Arrhythmogenic mutations and impaired calmodulin Ca2+ -sensing go hand in EF-hand. J Physiol. 2020 May 23;: Authors: Noble M, Sirko C, Denezis PW PMID: 32445487 [PubMed - as supplied by publisher]
Sun May 24, 2020 15:47
Linking lymphatic function to disease. J Physiol. 2020 May 23;: Authors: Murfee WL, Breslin JW PMID: 32445485 [PubMed - as supplied by publisher]
Sun May 24, 2020 15:47
Transcapillary PO2 Gradients in contracting muscles across the fibre type and oxidative continuum. J Physiol. 2020 May 22;: Authors: Colburn TD, Hirai DM, Craig JC, Ferguson SK, Weber RE, Schulze KM, Behnke BJ, Musch TI, Poole DC Abstract KEY POINTS: Within skeletal muscle the greatest resistance to oxygen transport is thought to reside across the short distance at the red blood cell-myocyte interface. These structures generate a significant transmural...
Sun May 24, 2020 15:47
Blood viscosity and its determinants in the highest city in the world. J Physiol. 2020 May 22;: Authors: Stauffer E, Loyrion E, Hancco I, Waltz X, Ulliel-Roche M, Oberholzer L, Robach P, Pichon A, Brugniaux JV, Bouzat P, Doutreleau S, Connes P, Verges S Abstract KEY POINTS: Highlanders developed unique adaptative mechanisms to chronic hypoxic exposure, including substantial haemoglobin and haematocrit increases. A significant proportion of populations...
Sun May 24, 2020 15:47
Publication date: Available online 23 May 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Carlo Buonerba, Matteo Ferro, Pasquale Dolce, Felice Crocetto, Antonio Verde, Giuseppe Lucarelli, Luca Scafuri, Sergio Facchini, Angelo Vaia, Alfredo Marinelli, Daniela Terracciano, Liliana Montella, Nicola Longo, Ciro Imbimbo, Vincenzo Mirone, Giuseppe Di Lorenzo, Sabino De Placido, Guru Sonpavde
Sun May 24, 2020 15:47
Publication date: Available online 22 May 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Hagar Elghazawy, Bhanu Prasad Venkatesulu, Vivek Verma, Bala Pushpharaj, Dominique J. Monlezun, Konstantinos Marmagkiolis, Cezar A. Iliescu
Sat May 23, 2020 13:54
Publication date: Available online 22 May 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Arunan Jeyakumar, Terence Chua, Alfred King-Yin Lam, Vinod Gopalan
Fri May 22, 2020 14:34
Publication date: Available online 21 May 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Giandomenico Roviello, Sara Fancelli, Marta Rita Gatta Michelet, Giuseppe Aprile, Stefania Nobili, Franco Roviello, Fabio Cianchi, Enrico Mini, Daniele Lavacchi
Fri May 22, 2020 14:34
Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Doss BL, Pan M, Gupta M, Grenci G, Mège RM, Lim CT, Sheetz MP, Voituriez R, Ladoux B Abstract Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal adhesion behavior is locally regulated by stiffness; however, how cells globally adapt, detect, and respond to rigidity remains unknown....
Sun May 24, 2020 15:42
Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Xie J, Xia L, Xiang W, He W, Yin H, Wang F, Gao T, Qi W, Yang Z, Yang X, Zhou T, Gao G Abstract Metastatic colorectal cancer (mCRC) patients have poor overall survival despite using irinotecan- or oxaliplatin-based chemotherapy combined with anti-EGFR (epidermal growth...
Sun May 24, 2020 15:42
Time to activin on pathogenic T cells. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Ebering A, Waisman A PMID: 32444489 [PubMed - as supplied by publisher]
Sun May 24, 2020 15:42
The 6-4 photoproduct is the trigger of UV-induced replication blockage and ATR activation. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Hung KF, Sidorova JM, Nghiem P, Kawasumi M Abstract The most prevalent human carcinogen is sunlight-associated ultraviolet (UV), a physiologic dose of which generates thousands of DNA lesions per cell, mostly of two types: cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). It has not been possible,...
Sun May 24, 2020 15:42
Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Chaudhry MZ, Casalegno-Garduno R, Sitnik KM, Kasmapour B, Pulm AK, Brizic I, Eiz-Vesper B, Moosmann A, Jonjic S, Mocarski ES, Cicin-Sain L Abstract Viral immune evasion is currently understood to focus on deflecting CD8 T cell recognition of infected cells by disrupting antigen presentation pathways....
Sun May 24, 2020 15:42
Hydrodynamic and frictional modulation of deformations in switchable colloidal crystallites. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Lee YK, Li X, Perdikaris P, Crocker JC, Reina C, Sinno T Abstract Displacive transformations in colloidal crystals may offer a pathway for increasing the diversity of accessible configurations without the need to engineer particle shape or interaction complexity. To date, binary crystals composed of spherically...
