Related ArticlesPreservation of fertility in patients with hematological malignancies. Jpn J Clin Oncol. 2020 May 18;: Authors: Ashizawa M, Kanda Y Abstract Oncofertility is the medical field that bridges oncology and reproduction that seeks to give healthcare providers and patients the opportunity to optimize residual fertility. The treatment for hematological malignancies carries gonadal toxicity, so that the preservation of fertility should be considered...
Tue May 19, 2020 13:56
Related ArticlesA Dedicated Education Unit and a Novel Resident Nurse Transition-to-Practice Program in an Ambulatory Oncology Setting. Semin Oncol Nurs. 2020 May 15;:151027 Authors: Kidd S, Christiansen K, Coumar A, Williams J, Ito K, Petersen A, Niculescu R, Eisenberg S, Schwab D, Wojnar DM, Jablonski A, Shannon Dorcy K Abstract OBJECTIVE: To summarize an innovative initiative in oncology nurse workforce development that addresses critical current...
Tue May 19, 2020 13:56
Related ArticlesThe opportunities and shortcomings of using big data and national databases for sarcoma research. Cancer. 2019 09 01;125(17):2926-2934 Authors: Lyu HG, Haider AH, Landman AB, Raut CP Abstract The rarity and heterogeneity of sarcomas make performing appropriately powered studies challenging and magnify the significance of large databases in sarcoma research. Established large tumor registries and population-based databases have become...
Tue May 19, 2020 13:56
Related ArticlesExternal validation of a combined PET and MRI radiomics model for prediction of recurrence in cervical cancer patients treated with chemoradiotherapy. Eur J Nucl Med Mol Imaging. 2019 Apr;46(4):864-877 Authors: Lucia F, Visvikis D, Vallières M, Desseroit MC, Miranda O, Robin P, Bonaffini PA, Alfieri J, Masson I, Mervoyer A, Reinhold C, Pradier O, Hatt M, Schick U Abstract PURPOSE: The aim of this study was to validate previously developed...
Tue May 19, 2020 13:56
Related ArticlesSteroid-Induced Diabetes Ketoacidosis in an Immune Thrombocytopenia Patient: A Case Report and Literature Review. Am J Case Rep. 2020 May 18;21:e923372 Authors: Alakkas Z, Alzaedi OA, Somannavar SS, Alfaifi A Abstract BACKGROUND Steroids are used as anti-inflammatory agents, administered for a variety of medical conditions, either as short- or long-term treatment. Steroid use is associated with many adverse effects, including hyperglycemia,...
Tue May 19, 2020 13:55
Related ArticlesImplantation of Squamous Cell Carcinoma in a Free Flap Donor Site. Ann Otol Rhinol Laryngol. 2020 May 17;:3489420917418 Authors: Pichardo P, Purdy N, Haugen T Abstract INTRODUCTION: It is well known that malignant cells can be implanted at distant donor sites due to iatrogenic surgical contamination. Only a small number of reports, however, have been published describing this. CASE PRESENTATION: We present a case of oral...
Tue May 19, 2020 13:52
Publication date: September 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 31Author(s): Il-hyung Kim, Yesel Kim, Jinhyuk Choi, Jeong-Kui Ku
Tue May 19, 2020 13:46
ATP binding cassette subfamily A member 8 (ABCA8) belongs to the ATP binding cassette (ABC) transporter superfamily. ABCA8 is a transmembrane transporter responsible for the transport of organics, such as chol...
Tue May 19, 2020 03:00
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive ...
Mon May 18, 2020 03:00
Abstract Purpose of Review There has been an explosion of monoclonal antibodies in the treatment of severe uncontrolled adult asthma. Studies have now been published in severe pediatric asthma. There are numerous questions that need to be answered in determining whether these modalities are appropriate and safe in children. Recent Findings ...
Tue May 19, 2020 03:00
Abstract Purpose of Review This systematic review and meta-analysis evaluated the association between asthma and mouth breathing. We performed a systematic search in the PubMed, SCOPUS, Lilacs, Web of Science, Google Scholar and OpenThesis databases. Recent Findings Asthma is defined as a heterogeneous disease characterized by variable...
Tue May 19, 2020 03:00
Abstract Purpose of Review The objective of this article is to provide a recent update of the association between allergic inflammation and chronic rhinosinusitis. The systematic approach of this review article critically evaluates the literature published over the past few years and summarizes the specific pathophysiologic pathway of chronic sinonasal inflammation that has been postulated. ...
