
Sat May 23, 2020 13:11
Related ArticlesAn Adult Case of Nasal Chondromesenchymal Hamartoma: Imaging Characteristics Including Diffusion-Weighted Images. Acta Med Okayama. 2019 Dec;73(6):529-532 Authors: Kitayama T, Akaki S, Hisazumi K, Yoshio K, Inoue D, Tajiri N, Shiode T, Kanazawa S, Fujimoto S, Kanai K, Hirata Y Abstract Nasal chondromesenchymal hamartoma (NCMH), a rare, benign, nasal cavity tumor, typically occurs in children. Differential diagnosis is difficult because...
Sat May 23, 2020 13:11
Related ArticlesRecurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria. J Med Case Rep. 2019 Dec 21;13(1):378 Authors: Ismail S, Alaidi S, Jouni S, Kassab Y, Al-Shehabi Z Abstract BACKGROUND: Fibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not...
Sat May 23, 2020 13:11
Related ArticlesEndonasal surgery for suprasellar germ cell tumors: two cases and review of the literature. Acta Neurochir (Wien). 2019 08;161(8):1699-1704 Authors: Arnaout MM, Gerges MM, Cummock MD, El Asri AC, Greenfield JP, Anand VK, Schwartz TH Abstract Germ cell tumors are rare malignant tumors frequently located in the suprasellar region. Definitive treatment is chemotherapy and radiation. However, in some circumstances, surgery is indicated for...
Sat May 23, 2020 13:11
Related ArticlesHow I do it: endoscopic supracerebellar infratentorial approach for torcular meningioma removal. Acta Neurochir (Wien). 2019 08;161(8):1669-1673 Authors: Ishikawa T, Watanabe T, Seki Y Abstract BACKGROUND: Torcular meningioma is a rare type of brain tumor with few reports regarding the appropriate resection approach for this disease. In cases without sinus occlusion, surgeons are advised to spare the sinus; however, the sinus may interfere...
Sat May 23, 2020 13:11
Related ArticlesMetastatic Pleomorphic Adenoma in the infratemporal fossa and neck following total parotidectomy after 30 years. Med J Malaysia. 2019 04;74(2):85-86 Authors: Wong DKC, Muhamad NS, Sobri SS, Amin WAM, Yusof Z Abstract Metastasising pleomorphic adenoma is rare and may occur years after surgical excision of a pleomorphic adenoma (PA). We present a 61-year-old woman with a right infratemporal PA with metastases to the cervical lymph nodes...
Sat May 23, 2020 13:11
Related ArticlesMultimodal imaging evaluation of combined hamartoma of the retina and retinal pigment epithelium. Eur J Ophthalmol. 2020 May;30(3):595-599 Authors: Scupola A, Grimaldi G, Sammarco MG, Sasso P, Marullo M, Blasi MA Abstract PURPOSE: Combined hamartoma of the retina and retinal pigment epithelium is a rare benign tumor characterized by a variable combination of glial, vascular, and pigmented components. The purpose of our study was to analyze...
Sat May 23, 2020 13:11
Inferior vena cava resection and reconstruction with a peritoneal patch for a leiomyosarcoma: A case report. Int J Surg Case Rep. 2020 May 08;71:37-40 Authors: Risaliti M, Fortuna L, Bartolini I, Taddei A, Muiesan P Abstract INTRODUCTION: Leiomyosarcomas (LMs) of the inferior vena cava (IVC) are very rare neoplasms seldom reported in the literature. The majority of patients does not present with specific abdominal pain and IVC LMs are used to become...
Fri May 22, 2020 13:57
Incidence and survival of rare cancers in the US and Europe. Cancer Med. 2020 May 21;: Authors: Botta L, Gatta G, Trama A, Bernasconi A, Sharon E, Capocaccia R, Mariotto AB Abstract Geographical variability of cancer burden was almost exclusively estimated for common cancers. Since rare cancers (RC) have become an area of priority for basic and clinical research and public health organizations, this paper provides, using a common methodology, a detailed...
Fri May 22, 2020 13:57
Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study. Cancer. 2020 May 21;: Authors: Poort H, de Rooij BH, Uno H, Weng S, Ezendam NPM, van de Poll-Franse L, Wright AA Abstract BACKGROUND: Fatigue is a common and distressing symptom for patients with gynecologic cancers. Few studies have empirically examined whether it spontaneously resolves. This study was aimed at identifying longitudinal patterns...
Fri May 22, 2020 13:57
Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis. Hum Genet. 2020 May 20;: Authors: Béziat V Abstract Human papillomaviruses (HPVs) infect mucosal or cutaneous stratified epithelia. There are 5 genera and more than 200 types of HPV, each with a specific tropism and virulence. HPV infections are typically asymptomatic or result in benign tumors, which may be disseminated or persistent in rare cases, but a...