Sun May 24, 2020 15:42
Magnetotransport studies of Fe vacancy-ordered Fe4+δSe5 nanowires. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Yeh KY, Lo TS, Wu PM, Chang-Liao KS, Wang MJ, Wu MK Abstract We studied the electrical transport of Fe4+δSe5 single-crystal nanowires exhibiting √5 × √5 Fe-vacancy order and mixed valence of Fe. Fe4+δSe5 compound has been identified as the parent phase of FeSe superconductor. A first-order metal-insulator (MI) transition of transition temperature...
Sun May 24, 2020 15:42
The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Padrón R, Ma W, Duno-Miranda S, Koubassova N, Lee KH, Pinto A, Alamo L, Bolaños P, Tsaturyan A, Irving T, Craig R Abstract Striated muscle contraction involves sliding of actin thin filaments along myosin thick filaments, controlled by calcium through thin filament activation....
Sun May 24, 2020 15:42
Complete encapsulation of sulfur through interfacial energy control of sulfur solutions for high-performance Li-S batteries. Proc Natl Acad Sci U S A. 2020 May 22;: Authors: Gueon D, Ju MY, Moon JH Abstract Complete encapsulation of high-content sulfur in porous carbon is crucial for high performance Li-S batteries. To this end, unlike conventional approaches to control the pore of carbon hosts, we demonstrate controlling the interfacial energy of the...
Sun May 24, 2020 15:42
Related ArticlesUltrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils. Proc Natl Acad Sci U S A. 2020 May 21;: Authors: Törnquist M, Cukalevski R, Weininger U, Meisl G, Knowles TPJ, Leiding T, Malmendal A, Akke M, Linse S Abstract The nucleation of Alzheimer-associated Aβ peptide monomers can be catalyzed by preexisting Aβ fibrils. This leads to autocatalytic amplification of aggregate mass and...
Sat May 23, 2020 15:24
Related ArticlesUltrasensitive detection of malignant melanoma using PET molecular imaging probes. Proc Natl Acad Sci U S A. 2020 May 21;: Authors: Pyo A, Kim DY, Kim H, Lim D, Kwon SY, Kang SR, Kim HS, Bom HS, Min JJ Abstract Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis...
Sat May 23, 2020 15:24
Related ArticlesTRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection. Proc Natl Acad Sci U S A. 2020 May 21;: Authors: Reilly EC, Lambert Emo K, Buckley PM, Reilly NS, Smith I, Chaves FA, Yang H, Oakes PW, Topham DJ Abstract Tissue-resident memory CD8 T (TRM) cells are a unique immune memory subset that develops and remains in peripheral tissues at the site of infection, providing future...
Sat May 23, 2020 15:24
Related ArticlesPlasmodium vivax spleen-dependent genes encode antigens associated with cytoadhesion and clinical protection. Proc Natl Acad Sci U S A. 2020 May 21;: Authors: Fernandez-Becerra C, Bernabeu M, Castellanos A, Correa BR, Obadia T, Ramirez M, Rui E, Hentzschel F, López-Montañés M, Ayllon-Hermida A, Martin-Jaular L, Elizalde-Torrent A, Siba P, Vêncio RZ, Arevalo-Herrera M, Herrera S, Alonso PL, Mueller I, Del Portillo HA Abstract Plasmodium...
Sat May 23, 2020 15:24
Related ArticlesMolecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics. Proc Natl Acad Sci U S A. 2020 May 21;: Authors: Patel G, Fury W, Yang H, Gomez-Caraballo M, Bai Y, Yang T, Adler C, Wei Y, Ni M, Schmitt H, Hu Y, Yancopoulos G, Stamer WD, Romano C Abstract The conventional outflow pathway is a complex tissue responsible for maintaining intraocular pressure (IOP) homeostasis. The coordinated effort of multiple...
Sat May 23, 2020 15:24
Related ArticlesReply to Sánchez-Pacheco et al., Chookajorn, and Mavian et al.: Explaining phylogenetic network analysis of SARS-CoV-2 genomes. Proc Natl Acad Sci U S A. 2020 May 21;: Authors: Forster P, Forster L, Renfrew C, Forster M PMID: 32439706 [PubMed - as supplied by publisher]
Sat May 23, 2020 15:24
Related ArticlesThe transient joys of others-neural ensembles encode social approach in bonded voles. Proc Natl Acad Sci U S A. 2020 May 21;: Authors: Phelps SM, Gustison ML PMID: 32439705 [PubMed - as supplied by publisher]
Sat May 23, 2020 15:24
Protein phosphatase 2A promotes stomatal development by stabilizing SPEECHLESS in Arabidopsis. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Bian C, Guo X, Zhang Y, Wang L, Xu T, DeLong A, Dong J Abstract Stomatal guard cells control gas exchange that allows plant photosynthesis but limits water loss from plants to the environment. In Arabidopsis, stomatal development is mainly controlled by a signaling pathway comprising peptide ligands, membrane...
Fri May 22, 2020 15:08
Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Verma D, Church TM, Swaminathan S Abstract Epstein-Barr virus (EBV) is associated with epithelial and lymphoid malignancies, establishes latent infection in memory B cells, and intermittently produces infectious virions through lytic replication. Released virions play a key role in latent reservoir...