Tue May 19, 2020 03:00
Abstract Purpose of Review Pathogenesis-related class 10 (PR-10) proteins are highly conserved plant proteins, which are induced in response to abiotic and biotic stress factors. To date, no unique biological function could be assigned to them. Rather a more general role of PR-10 in plant development and defense mechanisms has been proposed. In addition, some PR-10 proteins act as allergens by triggering allergic symptoms in sensitized...
Tue May 19, 2020 03:00
Abstract Purpose of Review Allergic rhinitis and allergic asthma are well-described disease entities with broad exposure in clinical and research allergy forums. Associations between allergic inflammation and upper airway diseases of chronic laryngitis, otitis media, obstructive sleep apnea, and oral allergy syndrome are less well understood and described in the literature. ...
Tue May 19, 2020 03:00
Abstract Purpose of Reviesw Local respiratory allergy (LRA) is an eosinophilic phenotype of chronic airway disease. Three entities have been described within the LRA spectrum: local allergic rhinitis (LAR) and local allergic asthma (LAA) in non-atopic patients, and dual allergic rhinitis (DAR) in atopic patients (coexistence of LAR and allergic rhinitis). In this article, we aim to review the current evidence on the therapeutic...
Tue May 19, 2020 03:00
Abstract Purpose of Review Chronic rhinosinusitis (CRS) is a heterogenous disease process affecting a significant proportion of the population and impacting quality of life and productivity. Historically, CRS has been classified broadly into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Increased understanding regarding unique presentations of CRS subsets and their underlying inflammatory profiles has led...
Tue May 19, 2020 03:00
Abstract Purpose of Review Local allergic rhinitis (LAR) represents a diagnostic and therapeutic challenge for clinicians. Even though it affects a considerable number of chronic rhinitis patients and a significant number of articles regarding prevalence, evolution, diagnosis, and treatment have been published, the condition remains still largely unrecognized and therefore misdiagnosed and mistreated. ...
Tue May 19, 2020 03:00
Related ArticlesPalliative care physicians' perspectives of management for terminally ill cancer patients with death rattle: a nationwide survey. Jpn J Clin Oncol. 2020 May 18;: Authors: Matsunuma R, Suzuki K, Matsuda Y, Mori M, Watanabe H, Yamaguchi T Abstract Death rattle occurs during the last days of life, and relatives of those afflicted frequently report that it is very distressful. However, there is no effective treatment for it. The purpose of...
Tue May 19, 2020 13:30
Related ArticlesConcordance between treatment recommendations provided by IBM Watson for Oncology and a multidisciplinary tumor board for breast cancer in China. Jpn J Clin Oncol. 2020 May 18;: Authors: Zhao X, Zhang Y, Ma X, Chen Y, Xi J, Yin X, Kang H, Guan H, Dai Z, Liu D, Zhao F, Sun C, Li Z, Zhang S Abstract OBJECTIVE: Watson for Oncology (WFO), an artificial intelligence from IBM Corporation, can provide a treatment plan by analyzing patient's...
Tue May 19, 2020 13:30
Related ArticlesLoss of tumor susceptibility gene 101 (TSG101) perturbs endoplasmic reticulum structure and function. Biochim Biophys Acta Mol Cell Res. 2020 May 15;:118741 Authors: Kaul Z, Mookherjee D, Das S, Chatterjee D, Chakrabarti S, Chakrabarti O Abstract Tumor susceptibility gene 101 (TSG101), an ESCRT-I protein, is implicated in multiple cellular processes and its functional depletion can lead to blocked lysosomal degradation, cell cycle...
Tue May 19, 2020 13:22
Related ArticlesChe-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription. Nucleic Acids Res. 2020 May 18;: Authors: Sorino C, Catena V, Bruno T, De Nicola F, Scalera S, Bossi G, Fabretti F, Mano M, De Smaele E, Fanciulli M, Iezzi S Abstract Originally identified as an RNA polymerase II interactor, Che-1/AATF (Che-1) has now been recognized as a multifunctional protein involved in cell-cycle regulation and cancer...
Tue May 19, 2020 13:22
Related ArticlesThe Evolution of Human Cancer Gene Duplications across Mammals. Mol Biol Evol. 2020 May 18;: Authors: Tollis M, Schneider-Utaka AK, Maley CC Abstract Cancer is caused by genetic alterations that affect cellular fitness, and multicellular organisms have evolved mechanisms to suppress cancer such as cell cycle checkpoints and apoptosis. These pathways may be enhanced by the addition of tumor suppressor gene paralogs or deletion of oncogenes....