Fri May 22, 2020 13:57
Study Protocol of the ESAP Study: Endoscopic Papillectomy vs. Surgical Ampullectomy vs. Pancreaticoduodenectomy for Ampullary Neoplasm-A Pancreas2000/EPC Study. Front Med (Lausanne). 2020;7:152 Authors: Hollenbach M, Ali EA, Auriemma F, Gulla A, Heise C, Regnér S, Gaujoux S Abstract Background: Lesions of the Ampulla of Vater are a rare condition and represent <10% of peri-ampullary neoplasms. Nevertheless, ampullary adenomas have the potential for...
Fri May 22, 2020 13:57
Intraparotid facial nerve plexiform neurofibroma in a child (case report). Ann Med Surg (Lond). 2020 Jul;55:9-12 Authors: Lekhbal A, Lyoubi H, Wydadi O, Bouzbouz A, Abada RL, Rouadi S, Roubal M, Mahtar M Abstract Background: Intraparotid facial nerve neurofibromas are benign neoplasms, extremely rare, difficult to diagnose and to manage. Only three pediatric cases have been reported in the literature. Case presentation: We report the 4th case...
Fri May 22, 2020 13:57
Related ArticlesSkeletal muscle metastasis as a first site of recurrence of cervical cancer: A case report and review of the literature. Medicine (Baltimore). 2020 May;99(19):e20056 Authors: Omokawa N, Mabuchi S, Iwai K, Kawahara N, Kawaguchi R, Sugimoto S, Ohbayashi C, Honoki K, Nagai A, Kobayashi H Abstract RATIONALE: Cervical cancer primarily spreads through direct invasion or via local lymphatics, and hematogenous metastasis is infrequent. Previous...
Fri May 22, 2020 13:57
Related ArticlesPrimary hepatoid carcinoma of the ovary: A case report and review of the literature. Medicine (Baltimore). 2020 May;99(19):e20051 Authors: Choi WK, Cho DH, Yim CY, Lee NR Abstract INTRODUCTION: Hepatoid carcinoma of the ovary (HCO) is a rare disease that originates from the ovarian surface epithelium. It is histologically characterized as hepatocellular carcinoma (HCC) with a hepatocyte-rich granular cytoplasm. PATIENT CONCERNS:...
Fri May 22, 2020 13:57
Related ArticlesPancreatoblastoma: Cytologic and histologic analysis of 12 adult cases reveals helpful criteria in their diagnosis and distinction from common mimics. Cancer Cytopathol. 2019 Nov;127(11):708-719 Authors: Reid MD, Bhattarai S, Graham RP, Pehlivanoglu B, Sigel CS, Shi J, Saqi A, Shirazi M, Xue Y, Basturk O, Adsay V Abstract BACKGROUND: Pancreatoblastoma (PBL) is a rare malignant pancreatic tumor seen predominantly in childhood, and its...
Fri May 22, 2020 13:57
Related ArticlesBile duct involvement by hepatocellular carcinoma: A rare occurrence and poor prognostic indicator in bile duct brushing samples. Cancer Cytopathol. 2019 Nov;127(11):691-699 Authors: Bhattarai S, Graham RP, Sigel CS, Shi J, Gonzalez RS, Xue Y, Krasinskas AM, HooKim K, Adsay V, Reid MD Abstract BACKGROUND: Hepatocellular carcinoma (HCC) rarely involves the biliary tree and may be inadvertently sampled on bile duct brushings (BDBs). ...
Fri May 22, 2020 13:57
Related ArticlesMyasthenia gravis induced by avelumab. Immunotherapy. 2019 10;11(14):1181-1185 Authors: Yuen C, Fleming G, Meyers M, Soliven B, Rezania K Abstract Neurological immune-related adverse events are potentially life-threatening complications of immune checkpoint inhibitors. Myasthenia gravis (MG) is a rare complication of treatment with inhibitors of programmed cell death protein 1 (PD)-1 and PD ligand 1 (PD-L1). We present a patient who developed...
Fri May 22, 2020 13:57
Related ArticlesEpidemiologic and survival trends in adult primary bone tumors of the spine. Spine J. 2019 12;19(12):1941-1949 Authors: Kerr DL, Dial BL, Lazarides AL, Catanzano AA, Lane WO, Blazer DG, Brigman BE, Mendoza-Lattes S, Eward WC, Erickson ME Abstract BACKGROUND CONTEXT: Malignant primary spinal tumors are rare making it difficult to perform large studies comparing epidemiologic, survival, and treatment trends. We investigated the largest...
Fri May 22, 2020 13:57
Related ArticlesEsophageal tuberculosis in an HIV-positive patient mimicking a spindle cell tumor. Rev Esp Patol. 2019 Jul - Sep;52(3):199-201 Authors: Suarez-Zamora DA, Palau-Lazaro MA, Rodriguez-Urrego PA Abstract Tuberculosis (TB) of the esophagus is an extremely rare condition, even in immunocompromised patients. We report the case of a 24-year-old man with a past history of HIV and pulmonary tuberculosis who presented with dysphagia and a 2cm submucosal...