Fri May 22, 2020 15:08
Transition between solid and liquid state of yield-stress fluids under purely extensional deformations. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Varchanis S, Haward SJ, Hopkins CC, Syrakos A, Shen AQ, Dimakopoulos Y, Tsamopoulos J Abstract We report experimental microfluidic measurements and theoretical modeling of elastoviscoplastic materials under steady, planar elongation. Employing a theory that allows the solid state to deform, we predict...
Fri May 22, 2020 15:08
Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Lu WC, Saha A, Yan W, Garrison K, Lamb C, Pandey R, Irani S, Lodi A, Lu X, Tiziani S, Zhang YJ, Georgiou G, DiGiovanni J, Stone E Abstract Extensive studies in prostate cancer and other malignancies have revealed that l-methionine (l-Met) and its metabolites play a critical...
Fri May 22, 2020 15:08
Induction of defense in cereals by 4-fluorophenoxyacetic acid suppresses insect pest populations and increases crop yields in the field. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Wang W, Zhou P, Mo X, Hu L, Jin N, Chen X, Yu Z, Meng J, Erb M, Shang Z, Gatehouse AMR, Wu J, Lou Y Abstract Synthetic chemical elicitors, so called plant strengtheners, can protect plants from pests and pathogens. Most plant strengtheners act by modifying defense signaling...
Fri May 22, 2020 15:08
Viral infection impacts transposable element transcript amounts in Drosophila. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Roy M, Viginier B, Saint-Michel É, Arnaud F, Ratinier M, Fablet M Abstract Transposable elements (TEs) are genomic parasites that are found in all genomes, some of which display sequence similarity to certain viruses. In insects, TEs are controlled by the Piwi-interacting small interfering RNA (piRNA) pathway in gonads, while...
Fri May 22, 2020 15:08
Untangling the sequence of events during the S2 → S3 transition in photosystem II and implications for the water oxidation mechanism. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Ibrahim M, Fransson T, Chatterjee R, Cheah MH, Hussein R, Lassalle L, Sutherlin KD, Young ID, Fuller FD, Gul S, Kim IS, Simon PS, de Lichtenberg C, Chernev P, Bogacz I, Pham CC, Orville AM, Saichek N, Northen T, Batyuk A, Carbajo S, Alonso-Mori R, Tono K, Owada S, Bhowmick A, Bolotovsky R,...
Fri May 22, 2020 15:08
Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Cheng SY, Cipi J, Ma S, Hafler BP, Kanadia RN, Brush RS, Agbaga MP, Punzo C Abstract Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. While the histopathology of the different disease stages is well characterized, the cause underlying the progression, from...
Fri May 22, 2020 15:08
As diversity increases, people paradoxically perceive social groups as more similar. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Bai X, Ramos MR, Fiske ST Abstract With globalization and immigration, societal contexts differ in sheer variety of resident social groups. Social diversity challenges individuals to think in new ways about new kinds of people and where their groups all stand, relative to each other. However, psychological science does...
Fri May 22, 2020 15:08
Opinion: The unintended consequences of antiflaring policies-and measures for mitigation. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Calel R, Mahdavi P PMID: 32434912 [PubMed - as supplied by publisher]
Fri May 22, 2020 15:08
CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Blaize G, Daniels-Treffandier H, Aloulou M, Rouquié N, Yang C, Marcellin M, Gador M, Benamar M, Ducatez M, Song KD, Burlet-Schiltz O, Saoudi A, Love PE, Fazilleau N, Gonzalez de Peredo A, Lesourne R Abstract CD5 is characterized as an inhibitory coreceptor with an important regulatory...
Fri May 22, 2020 15:08
Multiple areas of the cerebral cortex influence the stomach. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Levinthal DJ, Strick PL Abstract The central nervous system both influences and is influenced by the gastrointestinal system. Most research on this gut-brain connection has focused on how ascending signals from the gut and its microbiome alter brain function. Less attention has focused on how descending signals from the central nervous system...
Fri May 22, 2020 15:08
Turning the body into a clock: Accurate timing is facilitated by simple stereotyped interactions with the environment. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Safaie M, Jurado-Parras MT, Sarno S, Louis J, Karoutchi C, Petit LF, Pasquet MO, Eloy C, Robbe D Abstract How animals adapt their behavior according to regular time intervals between events is not well understood, especially when intervals last several seconds. One possibility is that...
Fri May 22, 2020 15:08
Caring for the future can turn tragedy into comedy for long-term collective action under risk of collapse. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Barfuss W, Donges JF, Vasconcelos VV, Kurths J, Levin SA Abstract We will need collective action to avoid catastrophic climate change, and this will require valuing the long term as well as the short term. Shortsightedness and uncertainty have hindered progress in resolving this collective action...
Fri May 22, 2020 15:08
DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery. Proc Natl Acad Sci U S A. 2020 May 20;: Authors: Kapolka NJ, Taghon GJ, Rowe JB, Morgan WM, Enten JF, Lambert NA, Isom DG Abstract More than 800 G protein-coupled receptors (GPCRs) comprise the largest class of membrane receptors in humans. While there is ample biological understanding and many approved drugs for prototypic GPCRs, most...
Fri May 22, 2020 15:08
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