Tue May 19, 2020 13:22
Related ArticlesEssential Oils of Lemongrass (Cymbopogon citratus Stapf) Induces Apoptosis and Cell Cycle Arrest in A549 Lung Cancer Cells. Biomed Res Int. 2020;2020:5924856 Authors: Trang DT, Hoang TKV, Nguyen TTM, Van Cuong P, Dang NH, Dang HD, Nguyen Quang T, Dat NT Abstract Essential oils were extracted from the culm and leaf of Cymbopogon citratus collected from different regions of Vietnam and analyzed using GC/MS. The results showed that citral...
Tue May 19, 2020 13:22
Related ArticlesResearch Progress on Chemical Constituents and Anticancer Pharmacological Activities of Euphorbia lunulata Bunge. Biomed Res Int. 2020;2020:3618941 Authors: Wang Y, Yu X, Wang L, Zhang F, Zhang Y Abstract Euphorbia lunulata Bunge (ELB) is a traditional Chinese medicine possessing the functions of expectoration, cough relief, asthma relief, detoxification, and itching relief. Modern pharmacological studies have showed that ELB exhibits...
Tue May 19, 2020 13:22
Related ArticlesAccumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma. Biomed Res Int. 2020;2020:1631843 Authors: Yang Y, Mei Q Abstract AGO2 (Argonaute RISC Catalytic Component 2) plays an important role in small RNA-guided gene silencing processes. It has been implied in tumorigenesis of different types of tumors. In this study, we found that AGO2 expression was remarkably increased in human hepatocellular carcinoma (HCC)...
Tue May 19, 2020 13:22
Related ArticlesNovel indole hydrazide derivatives: Synthesis and their antiproliferative activities through inducing apoptosis and DNA damage. Arch Pharm (Weinheim). 2020 May 17;:e2000059 Authors: Kilic-Kurt Z, Acar C, Ergul M, Bakar-Ates F, Altuntas TG Abstract A series of novel indole hydrazide derivatives was synthesized and evaluated for their anticancer activities. Compound 12 exhibited the highest antiproliferative activity against the MCF-7...
Tue May 19, 2020 13:22
14,15β-dihydroxyklaineanone inhibits HepG2 cell proliferation and migration through p38MAPK pathway.
Related Articles14,15β-dihydroxyklaineanone inhibits HepG2 cell proliferation and migration through p38MAPK pathway. J Pharm Pharmacol. 2020 May 17;: Authors: Pei XD, He SQ, Shen LQ, Wei JC, Li XS, Wei YY, Zhang YM, Wang XY, Lin F, He ZL, Jiang LH Abstract OBJECTIVES: Eurycoma longifolia Jack (Simaroubaceae) is commonly distributed in the Southeast Asia and Indo China, which has been shown to possess antianxiety, antibacterial, anticancer, antifungal,...
Tue May 19, 2020 13:22
Related ArticlesCDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms. Br J Cancer. 2020 May 18;: Authors: Skowron MA, Vermeulen M, Winkelhausen A, Becker TK, Bremmer F, Petzsch P, Schönberger S, Calaminus G, Köhrer K, Albers P, Nettersheim D Abstract BACKGROUND: Germ cell tumours (GCTs) are the most common solid malignancies...
Tue May 19, 2020 13:22
Related ArticlesBasal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions. J Cell Biol. 2019 09 02;218(9):2865-2875 Authors: Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M Abstract The DNA replication machinery frequently encounters impediments that slow replication fork progression and threaten timely and error-free replication. The CHK1 protein kinase is essential to deal with replication stress (RS) and...
Tue May 19, 2020 13:22
Related ArticlesSET binding to Sgo1 inhibits Sgo1-cohesin interactions and promotes chromosome segregation. J Cell Biol. 2019 08 05;218(8):2514-2528 Authors: Qu Q, Zhang Q, Yang L, Chen Y, Liu H Abstract At anaphase onset, Sgo1 function of cohesion protection must be disabled to allow timely chromosome segregation, but how this is achieved is not fully understood. Here, we show that SET, a known PP2A inhibitor, directly binds to a domain in Sgo1 in...
Tue May 19, 2020 13:22
Related ArticlesIBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis. Cell Death Dis. 2019 04 11;10(4):320 Authors: Vecchio E, Golino G, Pisano A, Albano F, Falcone C, Ceglia S, Iaccino E, Mimmi S, Fiume G, Giurato G, Britti D, Scala G, Quinto I Abstract Increasing evidence supports the involvement of IBTK in cell survival and tumor growth. Previously, we have shown that IBTK RNA interference affects...