Fri May 22, 2020 13:57
Related ArticlesChondroid atypical spitzoid melanocytic tumor. Rev Esp Patol. 2019 Jul - Sep;52(3):190-193 Authors: Fernandez-Flores A, Cassarino DS Abstract Chondroid stromal change is very rare in melanocytic nevi. We present a severely atypical symmetrical Spitz tumor on the right arm of a 24-years-old man. It showed maturation and occasional mitotic figures. The melanocytes were intermingled with cartilaginous stroma. The Ki67 proliferative rate...
Fri May 22, 2020 13:57
Related ArticlesA phase 2 trial of the oral smoothened inhibitor glasdegib in refractory myelodysplastic syndromes (MDS). Leuk Res. 2019 06;81:56-61 Authors: Sallman DA, Komrokji RS, Sweet KL, Mo Q, McGraw KL, Duong VH, Zhang L, Nardelli LA, Padron E, List AF, Lancet JE Abstract Hypomethylating agent (HMA) failure myelodysplastic syndrome (MDS) patients have poor outcomes and urgent need for novel therapies. Hedgehog pathway signaling upregulation plays...
Fri May 22, 2020 13:57
Related ArticlesMolecular features, prognosis, and novel treatment options for pediatric acute megakaryoblastic leukemia. Expert Rev Hematol. 2019 05;12(5):285-293 Authors: De Marchi F, Araki M, Komatsu N Abstract INTRODUCTION: Acute megakaryoblastic leukemia (AMegL) is a rare hematological neoplasm most often diagnosed in children and is commonly associated with Down's syndrome (DS). Although AMegLs are specifically characterized and typically diagnosed...
Fri May 22, 2020 13:57
Related ArticlesRelevant updates in systemic mastocytosis. Leuk Res. 2019 06;81:10-18 Authors: Coltoff A, Mascarenhas J Abstract Systemic Mastocytosis (SM) is a rare myeloproliferative neoplasm (MPN) that is characterized by a clonal proliferation of mast cells (MCs). The symptoms and clinical presentation of SM are the result of both MC proliferation as well as activation and degranulation, causing hyperactive and over-exaggerated hypersensitivity...
Fri May 22, 2020 13:57
Related ArticlesSynchronous renal cell carcinoma and pheochromocytoma presenting as acute decompensated heart failure. J Postgrad Med. 2019 Jan-Mar;65(1):44-46 Authors: Chen HH, Wu ST, Lin YC, Lin CS Abstract We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right...
Fri May 22, 2020 13:57
Related ArticlesSurvival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort. Eur J Cancer. 2019 03;109:36-50 Authors: Smeland S, Bielack SS, Whelan J, Bernstein M, Hogendoorn P, Krailo MD, Gorlick R, Janeway KA, Ingleby FC, Anninga J, Antal I, Arndt C, Brown KLB, Butterfass-Bahloul T, Calaminus G, Capra M, Dhooge C, Eriksson M, Flanagan AM, Friedel G, Gebhardt MC, Gelderblom H, Goldsby...
Fri May 22, 2020 13:57
Related ArticlesNatural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. Lancet Diabetes Endocrinol. 2019 03;7(3):213-220 Authors: Castinetti F, Waguespack SG, Machens A, Uchino S, Hasse-Lazar K, Sanso G, Else T, Dvorakova S, Qi XP, Elisei R, Maia AL, Glod J, Lourenço DM, Valdes N, Mathiesen J, Wohllk N, Bandgar TR, Drui D, Korbonits M, Druce MR, Brain C, Kurzawinski...
Fri May 22, 2020 13:57
Related ArticlesCreating a capture zone in microfluidic flow greatly enhances the throughput and efficiency of cancer detection. Biomaterials. 2019 03;197:161-170 Authors: Sun M, Xu J, Shamul JG, Lu X, Husain S, He X Abstract Efficient capture of rare circulating tumor cells (CTCs) from blood samples is valuable for early cancer detection to improve the management of cancer. In this work, we developed a highly efficient microfluidics-based method for...
Fri May 22, 2020 13:57
Related ArticlesA multinational, multi-tumour basket study in very rare cancer types: The European Organization for Research and Treatment of Cancer phase II 90101 'CREATE' trial. Eur J Cancer. 2019 03;109:192-195 Authors: Péron J, Marreaud S, Staelens D, Raveloarivahy T, Nzokirantevye A, Flament J, Steuve J, Lia M, Collette L, Schöffski P PMID: 30655100 [PubMed - indexed for MEDLINE]
Fri May 22, 2020 13:57
Related ArticlesExpression profiles of exosomal miRNAs isolated from plasma of patients with desmoplastic small round cell tumor. Epigenomics. 2019 04;11(5):489-500 Authors: Colletti M, Paolini A, Galardi A, Di Paolo V, Pascucci L, Russo I, De Angelis B, Peinado H, De Vito R, Milano GM, Locatelli F, Masotti A, Di Giannatale A Abstract AIM: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive mesenchymal tumor, lacking biomarkers for diagnosis,...
Fri May 22, 2020 13:57
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