Tue May 19, 2020 13:22
Related ArticlesImbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics. Cell Death Dis. 2019 04 05;10(4):314 Authors: Zeng X, Xu WK, Lok TM, Ma HT, Poon RYC Abstract Disrupting microtubule dynamics with spindle poisons activates the spindle-assembly checkpoint (SAC) and induces mitotic cell death. However, mitotic exit can occur prematurely without proper chromosomal segregation or cytokinesis...
Tue May 19, 2020 13:22
Related Articles[Prevention and treatment of antineoplastic drug-induced nausea and vomiting in pediatric onco-hematology: An update]. Bull Cancer. 2020 May 14;: Authors: Delmotte M, Mouffak S, Mongaret C, Michelet-Huot E, Roques G, Slimano F Abstract Antineoplastic drug induced nausea and vomiting are common adverse events in cancer care of paediatric patients ; therefore, prevention and management of these adverse events is a major concern for healthcare...
Tue May 19, 2020 13:20
Related ArticlesA rare case of invasive sinonasal carcinosarcoma. Int J Surg Case Rep. 2020 May 07;70:243-248 Authors: de Souza Cruz EL, de Moraes ATL, de Souza Neves Filho F, Carneiro Junior JT, Cruz E Silva BT, Montalli VAM, de Melo Alves Júnior S, de Jesus Viana Pinheiro J Abstract INTRODUCTION: Carcinosarcomas are rare malignant neoplasms formed by embryonic tissues (ectoderm and mesoderm) and present remarkably aggressive character with unfavourable...
Tue May 19, 2020 13:17
Related ArticlesThe first malignant primary hepatic glomus tumor: A case report. Int J Surg Case Rep. 2020 May 11;70:197-200 Authors: Aversa JG, Monroe C, Levi A, Papanicolau-Sengos A, Kleiner DE, Hernandez JM Abstract INTRODUCTION: Glomus tumors (GTs) are rare neoplasms that originate from the modified smooth muscle cells of glomus bodies and occasionally arise from visceral primary sites. All previously reported primary hepatic GTs were benign. Here...
Tue May 19, 2020 13:17
Related ArticlesRecommendations for long-term follow-up of adults with heritable retinoblastoma. Ophthalmology. 2020 May 15;: Authors: Tonorezos ES, Friedman DN, Barnea D, Bosscha MI, Chantada G, Dommering CJ, de Graaf P, Dunkel IJ, Fabius AWM, Francis JH, Greer MC, Kleinerman RA, Kors WA, Laughlin S, Moll AC, Morton LM, Temming P, Tucker MA, van Leeuwen FE, Walsh MF, Oeffinger KC, Abramson DH Abstract OBJECTIVE: Generate recommendations for long-term...
Tue May 19, 2020 13:17
Related ArticlesFoundation OneTM Genomic Interrogation of Thyroid Cancers in Patients with Metastatic Disease Requiring Systemic Therapy. J Clin Endocrinol Metab. 2020 May 18;: Authors: Iñiguez-Ariza NM, Jasim S, Ryder MM, Chintakuntlawar AV, Morris JC, Hilger CR, Menefee ME, Smallridge RC, Karlin NJ, Alcain C, Bible KC Abstract CONTEXT: Clinical applications of genomic assessment of thyroid cancers are rapidly evolving. OBJECTIVES, DESIGN...
Tue May 19, 2020 13:17
Related ArticlesHow Technology Is Improving the Multidisciplinary Care of Sarcoma. Am Soc Clin Oncol Educ Book. 2020 May;40:445-462 Authors: Schaefer IM, Hong K, Kalbasi A Abstract Sarcomas are rare tumors but comprise a wide histologic spectrum. Advances in technology have emerged to address the biologic complexity and challenging diagnosis and treatment of this disease. The diagnostic approach to sarcomas has historically been based on morphologic...
Tue May 19, 2020 13:17
Related ArticlesNeuroendocrine pancreatic tumor causing chronic diarrhea in young adult, a case report. AME Case Rep. 2020;4:13 Authors: Mendes Filho O, Maués CAD, De Macedo FPPC, Monteiro SAC, Araújo EFC, Rodriguez JER, Cauduro JF, Filó MS, Bergamasco JJC, Silva Neto RA, Silva Júnior RA Abstract Secretory tumors of vasoactive intestinal polypeptides (VIPomas) are rare neuroendocrine pancreatic neoplasms usually associated with secretory diarrhea....
Tue May 19, 2020 13:17
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